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MSEPVTVYVPCDSAAKSVGADEVAHALTAAAERVGRPIRLVRNGSRGMLWLEPLIEVATPNGRVGYGPVT PDQVDELVGAGLFDAAEHPLRVGVVEDLPWMATQDRVTFARVGVTDPVSPDDYLDHGGLAGLRRALQMSP AEVVAEVTDSGLRGRGGAGFPAGIKWKTVLDCADALKFVCCNADEGDSGTFADRMVMEGDPFMLIEGMTI AAHAVGATEGYIYIRSEYPDAIATMRAAIDIARGRGWLGDDVLGSGLRFDMHVRVGGGAYICGEETSMLE SLEGKRGMVRAKPPIPAINGLFGKPTVVNNVLTLSSVPLVLAEGAQAYADFGVGRSRGTQIFQLGGNIRR GGIVERAFGITLGELVEHYGGGTLSGRPVRAVQVGGPLGAYLPSDRFDLPMDYEAFAEAGAMVGHGGIVV FDETVDMAAQARFAMEFCAAESCGKCTPCRVGSVRGMEVIDRITAGDHREENLALLDDLCDVMTEGSLCA MGGLTPMPVRSALTHFPDDFGPRQPSADATAAPLGARTEGPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0160 | - | - | 100% (532) | formate dehydrogenase, beta subunit |
| M. smegmatis MC2 155 | MSMEG_2058 | nuoF | 1e-83 | 39.34% (427) | NADH-quinone oxidoreductase, F subunit |
| M. smegmatis MC2 155 | MSMEG_4812 | - | 1e-27 | 26.26% (377) | respiratory-chain NADH dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3174 | nuoF | 2e-79 | 40.31% (387) | NADH dehydrogenase I chain F |
| M. gilvum PYR-GCK | Mflv_4486 | - | 9e-86 | 40.48% (420) | NADH-quinone oxidoreductase, F subunit |
| M. tuberculosis H37Rv | Rv3150 | nuoF | 2e-79 | 40.31% (387) | NADH dehydrogenase I chain F |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2139 | - | 1e-85 | 41.03% (390) | NADH-quinone oxidoreductase, F subunit NuoF |
| M. marinum M | MMAR_1478 | nuoF | 5e-80 | 40.05% (392) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
| M. avium 104 | MAV_4038 | nuoF | 3e-81 | 40.31% (392) | NADH-quinone oxidoreductase, F subunit |
| M. thermoresistible (build 8) | TH_0632 | nuoF | 9e-83 | 39.46% (408) | PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF |
| M. ulcerans Agy99 | MUL_2464 | nuoF | 1e-79 | 39.80% (392) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
| M. vanbaalenii PYR-1 | Mvan_1880 | - | 7e-84 | 41.13% (423) | NADH-quinone oxidoreductase, F subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3174|M.bovis_AF2122/97 --------MTT-----------QATPLTPVISRH---------------W
Rv3150|M.tuberculosis_H37Rv --------MTT-----------QATPLTPVISRH---------------W
MMAR_1478|M.marinum_M --------MTS-----------QATPLTPVISRY---------------W
MUL_2464|M.ulcerans_Agy99 --------MTS-----------QATPLTPVISRY---------------W
MAV_4038|M.avium_104 --------MTTTSETSEASGAPQATPLTPVISRF---------------W
Mflv_4486|M.gilvum_PYR-GCK -----------------------MTSLTPVLSRF---------------W
Mvan_1880|M.vanbaalenii_PYR-1 -----------------------MTALTPVLSRF---------------W
TH_0632|M.thermoresistible__bu -----------------------MTPLTPVLTRF---------------W
MAB_2139|M.abscessus_ATCC_1997 ---------------------MTSSILSPVLSEH---------------W
MSMEG_0160|M.smegmatis_MC2_155 MSEPVTVYVPCDSAAKSVGADEVAHALTAAAERVGRPIRLVRNGSRGMLW
*:.. . *
Mb3174|M.bovis_AF2122/97 DDP-----------------------------------------------
Rv3150|M.tuberculosis_H37Rv DDP-----------------------------------------------
MMAR_1478|M.marinum_M DDP-----------------------------------------------
MUL_2464|M.ulcerans_Agy99 DDP-----------------------------------------------
MAV_4038|M.avium_104 DDP-----------------------------------------------
Mflv_4486|M.gilvum_PYR-GCK DEP-----------------------------------------------
Mvan_1880|M.vanbaalenii_PYR-1 DEP-----------------------------------------------
TH_0632|M.thermoresistible__bu DEP-----------------------------------------------
MAB_2139|M.abscessus_ATCC_1997 DEP-----------------------------------------------
MSMEG_0160|M.smegmatis_MC2_155 LEPLIEVATPNGRVGYGPVTPDQVDELVGAGLFDAAEHPLRVGVVEDLPW
:*
Mb3174|M.bovis_AF2122/97 ---------------ESWTLATYQRHDRYRGYQALQKALTMPPDDVISIV
Rv3150|M.tuberculosis_H37Rv ---------------ESWTLATYQRHDRYRGYQALQKALTMPPDDVISIV
MMAR_1478|M.marinum_M ---------------ESWTLATYRRHDGYR---ALEKALAMGPDAVIGTV
MUL_2464|M.ulcerans_Agy99 ---------------ESWTLATYRRHDGYR---ALEKALAMGPDAVIGTV
MAV_4038|M.avium_104 ---------------ESWTLQTYHRHGGYA---AMKKALAMEPDAVIGMV
Mflv_4486|M.gilvum_PYR-GCK ---------------QPWTMDTYIRHGGYQ---ALERALAMSPDDVIGTV
Mvan_1880|M.vanbaalenii_PYR-1 ---------------QPWSLDTYRRHGGYQ---ALDRALAMTPDQVITTV
TH_0632|M.thermoresistible__bu ---------------EPWSLDTYRRHDGYR---ALEKALKMAPDEVIALV
MAB_2139|M.abscessus_ATCC_1997 ---------------DAWTLDGYLRHGGYR---GLRTALGMDPDAVIALV
MSMEG_0160|M.smegmatis_MC2_155 MATQDRVTFARVGVTDPVSPDDYLDHGGLA---GLRRALQMSPAEVVAEV
:. : * *. .: ** * * *: *
Mb3174|M.bovis_AF2122/97 KDSGLRGRGGAGFATGTKWSFIPQ---------GDTGAAAKPHYLVVNAD
Rv3150|M.tuberculosis_H37Rv KDSGLRGRGGAGFATGTKWSFIPQ---------GDTGAAAKPHYLVVNAD
MMAR_1478|M.marinum_M KDSGLRGRGGAGFSTGTKWSFIPQ---------GDAGPAAKPHYLVVNAD
MUL_2464|M.ulcerans_Agy99 KDSGLRGRGGAGFSTGTKWSFIPQ---------GDAGPAAKPHYLVVNAD
MAV_4038|M.avium_104 KDSGLRGRGGAGFSTGTKWSFIPQ---------GDTGAAAKPHYLVVNAD
Mflv_4486|M.gilvum_PYR-GCK KDSGLRGRGGAGFPTGTKWSFIPQ---------GGEGAAAKPHYLVINAD
Mvan_1880|M.vanbaalenii_PYR-1 KDSGLRGRGGAGFPTGTKWSFIPQ---------GDEGPAAKPHYLVINAD
TH_0632|M.thermoresistible__bu KESGLRGRGGAGFPTGTKWSFIPQAASTQAGAAGGSDPAARPHYLVVNAD
MAB_2139|M.abscessus_ATCC_1997 KEAGLRGRGGAGFPTGAKWSFIPQ-------------GDGKPHYLVVNAD
MSMEG_0160|M.smegmatis_MC2_155 TDSGLRGRGGAGFPAGIKWKTVLD-------------CADALKFVCCNAD
.::**********.:* **. : : ::: ***
Mb3174|M.bovis_AF2122/97 ESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRR
Rv3150|M.tuberculosis_H37Rv ESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRR
MMAR_1478|M.marinum_M ESEPGTCKDIPLMLATPHVLVEGVIIAAYAIRASHAFIYVRGEVLPVLRR
MUL_2464|M.ulcerans_Agy99 ESEPGTCKDIPLMLATPHVLVEGVIIAAYAIRASHAFIYVRGEVLPVLRR
MAV_4038|M.avium_104 ESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRR
Mflv_4486|M.gilvum_PYR-GCK ESEPGTCKDIPLMLTTPHFLVEGAIIAAYAIRANHAFIYLRGEVVPVLRR
Mvan_1880|M.vanbaalenii_PYR-1 ESEPGTCKDIPLMLTTPHFLVEGAIIAAYAIRAHHAFIYLRGEVVPVLRR
TH_0632|M.thermoresistible__bu ESEPGTCKDIPLMLTTPHFLVEGAIIAAYAIRARHAFIYLRGEVVPVLRR
MAB_2139|M.abscessus_ATCC_1997 ESEPGTCKDIPLMLATPHTLIEGIVIAAFAIRASQAFIYVRGEVISVIRR
MSMEG_0160|M.smegmatis_MC2_155 EGDSGTFADRMVMEGDPFMLIEGMTIAAHAVGATEGYIYIRSEYPDAIAT
*.:.** * :* *. *:** ***.*: * ..::*:*.* .:
Mb3174|M.bovis_AF2122/97 LHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGAYICGEETALLDSLEG
Rv3150|M.tuberculosis_H37Rv LHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGAYICGEETALLDSLEG
MMAR_1478|M.marinum_M LQNAVAEAYAAGLLGRNINGSGFDLELVVHAGAGAYICGEETALLDSLEG
MUL_2464|M.ulcerans_Agy99 LQNAVAEAYAAGLLGRNINGSGFDLELVVHAGAGAYICGEETALLDSLEG
MAV_4038|M.avium_104 LQNAVAEAYAAGYLGRDIDGSGFDLELVVHAGAGAYICGEETALLDSLEG
Mflv_4486|M.gilvum_PYR-GCK LQAAVAEAYAAGHLGHDIHGSGFDLELTVHAGAGAYICGEETALLDSLEG
Mvan_1880|M.vanbaalenii_PYR-1 LQAAVAEAYAAGHLGSDIHGSGFDLELIVHAGAGAYICGEETALLDSLEG
TH_0632|M.thermoresistible__bu LQQAVAEAYEAGYLGADIRGSGFDLDLIVHAGAGAYICGEETALLDSLEG
MAB_2139|M.abscessus_ATCC_1997 LHAAVAQAYKAGYLGRNILDSGFDLELVVHAGAGAYICGEETALLDSLEG
MSMEG_0160|M.smegmatis_MC2_155 MRAAIDIARGRGWLGDDVLGSGLRFDMHVRVGGGAYICGEETSMLESLEG
:: *: * * ** :: .**: ::: *:.*.*********::*:****
Mb3174|M.bovis_AF2122/97 RRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFRSMGSE
Rv3150|M.tuberculosis_H37Rv RRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFRSMGSE
MMAR_1478|M.marinum_M RRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILNGVDWFRSMGSE
MUL_2464|M.ulcerans_Agy99 RRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILNGVDWFRSMGSE
MAV_4038|M.avium_104 RRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIIGNGVDWFRSMGSE
Mflv_4486|M.gilvum_PYR-GCK RRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPILLNGVDWFRSMGSE
Mvan_1880|M.vanbaalenii_PYR-1 RRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPVLLNGVDWFRSMGSE
TH_0632|M.thermoresistible__bu RRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPPIVLNGIDWFRSMGSE
MAB_2139|M.abscessus_ATCC_1997 RRGQPRLRPPFPAVAGLYASPTVVNNVESIASVPVILRRGAEWFRTMGTE
MSMEG_0160|M.smegmatis_MC2_155 KRGMVRAKPPIPAINGLFGKPTVVNNVLTLSSVPLVLAEGAQAYADFGVG
:** * :**:**: **:. ***:*** :::*** :: * : : :*
Mb3174|M.bovis_AF2122/97 KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-VRAGHRLKFWTP
Rv3150|M.tuberculosis_H37Rv KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-VRAGHRLKFWTP
MMAR_1478|M.marinum_M KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-IRAGHQLKFWTP
MUL_2464|M.ulcerans_Agy99 KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-IRAGHQLKFWTP
MAV_4038|M.avium_104 KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-VRAGHRLKFWTP
Mflv_4486|M.gilvum_PYR-GCK KSPGFTLYSLSGHVTTPGQYEAPLGITLRELLDYAGG-VRAGHELKFWTP
Mvan_1880|M.vanbaalenii_PYR-1 KSPGFTLYSLSGHVTTPGQYEAPLGITLRELLEYAGG-VRAGHELKFWTP
TH_0632|M.thermoresistible__bu KSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGG-VRAGRSLKFWTP
MAB_2139|M.abscessus_ATCC_1997 KSPGFTLYSLSGHVRTPGQYEAPLGVTLRQLLELAGG-VRDGRALKFWTP
MSMEG_0160|M.smegmatis_MC2_155 RSRGTQIFQLGGNIRRGGIVERAFGITLGELVEHYGGGTLSGRPVRAVQV
:* * ::.*.*:: * * .:*:** :*:: ** *: ::
Mb3174|M.bovis_AF2122/97 GGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRAVRRW
Rv3150|M.tuberculosis_H37Rv GGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRAVRRW
MMAR_1478|M.marinum_M GGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRAVRRW
MUL_2464|M.ulcerans_Agy99 GGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRAVRRW
MAV_4038|M.avium_104 GGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRAVRRW
Mflv_4486|M.gilvum_PYR-GCK GGSSTPLLTADHLDVPLDYEGMAGVGSMLGTKALQIFDDTTCVVRAVRRW
Mvan_1880|M.vanbaalenii_PYR-1 GGSSTPLLTAEHLDVPLDYEGMAGVGSMLGTKALQIFDETTCVVRAVRRW
TH_0632|M.thermoresistible__bu GGSSTPLLTAEHLDVPLDYEGIAGVGSMLGTKALQIFDDTTCVVRAVARW
MAB_2139|M.abscessus_ATCC_1997 GGSSTPLFTAEQLDVPLDYEGVSAAGSMLGTKALQIFDDTTCVVRAVLRW
MSMEG_0160|M.smegmatis_MC2_155 GGPLGAYLPSDRFDLPMDYEAFAEAGAMVGHGGIVVFDETVDMAAQARFA
**. . :. :::*:*:***... .*:*:* .: :**:*. :. .
Mb3174|M.bovis_AF2122/97 TEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDSIL
Rv3150|M.tuberculosis_H37Rv TEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDSIL
MMAR_1478|M.marinum_M TEFYKHESCGKCTPCREGTFWLDKIYARLETGKGTREDIDKLLDISDSIL
MUL_2464|M.ulcerans_Agy99 TEFYKHESCGKCTPCREGTFWLDKIYARLETGKGTREDIDKLLDISDSIL
MAV_4038|M.avium_104 TYFYKHESCGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDTIL
Mflv_4486|M.gilvum_PYR-GCK TQFYAHESCGKCTPCREGTYWLAQIYERLETGRGTEADLDKLLDISDNIF
Mvan_1880|M.vanbaalenii_PYR-1 TQFYAHESCGKCTPCREGTYWLAQIYERLETGAGTEADLDKLLDISDNIF
TH_0632|M.thermoresistible__bu TDFYAHESCGKCTPCREGTYWLKQIYARLESGAGTRADLDKLLDISDIVL
MAB_2139|M.abscessus_ATCC_1997 TEFYAHESCGKCTPCREGTYWLVRILQRLESGEGKAEDLDKLLDISDIVL
MSMEG_0160|M.smegmatis_MC2_155 MEFCAAESCGKCTPCRVGSVRGMEVIDRITAGDHREENLALLDDLCDVMT
* ********** *: .: *: :* :: * *:.* :
Mb3174|M.bovis_AF2122/97 GKSFCALGDGAASPVMSSIKHFRDEYLAHVE--GGGCPFDPRDSMLVANG
Rv3150|M.tuberculosis_H37Rv GKSFCALGDGAASPVMSSIKHFRDEYLAHVE--GGGCPFDPRDSMLVANG
MMAR_1478|M.marinum_M GKSFCALGDGAASPVMSSIKHFQDEYIAHVE--QGGCPFDPRDSMLTAGR
MUL_2464|M.ulcerans_Agy99 GKSFCALGDGAASPVMSSIKHFQNEYIAHAE--QGGCPFDPRDSMLTAGR
MAV_4038|M.avium_104 GKSFCALGDGAASPVMSSIKYFRDEYVAHVE--NGRCPFDPRDSMLTPNG
Mflv_4486|M.gilvum_PYR-GCK GKSFCALGDGAASPIMSSLKHFRDEYEAHLG---NACPFDPYASMLAAPE
Mvan_1880|M.vanbaalenii_PYR-1 GKSFCALGDGAASPIMSSLKHFRAEYEAHLDPVGKGCPFDPYASMLAAPE
TH_0632|M.thermoresistible__bu GKSFCALGDGAAMPIQSSLRYFRDEYEAHLDPASPGCPFDPHASTLMATE
MAB_2139|M.abscessus_ATCC_1997 GKSFCALGDGAASPIMSSLKYFRTEYEAHLD---NGCPFDPAASTVFGEV
MSMEG_0160|M.smegmatis_MC2_155 EGSLCAMGGLTPMPVRSALTHFPDDFGPRQP------SADATAAPLGART
*:**:*. :. *: *:: :* :: .: . *. : :
Mb3174|M.bovis_AF2122/97 VDA------
Rv3150|M.tuberculosis_H37Rv VDA------
MMAR_1478|M.marinum_M NTAKGTGPQ
MUL_2464|M.ulcerans_Agy99 NTAKGTGPQ
MAV_4038|M.avium_104 SDS------
Mflv_4486|M.gilvum_PYR-GCK GVGV-----
Mvan_1880|M.vanbaalenii_PYR-1 GVGA-----
TH_0632|M.thermoresistible__bu EVRA-----
MAB_2139|M.abscessus_ATCC_1997 SA-------
MSMEG_0160|M.smegmatis_MC2_155 EGPR-----