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MLGYKVPDPDEAMLISGGRVKGNAPFRVVTGHGSFVVPFFRKVRFLTLAMCEAEVAEKCVTQQGITLNVR AVIAFKVGNDTESIIAAAQRFLSEQDQMSVLTGRIFAGHLRSIIGSMTVEEIIRERQKLATEVLDGSKEE MARIGLNVDALQIQSIDDDGLGYIDAMSAPHNAAIQQQAQIAQAQANQLSAEAEQESQRKQAEFARETAI VKAQYKAEVDKAQAQAAQAGPLAEAQSQREVLEMRTELAERAAELRQQELVAEVVKPAEAEAERVRILAV ADAEKMKIQAEAAASHNRVALDRMLIDQLPDIVEKAALGLSGANLTVLNGADGLSQVAAGLVSQGVAIFD AMRGSVADDNDGENAVAPWNAGTTDNV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5349 | - | - | 100% (377) | hypothetical protein MMAR_5349 |
| M. marinum M | MMAR_2294 | - | 4e-12 | 22.89% (284) | hypothetical protein MMAR_2294 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1524 | - | 4e-13 | 23.24% (284) | hypothetical protein Mb1524 |
| M. gilvum PYR-GCK | Mflv_3653 | - | 3e-13 | 23.13% (281) | band 7 protein |
| M. tuberculosis H37Rv | Rv1488 | - | 4e-13 | 23.24% (284) | hypothetical protein Rv1488 |
| M. leprae Br4923 | MLBr_01802 | - | 3e-11 | 23.66% (224) | hypothetical protein MLBr_01802 |
| M. abscessus ATCC 19977 | MAB_3777 | - | 1e-33 | 29.02% (386) | Band 7 protein |
| M. avium 104 | MAV_3290 | - | 4e-13 | 21.95% (369) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_1517 | - | 7e-33 | 32.61% (322) | SPFH domain-containing protein/band 7 family protein |
| M. thermoresistible (build 8) | TH_1418 | - | 6e-12 | 25.36% (280) | POSSIBLE EXPORTED CONSERVED PROTEIN |
| M. ulcerans Agy99 | MUL_2028 | - | 7e-05 | 27.78% (126) | hypothetical protein MUL_2028 |
| M. vanbaalenii PYR-1 | Mvan_1428 | - | 2e-33 | 29.24% (407) | band 7 protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1517|M.smegmatis_MC2_155 MSTLLIVVLAAIAAILILVVVPLIYVKNYIKVPPNEVAVFTGRG-APKVV
Mvan_1428|M.vanbaalenii_PYR-1 MSVLLITVIAGIAALLLFVALPIVYVKNYIKVPPNEVAVFTGRG-QPKVV
MAB_3777|M.abscessus_ATCC_1997 MSSLVIIVIIAIAALVLFVALPLIYVRNYVKVPPNEVAVFTGRG-QPKVV
Mb1524|M.bovis_AF2122/97 ---MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTV
Rv1488|M.tuberculosis_H37Rv ---MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTV
MAV_3290|M.avium_104 ---MQGAVAGLVLLAVLVIFAIVVVAKSVALIPQAEAAVIERLGRYSRTV
MLBr_01802|M.leprae_Br4923 ---MQGVVAGLVLLAVLTIFAIVVVAKSIVLIPQAEAAVVERLGRYGRTV
Mflv_3653|M.gilvum_PYR-GCK ---MDGALAGLVLLAVLVVFAAVIVAKSVALIPQAEAAVIERLGRYSKTV
TH_1418|M.thermoresistible__bu ---MDGAVAGLVILIVLVVFAAILVAKSVALIPQAEAAVIERLGRYSRTV
MMAR_5349|M.marinum_M -----------------MLGYKVPDPDEAMLISGGRVKGNAPFR----VV
MUL_2028|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1517|M.smegmatis_MC2_155 RGGARFRMPGIERVDI-MSLEPFNVSINLQNALSNNGVPVNVEAVGLVRI
Mvan_1428|M.vanbaalenii_PYR-1 RGGARFRVPGIERVDI-MSLEPFNVSINLQNALSNNGVPVNVEAVGLVRI
MAB_3777|M.abscessus_ATCC_1997 RGGARFKMPGIERVDI-MSLEPFNVNINLQNALYNNGVPVNVEAVGLVRI
Mb1524|M.bovis_AF2122/97 SGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQV
Rv1488|M.tuberculosis_H37Rv SGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQV
MAV_3290|M.avium_104 SGQLTLLVPFIDRIRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQV
MLBr_01802|M.leprae_Br4923 SGQLTLLVLFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQV
Mflv_3653|M.gilvum_PYR-GCK SGQLTLLLPFVDKIRARVDLRERVVSFPPQPVITEDNLTVNIDTVVYFQV
TH_1418|M.thermoresistible__bu SGQLTLLVPFIDRIRARVDLRERVVSFPPRAVITQDNLTVSIDTVVYFRV
MMAR_5349|M.marinum_M TGHGSFVVPFFRKVRF-LTLAMCEAEVA-EKCVTQQGITLNVRAVIAFKV
MUL_2028|M.ulcerans_Agy99 -----------------MAVYRVFEALDELGAIVEEARGVPMTAGCVVPR
: : . : :: : : : .
MSMEG_1517|M.smegmatis_MC2_155 GSADEAVQTAVQRFLTSDLNELQRQINEILAGSLRGITATMTVEDLNSNR
Mvan_1428|M.vanbaalenii_PYR-1 GSADEAVQTAVQRFLTSDLNELQRQINEILAGSLRGITATMTVEDLNSNR
MAB_3777|M.abscessus_ATCC_1997 GSNDEAVQTAVQRFLTSDLSELQRQINEILAGSLRGITATMTVEDLNSNR
Mb1524|M.bovis_AF2122/97 TVPQAAVYEISNYIVG---------VEQLTTTTLRNVVGGMTLEQTLTSR
Rv1488|M.tuberculosis_H37Rv TVPQAAVYEISNYIVG---------VEQLTTTTLRNVVGGMTLEQTLTSR
MAV_3290|M.avium_104 TVPQAAVYEISNYIVG---------VEQLTTTTLRNVVGGMTLEQTLTSR
MLBr_01802|M.leprae_Br4923 TVPQAAVYEISNYIVG---------VEQLTTTTLRNVVGGMTLEQTLTSR
Mflv_3653|M.gilvum_PYR-GCK TNPQAAVYQISNYIVG---------VEQLTTTTLRNVVGGMTLEQTLTSR
TH_1418|M.thermoresistible__bu NNPHDAVYQISNYIAA---------VEELTTTTLRNVVGGMTLEEALTSR
MMAR_5349|M.marinum_M GNDTESIIAAAQRFLS-EQDQMSVLTGRIFAGHLRSIIGSMTVEEIIRER
MUL_2028|M.ulcerans_Agy99 GDVLELLDDIKDAIPG----------------------ELDDAQDVLDAR
: : : :: *
MSMEG_1517|M.smegmatis_MC2_155 DTLARSVVEEAGADLARIGMEVDVLKIAGISDR-NGYLESLGQRRIAEVK
Mvan_1428|M.vanbaalenii_PYR-1 DTLARSVVDEAGGDLARIGMEVDVLKIAGISDR-NGYLESLGQRRIAEVK
MAB_3777|M.abscessus_ATCC_1997 DSLARSVVEEAGGDLARIGMEVDVLKIAGISDR-NGYLESLGQRRIAEVR
Mb1524|M.bovis_AF2122/97 DQINAQLRGVLDEATGRWGLRVARVELRSIDPP-PSIQASMEKQMKADRE
Rv1488|M.tuberculosis_H37Rv DQINAQLRGVLDEATGRWGLRVARVELRSIDPP-PSIQASMEKQMKADRE
MAV_3290|M.avium_104 DQINGQLRGVLDEATGRWGLRVARVELRSIDPP-PSIQASMEKQMKADRE
MLBr_01802|M.leprae_Br4923 DQINAQLRGVLDEATGRWGLRVARVELRSIDPP-PSIQTSMEKQMKADRE
Mflv_3653|M.gilvum_PYR-GCK DSINGQLRGVLDEATNRWGLRVARVELRSIDPP-PSIQDSMEKQMRADRE
TH_1418|M.thermoresistible__bu DRINEQLRAVLDGATDRWGLRVQRVELKAIDPP-PTIQDAMEKQMRADRE
MMAR_5349|M.marinum_M QKLATEVLDGSKEEMARIGLNVDALQIQSIDDDGLGYIDAMSAPHNAAIQ
MUL_2028|M.ulcerans_Agy99 DSMLQEATAHADSMVSSATTESESMLNHARAEA---------DRILSDAK
: : . . : . : .
MSMEG_1517|M.smegmatis_MC2_155 RDATVGTAEAERDAQIQSAKARQEGSIAQAEADTAIASANQKRDVELARL
Mvan_1428|M.vanbaalenii_PYR-1 RDAAVGTAEAERDAQIQSAKARQAGAVAQAEADTAIATANQKRDVELARL
MAB_3777|M.abscessus_ATCC_1997 RDATVGTAEAERDAQIQSAQARQAGAIAQAEADTAIATATQKRDVELARL
Mb1524|M.bovis_AF2122/97 KRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRML
Rv1488|M.tuberculosis_H37Rv KRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRML
MAV_3290|M.avium_104 KRAMILTAEGMRESAIKEAEGQKQAQILAAEGAKQAAILAAEADRQSRML
MLBr_01802|M.leprae_Br4923 KRAMILTAEGTREAAIKQAEGNKQAQILAAEGAKQAVILAAEADRQSRML
Mflv_3653|M.gilvum_PYR-GCK KRAMILTAEGSREAAIKQAEGQKQAQILAAEGAKQASILAAEGDRQSRML
TH_1418|M.thermoresistible__bu KRAMILTAEGQRESAIKEAEGQKQAQILAAEGAKQAAILTAEAERQSRIL
MMAR_5349|M.marinum_M QQAQIAQAQAN----QLSAEAEQESQRKQAEFARETAIVKAQYKAEVDKA
MUL_2028|M.ulcerans_Agy99 AQADRMVGEARQHSERMVGEAREEAIRIAAAAKREYEASMSRAKSECDRL
* .:. .:..: . * . . :
MSMEG_1517|M.smegmatis_MC2_155 RAQTEAENAQADQAGPLANARAQKDVGIAIEQAEAARVQARIEVEQRRSE
Mvan_1428|M.vanbaalenii_PYR-1 RAQTEAENAQADQAGPLANARAQKDVGIAIEQAEAARVQARIEVEQRRAE
MAB_3777|M.abscessus_ATCC_1997 RAQTEAENAQADQAGPLAQARAEKDVGIAREQAEAARVQARTEVEQRRTE
Mb1524|M.bovis_AF2122/97 RAQGERAAAYLQAQG---QAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPE
Rv1488|M.tuberculosis_H37Rv RAQGERAAAYLQAQG---QAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPE
MAV_3290|M.avium_104 RAQGERAAAYLQAQG---QAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPE
MLBr_01802|M.leprae_Br4923 RAQGKRAAAYLQAQG---QAKAIEKTFAAIKAGRPTPEMLAYQYLQILPQ
Mflv_3653|M.gilvum_PYR-GCK RAQGERAAAYLQAQG---QAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPQ
TH_1418|M.thermoresistible__bu RAQGERAAQYLQAQG---QAKAIEKTFAAIKAGRPTPELLAYQYLQTLPK
MMAR_5349|M.marinum_M QAQAAQAGPLAEAQS----QREVLEMRTELAERAAELRQQELVAEVVKPA
MUL_2028|M.ulcerans_Agy99 IESGNISYENAVQEG--------------------IKEQQRLVSQNEVVQ
. .
MSMEG_1517|M.smegmatis_MC2_155 QAQAALQADVIAPAEAQRQADVARAEGQRQAAILAAEAAAEAKRRAGQAE
Mvan_1428|M.vanbaalenii_PYR-1 QSQAALQADVIAPAEAQRAADIARAEGQRQATILA-----------GQAE
MAB_3777|M.abscessus_ATCC_1997 QAQAALQADVIAPAEARRQADIAIAEGARQAAILKAQSDAEAERQKGAAE
Mb1524|M.bovis_AF2122/97 MARGDANKVWVVPSDFN-----AALQG--------------------FTR
Rv1488|M.tuberculosis_H37Rv MARGDANKVWVVPSDFN-----AALQG--------------------FTR
MAV_3290|M.avium_104 MARGDANKVWVVPSDFS-----AALQG--------------------FTK
MLBr_01802|M.leprae_Br4923 MARGDANKVWVVPSDFS-----TALQG--------------------FTK
Mflv_3653|M.gilvum_PYR-GCK MAKGEANKVWLVPSDFG-----SALQG--------------------FTK
TH_1418|M.thermoresistible__bu IAEGEASKVWIVPNDFG-----AALQG--------------------FTK
MMAR_5349|M.marinum_M EAEAERVRILAVADAEK------------------------------MKI
MUL_2028|M.ulcerans_Agy99 AANAEATRLVDTAHAES---------------------------------
:.. ..
MSMEG_1517|M.smegmatis_MC2_155 ADARKAAADALRVERQAEADSLQANLVAEAAGKKELADALRVEQQAEAAG
Mvan_1428|M.vanbaalenii_PYR-1 ADARKAAADALRVERQAEAD-----------------------------G
MAB_3777|M.abscessus_ATCC_1997 ADARKAAADAFRVEQQAAADGAKAKLIAEADG-------TKAKLLADAEG
Mb1524|M.bovis_AF2122/97 LLGKPGEDGVFRFEPSPVE-------------------------------
Rv1488|M.tuberculosis_H37Rv LLGKPGEDGVFRFEPSPVE-------------------------------
MAV_3290|M.avium_104 LLGTPGQDGVFRFQPSPVE-------------------------------
MLBr_01802|M.leprae_Br4923 LLGAPGEDGVFRFQPSPVDS------------------------------
Mflv_3653|M.gilvum_PYR-GCK LLGAPGEDGVFRYTPSPVD-------------------------------
TH_1418|M.thermoresistible__bu LLGAPGEDGVFRFEPSPVE-------------------------------
MMAR_5349|M.marinum_M QAEAAASHNRVALDRMLID-------------------------------
MUL_2028|M.ulcerans_Agy99 -DRLRGECDVY---------------------------------------
. .
MSMEG_1517|M.smegmatis_MC2_155 IEARLLAEANGKKEIAAALNSYTAEAARMLMLPDVLNSVVKATEAAASPL
Mvan_1428|M.vanbaalenii_PYR-1 IKARLVAEAAGKKEIAAALNTYSPEAARLQTLPDVLQSVVKATEAAAMPL
MAB_3777|M.abscessus_ATCC_1997 IKAKLLAEADGKKEVAAALNAYTPEAARLLTLPDILNSVVQATEAASKPI
Mb1524|M.bovis_AF2122/97 ----DQPKHAADGDDAEVAGWFSTDTD-----PSIARAVATAEAIARKPV
Rv1488|M.tuberculosis_H37Rv ----DQPKHAADGDDAEVAGWFSTDTD-----PSIARAVATAEAIARKPV
MAV_3290|M.avium_104 ----DVPKHSAE-DDADVADWFSTETD-----PAIAQAVAKAEAIARQPA
MLBr_01802|M.leprae_Br4923 --SDQVVKHAADEDDAEVADWFSVETD-----PAIAQAVAKAEAMVYQPV
Mflv_3653|M.gilvum_PYR-GCK -----DAGTRPEDDSDEVADWFSTETD-----PVIAQAVAKAEAEARAPV
TH_1418|M.thermoresistible__bu -----EDLPRPEDDSEEVADWFTTQTD-----PAIAQAVAKAEAEARTPV
MMAR_5349|M.marinum_M ----QLPDIVEKAALGLSGANLTVLNG-----ADGLSQVAAGLVSQGVAI
MUL_2028|M.ulcerans_Agy99 --------------VDTKLAEFEEMLN------GTLRSVGRGRHQLRTAA
* . .
MSMEG_1517|M.smegmatis_MC2_155 GEIERLSIIGGAGDAQDAVGGLLGISPLAVAKIIESLKSSGVDVAALLGG
Mvan_1428|M.vanbaalenii_PYR-1 SEIERLSIIGGASDAQDAVGGLLGVSPLAVAKIVETLKSSGIDVAAMLN-
MAB_3777|M.abscessus_ATCC_1997 GEIENLSIIGGAGDAQDALGTLFGVSPQAVAKVIESLRVSGIDVPDLLKR
Mb1524|M.bovis_AF2122/97 EGSLGTPPRLTQ--------------------------------------
Rv1488|M.tuberculosis_H37Rv EGSLGTPPRLTQ--------------------------------------
MAV_3290|M.avium_104 DGPTG---ELTQ--------------------------------------
MLBr_01802|M.leprae_Br4923 DE------------------------------------------------
Mflv_3653|M.gilvum_PYR-GCK PGALDGPKQYPPLSQQVQPTATDYAQQPRHGSPDQ---------------
TH_1418|M.thermoresistible__bu DTGLTTPPLTERSRQQELP-------------------------------
MMAR_5349|M.marinum_M FDAMRGSVADDNDGENAVAPWNAGTTDNV---------------------
MUL_2028|M.ulcerans_Agy99 GTHDYATR------------------------------------------
MSMEG_1517|M.smegmatis_MC2_155 SGASTGPNGSNVSTPPATNGDIAATAPAE
Mvan_1428|M.vanbaalenii_PYR-1 ------PSPEPPIAPAEANGEGAAQPL--
MAB_3777|M.abscessus_ATCC_1997 --TQQADAPASPAPAPAVHPEGWVQE---
Mb1524|M.bovis_AF2122/97 -----------------------------
Rv1488|M.tuberculosis_H37Rv -----------------------------
MAV_3290|M.avium_104 -----------------------------
MLBr_01802|M.leprae_Br4923 -----------------------------
Mflv_3653|M.gilvum_PYR-GCK -----------------------------
TH_1418|M.thermoresistible__bu -----------------------------
MMAR_5349|M.marinum_M -----------------------------
MUL_2028|M.ulcerans_Agy99 -----------------------------