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MKIANEFTVSVPIEDAWDLLTDLDQVVPLMPGARLTGHDGDDVLGAVKVKVGPVTSEFAGKVHFVEQDRE HFRAVIDAKGKETRGTGNAAATVTAQLHEAGTSTRVTVDTDLKVVGKLAQFGSGMLQQVSEKLLGQFVDS LEAKLAGEREKPSETTQTPQTPVAQAAEKPQETLASTAPAVADPEPIDLLDLAGGAALKKYGPAVAGAFL LAALLFTIGRLRMARKALRGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0749 | - | - | 100% (231) | carbon monoxide dehydrogenase subunit G (CoxG) family protein |
| M. smegmatis MC2 155 | MSMEG_5881 | - | 2e-41 | 42.86% (231) | putative carbon monoxide dehydrogenase subunit G |
| M. smegmatis MC2 155 | MSMEG_2455 | - | 1e-29 | 35.16% (182) | carbon monoxide dehydrogenase subunit G (CoxG) superfamily |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0376c | - | 8e-61 | 64.25% (193) | membrane oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1572 | - | 2e-41 | 40.69% (231) | carbon monoxide dehydrogenase subunit G |
| M. tuberculosis H37Rv | Rv0369c | - | 8e-61 | 64.25% (193) | membrane oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1436 | - | 9e-05 | 28.14% (167) | threonine synthase |
| M. marinum M | MMAR_0661 | - | 2e-80 | 67.41% (224) | membrane oxidoreductase |
| M. avium 104 | MAV_1510 | thrC | 9e-05 | 28.14% (167) | threonine synthase |
| M. thermoresistible (build 8) | TH_1270 | - | 2e-45 | 44.55% (220) | putative carbon monoxide dehydrogenase subunit G |
| M. ulcerans Agy99 | MUL_0111 | - | 6e-80 | 66.52% (224) | membrane oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5184 | - | 7e-44 | 43.69% (222) | carbon monoxide dehydrogenase subunit G |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1572|M.gilvum_PYR-GCK ------------MELNNEFRVAVPSAKVWEMFTDGERVAPCLPGATLLST
Mvan_5184|M.vanbaalenii_PYR-1 ------------MELNNEFRVAVPAATVWDVFTDVERVAPCLPGATLLSI
TH_1270|M.thermoresistible__bu ------------VELINEFRVPVPAEQAWDVLTDVERIAPCIPGATLLSV
MMAR_0661|M.marinum_M ------------MKIANQFTVSAPIEQAWDVLCDLEQVIPLMPGAQLTGH
MUL_0111|M.ulcerans_Agy99 ------------MKIANQFTVSAPIEQAWDVLCDLEQVIPLMPGAQLTGH
Mb0376c|M.bovis_AF2122/97 -----------------------------------------MPGAQLIGH
Rv0369c|M.tuberculosis_H37Rv -----------------------------------------MPGAQLIGH
MSMEG_0749|M.smegmatis_MC2_155 ------------MKIANEFTVSVPIEDAWDLLTDLDQVVPLMPGARLTGH
MAB_1436|M.abscessus_ATCC_1997 -----MTVHTPWPGLIAAYRDRLPIGENWQPVTLREGGTPLLPAARLSEL
MAV_1510|M.avium_104 MSAQRTAVHQPWPGLIEAYRDRLPVGDDWTPVTLLEGGTPLIPARRLSEK
:*. *
Mflv_1572|M.gilvum_PYR-GCK EG--------------------------DTFHGSVKVKVGPITVSYKGTA
Mvan_5184|M.vanbaalenii_PYR-1 DG--------------------------DTFNGAVKVKVGPITVSYKGVA
TH_1270|M.thermoresistible__bu DG--------------------------DDFTGQVKVKVGPITVQYKGKA
MMAR_0661|M.marinum_M QD--------------------------DDYLGKVKVKVGPVTSEFSGKV
MUL_0111|M.ulcerans_Agy99 QD--------------------------DDYLGKVKVKVGPVTSEFSGKV
Mb0376c|M.bovis_AF2122/97 EG--------------------------DEYLGKVKVKVGPVTSEFSGKV
Rv0369c|M.tuberculosis_H37Rv EG--------------------------DEYLGKVKVKVGPVTSEFSGKV
MSMEG_0749|M.smegmatis_MC2_155 DG--------------------------DDVLGAVKVKVGPVTSEFAGKV
MAB_1436|M.abscessus_ATCC_1997 TGCTVHLKVEGLNPTGSFKDRGMTMAVTDALARGQRAVLCASTGNTSASA
MAV_1510|M.avium_104 TGCTVHLKVEGLNPTGSFKDRGMTMAVTDALARGQQAVLCASTGNTSASA
. * :. : . * . . .
Mflv_1572|M.gilvum_PYR-GCK TYKEKDAAGQRIVLRAEGKETRGSGTAAATVTAQLKDEG-----------
Mvan_5184|M.vanbaalenii_PYR-1 SYQEKDAVARRIVLRAEGKETRGNGTAAATVTAQLKDEG-----------
TH_1270|M.thermoresistible__bu SFEQKDTAARRAVIRANGKETRGQGNAAAVVTAELKEEG-----------
MMAR_0661|M.marinum_M HFVERDRDQHRAVIDAKGKESRGTGNAAATVTAQLAEAG-----------
MUL_0111|M.ulcerans_Agy99 HFVERDRDQHRAVIDAKGKESRGTGNAAATVTAQLAEAG-----------
Mb0376c|M.bovis_AF2122/97 HFVEQDRNQHRAVFDAKGKEARGTGNAAATVAAQLHEVG-----------
Rv0369c|M.tuberculosis_H37Rv HFVEQDRNQHRAVFDAKGKEARGTGNAAATVAAQLHEVG-----------
MSMEG_0749|M.smegmatis_MC2_155 HFVEQDREHFRAVIDAKGKETRGTGNAAATVTAQLHEAG-----------
MAB_1436|M.abscessus_ATCC_1997 AAYAAKAGITCAVLIPQGKIAMGKLAQAVIHGARIIQVDGNFDDCLELAR
MAV_1510|M.avium_104 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
*: .:** : * *. *.: : .
Mflv_1572|M.gilvum_PYR-GCK -------DSTHVAIVTDLAISG---------------------------K
Mvan_5184|M.vanbaalenii_PYR-1 -------ESTYVGIVTDLAISG---------------------------K
TH_1270|M.thermoresistible__bu -------DSTLCILTTDLTISG---------------------------K
MMAR_0661|M.marinum_M -------ERTQVTVDTDLKIVG---------------------------K
MUL_0111|M.ulcerans_Agy99 -------ERTQVTVDTDLKIVG---------------------------K
Mb0376c|M.bovis_AF2122/97 -------ERTRVTVDTDLKIVG---------------------------K
Rv0369c|M.tuberculosis_H37Rv -------ERTRVTVDTDLKIVG---------------------------K
MSMEG_0749|M.smegmatis_MC2_155 -------TSTRVTVDTDLKVVG---------------------------K
MAB_1436|M.abscessus_ATCC_1997 KTTADYPTIALVNSVNPVRIEGQKTAAFEIVDALGTAPDIHALPVGNAGN
MAV_1510|M.avium_104 KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGAAPDVHALPVGNAGN
: . : : * :
Mflv_1572|M.gilvum_PYR-GCK AAQFGRGVLADVSGNLIAQFARSLEAELLGG--------------AAPAS
Mvan_5184|M.vanbaalenii_PYR-1 AAQFGRGVLADVSSNLIAQFARSLEAELLGG--------------AAPSG
TH_1270|M.thermoresistible__bu AAQFGRGVLADVAGKLIGQFAERLEADVLSQHT------------TAPAP
MMAR_0661|M.marinum_M LAQFGSGMLQQVSEKLLGQFVDSLEAELASRNAATA---------APESP
MUL_0111|M.ulcerans_Agy99 LAQFGSGMLQQVSEKLIGQFVDSLEAELASRNAATA---------APESP
Mb0376c|M.bovis_AF2122/97 LAQFGSGMLQQVSEKLLGQFVDSLEAELAAQ--------------SSESP
Rv0369c|M.tuberculosis_H37Rv LAQFGSGMLQQVSEKLLGQFVDSLEAELAAQ--------------SSESP
MSMEG_0749|M.smegmatis_MC2_155 LAQFGSGMLQQVSEKLLGQFVDSLEAKLAGERE--K---------PSETT
MAB_1436|M.abscessus_ATCC_1997 ITAYWRGYNEYHRDGLSDRLPKMLGAQAAGAAPLVNGAPVANPETIATAI
MAV_1510|M.avium_104 ITAYWKGYTEYHHEGLIEKLPRMLGTQAAGAAPLVHGEPVKNPETIATAI
: : * * :: * :. . . :
Mflv_1572|M.gilvum_PYR-GCK AGSAAAAPTHTTQAPSAETAAAAAQPGGDSVDLLKVVAVPMAKRFAPVLV
Mvan_5184|M.vanbaalenii_PYR-1 QASENGS------APAAS--VAAAPPAEDSVDLLKVVAVPMAKRYAPVLA
TH_1270|M.thermoresistible__bu QGSADEP----AVQPAPVAAPTQAPAADASVNMLALVAVPIAKRVAPVAA
MMAR_0661|M.marinum_M ESPGSPESPASPQPRPVEARKPTTSAEPEPIDLLELAGGDQLKKYGPAVL
MUL_0111|M.ulcerans_Agy99 ESPGSPESPVSPQPRPVEARKPTTSAEPEPIDLLELAGGDQLKKYGPAVL
Mb0376c|M.bovis_AF2122/97 Q--GTP---------------PATEAAP--IDLLQLADGGQLKKYGSALL
Rv0369c|M.tuberculosis_H37Rv Q--GTP---------------PATEAAP--IDLLQLADGGQLKKYGSALL
MSMEG_0749|M.smegmatis_MC2_155 QTPQTPVAQAAEKPQETLASTAPAVADPEPIDLLDLAGGAALKKYGPAVA
MAB_1436|M.abscessus_ATCC_1997 RIGSPASWSGAVAAQQESGGKFLAVTDEEILNAYRLVASSEGVFVEPASA
MAV_1510|M.avium_104 RIGAPASWTAAVDAQQQSHGRFLAATDDEILAAYHLVAESEGVFVEPASA
: . : :. ..
Mflv_1572|M.gilvum_PYR-GCK AATVAGAVGFLIGSRRRRKTPAAVLADDLQAVLARLLS------------
Mvan_5184|M.vanbaalenii_PYR-1 AAAVAGVIGYLIG-RRRRRGPAAVLADDLQAALARLLS------------
TH_1270|M.thermoresistible__bu GLAVGLALGWVLG---RRSGGAA---------------------------
MMAR_0661|M.marinum_M AVLAVLVLIWVLR--RRR--------------------------------
MUL_0111|M.ulcerans_Agy99 AVLAVLVLIWVLR--RRR--------------------------------
Mb0376c|M.bovis_AF2122/97 AALTVLLLIWVLR--RRR--------------------------------
Rv0369c|M.tuberculosis_H37Rv AALTVLLLIWVLR--RRR--------------------------------
MSMEG_0749|M.smegmatis_MC2_155 GAFLLAALLFTIG--RLRMARKALRGR-----------------------
MAB_1436|M.abscessus_ATCC_1997 ASIAGLLKSVADGWVAKGSTVVCTVTGNGLKDPDNALSGMPEVTPIPVQA
MAV_1510|M.avium_104 ASIAGLLKAVEDGWVARGSTVVCTVTGNGLKDPDTALRDMPTVTPLPVDP
.
Mflv_1572|M.gilvum_PYR-GCK ----------
Mvan_5184|M.vanbaalenii_PYR-1 ----------
TH_1270|M.thermoresistible__bu ----------
MMAR_0661|M.marinum_M ----------
MUL_0111|M.ulcerans_Agy99 ----------
Mb0376c|M.bovis_AF2122/97 ----------
Rv0369c|M.tuberculosis_H37Rv ----------
MSMEG_0749|M.smegmatis_MC2_155 ----------
MAB_1436|M.abscessus_ATCC_1997 SAVAEALELA
MAV_1510|M.avium_104 VLVVEKLGLA