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GHRISRSHYAELYGPTTGDRVRLADTELLAKVEHDATVYGDESVFGGGKTMREGMAVHGDITNADGALDF VITNVLIIDAVLGIRKADIGIRDGRIAGIGKSGNPRTMDGVDPDLVIGAGTDIRAGEGMIATAGGIDVHV HFDSAGLVEEAISSGITTMIGGGLGPVTVGITTSGPNNLARMLRAAEGFPMNFGFIANGSASSTAPLIEQ GLAGAIGYKIHEDWGATPAAIRASLDAGDELDLQVQIHTDTLNESGFFEDTMRAIGGRPIHTYHAEGAGG GHAPDIMRVVGEPYCLPSSTNPTNPYTLNTFDEHLDMVMVCHHLSPRIPEDVAFAESRIRRETIAAEDVL HDLGAISAMGSDSQGMGRIGETIARTWQLASHMRATRGPLPGDEGTGADNARILRYVAKLTINPARLFGI DHEVGSLEPGKLADIVLWEPKFFGIRPEVVFKGGFPAWSVMGEANASLMTCEPLRYRPQWAAFGRAPADV SVNFVAGAAIDAGLGQQLGLDTRLVACRGARALTKADLLHNDHLPDIRIEPDTYRVTVDGQPCVSTPMTE VPLGRRYTLK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1685 | ureC | - | 100% (571) | urease subunit alpha |
| M. gilvum PYR-GCK | Mflv_3352 | ureC | e-178 | 55.92% (574) | urease subunit alpha |
| M. gilvum PYR-GCK | Mflv_3315 | - | 3e-06 | 30.16% (126) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1881 | ureC | 1e-177 | 55.73% (576) | urease subunit alpha |
| M. tuberculosis H37Rv | Rv1850 | ureC | 1e-177 | 55.73% (576) | urease subunit alpha |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2425 | ureC | 0.0 | 56.25% (576) | urease subunit alpha |
| M. marinum M | MMAR_2724 | ureC | 0.0 | 56.42% (576) | urease alpha subunit UreC |
| M. avium 104 | MAV_5277 | - | 4e-06 | 27.78% (126) | amidohydrolase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_3625 | ureC | 1e-179 | 56.35% (575) | urease subunit alpha |
| M. thermoresistible (build 8) | TH_1059 | ureC | 1e-159 | 59.17% (480) | Urease alpha subunit ureC (Urea amidohydrolase) |
| M. ulcerans Agy99 | MUL_3029 | ureC | 1e-180 | 56.08% (576) | urease subunit alpha |
| M. vanbaalenii PYR-1 | Mvan_3082 | ureC | 1e-177 | 55.57% (574) | urease subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3625|M.smegmatis_MC2_155 -MTALSRSNYAALFGPTTG---DRIRLADTDLLIEITEDRSGGPELAGDE
Mvan_3082|M.vanbaalenii_PYR-1 -MTQLSRERYAALYGPTTG---DRIRLADTDLLIEITEDRSGGPGLAGDE
Mb1881|M.bovis_AF2122/97 -MARLSRERYAQLYGPTTG---DRIRLADTNLLVEVTEDRCGGPGLAGDE
Rv1850|M.tuberculosis_H37Rv -MARLSRERYAQLYGPTTG---DRIRLADTNLLVEVTEDRCGGPGLAGDE
MMAR_2724|M.marinum_M -MARLSRERYAQLYGPTTG---DRIRLADTDLLVEITEDRCGGPGLAGDE
MUL_3029|M.ulcerans_Agy99 -MARLSRERYAQLYGPTTG---DRIRLADTDLLVEITEDRCGGPGLAGDE
MAB_2425|M.abscessus_ATCC_1997 -MTRLTREHYAKLYGPTTG---DRIRLADTDLIIEITEDRCGGPGLAGEE
TH_1059|M.thermoresistible__bu -MTELSRARYGDLYGPTTG---DRIRLADTDLFIEITEDRSGGPGRAGDE
Mflv_1685|M.gilvum_PYR-GCK MGHRISRSHYAELYGPTTG---DRVRLADTELLAKVEHDAT----VYGDE
MAV_5277|M.avium_104 -MFDLKITGGTVVDGTGAQRYRADVGIRDGKIVDVVRADGSEAGGLATAE
:. : *. : : : * .:. : * *
MSMEG_3625|M.smegmatis_MC2_155 A---VFGGGKVLRESMG-QGRATRADGAPDTVITGAVILD-HWGIIKADI
Mvan_3082|M.vanbaalenii_PYR-1 A---VFGGGKVLRESMG-QSRVTRADGAPDTVITGAVILD-YWGIIKADI
Mb1881|M.bovis_AF2122/97 A---VFGGGKVLRESMG-QGRASRADGAPDTVITGAVIID-YWGIIKADI
Rv1850|M.tuberculosis_H37Rv A---VFGGGKVLRESMG-QGRASRADGAPDTVITGAVIID-YWGIIKADI
MMAR_2724|M.marinum_M A---VFGGGKVLRESMG-QGRVTRAEGAPDTVITGAVIID-YWGIIKADI
MUL_3029|M.ulcerans_Agy99 A---VFGGGKVLRESMG-QGRVTRAEGAPDTVITGAVIID-YWGIIKANI
MAB_2425|M.abscessus_ATCC_1997 A---VFGGGKVLRESMG-QSRLTRAGGAPDTVITGAIIID-HWGIIKADI
TH_1059|M.thermoresistible__bu A---VFGGGKVLRESMG-QGRATRADGTPDTVITGAVIVD-HWGIIKADI
Mflv_1685|M.gilvum_PYR-GCK S---VFGGGKTMREGMAVHGDITNADGALDFVITNVLIIDAVLGIRKADI
MAV_5277|M.avium_104 AAETIDATGKIVAPGFVDIHTHYDGQVSWDSLLEPSSGHG-VTTVVTGNC
: : . ** : .: . : * :: . : ..:
MSMEG_3625|M.smegmatis_MC2_155 GIRDGRIVAIGKAGNPDIMSGVHPDLVVGPSTEIIAGNGRILTAGAIDCH
Mvan_3082|M.vanbaalenii_PYR-1 GIRDGRITAIGKAGNPDIMTGVHPGLVVGPSTEIIAGNGRIVTAGAIDCH
Mb1881|M.bovis_AF2122/97 GIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCH
Rv1850|M.tuberculosis_H37Rv GIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCH
MMAR_2724|M.marinum_M GIRDGRIVAIGKAGNPNIMSGIHPDLVVGPSTEIIGGNGRIVTAGAIDCH
MUL_3029|M.ulcerans_Agy99 GIRDGRIVAIGKAGNPNIMSGIHPDLVVGPSTEIIGGNGRIVTAGAIDCH
MAB_2425|M.abscessus_ATCC_1997 GIRDGRIVGIGKAGNPDIMDGVDPALIVGPSTEIIAGNNRIVTAGGIDCH
TH_1059|M.thermoresistible__bu GIRDGRIVAIGKAGNPDIMTGVHPDLVVGPSTEIIAGNGRILTAGGVDCH
Mflv_1685|M.gilvum_PYR-GCK GIRDGRIAGIGKSGNPRTMDGVDPDLVIGAGTDIRAGEGMIATAGGIDVH
MAV_5277|M.avium_104 GVG----FAPVRPGTEQWLIELMEGVEDIPGTALTEG----ITWGWETYP
*: . :.*. : : : ..* : * * *
MSMEG_3625|M.smegmatis_MC2_155 VHLICPQIMDEALGGGITTIIGGGTGPAEGTKATTVTPGAWHLARMLESL
Mvan_3082|M.vanbaalenii_PYR-1 VHLICPQIMAEALGGGITTIVAGGTGPAEGSKATTVTPGAWHLARMLEAL
Mb1881|M.bovis_AF2122/97 VHLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPGEWHLARMLESL
Rv1850|M.tuberculosis_H37Rv VHLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPGEWHLARMLESL
MMAR_2724|M.marinum_M VHLICPQVIAEALGSGITTIIGGGTGPAEGSKSTTVTPGGWHLARMLEAL
MUL_3029|M.ulcerans_Agy99 VHLICPQVIAEALSSGITTIIGGGTGPAEGSKSTTVTPGGWHLARMLEAL
MAB_2425|M.abscessus_ATCC_1997 VHFICPQILPEALSGGITTMIGGGTGPAEGSKATTVTPGAWHLGRMLQAL
TH_1059|M.thermoresistible__bu VHLICPQLAAEALGSGITTLIGGGTGPAEGSKATTVSPGAWHLGRMLEAL
Mflv_1685|M.gilvum_PYR-GCK VHFDSAGLVEEAISSGITTMIGGGLGPVTVG---ITTSGPNNLARMLRAA
MAV_5277|M.avium_104 EYLDAIGKQKFAIDVGSQVAHGAIRAYAMGERGARNEPATPDDIEAMGRL
:: . *: * . .. . . .. . . :
MSMEG_3625|M.smegmatis_MC2_155 DSWPMNIVLLGKGNTVSADSMWEQLRGGAAGFKLHEDWGTTPAAIDACLT
Mvan_3082|M.vanbaalenii_PYR-1 DTWPLNIALLGKGNTVSAEAMWEQLRGGAAGFKLHEDWGTTPAAIDACLT
Mb1881|M.bovis_AF2122/97 DGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCLA
Rv1850|M.tuberculosis_H37Rv DGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCLA
MMAR_2724|M.marinum_M DSWPVNIALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSSPAAIDACLT
MUL_3029|M.ulcerans_Agy99 DSWPVNIALLGKGNTVNPDALWEQLRGGASGFKLHEDWGKSPAAIDACLT
MAB_2425|M.abscessus_ATCC_1997 DGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACLR
TH_1059|M.thermoresistible__bu DCWPLNIALLGKGNTVNPSALWEQLRGGAAGFKLHEDWGSTPAAIDACLT
Mflv_1685|M.gilvum_PYR-GCK EGFPMNFGFIANGSASSTAPLIEQGLAGAIGYKIHEDWGATPAAIRASLD
MAV_5277|M.avium_104 VREAIEAGALGFSTSRTMGHRAMDGEPVPGTFAAEEELFGLGRAMAAGGQ
.:: :. ..: . : . : .*: .: :
MSMEG_3625|M.smegmatis_MC2_155 VCDAAGVQAAIHTDTLN---EMGFVEDTLAAIGGRSIHAYHTEGAGGGHA
Mvan_3082|M.vanbaalenii_PYR-1 VCDAAGVQANIHTDTLN---EAGFVEHTLAAIKGRSIHAYHTEGAGGGHA
Mb1881|M.bovis_AF2122/97 VADVAGVQVALHSDTLN---ETGFVEDTIGAIAGRSIHAYHTEGAGGGHA
Rv1850|M.tuberculosis_H37Rv VADVAGVQVALHSDTLN---ETGFVEDTIGAIAGRSIHAYHTEGAGGGHA
MMAR_2724|M.marinum_M VADAAGVQVALHSDTLN---EMGFVEDTLAAIAGRSIHTYHTEGAGGGHA
MUL_3029|M.ulcerans_Agy99 VADAAGVQVALHSDTLN---EMGFVEDTLAAIAGRSIHTYHTEGAGGGHA
MAB_2425|M.abscessus_ATCC_1997 VADEADVQVALHSDTLN---ETGFVEGTLAAIGGRAIHAYHTEGAGGGHA
TH_1059|M.thermoresistible__bu VADAAGVQVALHSDTLN---EAGFVESTLAAIAGRSIHAYHTEGAGGGHA
Mflv_1685|M.gilvum_PYR-GCK AGDELDLQVQIHTDTLN---ESGFFEDTMRAIGGRPIHTYHAEGAGGGHA
MAV_5277|M.avium_104 AVFELAPQGAAGEDIIGPKKELDWMRRLSGEIDRPVSFALIQVDADPNLW
. * * :. * .:.. * .: .*. .
MSMEG_3625|M.smegmatis_MC2_155 PDIITVAGHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLKPSVPEDLA
Mvan_3082|M.vanbaalenii_PYR-1 PDIITVAGHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPSVPEDLA
Mb1881|M.bovis_AF2122/97 PDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLA
Rv1850|M.tuberculosis_H37Rv PDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLA
MMAR_2724|M.marinum_M PDIITVAAHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLA
MUL_3029|M.ulcerans_Agy99 PDIITVAAHPNVLPSSTNPTRPHTVNALDEHLDMLMVCHHLNPRIPDDLA
MAB_2425|M.abscessus_ATCC_1997 PDIITVASHPNVMPSSTNPTRPHTVNTLDEHLDMLMVCHHLNAAVPEDLA
TH_1059|M.thermoresistible__bu PDIITVAAHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLHPGVPEDLA
Mflv_1685|M.gilvum_PYR-GCK PDIMRVVGEPYCLPSSTNPTNPYTLNTFDEHLDMVMVCHHLSPRIPEDVA
MAV_5277|M.avium_104 REMLDLSADAHAAGARLYP----QIAARPFGMMIGFQGHHGFSHRPTYRR
::: : ... : * : : : : : ** . *
MSMEG_3625|M.smegmatis_MC2_155 FAESRIRPSTIAAEDLLHDIGAISMIGSDAQAMGRIGEVVMRTWQTAHVM
Mvan_3082|M.vanbaalenii_PYR-1 FAESRIRPSTIAAEDLLHDIGAISMIGSDAQAMGRIGEVVMRTWQTAHVM
Mb1881|M.bovis_AF2122/97 FAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVM
Rv1850|M.tuberculosis_H37Rv FAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVM
MMAR_2724|M.marinum_M FAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRVGEVVMRTWQTAHVM
MUL_3029|M.ulcerans_Agy99 FAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRVGEVVMRTWQTAHVM
MAB_2425|M.abscessus_ATCC_1997 FAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVMRTWQTAHVM
TH_1059|M.thermoresistible__bu FAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVLRTWQTAHVM
Mflv_1685|M.gilvum_PYR-GCK FAESRIRRETIAAEDVLHDLGAISAMGSDSQGMGRIGETIARTWQLASHM
MAV_5277|M.avium_104 LAAECSREE--LAQRLADPAVKAAILGEDDLPVDPT-LLFDGMFALVQHS
:* . * . *: : . : :*.* :. . : .
MSMEG_3625|M.smegmatis_MC2_155 KRRRGALEGDGSGKNGADNLRARRYVAKYTICPAVAHGLDHEIGSVEVGK
Mvan_3082|M.vanbaalenii_PYR-1 KRRRGFLPGD----TKADNARAKRYVAKYTICPAVAHGLDGEIGSVEVGK
Mb1881|M.bovis_AF2122/97 KARRGALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGK
Rv1850|M.tuberculosis_H37Rv KARRGALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGK
MMAR_2724|M.marinum_M KQRRGALEGDPSGRYSADNNRARRYVAKYTICPAVAHGLDHEVGSVEVGK
MUL_3029|M.ulcerans_Agy99 KQRRGALEGDPSGRYSADNNRARRYVAKYTICPAVAHGLDHEVGSVEVGK
MAB_2425|M.abscessus_ATCC_1997 KKRRGALPGDPSGPNGNDNNRVRRYVAKYTICPAITHGIDHEIGSVEVGK
TH_1059|M.thermoresistible__bu KRRRGALPGDTGGPHGADNHRVRRYVAKYTICPAIAHGLDREVGSVEVGK
Mflv_1685|M.gilvum_PYR-GCK RATRGPLPGDEG--TGADNARILRYVAKLTINPARLFGIDHEVGSLEPGK
MAV_5277|M.avium_104 LHRLYALGDPPDYEPTPDRTVAAIAEARGEDPLATLYDLMLDADATNMLM
* . *. *: * ..: .: :
MSMEG_3625|M.smegmatis_MC2_155 LADLVLWEPAFFGVRPHAVIKGGMIAWAAMGDANASIPTP-QPVLPRPMF
Mvan_3082|M.vanbaalenii_PYR-1 LADLVLWEPAFFGVRPHAVVKGGMIAWAAMGDANASIPTP-QPVLPRPMF
Mb1881|M.bovis_AF2122/97 LADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTP-QPVLPRPMF
Rv1850|M.tuberculosis_H37Rv LADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTP-QPVLPRPMF
MMAR_2724|M.marinum_M LADLVLWEPAFFGVRPHAVVKGGAIAWAAMGDANASIPTP-QPVLPRPMF
MUL_3029|M.ulcerans_Agy99 LADLVLWEPAFFGVRPHAVVKGGAIAWAAMGDANASIPTP-QPVLPRPMF
MAB_2425|M.abscessus_ATCC_1997 LADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTP-QPVFPRPMF
TH_1059|M.thermoresistible__bu LADLVLWEPKFFGVRPHAVLKGGMIAWAAMGDANASIPTP-QPVLPXXXP
Mflv_1685|M.gilvum_PYR-GCK LADIVLWEPKFFGIRPEVVFKGGFPAWSVMGEANASLMTC-EPLRYRPQW
MAV_5277|M.avium_104 LPLFNYADGNCDAIREMLLHPAGVLGLSDGGAHCGMICDASYPTFLLTHW
*. : : .:* : .* : * . : *
MSMEG_3625|M.smegmatis_MC2_155 GAAPAAAAATSVHFVAPQAIEDGLAERIDVRRKLVA---VKDVRKVGKAQ
Mvan_3082|M.vanbaalenii_PYR-1 GAAPAAAAATSVHFVAPQAIEDGLADRIAVNRKLVA---VGNVRGVGKAQ
Mb1881|M.bovis_AF2122/97 GAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAP---VADVRAVGKTD
Rv1850|M.tuberculosis_H37Rv GAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAP---VADVRAVGKTD
MMAR_2724|M.marinum_M GASPAVAAATSVHFVAAQSIEAGLADQIAVDRRLVP---VADVRAVGKAD
MUL_3029|M.ulcerans_Agy99 GASPAVAAATSVHFVAAQSIEAGLADQIAVDRRLVP---VADVRAVGKAD
MAB_2425|M.abscessus_ATCC_1997 SAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVP---TRDVRNRGKAD
TH_1059|M.thermoresistible__bu PPPPDPYGPDRPRFVQSSHPLIGSAP-----DRRVP---CPQVGG-GPAC
Mflv_1685|M.gilvum_PYR-GCK AAFGRAPADVSVNFVAGAAIDAGLGQQLGLDTRLVA---CRGARALTKAD
MAV_5277|M.avium_104 ARDRSRGDKLALEYVIRKQSRDTAHLFGLTDRGTIEPGKKADINVIDMDA
.:*
MSMEG_3625|M.smegmatis_MC2_155 MPLNDALPRIEVEPDTFTVRIDGEVWDEQPAAELPMAQRYFLF-------
Mvan_3082|M.vanbaalenii_PYR-1 MPLNDATPDIEVDPDTFTVRIDGEVWQEQPATELPMAQRYFLF-------
Mb1881|M.bovis_AF2122/97 LPLNDALPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFLF-------
Rv1850|M.tuberculosis_H37Rv LPLNDALPSIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFLF-------
MMAR_2724|M.marinum_M MPLNDAQPRIEVDPDTFTVRIDGEVWEQQPATELPMAQRYFLF-------
MUL_3029|M.ulcerans_Agy99 MPLNDAQPRIEVDPDTFTVRIDGEVWEQQPATELPMAQRYFLF-------
MAB_2425|M.abscessus_ATCC_1997 LPLNDAMPDIRVDPDTFTVRIDGEVWEEHPAAELPMAQRYFLF-------
TH_1059|M.thermoresistible__bu APR----RRVSSHPGV----------------------------------
Mflv_1685|M.gilvum_PYR-GCK LLHNDHLPDIRIEPDTYRVTVDGQPCVSTPMTEVPLGRRYTLK-------
MAV_5277|M.avium_104 LRLHPAAMAFDLPAGGNRILQGASGYAATIVSGTVTRRNDVDTGARPGRL
. ..
MSMEG_3625|M.smegmatis_MC2_155 -----
Mvan_3082|M.vanbaalenii_PYR-1 -----
Mb1881|M.bovis_AF2122/97 -----
Rv1850|M.tuberculosis_H37Rv -----
MMAR_2724|M.marinum_M -----
MUL_3029|M.ulcerans_Agy99 -----
MAB_2425|M.abscessus_ATCC_1997 -----
TH_1059|M.thermoresistible__bu -----
Mflv_1685|M.gilvum_PYR-GCK -----
MAV_5277|M.avium_104 VRGAR