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TTEITRPPAPPSRPSESRKPSLPGLLHLVAIAAVLATIVSAWAIDFVPTALIDGSDNIVALLQRMIPPRL DDPARIGMLAVETLLMAVLGTTLAAIASVPLAFLAARNTTPHPAVQAVARAVITFCRAMPDLLFAVLFVR ALGIGVLPGVLALALHSIGMLGKVFADAIEQTDAGPREAVRSTGVGYFRELLNAVVPQVVPSWIAMFVYR IDINLRMSVVLGFVGAGGIGFALQDALRGLIYPRALGIVCVILVIIAGMELLAIAIRRILLDPSRSNPLR DRIARFGLSGVLVGSCVAAFVLLKINPLALFTWVFPSVGIFTRMVPPNFDALGVDLFTAAAQTVAIGVVA TAIGIALSIPAGILAARNVSPHPALYWPARAWILVVRAVPELILAVVFVAALGLGPIAGTCALAIGSIGF LAKLVADAVEEIDPGPMEAVRSVGGGWWKTLFAAVLPQSMPALVGSSLYLFDVNVRTSTILGIVGAGGVG YLLFESIRTLNFDVAGAIVIVIFVIVYAIERLSGWIRSRLV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0646 | - | - | 100% (532) | putative transporter |
| M. smegmatis MC2 155 | MSMEG_3057 | - | 8e-14 | 27.04% (196) | ABC-type metal ion transport system, permease component |
| M. smegmatis MC2 155 | MSMEG_5318 | - | 5e-13 | 25.37% (205) | glutamine ABC transporter, permease/substrate-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3782c | proZ | 1e-08 | 25.00% (204) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. gilvum PYR-GCK | Mflv_0858 | - | 3e-12 | 24.10% (195) | polar amino acid ABC transporter, inner membrane subunit |
| M. tuberculosis H37Rv | Rv3756c | proZ | 1e-08 | 25.00% (204) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2802c | - | 2e-13 | 27.52% (218) | ABC transporter permease |
| M. marinum M | MMAR_0061 | glnQ | 1e-12 | 25.65% (191) | ABC transporter permease protein GlnQ |
| M. avium 104 | MAV_0059 | - | 9e-13 | 24.62% (195) | amino acid ABC transporter, permease protein, |
| M. thermoresistible (build 8) | TH_3216 | - | 0.0 | 78.46% (506) | PUTATIVE phosphonate ABC transporter, inner membrane subunit |
| M. ulcerans Agy99 | MUL_4375 | proW | 3e-06 | 24.61% (191) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. vanbaalenii PYR-1 | Mvan_2906 | - | 0.0 | 79.72% (508) | phosphonate ABC transporter, inner membrane subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3782c|M.bovis_AF2122/97 ----------------------------------------------MNFL
Rv3756c|M.tuberculosis_H37Rv ----------------------------------------------MNFL
TH_3216|M.thermoresistible__bu --VSTLLNR---PATRLTTRPR----DPLAAVTAVAVVLTVVSAWYLDFA
Mvan_2906|M.vanbaalenii_PYR-1 -------------------MRR----GTMTALMAAALVATVVSAYVIDFA
MSMEG_0646|M.smegmatis_MC2_155 --MTTEITRPPAPPSRPSESRKPSLPGLLHLVAIAAVLATIVSAWAIDFV
MMAR_0061|M.marinum_M ----------MLAVSATILIVLG--LALAAPALADHNQCAPAGVDSAMVL
MAV_0059|M.avium_104 MGRRGTRRGKLLALTATVLMVCGSSALLAPPAAADRNQCAPAGPKSAAVL
Mflv_0858|M.gilvum_PYR-GCK MSCTRVLRPTVKTFALALIIGMVTAMGLAAPAGAQTDQCSPPGEQSASAL
MAB_2802c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4375|M.ulcerans_Agy99 --------------------------------------------------
Mb3782c|M.bovis_AF2122/97 QQALS--------------YLLTASNWTGPVGLAVRTCEHLEYTAVAVAA
Rv3756c|M.tuberculosis_H37Rv QQALS--------------YLLTASNWTGPVGLAVRTCEHLEYTAVAVAA
TH_3216|M.thermoresistible__bu PATLISGFENV----VALVERMLPPRVDDPGRIGVLAVETLLMAVLGTVL
Mvan_2906|M.vanbaalenii_PYR-1 PATLWGGLDDI----ANLLERMLPPRLDDPGRIGVLAVETLLMAVLGTVL
MSMEG_0646|M.smegmatis_MC2_155 PTALIDGSDNI----VALLQRMIPPRLDDPARIGMLAVETLLMAVLGTTL
MMAR_0061|M.marinum_M PADLSSATTAGSDEDVQTTAGVVPLSSVNIGDLGLGTPGVLTAGTLSDAP
MAV_0059|M.avium_104 PENLTRGGSMS-QPDEHTTPTVEPLSSVRIDTLGLGTPGVLTVGTLSGAP
Mflv_0858|M.gilvum_PYR-GCK PTNLAAAATGP-AADKYTTATVTPLDAVDVDALGLSEPGTLTVGTLSDAP
MAB_2802c|M.abscessus_ATCC_199 --------------MTTNWERLRPQLFEAFGDTLYMVSITLVVGGLVGLA
MUL_4375|M.ulcerans_Agy99 ----------------------MHYLMTHLGTAWALTMVHLRLSLIPVLI
* :
Mb3782c|M.bovis_AF2122/97 SALIAVPV---GLLIG--HTGRGTLLVVG--AVNGLRALPTLGVLLLGVL
Rv3756c|M.tuberculosis_H37Rv SALIAVPV---GLLIG--HTGRGTLLVVG--AVNGLRALPTLGVLLLGVL
TH_3216|M.thermoresistible__bu AAVASVPL---AFLAARNTTPHPVLHAAARAVITFCRAMPDLLFAVLFVR
Mvan_2906|M.vanbaalenii_PYR-1 AAVASVPL---AFLAARNTSPHPAVYAVARAIITFCRAMPDLLFAVLFVR
MSMEG_0646|M.smegmatis_MC2_155 AAIASVPL---AFLAARNTTPHPAVQAVARAVITFCRAMPDLLFAVLFVR
MMAR_0061|M.marinum_M PNTCINST---GQFTGFDNELLRAIAAKLGLQVRFVGTDFSGLLAQVAAR
MAV_0059|M.avium_104 PNVCITPT---GQYSGFDNQLLRAIAGKLGLQVRFVGTDFAGLLAQVASR
Mflv_0858|M.gilvum_PYR-GCK PSICIDSS---GQFTGFDNELLRAVADRLGLRINFVGTEFSGLLAQVASR
MAB_2802c|M.abscessus_ATCC_199 LGVLLYTTRSGGLLQNRLLHTLLNVVVNIVRPIPFVVLIAALGPITLGVV
MUL_4375|M.ulcerans_Agy99 GTAIAIPL-------GLFVQHAPTLRRLTTATASVVFTIPSLALFVVLPL
. : :
Mb3782c|M.bovis_AF2122/97 LFGLG---------------------------LGPP---LVALMLLGIPS
Rv3756c|M.tuberculosis_H37Rv LFGLG---------------------------LGPP---LVALMLLGIPS
TH_3216|M.thermoresistible__bu ALGIG---------------------------VLPG---ILALGLHSIGM
Mvan_2906|M.vanbaalenii_PYR-1 ALGIG---------------------------VLPG---ILALALHSIGM
MSMEG_0646|M.smegmatis_MC2_155 ALGIG---------------------------VLPG---VLALALHSIGM
MMAR_0061|M.marinum_M RFDVGSASVKLTEARRRTVAFTNGYDFGYYSLVVPPGSAITKFSDLAPGQ
MAV_0059|M.avium_104 RFDVGSSSIKATDERRQTVAFTNGYDFGYYALVVPPGSAIKEFTDLAAGQ
Mflv_0858|M.gilvum_PYR-GCK RFDVGSSSITTTDARRQTVGFTNGYDFGYFSLVVPKGSPITGFDELVAGQ
MAB_2802c|M.abscessus_ATCC_199 GTTIG------------------------------TTAVVFVMIVAASFA
MUL_4375|M.ulcerans_Agy99 IIKMR---------------------------ILQEANVIIALSAYTTAL
: : :
Mb3782c|M.bovis_AF2122/97 LLASTYAGIASVDPLVVDAARAMGMTESQVLLRVEVPNALPLMLGGLRSA
Rv3756c|M.tuberculosis_H37Rv LLASTYAGIASVDPLVVDAARAMGMTESQVLLRVEVPNALPLMLGGLRSA
TH_3216|M.thermoresistible__bu LGKLFADAIEHSDPGPREAVRAAGAGYLREMINAVVPQVLPSWIATFVYR
Mvan_2906|M.vanbaalenii_PYR-1 LGKLFADAIEQSDPGPREAVRSAGAGYLREMVNAVLPQVIPSWIGTFIYR
MSMEG_0646|M.smegmatis_MC2_155 LGKVFADAIEQTDAGPREAVRSTGVGYFRELLNAVVPQVVPSWIAMFVYR
MMAR_0061|M.marinum_M RIGVVQGTVEESYVVNSLHLQPVKYPDFATVYGNLKTHQIDAWVAPGNQA
MAV_0059|M.avium_104 RIGVVQGTVEESYVVDTLHLQPVKYPDFATVYASLKTRQIDAWVAPAGQA
Mflv_0858|M.gilvum_PYR-GCK RIGVVQGTVQEAYVIDTLKLQPVKFPDYNTVYASLKTGQIDAWVSPSQQA
MAB_2802c|M.abscessus_ATCC_199 IARIVEQNLVTIDPGVIEAARAVGAGPLRIIVTLLVPEALGPLILGYTFV
MUL_4375|M.ulcerans_Agy99 LVRAVLEALDAVPAQVRDAAVAVGYSPIARMLKVELPLSIPVLVSGLRVV
: . : . : :
Mb3782c|M.bovis_AF2122/97 TLQVVATATVAAYASLGG----LGGYLIDGIK------------------
Rv3756c|M.tuberculosis_H37Rv TLQVVATATVAAYASLGG----LGGYLIDGIK------------------
TH_3216|M.thermoresistible__bu IDINLRMSVVLGFVGAGG----IGFALQDALRGLIYPRALGIVCIIFAII
Mvan_2906|M.vanbaalenii_PYR-1 IDINLRMSVVLGFVGAGG----IGFALQDALRGLIYPRALGIVCVILAVI
MSMEG_0646|M.smegmatis_MC2_155 IDINLRMSVVLGFVGAGG----IGFALQDALRGLIYPRALGIVCVILVII
MMAR_0061|M.marinum_M EAAIRPGDPAVLVANTFGAGDFVAYVVARDNRPLLDALNSGLDAVIADGT
MAV_0059|M.avium_104 ATTIQPGDPAVVVANTISPGNFVAYAVAKDNKPLVDALNSGLDAVIADGT
Mflv_0858|M.gilvum_PYR-GCK QGTVQPADPVEIIENTFSLDNFIAWAVASDNQPLIDALNSGLDAVIADGT
MAB_2802c|M.abscessus_ATCC_199 LIGIVDMSAMAGLVGGGGLG---DFAIVQGYQR-----------------
MUL_4375|M.ulcerans_Agy99 VVTNIAMVSVGAVIGIGG----LGTWFTAGYLMD----------------
. . .
Mb3782c|M.bovis_AF2122/97 --------------------------------------------------
Rv3756c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3216|M.thermoresistible__bu AAMELLTIAIRRMLLTPSDSGPHRDRIARFVFSAMLLAAIAWAMITLRIP
Mvan_2906|M.vanbaalenii_PYR-1 SAMELLSIVVRRMLLTGSATDPRRDRAARVGFSALLVGTTAAAFVVLEIN
MSMEG_0646|M.smegmatis_MC2_155 AGMELLAIAIRRILLDPSRSNPLRDRIARFGLSGVLVGSCVAAFVLLKIN
MMAR_0061|M.marinum_M WSQLYSKWVPRTLPPGWKPGSRAVAAPTLPDFAAIAAAHRHK--PVGPAA
MAV_0059|M.avium_104 WSNLYSQWVPRTLPPGWKPGSQAVAPPKLPDFAAIAASQHHK--AVGPAA
Mflv_0858|M.gilvum_PYR-GCK WSRLYSDWVPRALPPGWKPGSKTAPTPVLPDFTAIAAQNQDTGAPVAPAE
MAB_2802c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4375|M.ulcerans_Agy99 --------------------------------------------------
Mb3782c|M.bovis_AF2122/97 --------------------------ERRFHIALVGAMMVAALALTLDGL
Rv3756c|M.tuberculosis_H37Rv --------------------------ERRFHIALVGAMMVAALALTLDGL
TH_3216|M.thermoresistible__bu PLSLVTWIGPAVEVFTRMVPPDFGALGADLVAAAVQTVAIGVVATSIGAA
Mvan_2906|M.vanbaalenii_PYR-1 PLSLFTWVWPALEVFTRMVPPNFGALGGDLFVAALQTVAIAVVATAIGIV
MSMEG_0646|M.smegmatis_MC2_155 PLALFTWVFPSVGIFTRMVPPNFDALGVDLFTAAAQTVAIGVVATAIGIA
MMAR_0061|M.marinum_M PKSALTQLRDSFFDWDMYRQAIPTLFKTGLPNTLILTLSASIIGLALGMA
MAV_0059|M.avium_104 PKSTLAQLRDSFFDWDMYRQAIPTLLRTGLPNTLILTFSASVIGLVLGMV
Mflv_0858|M.gilvum_PYR-GCK PKSTLSQLAASFLDWDLYKQAIPDLFKTGLPNTLILTICASIIGLILGMA
MAB_2802c|M.abscessus_ATCC_199 -------------------------------FNWQVTIVSTVIIIALVQA
MUL_4375|M.ulcerans_Agy99 ----------------------------KSDQIVAGITVMFVLAILIDMV
: :
Mb3782c|M.bovis_AF2122/97 LALAG------------------------------------WVSVPGTG-
Rv3756c|M.tuberculosis_H37Rv LALAG------------------------------------WVSVPGTG-
TH_3216|M.thermoresistible__bu LSIPVGILAAHNVTPHPAVYWAARGWILAVRAVPELILAVIFVAALGLGP
Mvan_2906|M.vanbaalenii_PYR-1 LSIPAGILAARNITPNAAVYWVARGWILLVRAVPELILAVVFVAALGLGP
MSMEG_0646|M.smegmatis_MC2_155 LSIPAGILAARNVSPHPALYWPARAWILVVRAVPELILAVVFVAALGLGP
MMAR_0061|M.marinum_M LAIAG-------ISHQRWLRWPARVYTDIFRGLP--EVVIILIIGLGVGP
MAV_0059|M.avium_104 LAVAG-------ISHARWLRWPARVYTDVFRGLP--EVVIILLIGLGIGP
Mflv_0858|M.gilvum_PYR-GCK LAIAG-------ISKSRWLRWPARVYTDIFRGLP--EVVIILLIGLGVGP
MAB_2802c|M.abscessus_ATCC_199 AQFFG---------------------------------------------
MUL_4375|M.ulcerans_Agy99 LNVAG---------------------------------------------
.
Mb3782c|M.bovis_AF2122/97 -------------------------RMRKLAAVVDKPAAGGGHALR----
Rv3756c|M.tuberculosis_H37Rv -------------------------RMRKLAAVVDKPAAGGGHALR----
TH_3216|M.thermoresistible__bu VA-----------GTCALAIGSIGLLAKLVADAVEEIDPGPVEAVRAVGG
Mvan_2906|M.vanbaalenii_PYR-1 VA-----------GACALALASIGFLAKLVADAVEEIDPGPLEAVRAVGG
MSMEG_0646|M.smegmatis_MC2_155 IA-----------GTCALAIGSIGFLAKLVADAVEEIDPGPMEAVRSVGG
MMAR_0061|M.marinum_M IVGGLTNNNPYPLGIAALGLMAGAYVGEILRSGIQSVDPGQLEASRALGF
MAV_0059|M.avium_104 IVGGLTNNNPYPLGIAALGMMAAAYIGEILRSGIQSVDPGQLEASRALGF
Mflv_0858|M.gilvum_PYR-GCK VVGHLTNNNPFPLGIAALGLMAAAYVGEIFRSGIQSVDPGQLEASRALGF
MAB_2802c|M.abscessus_ATCC_199 --------------------------NYLARKALRR--------------
MUL_4375|M.ulcerans_Agy99 ----------------------------RLATPWERSSRGRRRFRSPIVG
Mb3782c|M.bovis_AF2122/97 --------------------------------------------------
Rv3756c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3216|M.thermoresistible__bu GWWKTLFAAVIPQAVPAMTGSTLYLLDVNIRTSTILGIVGAGGIGYLLFE
Mvan_2906|M.vanbaalenii_PYR-1 GWWKTLFAAVIPQALPAMVGSSLYMFDVNVRTSTILGIVGAGGIGYLLFE
MSMEG_0646|M.smegmatis_MC2_155 GWWKTLFAAVLPQSMPALVGSSLYLFDVNVRTSTILGIVGAGGVGYLLFE
MMAR_0061|M.marinum_M SYSAAMRLVVVPQGVRRVLPALVNQFIALLKASALVYFLGLIAQQRELFQ
MAV_0059|M.avium_104 SYATAMRLVVVPQGVRRVLPALVNQFIALLKASALVYFLGLVADQRELFQ
Mflv_0858|M.gilvum_PYR-GCK SYSTSMRLVVVPQGVRRVLPALMNQFISLLKASSLVYFLGLIANQRELFQ
MAB_2802c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4375|M.ulcerans_Agy99 GAR-----------------------------------------------
Mb3782c|M.bovis_AF2122/97 --------------------------------------------------
Rv3756c|M.tuberculosis_H37Rv --------------------------------------------------
TH_3216|M.thermoresistible__bu SIRTLNFDVAGAIVIVVF-----AIVYAIEGVSGWIRARLV---------
Mvan_2906|M.vanbaalenii_PYR-1 SIRTLNFDVAGAIVLVIF-----VIVYAIERLSGWIRAQLV---------
MSMEG_0646|M.smegmatis_MC2_155 SIRTLNFDVAGAIVIVIF-----VIVYAIERLSGWIRSRLV---------
MMAR_0061|M.marinum_M VGRDLNAQTGNLSPLVAAGIFYLMLTVPLTHLVNYIDARLRRGRRRLDPE
MAV_0059|M.avium_104 VGRDLNAETGNLSPLVAAGACYLILTVPLTHLVNMIDARLRRGRAAVDPE
Mflv_0858|M.gilvum_PYR-GCK VGRDLNAQTGNLSPLVAAGLFYLALTIPLTHLVNYIDVRLRRGRR-PDEK
MAB_2802c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4375|M.ulcerans_Agy99 --------------------------------------------------
Mb3782c|M.bovis_AF2122/97 ---------------
Rv3756c|M.tuberculosis_H37Rv ---------------
TH_3216|M.thermoresistible__bu ---------------
Mvan_2906|M.vanbaalenii_PYR-1 ---------------
MSMEG_0646|M.smegmatis_MC2_155 ---------------
MMAR_0061|M.marinum_M DPPGVVSSTIGEEMT
MAV_0059|M.avium_104 EPAEMLT--FGQEIT
Mflv_0858|M.gilvum_PYR-GCK DPLVLAT---SQEMN
MAB_2802c|M.abscessus_ATCC_199 ---------------
MUL_4375|M.ulcerans_Agy99 ---------------