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TGPPPPPPPWPPGGQYPGQHPGQYPGWGGPGWSGYGEAPPAHQPPKPNKTPWILAALAGVVIIALVAGGL VWKFTSGGDDDTDAAGTTTSTSAAPDTPDTAGAQAPTTTAKPACEGRVAARTPDTPPQWIPVESPRGLNY AVPPDWTVNSCTSLVGWEKPCPEGPFGFCPVRSMSGSAMLPNKQCPDHARVLTGVPGASKTDDIDEAVQL ESQLVDDIFTSKNGVVPQVSLSDPREFTIDGQPAVQIVATVTGIETDECVAPEALHSMVATKVDGQPGSV MFIVSMEQGFPGAPSPSLIDEILETVHHAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0047 | - | - | 100% (311) | hypothetical protein MSMEG_0047 |
| M. smegmatis MC2 155 | MSMEG_5513 | - | 6e-10 | 29.73% (148) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_0700 | - | 2e-09 | 35.66% (129) | hypothetical protein MSMEG_0700 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2535 | - | 1e-09 | 35.29% (119) | proline rich membrane protein |
| M. gilvum PYR-GCK | Mflv_2026 | - | 3e-11 | 33.60% (125) | protein kinase |
| M. tuberculosis H37Rv | Rv2507 | - | 1e-09 | 35.29% (119) | proline rich membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2112 | - | 8e-07 | 27.22% (169) | hypothetical protein MAB_2112 |
| M. marinum M | MMAR_4156 | pknH | 3e-09 | 31.93% (119) | transmembrane serine/threonine-protein kinase H PknH |
| M. avium 104 | MAV_1219 | - | 8e-10 | 34.59% (159) | hypothetical protein MAV_1219 |
| M. thermoresistible (build 8) | TH_1385 | - | 8e-09 | 36.07% (122) | POSSIBLE CONSERVED PROLINE RICH MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_0182 | - | 2e-08 | 32.50% (120) | membrane glycine and proline rich protein |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 6e-10 | 39.50% (119) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2535|M.bovis_AF2122/97 MND-PRRPQR------------FGPPLSGYGPTGPQVPPNPPTADPAYAD
Rv2507|M.tuberculosis_H37Rv MND-PRRPQR------------FGPPLSGYGPTGPQVPPNPPTADPAYAD
TH_1385|M.thermoresistible__bu MTESPRR-----------------------GGTDPTEPMYPGYSDPAYAS
MAV_1219|M.avium_104 MTAPPGGP--------------YGPGSYGSNPYGQEPNWSGQPPGGQPQG
MUL_0182|M.ulcerans_Agy99 MTTPPGGP--------------YGQDPAGYNPYGQAPYGYGQPQAG----
Mflv_2026|M.gilvum_PYR-GCK MTDPQHGSRVGSQVGPYRLQRLLGKGGMGEVYEAYDTVKDRVVALKLLPE
Mvan_4693|M.vanbaalenii_PYR-1 MTDPQRGSRVGSQVGPYRLRRLLGKGGMGEVYEAEDTVKDRVVALKLLPE
MMAR_4156|M.marinum_M MGEAP-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTT
MSMEG_0047|M.smegmatis_MC2_155 MTGPPPPP---------------PPWPPGGQYPGQHPGQYPGWGGPGWSG
MAB_2112|M.abscessus_ATCC_1997 ------------------------------MTGPNDPYQYGGTGQWGAPE
Mb2535|M.bovis_AF2122/97 QSPYASTYGGYVSPPWSPGGPPPRPPQWPPGPHEASPTQQLPQYWQYDQP
Rv2507|M.tuberculosis_H37Rv QSPYASTYGGYVSPPWSPGGPPPRPPQWPPGPHEASPTQQLPQYWQYDQP
TH_1385|M.thermoresistible__bu QA-YGPTYPASPQPP-----PTEQLPAYPPYGYDPYGTGQQ----GYEYP
MAV_1219|M.avium_104 GQPQGGPYPQPGQYPAGGPYPYPPPGGGYPYPGGPYPGGPYPGAPYPGPG
MUL_0182|M.ulcerans_Agy99 -----GQYP----YPPTGPYTNPQ-GGAPSYGPGTYPPQQFPQAGQPYGT
Mflv_2026|M.gilvum_PYR-GCK SASHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEIDGLLFVDMRMIDGV
Mvan_4693|M.vanbaalenii_PYR-1 AVSHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEVDGLLFVDMRLIDGT
MMAR_4156|M.marinum_M EFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEIDGQMFLEMRLIEGT
MSMEG_0047|M.smegmatis_MC2_155 ----YGEAPPAHQPPKPNKTPWILAALAGVVIIALVAGGLVWKFTSGGDD
MAB_2112|M.abscessus_ATCC_1997 -----GQWQGAPPAQGQYGYAQEYFGQAPADYPDDSIGRLYDGVPQGYAV
Mb2535|M.bovis_AF2122/97 PPGGFPPDGLTPPPPQG---------------------PRTPRWLWFAAG
Rv2507|M.tuberculosis_H37Rv PPGGFPPDGLTPPPPQG---------------------PRTPRWLWFAAG
TH_1385|M.thermoresistible__bu PAE--------PPEPEK---------------------PKLPGWLWVLAA
MAV_1219|M.avium_104 QPFGPGGPYSPGPPPGG---------------------PGSKLPWLIVAG
MUL_0182|M.ulcerans_Agy99 GPGWPTGPYSPGPPPKG---------------------PGSKAPWLIIAG
Mflv_2026|M.gilvum_PYR-GCK DLRRILKEQGAMSPARATAIVRQIASALDAAHRAGIMHRDVKPENILVTR
Mvan_4693|M.vanbaalenii_PYR-1 DLRKLLKEQGPMTPARATAIVAQVASALDAAHQNGIMHRDVKPENILINR
MMAR_4156|M.marinum_M DLDSILKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPPNILITR
MSMEG_0047|M.smegmatis_MC2_155 DTDAAGTTTSTSAAPDT---------------------PDTAGAQAPTTT
MAB_2112|M.abscessus_ATCC_1997 PPMYPGLPGQDPFGPQK---------------------KSKPWLLIASVA
.
Mb2535|M.bovis_AF2122/97 SAVLLVVALVIALVIANGS--------------VKKQTAIEPLPPMPGP-
Rv2507|M.tuberculosis_H37Rv SAVLLVVALVIALVIANGS--------------VKKQTAIEPLPPMPGP-
TH_1385|M.thermoresistible__bu LAVLLVVGLVIALVITNSSQQD----T----VFAPGPSATEPSFPMPTPP
MAV_1219|M.avium_104 LVVLAVIALVATLVVMKGGHGSKPSG------ATPSSTSTSVSQPKNSAQ
MUL_0182|M.ulcerans_Agy99 VAVLGVLALVVVLVFTLGGNKSNNAGP----SGTPATSGASTSEPDNSEQ
Mflv_2026|M.gilvum_PYR-GCK DDFAYLVDFGIANAATDESLTELGTAVGTYAYMAPERFAAGEVTHRADVY
Mvan_4693|M.vanbaalenii_PYR-1 DDFAYLVDFGIANAVTDEALTELGTAVGTYAYMAPERFTNGEVTHRADVY
MMAR_4156|M.marinum_M DDFAYLVDFGIASATGDEKLTQLGTAVGTWKYMAPERFANEEVTYRADIY
MSMEG_0047|M.smegmatis_MC2_155 AKPACEGRVAARTPDTPPQ-------------WIPVESPRGLNYAVPPDW
MAB_2112|M.abscessus_ATCC_1997 GAVVVVLALVLVLILNRDSDPRQ---------AASSPTTTTVSYANPELP
.
Mb2535|M.bovis_AF2122/97 SPTRPTTTTPTPPSP-----SAAPAPTTTTGTP-SETVAG-AMQTVVYDV
Rv2507|M.tuberculosis_H37Rv SPTRPTTTTPTPPSP-----SAAPAPTTTTGTP-SETVAG-AMQTVVYDV
TH_1385|M.thermoresistible__bu TTTRRAPTTVLPPLP-----SPGPTTGPTTGPPGATTTPG-ATETVVYEV
MAV_1219|M.avium_104 NATDCTPNVSGGDMPRSDSIAAGKLSFPANAAPSGWTVFSDDQGPNLIGA
MUL_0182|M.ulcerans_Agy99 NATGCTPNVSAGERPLGEIISAGKLSFPISAAP-GWSVFGDDQSPNLIGA
Mflv_2026|M.gilvum_PYR-GCK ALTCVLHECLTGTQPFEGDSVSVVITAHLNQPAPRPSSLRQGIPAGLDEV
Mvan_4693|M.vanbaalenii_PYR-1 ALTCVLHECLTGAQPFQGDSVSVVITAHLNDPAPRPSQSRPGIPAGLDDV
MMAR_4156|M.marinum_M ALACVLFECLTGSPPYRSDSAGTLVTAHLMDPVPQVSTVRSGIPKAFDAV
MSMEG_0047|M.smegmatis_MC2_155 TVNSCTSLVG-WEKPCPEGPFGFCPVRSMSGSAMLPNKQCPDHARVLTGV
MAB_2112|M.abscessus_ATCC_1997 TAGGAPTYHPPTAQP---PTAQIPPPAPPQMPVPPPAPTGPPRAPGQVAS
* .
Mb2535|M.bovis_AF2122/97 TGEGRAIS--ITYMDSGNVIQTEFNVALPWRKEVSLSKSSLHPAS-----
Rv2507|M.tuberculosis_H37Rv TGEGRAIS--ITYMDSGNVIQTEFNVALPWRKEVSLSKSSLHPAS-----
TH_1385|M.thermoresistible__bu AGTGRAIN--ITYIDTGKVLQTEFNVQLPWRKQVELPSPAASSAS-----
MAV_1219|M.avium_104 LGVAQDVPGANQWMMTAEVGVTNFVPSMDLTAQATKLMQCLANGPGY---
MUL_0182|M.ulcerans_Agy99 LGVGQEVPDASQWMMQAEVAVTNFVASMDVSEQASKLMQCVVDGPGY---
Mflv_2026|M.gilvum_PYR-GCK IARGMAKRPEDRFASAGELADAATDALTRAEQDQAASILQRSQAATM--M
Mvan_4693|M.vanbaalenii_PYR-1 ISRGMAKRPEDRYASAGEMARAATAALTGAQQDQADSILQRSQAATM--M
MMAR_4156|M.marinum_M IARGMAKKPEERYASAGDLARAAHDALSNPDQDHAADILRRSRESTLPGT
MSMEG_0047|M.smegmatis_MC2_155 PGASKTDDIDEAVQLESQLVDDIFTSKNGVVPQVSLSDPR----------
MAB_2112|M.abscessus_ATCC_1997 VGDCIALAAPSDYKTVACTDPTAAWRVIEVVPGGKCRQTYTG--------
. .
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
TH_1385|M.thermoresistible__bu --------------------------------------------------
MAV_1219|M.avium_104 --------------------------------------------------
MUL_0182|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK APLPPPPPPPPPPPP--------PQFAATPP---PGGAA-----------
Mvan_4693|M.vanbaalenii_PYR-1 APLPPPPPPPPPSTPGGPLPYGGSPVPPPPP---PPGQP-----------
MMAR_4156|M.marinum_M AAITPQPPTMPAVTPPPAMPYADPASSGPLPQSAPTGQPGWAPASGPIPA
MSMEG_0047|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2112|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2535|M.bovis_AF2122/97 ----------------------------------------------VTIV
Rv2507|M.tuberculosis_H37Rv ----------------------------------------------VTIV
TH_1385|M.thermoresistible__bu ----------------------------------------------VSII
MAV_1219|M.avium_104 ---------------------------------------------ANAMP
MUL_0182|M.ulcerans_Agy99 ---------------------------------------------VQSSP
Mflv_2026|M.gilvum_PYR-GCK ---------TYQGGYQPPPPPGWGPP---PVPPGRPGGSGGSKGPLIAVV
Mvan_4693|M.vanbaalenii_PYR-1 ---------TQASGFHTPPPPGGPPPGWPPQPPQSSGGGGGSKGPMIALL
MMAR_4156|M.marinum_M AHQPAQVPQYYQSGSWASTPPGTPPQQPVGPTPWNQPPPKRNPWPIVAGV
MSMEG_0047|M.smegmatis_MC2_155 ----------------------------------------------EFTI
MAB_2112|M.abscessus_ATCC_1997 -----------------------------------------------FTA
Mb2535|M.bovis_AF2122/97 NIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS------------------
Rv2507|M.tuberculosis_H37Rv NIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS------------------
TH_1385|M.thermoresistible__bu NVGRDVTCTVTVDGALIQQRTGSGLTICVGAG------------------
MAV_1219|M.avium_104 TLGPIKTSPITVDGTKAVR-ADADVTIADPTRNVKGDSVTIIAVDTKPVS
MUL_0182|M.ulcerans_Agy99 TLGPTKKSSTTVDGVKAAR-VDADITIADTSRNVKGDSVVIIAVDTKPVT
Mflv_2026|M.gilvum_PYR-GCK AG-AVVLLVLAAVGIWLVTKSDDPGSTTASPTSSSAAP-TTSREPTRRTR
Mvan_4693|M.vanbaalenii_PYR-1 AGAAVIILVLAGLGIWLVVKPDSTSDPVASRTSTSAAPTTTSRGSTTRTR
MMAR_4156|M.marinum_M AA-LVFVLIVGGIGVWLVTNSDSTPKAGPGTTGS-----TTTTSPKPETT
MSMEG_0047|M.smegmatis_MC2_155 DGQPAVQIVATVTGIETDECVAPEALHSMVATKVDGQPGSVMFIVSMEQG
MAB_2112|M.abscessus_ATCC_1997 GDFSYCIAPQLRVGSCYQTAVVMGSTVFVAADSCQAPKAFVVLFVIPGTK
*
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
TH_1385|M.thermoresistible__bu --------------------------------------------------
MAV_1219|M.avium_104 VFIGSTPIGDSASAGLIGKIIAALKVAKS---------------------
MUL_0182|M.ulcerans_Agy99 IFLGATPIGDAASAATISKVIAALKVDKS---------------------
Mflv_2026|M.gilvum_PYR-GCK TTTSAPPATGSYDQQLMAMLSGGHDGSNCEPVSPPAQ----TAVATVDCT
Mvan_4693|M.vanbaalenii_PYR-1 TSTSTPPPTESYDQQLMALLSGGHDSSNCEPVDPPAP----TILATVDCT
MMAR_4156|M.marinum_M SPETTTTPAGDPQARLLSYLPSGYASGVCTATTPKPNSVWTGAVAMYNCG
MSMEG_0047|M.smegmatis_MC2_155 -------FPGAPSPSLIDEILETVHHAN----------------------
MAB_2112|M.abscessus_ATCC_1997 EASQCKGKPGVVHSFAFPDPPMAICTGEFAP-------------------
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
TH_1385|M.thermoresistible__bu --------------------------------------------------
MAV_1219|M.avium_104 --------------------------------------------------
MUL_0182|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK QNTNPGGPAFTRYSLFADRGALDAAFDEAIRVNSELLECPGSGVDSPTTW
Mvan_4693|M.vanbaalenii_PYR-1 QALTPGGPAFTRYSLFEDRGALDAAFEEAIRVNSELVQCPGSGVDSPTTW
MMAR_4156|M.marinum_M QNTNDGGPSRAVYGLFPSLEALKQAFNDDIAA-VDLANCPGEGP-SPDGW
MSMEG_0047|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2112|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
TH_1385|M.thermoresistible__bu --------------------------------------------------
MAV_1219|M.avium_104 --------------------------------------------------
MUL_0182|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2026|M.gilvum_PYR-GCK HYTETPDQVVGQVACGTYNENPDIVWTNDEKLLLADAQSP--NLEDLHDW
Mvan_4693|M.vanbaalenii_PYR-1 HYTETPDQVVGQIACGTYDGNPDLVWTKDDDLLLADAQGP--NLEELHNW
MMAR_4156|M.marinum_M HYDRTPDVTAGMIACGTYKNHPNVIWSNDDKLMLSDAFGDPATLDELHTW
MSMEG_0047|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2112|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2535|M.bovis_AF2122/97 -----
Rv2507|M.tuberculosis_H37Rv -----
TH_1385|M.thermoresistible__bu -----
MAV_1219|M.avium_104 -----
MUL_0182|M.ulcerans_Agy99 -----
Mflv_2026|M.gilvum_PYR-GCK WLEFG
Mvan_4693|M.vanbaalenii_PYR-1 WLEFG
MMAR_4156|M.marinum_M WAKYG
MSMEG_0047|M.smegmatis_MC2_155 -----
MAB_2112|M.abscessus_ATCC_1997 -----