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NTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWASANQVPVVTRG AGSGLSGGATALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIG GNIATNAGGLCCVKYGVTGDYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLR LLPAQNASSIVVASFGSVQAAVDAVLGVTGRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDE RGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGVPLPALGELVT GIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIMDLAVGLGGTITGEHGVGRLKR PWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1257c | - | - | 100% (455) | PROBABLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv2280 | - | 3e-63 | 36.02% (447) | dehydrogenase |
| M. tuberculosis H37Rv | Rv0161 | - | 3e-41 | 31.09% (460) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2301 | - | 3e-63 | 36.02% (447) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2230 | - | 0.0 | 78.22% (450) | FAD linked oxidase domain-containing protein |
| M. leprae Br4923 | MLBr_01103 | - | 0.0 | 85.81% (451) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_1407c | - | 0.0 | 70.99% (455) | oxidoreductase |
| M. marinum M | MMAR_4183 | - | 0.0 | 86.37% (455) | oxidoreductase |
| M. avium 104 | MAV_1405 | - | 0.0 | 87.47% (455) | oxidoreductase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_5037 | - | 0.0 | 77.14% (455) | oxidoreductase, FAD-binding |
| M. thermoresistible (build 8) | TH_3358 | - | 0.0 | 78.35% (448) | PUTATIVE FAD linked oxidase domain protein |
| M. ulcerans Agy99 | MUL_4485 | - | 0.0 | 86.15% (455) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4464 | - | 0.0 | 77.11% (450) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1257c|M.tuberculosis_H37Rv MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRT
MLBr_01103|M.leprae_Br4923 --MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRT
MMAR_4183|M.marinum_M MNADVLASLIAGLPDGMVVTDPTVTEGYRQDRALDPSAGKPLAVVRPRCT
MUL_4485|M.ulcerans_Agy99 MNADVLASLIAGLPDGMAVTDPTVTEGYRQDRALDPSAGKPLAVVRPRCT
MAV_1405|M.avium_104 MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRT
Mflv_2230|M.gilvum_PYR-GCK --MQPLASLIADLPDGTVVTDPDILESYRQDRAADPAAGTPLAVVRPRRT
Mvan_4464|M.vanbaalenii_PYR-1 --MQPLASLIAELPDGTVVTDPDIVASYRQDRAADPSAGTPIAVVRPRRT
MSMEG_5037|M.smegmatis_MC2_155 MTNAALAELVTELPEGTVVTDPDILASYRQDRAADPNAGMPLAVVRPHRT
TH_3358|M.thermoresistible__bu -VSAALSALIAELPDGTVVTDPDILASYRQDRARDPDAGTPLAVVRPRRT
MAB_1407c|M.abscessus_ATCC_199 MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRST
Mb2301|M.bovis_AF2122/97 -MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATP
: : :. :*. : .* :*. . * :* .
Rv1257c|M.tuberculosis_H37Rv EEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITV
MLBr_01103|M.leprae_Br4923 DEVQTVLRWASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITV
MMAR_4183|M.marinum_M EEVQTILRWAGANRVAVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITI
MUL_4485|M.ulcerans_Agy99 EEVQTILRWAGANRVAVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITI
MAV_1405|M.avium_104 EEVQTVLRWASAHGVPVVTRGAGSGLSGGATALDNGIVLSTEKMR-DITV
Mflv_2230|M.gilvum_PYR-GCK EEVQTVLRWAGTHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
Mvan_4464|M.vanbaalenii_PYR-1 EEVQATLRWATAHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
MSMEG_5037|M.smegmatis_MC2_155 EEVQAVMRWASANKVPVVPRGAGTGLSGGATAIDGGLVLSTEKMR-DISV
TH_3358|M.thermoresistible__bu EEVQTVLRWANAHRVPVVPRGAGTGLSGGASALDGGIVLSTEKMR-DITV
MAB_1407c|M.abscessus_ATCC_199 EEVSATLKWASAHHISVVPRGAGTGLSGGSTAQDGAVVLSTERMR-TITI
Mb2301|M.bovis_AF2122/97 EEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEV
:** :: * : :.*..** * ****.: . :..:::* ::*. : :
Rv1257c|M.tuberculosis_H37Rv DPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MLBr_01103|M.leprae_Br4923 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAG
MMAR_4183|M.marinum_M DPVTRIAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MUL_4485|M.ulcerans_Agy99 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MAV_1405|M.avium_104 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
Mflv_2230|M.gilvum_PYR-GCK DPVTRTAVVQPGLLNAEVKKVVAEHGLWYPPDPSSFEICSIGGNIATNAG
Mvan_4464|M.vanbaalenii_PYR-1 DPVTRTAVAQPGLLNAEVKKAVAEYGLWYPPDPSSFEICSIGGNIATNAG
MSMEG_5037|M.smegmatis_MC2_155 DTVTRTAVVQPGLLNAEVKKAVAEHGLWYPPDPSSFEICSIGGNIATNAG
TH_3358|M.thermoresistible__bu DPVTRTAVVQPGLLNAEVKQAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MAB_1407c|M.abscessus_ATCC_199 DTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAG
Mb2301|M.bovis_AF2122/97 DTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSS-VGGNVGTNAG
*...: *: *** :::. ..* ** *. *..:. . :***:.****
Rv1257c|M.tuberculosis_H37Rv GLCCVKYGVTGDYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSE
MLBr_01103|M.leprae_Br4923 GLCCVKYGVTGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MMAR_4183|M.marinum_M GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MUL_4485|M.ulcerans_Agy99 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MAV_1405|M.avium_104 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Mflv_2230|M.gilvum_PYR-GCK GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Mvan_4464|M.vanbaalenii_PYR-1 GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MSMEG_5037|M.smegmatis_MC2_155 GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
TH_3358|M.thermoresistible__bu GLCCVKYGVTTDYVMGLQVVLADGTAVRLGGPRIKDVAGLPLTKLFVGSE
MAB_1407c|M.abscessus_ATCC_199 GLCCVKYGVTTDYVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSE
Mb2301|M.bovis_AF2122/97 GMRAVKYGVARHNVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSE
*: .*****: . *:*:*.**. * :: ** * :* **:*::***
Rv1257c|M.tuberculosis_H37Rv GTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVTGR-LRPAML
MLBr_01103|M.leprae_Br4923 GTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR-LRPAML
MMAR_4183|M.marinum_M GTLGVITEVTLRLLPAQNAAAVVVASFASVESAVDAVLGVSAR-IRPSML
MUL_4485|M.ulcerans_Agy99 GTLGVITEVTLRLLPAQNAAAVVVASFASVESAVDAVLGVSAR-IRPSML
MAV_1405|M.avium_104 GTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVTGR-LRPSML
Mflv_2230|M.gilvum_PYR-GCK GTLGVVTEVTLKLLPAQHPACTVVATFDSVESAADAVVEITGR-IRPSML
Mvan_4464|M.vanbaalenii_PYR-1 GTLGVVTEVTLKLLPAQSGACTVVATFDSVEDAANAVVTITGK-IRPSML
MSMEG_5037|M.smegmatis_MC2_155 GTLGVVTEVTLRLLPPQNSPCTVVATFDSVEAAANAVVTITGK-IRPSML
TH_3358|M.thermoresistible__bu GTLGVVTEVTLRLLPPQHQASTVVATFASVEAAAESVLAITAR-IRPSML
MAB_1407c|M.abscessus_ATCC_199 GTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAITAQ-IRPSML
Mb2301|M.bovis_AF2122/97 GTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILASGLAPDIL
***.::*** ::* * . *:*.* .. . :* : . : * :*
Rv1257c|M.tuberculosis_H37Rv EFMDSVAINAVEDTLRMDL-------DRDAAAMLVAGSDERGRAATEDAA
MLBr_01103|M.leprae_Br4923 EFMDSVAINAVEDTFRMGL-------DREAAAMLVAGSDELGHAGTDEAK
MMAR_4183|M.marinum_M EFMDSVAINAVEDTLRMDL-------DRGAAAMLVASSDERGQAGRDDAE
MUL_4485|M.ulcerans_Agy99 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVASSDERGQADRDDAE
MAV_1405|M.avium_104 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVAGSDERGRAGSEDAE
Mflv_2230|M.gilvum_PYR-GCK EFMDSTAINAVEDKLKMGL-------DRDAAAMMVAASDDRGAAGAQDAE
Mvan_4464|M.vanbaalenii_PYR-1 EFMDSAAINAVEDKLKMGL-------DRSAAAMMVAASDDRGPSGAQDAE
MSMEG_5037|M.smegmatis_MC2_155 EFMDSVAINAVEDKLKMGL-------DRNAAAMMVAASDDRGAAGADDTE
TH_3358|M.thermoresistible__bu EFMDAVAINAVEDKLRMGL-------DRSAAAMMVAASDDRGPAGAEDAE
MAB_1407c|M.abscessus_ATCC_199 EFMDSVAINAVEDKLKMGL-------DRAAGAMLVARSDERGHTSTEDAE
Mb2301|M.bovis_AF2122/97 EYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQ
*::* .:: *: .. .: * * . ::** .: . ::
Rv1257c|M.tuberculosis_H37Rv VMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGV
MLBr_01103|M.leprae_Br4923 LIGAVFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGV
MMAR_4183|M.marinum_M LMAAVFAEHGATEVFSTTDPDEGEAFVAARRFCIPAVEAKGSLLLEDVGV
MUL_4485|M.ulcerans_Agy99 LMAAVFAEHGATEVFSTTDPDEGEPFVAARRFCIPAVEAKGSLLLEDVGV
MAV_1405|M.avium_104 IMAKVFAENAATEVFSTDDPDEGEAFVVARRFCIPAVEAKGSLLLEDVGV
Mflv_2230|M.gilvum_PYR-GCK YMARVFTEHGATEVFSTSDPDEGDAFVAARRFAIPAVESKGSLLLEDVGV
Mvan_4464|M.vanbaalenii_PYR-1 FMAGVFTEHGAREVFSTSDPDEGEAFVAARRFAIPAVEARGALLLEDVGV
MSMEG_5037|M.smegmatis_MC2_155 FMARVFSEAGATEVFSTSDPDEGEAFVAARRFAIPAVEAKGSLLLEDVGV
TH_3358|M.thermoresistible__bu FMAQVFTEHGATEVFSTADPDEGEAFVAARRFAIPAVEAKGALLLEDVGV
MAB_1407c|M.abscessus_ATCC_199 LIARIFTDHHAAEVFSTDDEEEGEAFVAARRFAIPAVEAKGSLLLEDVGV
Mb2301|M.bovis_AF2122/97 TVGEMLMELGAVDAYVLEG-GSARKLIEAREKAFWAAKALGADDIIDTVV
:. :: : * :. . .. :: **. .: *.:: *: : *. *
Rv1257c|M.tuberculosis_H37Rv PLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLER
MLBr_01103|M.leprae_Br4923 PLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTER
MMAR_4183|M.marinum_M PLPNLGKLVTGIARIAQERDLMISVIAHAGDGNTHPLLVYDPSDAAMAER
MUL_4485|M.ulcerans_Agy99 PLPNLRKLVTGIARIAQERDLMISVIAHAGDGNTHPLLVYDPSDAAMAER
MAV_1405|M.avium_104 PLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTER
Mflv_2230|M.gilvum_PYR-GCK PLPALAELVGGVEKIAAARDVMISVIAHAGDGNTHPLIVFDPSDTAMEQR
Mvan_4464|M.vanbaalenii_PYR-1 PLPALAELVGGVEKIAGHHELMISVIAHAGDGNTHPLIVFDPDDPDMERR
MSMEG_5037|M.smegmatis_MC2_155 PLPALADLVSGVEKIAAQREVMISVIAHAGDGNTHPLIVFDPADEAMTAR
TH_3358|M.thermoresistible__bu PLPALADLVGGVARLADHHELTISVIAHAGDGNTHPLIVYDPADAAMAER
MAB_1407c|M.abscessus_ATCC_199 PLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRR
Mb2301|M.bovis_AF2122/97 PRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDP-----EK
* . : :: :: .******.* :. . :
Rv1257c|M.tuberculosis_H37Rv AHLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQ
MLBr_01103|M.leprae_Br4923 AHRAFGEIMDMAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKH
MMAR_4183|M.marinum_M AQLAYGEIMDLAVSLGGTITGEHGVGRLKRPWLEGYLGPDVMDLNRRIKQ
MUL_4485|M.ulcerans_Agy99 AQLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLEGYLGPDVMDLNRRIKQ
MAV_1405|M.avium_104 AHLAFGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQ
Mflv_2230|M.gilvum_PYR-GCK AQQAFGEIMDLAVSLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
Mvan_4464|M.vanbaalenii_PYR-1 AQQAFGEIMDLAIGLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
MSMEG_5037|M.smegmatis_MC2_155 AQLAFGEIMELAVGLGGTITGEHGVGRLKRPWLANQIGPDAMELNHRIKR
TH_3358|M.thermoresistible__bu AAQAFGEIMELAIDLGGTITGEHGVGRLKRPWLADQIGPEAMELHRRIKD
MAB_1407c|M.abscessus_ATCC_199 AQTAFGQIMDLAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQ
Mb2301|M.bovis_AF2122/97 KKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQ
:*: :*: ***:*:******* * :: .* : : :***
Rv1257c|M.tuberculosis_H37Rv ALDPQGILNPGSAI---
MLBr_01103|M.leprae_Br4923 ALDPYGILNPGAAI---
MMAR_4183|M.marinum_M ALDPLDILNPGSGI---
MUL_4485|M.ulcerans_Agy99 ALDPLDILNPGSGI---
MAV_1405|M.avium_104 ALDPQGILNPGSGI---
Mflv_2230|M.gilvum_PYR-GCK ALDPDGILNPGAAI---
Mvan_4464|M.vanbaalenii_PYR-1 ALDPDGILNPGAAI---
MSMEG_5037|M.smegmatis_MC2_155 ALDPDNILNPGAAI---
TH_3358|M.thermoresistible__bu ALDPNGILNPGAGF---
MAB_1407c|M.abscessus_ATCC_199 ALDPDGILNPGTLI---
Mb2301|M.bovis_AF2122/97 SFDPAGILNPGVVFGDT
::** .***** :