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GAGHDHSHHTDARVSRMLVAAAILTAFFFVELITALMINSIALLADAGHMLTDLVAMFMGLTAVLLARRG STSPARTFGWHRAEVFTAVANAALLIGVAGFILYEAFERLGNAPEVPGVPMIVVALAGLIANAAVVLMLR SHSKDSLAVKGAYMEVVADTVGSIGVLIAGIVTVTTGWPYADVVVAVLVALWVLPRAIALARAALRILSE SSPAHIDVEKLRSALCAVDGVTDVHDLHVWTLVPGKDMVTAHLTSDADTARVLDDARAVLTAHGLEHATV QVEPPDAAGDCRCEAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0755 | - | - | 100% (297) | cobalt-zinc-cadmium resistance protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2050c | - | 2e-11 | 26.06% (284) | hypothetical protein Mb2050c |
| M. gilvum PYR-GCK | Mflv_0231 | - | 1e-142 | 85.91% (298) | cation diffusion facilitator family transporter |
| M. tuberculosis H37Rv | Rv2025c | - | 2e-11 | 26.06% (284) | hypothetical protein Rv2025c |
| M. leprae Br4923 | MLBr_00283 | - | 9e-78 | 65.50% (229) | putative cation-efflux transporter component |
| M. abscessus ATCC 19977 | MAB_0183c | - | 5e-46 | 33.55% (301) | putative cation transporter |
| M. marinum M | MMAR_0677 | - | 1e-120 | 74.92% (295) | efflux membrane protein |
| M. avium 104 | MAV_4782 | - | 1e-122 | 78.28% (290) | cobalt-zinc-cadmium resistance protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2837 | - | 1e-120 | 74.92% (295) | efflux membrane protein |
| M. vanbaalenii PYR-1 | Mvan_0673 | - | 1e-144 | 86.82% (296) | cation diffusion facilitator family transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0231|M.gilvum_PYR-GCK ----------MRIYFWPMGAGHDHSHGGG--DTKVS------RMVIAAGI
Mvan_0673|M.vanbaalenii_PYR-1 -----------------MGAGHDHSHGG---DTKVS------RMVLGAAI
MSMEG_0755|M.smegmatis_MC2_155 -----------------MGAGHDHSHHT---DARVS------RMLVAAAI
MMAR_0677|M.marinum_M -----------------MGAGHNHTPATAYASRMIP------RMVCAATI
MUL_2837|M.ulcerans_Agy99 -----------------MGAGHNHTPATAYASRMIP------RMVCAATI
MAV_4782|M.avium_104 -----------------MGAGHNHTPAETGDARLIP------RMVMAAAI
MLBr_00283|M.leprae_Br4923 -----MQCMRKHAYIAHMGSGGSYTPAEAAIYRMIR------RMIVAAAI
Mb2050c|M.bovis_AF2122/97 MTHDHAHSRGVPAMIKEIFAPHSHDAADSVDDTLESTAAGIRTVKISLLV
Rv2025c|M.tuberculosis_H37Rv MTHDHAHSRGVPAMIKEIFAPHSHDAADSVDDTLESTAAGIRTVKISLLV
MAB_0183c|M.abscessus_ATCC_199 ----------MAADAHEHGSGHSHGHGVNADADRKW-------LTIALIL
: .: : . :
Mflv_0231|M.gilvum_PYR-GCK LTIFFVVELTTALAINSIALLADAGHMLTDLVSMFMGLTAVLLAKRGSAS
Mvan_0673|M.vanbaalenii_PYR-1 LTVFFIVELSTALAINSIALLADAGHMLTDLVAMFMGLTAVLLARRGSTS
MSMEG_0755|M.smegmatis_MC2_155 LTAFFFVELITALMINSIALLADAGHMLTDLVAMFMGLTAVLLARRGSTS
MMAR_0677|M.marinum_M LAMFFVVELTTAWLINSIALLADAGHMLTDVVAVFMGLAAVILGRRGSSS
MUL_2837|M.ulcerans_Agy99 LAMFFVVELTTAWLINSIALLADAGHMLTDVVAVFMGLAAVILGRRGSSS
MAV_4782|M.avium_104 LAAFFVVELVTSLLINSIALLADAGHMLTDVVAVFMGLAAVTLARRGSSS
MLBr_00283|M.leprae_Br4923 LMVFFGVELTIALLINSITLLADAGHMLTDVVAVFMGLAALVLAKHGHSA
Mb2050c|M.bovis_AF2122/97 LGLTALIQIVIVVMSGSVALAADTIHNFADALTAVPLWIAFALGAKPATR
Rv2025c|M.tuberculosis_H37Rv LGLTALIQIVIVVMSGSVALAADTIHNFADALTAVPLWIAFALGAKPATR
MAB_0183c|M.abscessus_ATCC_199 IGGFMAIEVVIGIIAQSLALISDAGHMLTDAASIVLALIAIRLSSR-PAR
: ::: *::* :*: * ::* : . *. *. : :
Mflv_0231|M.gilvum_PYR-GCK PSRTYGWHRAEVFTAVANAALLLGVAGFILYEAVERLGDAPDVPGVPMIV
Mvan_0673|M.vanbaalenii_PYR-1 PSRTYGWHRAEVFTAVANAALLFGVAGFILYEAFERLGDAPDVPGVPMIV
MSMEG_0755|M.smegmatis_MC2_155 PARTFGWHRAEVFTAVANAALLIGVAGFILYEAFERLGNAPEVPGVPMIV
MMAR_0677|M.marinum_M PNRTYGWHRAEVFTAVANAALLIGVALFIVYEAIDRLREAPSVPGLPMIV
MUL_2837|M.ulcerans_Agy99 PNRTYGWHRAEVFTAVANAALLIGVALFIVYEAIDRLREAPSVPGLPMIV
MAV_4782|M.avium_104 PARTYGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAVPGVPMIV
MLBr_00283|M.leprae_Br4923 PNRPYSWHRAEVFTAMANAALLIGVATFILYEAIRRFKEAPYIPGMPIVV
Mb2050c|M.bovis_AF2122/97 -RYTYGFGRVEDLAGSFVVAMITMSAIIAGYEAIARLIHPQQIEHVGWVA
Rv2025c|M.tuberculosis_H37Rv -RYTYGFGRVEDLAGSFVVAMITMSAIIAGYEAIARLIHPQQIEHVGWVA
MAB_0183c|M.abscessus_ATCC_199 GSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLITPPEVSGLLVFI
.:. *.* ::. : : : **.. *: . : : .
Mflv_0231|M.gilvum_PYR-GCK VA-LAGLLANLIVVLLLR--SHSKESLAVKGAYMEVVADTVGSIGVLIAG
Mvan_0673|M.vanbaalenii_PYR-1 VA-LAGLLANAVVVLLLR--SHSKESLAVKGAYMEVVADTVGSIGVLIAG
MSMEG_0755|M.smegmatis_MC2_155 VA-LAGLIANAAVVLMLR--SHSKDSLAVKGAYMEVVADTVGSIGVLIAG
MMAR_0677|M.marinum_M VA-LAGLSANIVVALLLR--SHADSSLAVKGAYMEVVADTVGSLGVLAAG
MUL_2837|M.ulcerans_Agy99 VA-LAGLSANIVVALLLR--SHADSSLAVKGAYMEVVADTVGSLGVLAAG
MAV_4782|M.avium_104 VA-LAGLAANFVVALLLR--SHSSGSLAVKGAYLEVIADTVGSLGVLIAG
MLBr_00283|M.leprae_Br4923 AA-LAGLVTNFVVAPLLR--PHAEDSLAIKGAYMEAVADTVGNIGVLIAG
Mb2050c|M.bovis_AF2122/97 LAGLVGFIGNEWVALYRIRVGHRIGSAALIADGLHARTDGFTSLAVLCS-
Rv2025c|M.tuberculosis_H37Rv LAGLVGFIGNEWVALYRIRVGHRIGSAALIADGLHARTDGFTSLAVLCS-
MAB_0183c|M.abscessus_ATCC_199 TA-LAGIAVNVAATWCIS--KANRSSLNVEGAFQHILNDLYAFIATAVAG
* *.*: * .. * : . . * :.. :
Mflv_0231|M.gilvum_PYR-GCK IVTVTTAWPYADVVVAVLVALWVLPRAIALARAALRILSESSPAHIDVDE
Mvan_0673|M.vanbaalenii_PYR-1 IVTVTTRWPYADVVVAVLVALWVLPRAISLARAALRILSESSPRHIDVEE
MSMEG_0755|M.smegmatis_MC2_155 IVTVTTGWPYADVVVAVLVALWVLPRAIALARAALRILSESSPAHIDVEK
MMAR_0677|M.marinum_M VVTVTTSWPYADVVVAVLVALWVAPRAVSLARAALRILSESSPRHIDVDE
MUL_2837|M.ulcerans_Agy99 VVTVTTSWPYADVVVAVLVALWVAPRAVSLARAALRILSESSPRHIDVDE
MAV_4782|M.avium_104 VVTVTTRWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEE
MLBr_00283|M.leprae_Br4923 VVTLTTHWPYADVVVAVLVALWVLPRAISLARAACGSFPNCRRPTIDVEA
Mb2050c|M.bovis_AF2122/97 AGGVALGFPLADPIVGLLITAAILAVLRTAARDVFRRLLDG-VDPAMVDA
Rv2025c|M.tuberculosis_H37Rv AGGVALGFPLADPIVGLLITAAILAVLRTAARDVFRRLLDG-VDPAMVDA
MAB_0183c|M.abscessus_ATCC_199 AVVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGT
:. ** :..:::: : .* : :
Mflv_0231|M.gilvum_PYR-GCK LRDALCAVDGVTEVHDLHV----WTLVPGKDMVTAHLTSV--RESAAVLD
Mvan_0673|M.vanbaalenii_PYR-1 LRAALGAVDGVTEVHDLHV----WTLVPGKDMVTAHLTSD--RDSAQILD
MSMEG_0755|M.smegmatis_MC2_155 LRSALCAVDGVTDVHDLHV----WTLVPGKDMVTAHLTSD--ADTARVLD
MMAR_0677|M.marinum_M LRSALRAVDGVTEVHDLHV----WTLAPGKDMATAHLTSS--ADSARVLH
MUL_2837|M.ulcerans_Agy99 LRSALRAVDGVTEVHDLHV----WTLAPGKDMATAHLTSS--ADSARVLH
MAV_4782|M.avium_104 LRAALGAVDGVTGVHDLHV----WTLSPGKDMCTAHLIST--GDSARVLR
MLBr_00283|M.leprae_Br4923 LRSALGRRRRHRSARPARV----NTFAR----------------------
Mb2050c|M.bovis_AF2122/97 AEQALAARPGVQAVRSVRMRWIGHRLHADAELDVDPALDL--AQAHRIAH
Rv2025c|M.tuberculosis_H37Rv AEQALAARPGVQAVRSVRMRWIGHRLHADAELDVDPALDL--AQAHRIAH
MAB_0183c|M.abscessus_ATCC_199 IGTQLAAVHAVAEVHDLHI----WQITSGQPALSAHILVAPNADCHGIRR
* .: :: :
Mflv_0231|M.gilvum_PYR-GCK DARAVLTAR-GLGHATVQVEPPDSAADCECETEKR--------------
Mvan_0673|M.vanbaalenii_PYR-1 DARAVLAAR-GLDHSTVQVEPPDTAADCECESRKR--------------
MSMEG_0755|M.smegmatis_MC2_155 DARAVLTAH-GLEHATVQVEPPDAAGDCRCEAE----------------
MMAR_0677|M.marinum_M DARAVLSDR-GLHHATVQIEHTAGIQECPDSCSDAVPAIG---------
MUL_2837|M.ulcerans_Agy99 DARAVLSDR-GLHHATVQIEHTAGIQECPDSCSDAVPAIG---------
MAV_4782|M.avium_104 DARAVLSAR-GLAHATVQIDCPDDT-ECSDSF-----------------
MLBr_00283|M.leprae_Br4923 --RRYVPPR-T--------------------------------------
Mb2050c|M.bovis_AF2122/97 DAEHELTHT-VPKLTTALIHAYPAEHGSSIPDRGRTVE-----------
Rv2025c|M.tuberculosis_H37Rv DAEHELTHT-VPKLTTALIHAYPAEHGSSIPDRGRTVE-----------
MAB_0183c|M.abscessus_ATCC_199 EIEELLHTQYDIDHTTLQVDHEGTEASTHCFDPHGEPYRADGSALPGKG
. :