For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_0115 (dehII)

annotation: haloacid dehalogenase, type II
coordinates: 139607 - 140287
length: 226

TEHVLVFDVNETLIDLESLTPHFERTFSDPHVLREWFGQLVMHSMALTLSGNYTDFFTLGQGVLRMLADI
HGVTISDDDVQALAEGMRTMPAYPDVEEGLQRLRGNGYRLVTLTNSPHHQGATPLENAGLAGYFERQFTV
GEHRVFKPSTSLYTHVASALGVEPGQCTMVASHTWDLLGAQSAGYRGVLITRPGNAPLTAPGVPQPQIVA
ADLLQLNDVLTRQRL*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_0115dehII-100% (226)haloacid dehalogenase, type II
M. smegmatis MC2 155MSMEG_3450dehII1e-1027.63% (228) haloacid dehalogenase, type II

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_0739-2e-0929.07% (172) haloacid dehalogenase, type II
M. tuberculosis H37Rv-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2863-8e-0826.37% (201) HAD-superfamily hydrolase YfnB
M. marinum MMMAR_3371-4e-1128.64% (199) hypothetical protein MMAR_3371
M. avium 104MAV_2690dehII2e-0933.87% (124) haloacid dehalogenase, type II
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_1268-2e-1128.64% (199) hypothetical protein MUL_1268
M. vanbaalenii PYR-1Mvan_0108-1e-1029.65% (172) haloacid dehalogenase, type II

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3371|M.marinum_M               ----MSLMVTALLFDVQGTATDFHSTVCDEARRISAGRHPDADWPELVRR
MUL_1268|M.ulcerans_Agy99           -----------MLFDVQGTATDFHSTVCDEARRISAGRHPDADWPELVRR
MAV_2690|M.avium_104                MTHSARFAPKALLFDVQGTVTDFHSTVCSEAQRICGSRNQNVDWSDFVNS
Mflv_0739|M.gilvum_PYR-GCK          ------MPIRALAFDVFGTVVDWRSSIIAELSEFGREHGVDADWSRFADD
Mvan_0108|M.vanbaalenii_PYR-1       MREEQTVVIRALAFDVFGTVVDWRSSVIRELGDFGRRNGVSADWPRFADD
MAB_2863|M.abscessus_ATCC_1997      ------MRYKAYLFDVQGTLLDFFEPVSRAVAEYS----PDVDAAAFTRA
MSMEG_0115|M.smegmatis_MC2_155      ------MTEHVLVFDVNETLIDLESLTPHFERTFS--------DPHVLRE
                                                 ***  *  *  .                   . .   

MMAR_3371|M.marinum_M               WRAGYFSALDASSGGHGGWVSVYSVYRQVLDAVLDGCGVTGLSAAERDEL
MUL_1268|M.ulcerans_Agy99           WRAGYFSALDASSGGHGGWVSVYSVYRQVLDAVLDGCGVTGLSAAERDEL
MAV_2690|M.avium_104                WRAAYFSCLEAAKPDRDNWITVHSVYRSSLESLLAEYSITDLTAAERDEL
Mflv_0739|M.gilvum_PYR-GCK          WRAGYVPAMDRVRRGELPWTRIDDLHRGRLVELLDQAAIT-VSDTDIDHL
Mvan_0108|M.vanbaalenii_PYR-1       WRAGYVPAMDRVRRGELPWTRLDDLHRGRLVELLEGTGIT-VSDSEIDEL
MAB_2863|M.abscessus_ATCC_1997      WRADYFERVSSLTQSADHWTRVQDLYAAGFADVCQTFGLPCPDTATAEDV
MSMEG_0115|M.smegmatis_MC2_155      WFGQLVMHSMALTLSG-NYTDFFTLGQGVLRMLADIHGVT-ISDDDVQAL
                                    * .  .        .   :  .  :    :  :    .:.       : :

MMAR_3371|M.marinum_M               TLAWQRLRPWPDVVAGLTRLKTK-FTLATLSNADVSAVVNISKRAALP--
MUL_1268|M.ulcerans_Agy99           TLAWQRLRPWPDVVAGLTRLKTK-FTLATLSNADVSAVVNISKRAALP--
MAV_2690|M.avium_104                TLAWQRLVPWPDVLPGLTRLKKK-FIIATLSNADVSALINIAKRGGLP--
Mflv_0739|M.gilvum_PYR-GCK          NRAWHRLDPWPDSVAGLTRLKQR-FLITTLSNGNVSLLTDMAKRAGLP--
Mvan_0108|M.vanbaalenii_PYR-1       NRAWHRLDPWPDAVAGLTRLKRR-FVITTLSNGNVSLLTNMAKRAGLP--
MAB_2863|M.abscessus_ATCC_1997      ASSWQRLVPWPDVPAGLAALRMR-AVVATLSNTDMATMVNLFKRLDIS--
MSMEG_0115|M.smegmatis_MC2_155      AEGMRTMPAYPDVEEGLQRLRGNGYRLVTLTNSPHHQGATPLENAGLAGY
                                      . : : .:**   **  *: .   :.**:*          :.  :.  

MMAR_3371|M.marinum_M               WDAIFAAEMAGVFKPDPAAYRMAVGYLGCEPAEVMMVASHKYDLRAAARL
MUL_1268|M.ulcerans_Agy99           WDAIFAAEMAGVFKPDPAAYRMAVGYLGCEPAEVMMVASHKYDLRAAARL
MAV_2690|M.avium_104                WDAVFAAEMAGVFKPDPAIYHMAARYLGLAPRQIMMVASHKYDIRAAASL
Mflv_0739|M.gilvum_PYR-GCK          WDCVLSAEIFGHYKPDREAYLGTAHILDVAPGELMMVAAHPSDLRAARDA
Mvan_0108|M.vanbaalenii_PYR-1       WDCVLSAEIFGHYKPDREAYLGCAEILDVAPGELMLVAAHPSDLRGARRA
MAB_2863|M.abscessus_ATCC_1997      WDAIFTAEVFGRFKPDPSVYRGALRYLGVEPYEAAMVAAHPYDLRAARQL
MSMEG_0115|M.smegmatis_MC2_155      FERQFTVGEHRVFKPSTSLYTHVASALGVEPGQCTMVASHTWDLLGAQSA
                                    ::  ::.     :**.   *      *.  * :  :**:*  *: .*   

MMAR_3371|M.marinum_M               GLRTAFVARPLEFG--IGGAADATYADEFDINAADFLD---LAGQLGC--
MUL_1268|M.ulcerans_Agy99           GLRTAFVARPLEFGSVVRPMQPMPMSSTSTPQTSSILPGNSVADRCGVET
MAV_2690|M.avium_104                GFQTAFVTRPFEFG--PLGLADTAYDDAFDVNAADLLD---LATQLSC--
Mflv_0739|M.gilvum_PYR-GCK          GLVTAYVHRPLEQG--PDRTPERPGHDEFDITASDFGD---FADQLGA--
Mvan_0108|M.vanbaalenii_PYR-1       GLATAFVHRPLEQG--PDRAPARPADGEFDVMADDFHD---LADRLGV--
MAB_2863|M.abscessus_ATCC_1997      GMGTIFVSRPHEYG--DPVLAHTDPDEEFDQRVTAIGE---LS-------
MSMEG_0115|M.smegmatis_MC2_155      GYRGVLITRPGNAPLTAPGVPQPQIVAADLLQLNDVLT----RQRL----
                                    *     : ** :                       .              

MMAR_3371|M.marinum_M               --------
MUL_1268|M.ulcerans_Agy99           SFTRTEFG
MAV_2690|M.avium_104                --------
Mflv_0739|M.gilvum_PYR-GCK          --------
Mvan_0108|M.vanbaalenii_PYR-1       --------
MAB_2863|M.abscessus_ATCC_1997      --------
MSMEG_0115|M.smegmatis_MC2_155      --------