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MAGPVEGIKVVELGVWVAAPAAAAILADWGADVIKIEPQAGDPGRLFGRMLGCDLGMNPPFEMDNRCKRS VVLDLSTDTGRELAYELLSDADVFITNVRPAALRRLGLDFAAVSDRNPRLVYGLITGYGETGPDADRAAY DVAAFWSRGGLAHLLTRPGDTPPFQRGGMGDHTTGMTLAAAVCAALLARERTGTGQLVSTSLYRQGAYTV SFDLNTYLLTGQQIAIGQRESMGNPCMNNYTAGDGRRFWIVGLEIDRHWPALCRVVERPDWLADPRYGDA RGRAANAVELIAQLDQIFATRSLAEWTEIFDAEPDFFWSPINSLEDIVADEQFHAAGGIVDVPDGASSVP MVATPADFHGTPCTPRSVAPQLGQHTDQVLGELAARRKS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0396 | - | - | 100% (389) | acyl-CoA transferase |
| M. marinum M | MMAR_4713 | - | 9e-54 | 34.36% (390) | dehydratase |
| M. marinum M | MMAR_4009 | - | 1e-51 | 35.92% (387) | dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 1e-40 | 27.84% (388) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4116 | - | 1e-168 | 72.63% (391) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 3e-40 | 27.84% (388) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 1e-39 | 33.24% (343) | putative L-carnitine dehydratase |
| M. avium 104 | MAV_5126 | - | 0.0 | 80.61% (392) | caib/baif family protein |
| M. smegmatis MC2 155 | MSMEG_4798 | - | 6e-51 | 33.33% (396) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_4341 | - | 5e-62 | 37.63% (388) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_1046 | - | 0.0 | 98.71% (389) | acyl-CoA transferase |
| M. vanbaalenii PYR-1 | Mvan_2229 | - | 1e-168 | 72.24% (389) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0396|M.marinum_M MAG-------PVEGIKVVELGVWVAAPAAAAILADWGADVIKIEPQA-GD
MUL_1046|M.ulcerans_Agy99 MAG-------PVEGIKVVELGVWVAAPAAAAILADWGADVIKIEPPA-GD
MAV_5126|M.avium_104 MAG-------PVEGVTVVELGVWVAGPAAGGILADWGADVIKIEPPT-GD
Mflv_4116|M.gilvum_PYR-GCK MAG-------PLEGIRVVELGVWVAGPAAGGILADWGADVVKIEPPT-GD
Mvan_2229|M.vanbaalenii_PYR-1 MAG-------PLEGLRVVELGVWVAGPAAGGILADWGADVVKIEPPG-GD
MSMEG_4798|M.smegmatis_MC2_155 MSG-------PLEGIRILEVAMYGFVPSAGAVLGEWGADVIKVEHAVTGD
TH_4341|M.thermoresistible__bu MGDRAGRSVQVLEGIRVLELSGFAYVPSAGAILADWGADVIKVEHPAHGD
Mb3300|M.bovis_AF2122/97 MPTSN--PAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPG-GE
Rv3272|M.tuberculosis_H37Rv MPTSN--PAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPG-GE
MAB_4651c|M.abscessus_ATCC_199 MTG-------ALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPD
* ::*. :::. * *. :* : **:*:*:* :
MMAR_0396|M.marinum_M PGRLFGRMLGCDLG----MNPPFEMDNRCKRSVVLDLSTDTGRELAYELL
MUL_1046|M.ulcerans_Agy99 PGRLFGRMLGCDLG----MNPPFEMDNRCKRSVVLDLSTDTGRELAYELL
MAV_5126|M.avium_104 PARMFGRMLGCDLG----LNPPFEMDNRSKRSVVLDLSSEPDRRAAFELL
Mflv_4116|M.gilvum_PYR-GCK PARTFGRMLGIPPQDRHHVSPPFQMDNRGKRSVVLDLASPDGRRSARELI
Mvan_2229|M.vanbaalenii_PYR-1 PARTFGRMLGIQPQDRHHVSPPFQMDNRGKRSVVLDLATADGQSSARELL
MSMEG_4798|M.smegmatis_MC2_155 PQR--GLRQTGPLRVDGDPNPNIEHANRGKRSIGLDMSVPAGREVLLELA
TH_4341|M.thermoresistible__bu PSR--GITIGGIPPGTGGFTFMWELANRGKRSVGIDVSTDDGRRLVLELA
Mb3300|M.bovis_AF2122/97 AARQITSVLPGRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
Rv3272|M.tuberculosis_H37Rv AARQITSVLPGRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
MAB_4651c|M.abscessus_ATCC_199 PLRTWGQAEVDGHH------VFWTVHARNKKAITLDLRTEAGRALFLDLV
. * * *::: :*: : *
MMAR_0396|M.marinum_M SDADVFITNVRPAALRRLGLDFAAVSDRNPRLVYGLITGYGETGPDADRA
MUL_1046|M.ulcerans_Agy99 SDADVFITNVRPAALRGLGLDFAAVSDRNPRLVYGLITGYGETGPDADRA
MAV_5126|M.avium_104 SGADVFLTNVRPGALQRLGLDFASVSAANPRLVYGLITGYGESGPDADRA
Mflv_4116|M.gilvum_PYR-GCK DGADVFVTNIRVGGLRRIGLDFEALAAANPRLVYGLITGYGTEGPDADRP
Mvan_2229|M.vanbaalenii_PYR-1 AGADVFLTNIRTGALRRIGLDFPAVAAANPQLIYGLITGYGSDGPDADRP
MSMEG_4798|M.smegmatis_MC2_155 RRADVFLTSFLPGHREKFGIDVDDIRAVNPKIIYARGSALGPRGEESVKG
TH_4341|M.thermoresistible__bu KSADVFLTSYLPGVREKLRITEDDIRGVNPSIVYAVGSGQGHHGPENAAG
Mb3300|M.bovis_AF2122/97 DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
Rv3272|M.tuberculosis_H37Rv DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
MAB_4651c|M.abscessus_ATCC_199 DKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKA
:**.: . . : : * :: :. * * .
MMAR_0396|M.marinum_M AYDVAAFWSRGGLAHLLTRPGDTPPFQRGG--MGDHTTGMTLAAAVCAAL
MUL_1046|M.ulcerans_Agy99 AYDVAAFWSRGGLAHLLTRPGDTPPFQRGG--MGDHTTGMTLAAAVCAAP
MAV_5126|M.avium_104 AFDVAAFWSRAGVAHLLTRPGDTPPFQRGG--MGDHSAGMTMAAAVCAAL
Mflv_4116|M.gilvum_PYR-GCK AFDVAAFWARAGLAHLLTRPGDVPPFQRGG--MGDHMAGMTLAGAICAAL
Mvan_2229|M.vanbaalenii_PYR-1 AYDVAAFWARSGLAHLLTRPGEAPPFQRGG--MGDHMAGMTLAGAVCAAL
MSMEG_4798|M.smegmatis_MC2_155 GYDMTAFWCRAGAAATITPPGIEGMIGPPGPAYGDTISGTNLAGGIAAAL
TH_4341|M.thermoresistible__bu GFDQTSFWYRTGMASALTEAGGH-PPELPGPGFGDLSSGVALAGGISAAL
Mb3300|M.bovis_AF2122/97 GIDLVVAA-EAGMTTGMPTPEGKPQIIPFQ--LVDNASGHVLAQAVLAAL
Rv3272|M.tuberculosis_H37Rv GIDLVVAA-EAGMTTGMPTPEGKPQIIPFQ--LVDNASGHVLAQAVLAAL
MAB_4651c|M.abscessus_ATCC_199 GY-ASVAEAASGLRHLNGFPGGPPPRMALS--IGDTLAGMFAAQGALAAL
. * . * :* * . **
MMAR_0396|M.marinum_M LARERTGTGQLVSTSLYRQGAYTVSFDLNTYLLTGQ-------QIAIGQR
MUL_1046|M.ulcerans_Agy99 LARERTGTGQLVSTSLYRQGAYTVSFDLNTYLLTGQ-------QIAIGQR
MAV_5126|M.avium_104 LARERTGAGQLVTTSLYRQGAYTVSFDLNTYLMSGQ-------PIAIGQR
Mflv_4116|M.gilvum_PYR-GCK VARARTGTGQLVSTSLYRQGAYTVSFDLTTFLITGN-------PIAIGQR
Mvan_2229|M.vanbaalenii_PYR-1 VARARTGAGQLVSTSLYRQGAYTVSFDLNTFLLTGH-------PIAIGQR
MSMEG_4798|M.smegmatis_MC2_155 FKRERTGEPSVVDVSLLGSGLWAMGHTIALTSHLNE-------LMVQPPP
TH_4341|M.thermoresistible__bu LHRERTGAGVAVHGSLLATGMWMMQPSIVATEVTGE-------PEFRWLD
Mb3300|M.bovis_AF2122/97 LHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKR
Rv3272|M.tuberculosis_H37Rv LHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKR
MAB_4651c|M.abscessus_ATCC_199 YRRTVTGRGQVVDAALTESCLAVQESTIPDYDVGRV---------VRGPS
* .* * :: :
MMAR_0396|M.marinum_M ESMGN---PCMNNYTAGDGRRFWIVGLEIDRHWPALCRVVERPDWLADPR
MUL_1046|M.ulcerans_Agy99 ESMGN---PCMNNYTAGDGRRFWIVGLEIDRHWPALCRVVERPDWLADPR
MAV_5126|M.avium_104 ESMGN---PCMNNYAASDGRRFWIVGLEPERHWPALCRAVGRPEWRDDPR
Mflv_4116|M.gilvum_PYR-GCK EVMGN---PCMNNYSAADGKRFWLVGLQGDRHWPALCAAVQRPDWPTDER
Mvan_2229|M.vanbaalenii_PYR-1 ETMGN---PCMNNYTAADGRRFWLVGLQGERHWPALCAAVERTDWLSDER
MSMEG_4798|M.smegmatis_MC2_155 GVHGSPINPLVGLYGTADGRYISFVMMQPTKFWADVCRHMDLEHYIDDPR
TH_4341|M.thermoresistible__bu RFETT--NPLVNSYRTADGRYIGLTVLHADKHWREFCEAIGHPELADDER
Mb3300|M.bovis_AF2122/97 RKGVGFATQPSDAFRTADG--YIVISAYVPKHWQKLCYLIGRPDLVEDQR
Rv3272|M.tuberculosis_H37Rv RKGVGFATQPSDAFRTADG--YIVISAYVPKHWQKLCYLIGRPDLVEDQR
MAB_4651c|M.abscessus_ATCC_199 GTRLEG-IAPSNIYQSADG-SWVVIAANQDTVFRRLCEAMGRPELSSDAR
. : :.** . : .* : . * *
MMAR_0396|M.marinum_M YGDARGRAANAVELIAQLDQIFATRSLAEWTEIFDAEPDFFWSPINSLED
MUL_1046|M.ulcerans_Agy99 YGDARGRATNAVELIAQLDQIFATRSLAEWTEIFDAEPDFFWSPINSLED
MAV_5126|M.avium_104 FADARARAANSVALIAALDEIFATRPLDEWAQIFAGEPDFFWSPVNSLED
Mflv_4116|M.gilvum_PYR-GCK FATGRARAANAAELIAELDAIFARRTLAEWTEVFAAHPDLFWSPINSMED
Mvan_2229|M.vanbaalenii_PYR-1 FATGRARAANAVELIAELDTVFAGKTLEEWAEVFSGQPDLFWSPINSMED
MSMEG_4798|M.smegmatis_MC2_155 FATAESIAENTAAAVDILTEAMKKRTLPEWSERFATLA-GPWAPVQDTLQ
TH_4341|M.thermoresistible__bu FADHDARAANSAACVKLLDEIFATRTLEHWKAVLSAQG-AQWAVIQQCAE
Mb3300|M.bovis_AF2122/97 FAEQRSRSINYAELTAELELALASKTATEWVQLLQANG-LMACLAHTWKQ
Rv3272|M.tuberculosis_H37Rv FAEQRSRSINYAELTAELELALASKTATEWVQLLQANG-LMACLAHTWKQ
MAB_4651c|M.abscessus_ATCC_199 FANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAG-VIAGPINTVAD
:. . . * : : . : : :
MMAR_0396|M.marinum_M IVADEQFHAAGGIVDVPDGAS---SVPMVATPADFHGTPCTPRSVAPQLG
MUL_1046|M.ulcerans_Agy99 IVADEQFHAAGGIVDVPDGAS---SVPMVATPADFHGTPCTPRSVAPQLG
MAV_5126|M.avium_104 VVADEQFHAAGGIVYVPDGADDQAAVPMVATPADFHGTPWAPRSAAPELG
Mflv_4116|M.gilvum_PYR-GCK VIGDEQFHAAGGIVYVPDDEA--GSVPMVATPADFHGTPAQIRCSAPELG
Mvan_2229|M.vanbaalenii_PYR-1 VIADEQFHASGGIVYVPDSDG--GAVPMVATPADFHGTPAEVRCAAPELG
MSMEG_4798|M.smegmatis_MC2_155 AAQDAQIRANEYLVQAG-------ELELVTNPVQFDVSAPSPG-PAPGFA
TH_4341|M.thermoresistible__bu TRSDPQVVANGYLQAVDYGGG--RSISLVPAPVQYGDGPPRLR-PAPELG
Mb3300|M.bovis_AF2122/97 VVDTPLFAESDLTLEVGRGAD---TITVIRTPARYASFRAVVTDPPPTAG
Rv3272|M.tuberculosis_H37Rv VVDTPLFAENDLTLEVGRGAD---TITVIRTPARYASFRAVVTDPPPTAG
MAB_4651c|M.abscessus_ATCC_199 VVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPG
. : *. .. .
MMAR_0396|M.marinum_M QHTDQVLGELAARRKS-----------
MUL_1046|M.ulcerans_Agy99 QHTDQVLGELAARRRS-----------
MAV_5126|M.avium_104 QHTAEVLAELKARRGS-----------
Mflv_4116|M.gilvum_PYR-GCK AHTEEVLTELAQRTNRST---------
Mvan_2229|M.vanbaalenii_PYR-1 EHTEEVLAELAQWTNRSM---------
MSMEG_4798|M.smegmatis_MC2_155 EQTDDILAELGLDWDRIIELKTAGAVT
TH_4341|M.thermoresistible__bu ANTEEVLLDNGLEWEEIERLKDQRVIT
Mb3300|M.bovis_AF2122/97 EHNAVFLARP-----------------
Rv3272|M.tuberculosis_H37Rv EHNAVFLARP-----------------
MAB_4651c|M.abscessus_ATCC_199 QDNDDVYVGLLGKSAQDIERLRAEGVL
.. .