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MEALDIAFKATAWPGCPPRLLRVAGGHADQQDHEDVAAYRAQGGYRPLGDADKLLREIDASGLLGRGGAA FPLAVKMRAVRDNCRRAGPAGGAVVIANGEEGEPASFKDRWLLRNRPHLVLDGLRLAAALVAATRAYVYV SDPESARSVERALTQLDPDAFGGVAVSVWAVPPGYVAGEETAAVRAINGGPVKPSDKPPRPFEYGVSGRP TLVSNVETLANLPYLHRHGASEYRALGTPSSPGTFLATITGAGRAPVLYELPYGLPFSELLALHAVAPTK IRGVLMGGYFAGLLNRGVLGTTLDHETMRRLGSGLGCGAISVITDDCPVAVAASVLSYFDRENAGQCGSC FNGTAAMAAVGGALRDFAATSEDIDRLRRWSVVLRGRGACATLDAATNAAATLLSQFPDEVASHLEGACQ DCSSGTGGAFRAERPYQATAPVRQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4729 | nuoF_1 | - | 100% (445) | NADH dehydrogenase I (chain F) (NADH-ubiquinone oxidoreductase chain F), NuoF_1 |
| M. marinum M | MMAR_1478 | nuoF | 8e-44 | 30.26% (423) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3174 | nuoF | 9e-41 | 29.48% (424) | NADH dehydrogenase I chain F |
| M. gilvum PYR-GCK | Mflv_2485 | - | 1e-151 | 61.64% (438) | respiratory-chain NADH dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3150 | nuoF | 9e-41 | 29.48% (424) | NADH dehydrogenase I chain F |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2139 | - | 2e-45 | 29.57% (416) | NADH-quinone oxidoreductase, F subunit NuoF |
| M. avium 104 | MAV_0925 | - | 0.0 | 76.00% (425) | respiratory-chain NADH dehydrogenase 51 kd subunit family |
| M. smegmatis MC2 155 | MSMEG_4812 | - | 1e-159 | 67.84% (426) | respiratory-chain NADH dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_0528 | - | 1e-169 | 68.04% (438) | respiratory-chain NADH dehydrogenase domain, 51 kda subunit |
| M. ulcerans Agy99 | MUL_2464 | nuoF | 3e-43 | 30.02% (423) | NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone |
| M. vanbaalenii PYR-1 | Mvan_4169 | - | 1e-158 | 64.68% (436) | respiratory-chain NADH dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4729|M.marinum_M --MEALDIAFKATAWP-GCPPRLLRVAGGHADQQDHEDVAAYRAQGGYRP
MAV_0925|M.avium_104 --MNTTQSTTVVTAIAPGCRPRLL------TGQPGREDLAAYRGLGGYRP
MSMEG_4812|M.smegmatis_MC2_155 ---MTMAADLTVAAWS-GITPRLLR--------DEPETATTYLAAGGYRA
TH_0528|M.thermoresistible__bu MKSTAAPVDLTVAAWP-GITPRLLG--------AGAEDGAAYAAAGGYRP
Mflv_2485|M.gilvum_PYR-GCK -MSTAMNTELTVSAWP-GLTPRLLR------AEQGTETLAEYRAAGGYVA
Mvan_4169|M.vanbaalenii_PYR-1 -MSTAMNTELTVAAWP-GLAPRLLR------DGTDTESAAQYRDAGGYLP
Mb3174|M.bovis_AF2122/97 --MTTQATPLTPVISRHWDDPESWT-------LATYQRHDRYRGYQALQK
Rv3150|M.tuberculosis_H37Rv --MTTQATPLTPVISRHWDDPESWT-------LATYQRHDRYRGYQALQK
MUL_2464|M.ulcerans_Agy99 --MTSQATPLTPVISRYWDDPESWT-------LATYRRHDGYR---ALEK
MAB_2139|M.abscessus_ATCC_1997 --MTS--SILSPVLSEHWDEPDAWT-------LDGYLRHGGYR---GLRT
: * * .
MMAR_4729|M.marinum_M LG--DADKLLREIDASGLLGRGGAAFPLAVKMRAVRDNCRRAGPAGGAVV
MAV_0925|M.avium_104 LA--AGEQLLSEVEASGLVGRGGAAFPLGVKLRTVRDNGRAAAGAGGTVV
MSMEG_4812|M.smegmatis_MC2_155 LD--DPQGLLDAVEASGLLGRGGAAFPLAVKLRTVRDNGR---AAGGAVV
TH_0528|M.thermoresistible__bu LT--DAPALLEQTELSGLSGRGGAAFPLATKLRSVADNGRR--RATAPVV
Mflv_2485|M.gilvum_PYR-GCK HD--DPATLLDEIDRAGVLGRGGAAFPLAVKLTTVRSASLR---GVDTVL
Mvan_4169|M.vanbaalenii_PYR-1 LS--DVDALHDEIARAGVLGRGGAAFPLAVKLSTVRRAHQS---GRDTVL
Mb3174|M.bovis_AF2122/97 ALTMPPDDVISIVKDSGLRGRGGAGFATGTKWSFIP-QGDTGAAAKPHYL
Rv3150|M.tuberculosis_H37Rv ALTMPPDDVISIVKDSGLRGRGGAGFATGTKWSFIP-QGDTGAAAKPHYL
MUL_2464|M.ulcerans_Agy99 ALAMGPDAVIGTVKDSGLRGRGGAGFSTGTKWSFIP-QGDAGPAAKPHYL
MAB_2139|M.abscessus_ATCC_1997 ALGMDPDAVIALVKEAGLRGRGGAGFPTGAKWSFIP-QGDG----KPHYL
: :*: *****.*. ..* : :
MMAR_4729|M.marinum_M IANGEEGEPASFKDRWLLRNRPHLVLDGLRLAAALVAATRAYVYVS----
MAV_0925|M.avium_104 VANGEEGEPASIKDRWLLRNRPHLVLDGLRLAAAVVGAERGYVYVS----
MSMEG_4812|M.smegmatis_MC2_155 IANGEEGEPASIKDRWLLRNRPHAVLDGLRLAALMVGAHRAVLYTS----
TH_0528|M.thermoresistible__bu VANGEEGEPASVKDRWLLRNRPHLVLDGLRLAARVVGADRGYVYVS----
Mflv_2485|M.gilvum_PYR-GCK VANGEEGEPASVKDRWLLRNRPHLVLDGLRLAARIIGARHAHVYLS----
Mvan_4169|M.vanbaalenii_PYR-1 VANGEEGEPASVKDRWLLRHRPHLVLDGLRLAARIIGARHTHVYVS----
Mb3174|M.bovis_AF2122/97 VVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVV
Rv3150|M.tuberculosis_H37Rv VVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVV
MUL_2464|M.ulcerans_Agy99 VVNADESEPGTCKDIPLMLATPHVLVEGVIIAAYAIRASHAFIYVRGEVL
MAB_2139|M.abscessus_ATCC_1997 VVNADESEPGTCKDIPLMLATPHTLIEGIVIAAFAIRASQAFIYVRGEVI
:.*.:*.**.: ** *: ** :::*: :** : * : :*
MMAR_4729|M.marinum_M -------DPESARSVERALTQLDPDAFGGVAVSVWAVPPGYVAGEETAAV
MAV_0925|M.avium_104 -------DPEAAHSVESALGELDPDTLGGVTVTLSTVPAGYVAGEETAAV
MSMEG_4812|M.smegmatis_MC2_155 -------DAQSARSVEHALAET-GGSSGGVAVELITVTTGYVAGEESAAV
TH_0528|M.thermoresistible__bu -------DPRAAAAVESALAEAPADSFDGLRVTPAIVDPGYVAGEETAAV
Mflv_2485|M.gilvum_PYR-GCK -------DERAEGAVQAALAETTPDLLDGVTVSVRRVEAGYVAGEETAAV
Mvan_4169|M.vanbaalenii_PYR-1 -------DDRAAAAVLAALDEITPDALDGVTVSVHTVAPGYVAGEETAAV
Mb3174|M.bovis_AF2122/97 PVLRRLHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGAYICGEETALL
Rv3150|M.tuberculosis_H37Rv PVLRRLHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGAYICGEETALL
MUL_2464|M.ulcerans_Agy99 PVLRRLQNAVAEAYAAGLLGRNINGSGFDLELVVHAGAGAYICGEETALL
MAB_2139|M.abscessus_ATCC_1997 SVIRRLHAAVAQAYKAGYLGRNILDSGFDLELVVHAGAGAYICGEETALL
: * . . .: : .*:.***:* :
MMAR_4729|M.marinum_M RAINGGPVKPSDKPPRPFEYGVSGRPTLVSNVETLANLPYLHRHGASEYR
MAV_0925|M.avium_104 RALNGGPAKPTDKPPRPFEAGVGDRPTLVSNVETLANVPFLQSHGASAFR
MSMEG_4812|M.smegmatis_MC2_155 RVVDGGPAKPTDKPPRPFEEGVGGYPTLISNVETLAHLAYLNLHGAADFR
TH_0528|M.thermoresistible__bu RMLNGGPAKPTDKPPRPFEQGVDGRPTLVSNVETLANLVYVHRHGAEAFR
Mflv_2485|M.gilvum_PYR-GCK RAINGGPAKPTDKPPRPFEEGVGGLPTAVCNVETLANLPYVQRHGADEYR
Mvan_4169|M.vanbaalenii_PYR-1 RAINGGPAKPTDKPPRPFEEGVGGLPTVVSNVETLANLPYVHRHDAAAYR
Mb3174|M.bovis_AF2122/97 DSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFR
Rv3150|M.tuberculosis_H37Rv DSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFR
MUL_2464|M.ulcerans_Agy99 DSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILNGVDWFR
MAB_2139|M.abscessus_ATCC_1997 DSLEGRRGQPRLRPPFPAVAGLYASPTVVNNVESIASVPVILRRGAEWFR
::* :* :** * *: ** : ***::* : : . :*
MMAR_4729|M.marinum_M ALGTPSSPGTFLATITGAGRAPVLYELPYGLPFSELLALHA--VAPTKIR
MAV_0925|M.avium_104 AQGTPLSPGTFLATISGAGRPPVLYELAHGTPFTELLALHG--VSADAVR
MSMEG_4812|M.smegmatis_MC2_155 EYGTEGSPGTFLATITGAGRAPALYELPHGVAFTDVLALHG--VSPDTVT
TH_0528|M.thermoresistible__bu SLGTPMSPGTFLATVTGAGRPPALYELPYGIAFTDLLAHHG--VPAESVR
Mflv_2485|M.gilvum_PYR-GCK RIGTDGSPGTFLATLTGGGIAPGLYELPFGITAGEVIALHG--IPAERVR
Mvan_4169|M.vanbaalenii_PYR-1 ELGTDGSPGTFLATLTGGGRPPGLYEIPFGTAAAELIALHG--VPAERVR
Mb3174|M.bovis_AF2122/97 SMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLK
Rv3150|M.tuberculosis_H37Rv SMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLK
MUL_2464|M.ulcerans_Agy99 SMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGIRAGHQLK
MAB_2139|M.abscessus_ATCC_1997 TMGTEKSPGFTLYSLSGHVRTPGQYEAPLGVTLRQLLELAGGVRDGRALK
*: *** * :::* * ** . * . ::: . :
MMAR_4729|M.marinum_M GVLMGGYFAGLLNRGVLGTTLDHETMRRLGSGLGCGAISVITD-DCPVAV
MAV_0925|M.avium_104 GALMGGYFAGLLNRSVLQTTLDHETMRRFGSGLGCGAISVLTD-DCPVAV
MSMEG_4812|M.smegmatis_MC2_155 GALMGGYFAGLLGREIVGATLDHETIRGLGSGLGCGAISVLTD-DCPVAV
TH_0528|M.thermoresistible__bu GVLMGGYFAGLLNTDVLDATLDHESIRRLGSGLGCGAISILTD-DCPVAV
Mflv_2485|M.gilvum_PYR-GCK GALMGGYFAGLLDRRVLDSTLDHEALRALGSGLGCGAVSVLTE-ECPVAV
Mvan_4169|M.vanbaalenii_PYR-1 GALMGGYFAGLVDRRILGGVLDHESLRGLGSGLGCGAVSVITD-ECPVAV
Mb3174|M.bovis_AF2122/97 FWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRA
Rv3150|M.tuberculosis_H37Rv FWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRA
MUL_2464|M.ulcerans_Agy99 FWTPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRA
MAB_2139|M.abscessus_ATCC_1997 FWTPGGSSTPLFTAEQLDVPLDYEGVSAAGSMLGTKALQIFDDTTCVVRA
** : *. : **:* : ** ** *:.:: : * * .
MMAR_4729|M.marinum_M AASVLSYFDRENAGQCGSCFNGTAAMAAVGGALRDFAATSEDIDRLRRWS
MAV_0925|M.avium_104 AASVLAYFDRENAGQCGSCFNGTAAMAAAGGALRDGAATTEDVDRLRRWS
MSMEG_4812|M.smegmatis_MC2_155 AAAVLSYFDRENAGQCGSCFNGTAAMAAVATALRDGTATDDDVARLKRWS
TH_0528|M.thermoresistible__bu AAAVMDYFDRENAGQCGSCFNGTAAMAAVTGALRDGVATDEDLARLERWS
Mflv_2485|M.gilvum_PYR-GCK GASVLAYYDRENADQCGSCFNGTAAMAAAAEALRDGSADADDLARLERWS
Mvan_4169|M.vanbaalenii_PYR-1 GASVLAYYDRENAGQCGSCFNGTAAMSAAATALRDGIADGEDLARLRRWS
Mb3174|M.bovis_AF2122/97 VRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDIS
Rv3150|M.tuberculosis_H37Rv VRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDIS
MUL_2464|M.ulcerans_Agy99 VRRWTEFYKHESCGKCTPCREGTFWLDKIYARLETGKGTREDIDKLLDIS
MAB_2139|M.abscessus_ATCC_1997 VLRWTEFYAHESCGKCTPCREGTYWLVRILQRLESGEGKAEDLDKLLDIS
:: :*...:* .* :** : *. . :*: :* *
MMAR_4729|M.marinum_M VVLRGRGACATLDAATNAAATLLSQFPDEVASHLEGACQDCSSGTGGAFR
MAV_0925|M.avium_104 VLLRGRGACATLDAATNMAASLLDQFPDDVTAHLDGSCPDCTR---GAFR
MSMEG_4812|M.smegmatis_MC2_155 VVLRGRGACATLDGACNVAASLLSGFDDVVRRHLDNNCPVCRS---GPFT
TH_0528|M.thermoresistible__bu VVLRGRGACGTLDGATNIAASLLRHFPQVVARHLDNSCETCRP---GPFR
Mflv_2485|M.gilvum_PYR-GCK QVLRGRGACATLDAACNIAASMLALFADDVARHADNSCSVCAA---DLFT
Mvan_4169|M.vanbaalenii_PYR-1 EVLRGRGACATLDAACNIAASMLAMFPEEVARHLDGTCVGCDA---GGFT
Mb3174|M.bovis_AF2122/97 DSILGKSFCALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDP----RDS
Rv3150|M.tuberculosis_H37Rv DSILGKSFCALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDP----RDS
MUL_2464|M.ulcerans_Agy99 DSILGKSFCALGDGAASPVMSSIKHFQNEYIAHAEQGGCPFDP----RDS
MAB_2139|M.abscessus_ATCC_1997 DIVLGKSFCALGDGAASPIMSSLKYFRTEYEAHLDNG-CPFDP----AAS
: *:. *. *.* . : : * * :
MMAR_4729|M.marinum_M AERPYQATAPVRQP--
MAV_0925|M.avium_104 ADRPYQAEVARQA---
MSMEG_4812|M.smegmatis_MC2_155 ATRPYEVEQLESVVAV
TH_0528|M.thermoresistible__bu AQRPYEVEAVTES---
Mflv_2485|M.gilvum_PYR-GCK ARRPFEVEAL------
Mvan_4169|M.vanbaalenii_PYR-1 ATRPFEVESL------
Mb3174|M.bovis_AF2122/97 MLVANGVDA-------
Rv3150|M.tuberculosis_H37Rv MLVANGVDA-------
MUL_2464|M.ulcerans_Agy99 MLTAGRNTAKGTGPQ-
MAB_2139|M.abscessus_ATCC_1997 TVFG-EVSA-------