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KDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGYEYARTGNPTRTALEAAL AAVEDAAFGRAFSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVR AAIRPTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLGADVVLHSTTKYIG GHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPA ISTVLYPGLPSHPGHAVAARQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGGVESLIEHPSAMT HASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4388 | metB | - | 100% (388) | cystathionine gamma-synthase MetB (cgs) |
| M. marinum M | MMAR_0688 | metZ | 1e-62 | 36.94% (360) | O-succinylhomoserine sulfhydrylase, MetZ |
| M. marinum M | MMAR_1185 | metC | 5e-58 | 34.06% (411) | O-acetylhomoserine sulfhydrylase MetC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1108 | metB | 0.0 | 87.11% (388) | cystathionine gamma-synthase |
| M. gilvum PYR-GCK | Mflv_2046 | - | 1e-179 | 80.58% (381) | cystathionine gamma-synthase |
| M. tuberculosis H37Rv | Rv1079 | metB | 0.0 | 87.11% (388) | cystathionine gamma-synthase |
| M. leprae Br4923 | MLBr_02394 | metB | 0.0 | 83.20% (387) | cystathionine gamma-synthase |
| M. abscessus ATCC 19977 | MAB_1197 | - | 1e-175 | 78.57% (378) | cystathionine gamma-synthase (CGS) |
| M. avium 104 | MAV_1203 | - | 0.0 | 84.75% (387) | cystathionine gamma-synthase |
| M. smegmatis MC2 155 | MSMEG_5265 | - | 0.0 | 81.98% (383) | cystathionine gamma-synthase |
| M. thermoresistible (build 8) | TH_2171 | - | 1e-178 | 82.28% (378) | putative cystathionine gamma-synthase |
| M. ulcerans Agy99 | MUL_0201 | metB | 0.0 | 99.74% (388) | cystathionine gamma-synthase |
| M. vanbaalenii PYR-1 | Mvan_4670 | - | 1e-179 | 81.58% (380) | cystathionine gamma-synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4388|M.marinum_M MKDDHK--AQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVG
MUL_0201|M.ulcerans_Agy99 MKDDHK--AQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVG
Mb1108|M.bovis_AF2122/97 MSEDRT--GHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVG
Rv1079|M.tuberculosis_H37Rv MSEDRT--GHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVG
MLBr_02394|M.leprae_Br4923 MSEDYR--GHHGITGLATKAIHAGYRPDPATGAVNVPIYASSTFAQDGVG
MAV_1203|M.avium_104 MSDDGN--AHPEFSGLATKAIHAGYRPDPATGAVNTPIYASSTFAQDGVG
MSMEG_5265|M.smegmatis_MC2_155 MSE------HRKWHGLATKAIHAGYQPDPATGAVNTPIYASSTFAQDGVG
TH_2171|M.thermoresistible__bu MSE------HRRWQGLATKAIHAGYRPDPATGAVNAPIYASSTFAQDGVG
Mflv_2046|M.gilvum_PYR-GCK MGEQRSNADRYRAYGPATKAIHAGYRPDPATGVVNPPIYASSTFAQDGVG
Mvan_4670|M.vanbaalenii_PYR-1 MSEQRSASDHYRAFGPATRAIHAGYRPDPATGVVNPPIYASSTFAQDGVG
MAB_1197|M.abscessus_ATCC_1997 MSEQRSAADASRWQGFSTRAIHGGFHADPQTGAVNVPIYASSTFAQDGVG
* : * :*:***.*::.** **.** **************
MMAR_4388|M.marinum_M GLRGGYEYARTGNPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAML
MUL_0201|M.ulcerans_Agy99 GLRGGYEYARTGNPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAML
Mb1108|M.bovis_AF2122/97 GLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAML
Rv1079|M.tuberculosis_H37Rv GLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAML
MLBr_02394|M.leprae_Br4923 ELRGGFEYARTGNPMRAALEASLATVEEGVFARAFSSGMAASDCALRVML
MAV_1203|M.avium_104 ALRGGYEYARTGNPTRAALEATLAAVEAGSHGRAFASGMAATDCALRAVL
MSMEG_5265|M.smegmatis_MC2_155 GLRGGFEYARTGNPTRQSLEAALAAVEEARFGRAFSSGMAATDCALRAVL
TH_2171|M.thermoresistible__bu GLRGGFEYGRTGNPTRSALEASLAAVEEAGYGRAFSSGMAATDCALRAVL
Mflv_2046|M.gilvum_PYR-GCK GLRGGFEYARTGNPTRSVLESALAAMEGASYGRAFSSGMAATDCVLRAVL
Mvan_4670|M.vanbaalenii_PYR-1 GLRGGFEYSRTGNPTRSVLEGALAAMEGASHGRAFSSGMAATDCVLRAVL
MAB_1197|M.abscessus_ATCC_1997 QLRGGFEYARTGNPTRAVLEASLAALEDAHFGRAFSSGMAATDCVLRALL
****:**.***** * **.:**::* . ..***:*****:**.**.:*
MMAR_4388|M.marinum_M RPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTT
MUL_0201|M.ulcerans_Agy99 RPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTT
Mb1108|M.bovis_AF2122/97 RPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRT
Rv1079|M.tuberculosis_H37Rv RPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRT
MLBr_02394|M.leprae_Br4923 RPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVPLSDLDAVRAAITSRT
MAV_1203|M.avium_104 RPGDHVVIPNDAYGGTFRLIDKVFTRWNVEYTPVPLHQLDAVAAAITPRT
MSMEG_5265|M.smegmatis_MC2_155 RPGDHVVIPDDAYGGTFRLIDKVFTHWGISHTPAALSDLDSVRSAITPKT
TH_2171|M.thermoresistible__bu RPGDHIVIPNDAYGGTFRLIDKVLTNWGIHYTPVDLSDLDALRVAITSRT
Mflv_2046|M.gilvum_PYR-GCK RPGDHIVIPDDAYGGTFRLIDKVFSLWGISYTAVALSDLDRVRAAITDRT
Mvan_4670|M.vanbaalenii_PYR-1 RPGDHLVIPDDAYGGTFRLIDKVFSLWGISYTAVALGDLDRVRAAVTDRT
MAB_1197|M.abscessus_ATCC_1997 RPGDHLIIPNDAYGGTFRLIDKVFSQWGIRHTPVPVADVDAIRAAITPTT
*****::**:*.***********:: *.: :*.. : ::* : *: *
MMAR_4388|M.marinum_M RLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLG
MUL_0201|M.ulcerans_Agy99 RLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLG
Mb1108|M.bovis_AF2122/97 RLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLG
Rv1079|M.tuberculosis_H37Rv RLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLG
MLBr_02394|M.leprae_Br4923 RLIWVETPTNPLLSIADITSIGELGKKHSVKVLVDNTFASPALQQPLMLG
MAV_1203|M.avium_104 RLIWVETPTNPLLSIADIAALAQLGHQHSAKVLVDNTFASPALQQPLTLG
MSMEG_5265|M.smegmatis_MC2_155 RLIWVETPTNPLLNVADIAGIVQIASSTGVKVLVDNTFASPALQQPLLLG
TH_2171|M.thermoresistible__bu RLIVVETPTNPLLSIADIAAIAQIAGTSGVKVLVDNTFASPALQQPLLLG
Mflv_2046|M.gilvum_PYR-GCK RLVWIETPTNPLLSIADIAAISALGAEKDVKVLVDNTFASPALQQPLALG
Mvan_4670|M.vanbaalenii_PYR-1 KLIWIETPTNPLLSIADIAAIAEVGAATGAKVLVDNTFASPALQQPLALG
MAB_1197|M.abscessus_ATCC_1997 KLIWLETPTNPLLSIADIAAVAQVAAEHSVKLLVDNTFASPALQQPLNLG
:*: :********.:***:.: :. ..*:*************** **
MMAR_4388|M.marinum_M ADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDA
MUL_0201|M.ulcerans_Agy99 ADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDA
Mb1108|M.bovis_AF2122/97 ADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDA
Rv1079|M.tuberculosis_H37Rv ADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDA
MLBr_02394|M.leprae_Br4923 ADVVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDA
MAV_1203|M.avium_104 ADIVLHSTTKYIGGHSDVVGGALVTNDAELDDAFGFLQNGAGAVPGPFDA
MSMEG_5265|M.smegmatis_MC2_155 ADIVLHSTTKYIGGHSDVVGGALLTNDEELDAAFAFLQNGAGGVPGPFDA
TH_2171|M.thermoresistible__bu ADIVLHSTTKYIGGHSDVVGGALLTNDEELDAAFGFLQNGAGAVPGPFDA
Mflv_2046|M.gilvum_PYR-GCK ADIVLHSTTKYIGGHSDVVGGAVLTNDEALDGAFAFLQNGAGAVPGPFDA
Mvan_4670|M.vanbaalenii_PYR-1 ADIVLHSTTKYIGGHSDVVGGALLTNDEALDDAFAFLQNGAGAVPGPFDA
MAB_1197|M.abscessus_ATCC_1997 ADIALHSTTKYIGGHSDVVGGALLTNDEELDTAFAFLQNGAGAVPGPFDG
**:.******************::*** ** *.*******.**.***.
MMAR_4388|M.marinum_M YLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAV
MUL_0201|M.ulcerans_Agy99 YLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAV
Mb1108|M.bovis_AF2122/97 YLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI
Rv1079|M.tuberculosis_H37Rv YLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI
MLBr_02394|M.leprae_Br4923 YLTMRGLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEV
MAV_1203|M.avium_104 YLTMRGLKTLVLRMQRHTENASAVAQFLAGHPAVSAVLYPGLPGHPGHDV
MSMEG_5265|M.smegmatis_MC2_155 YLTMRGLKTLVLRMRQHSENAALIAEFLDGHPAVQTVLYPGLPSHPNHDV
TH_2171|M.thermoresistible__bu YLTMRGLKTLDLRMQKHCANAALVAEFLDGHPAIETVLYPGLAEHPGHDI
Mflv_2046|M.gilvum_PYR-GCK YLTIRGLKTLPLRMQRHSENATAVAEFLDGHPAVDTVLYPGLPSHPGHEV
Mvan_4670|M.vanbaalenii_PYR-1 YLTIRGLKTLPLRMQRHSENAAAIAEFLDGHPAVTTVLYPGLPSHPNHDV
MAB_1197|M.abscessus_ATCC_1997 YLTYRGIKTLALRMQRHSENAQAVAEYLAGHSAVAQTIYPGLESHPGHAV
*** **:*** ***::* ** :*::* *.:: .:**** **.* :
MMAR_4388|M.marinum_M AARQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGGVESLIEHPS
MUL_0201|M.ulcerans_Agy99 AARQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGSVESLIEHPS
Mb1108|M.bovis_AF2122/97 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPS
Rv1079|M.tuberculosis_H37Rv AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPS
MLBr_02394|M.leprae_Br4923 AARQMRGFGGMVSLRMRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPS
MAV_1203|M.avium_104 AARQMSGFGGMVSVRMRGGRQAARKLCANTRVFILAESLGGVESLIEHPS
MSMEG_5265|M.smegmatis_MC2_155 AARQMTGFGGMVSVRLRGGPQAARDLCSRTEIFILAESLGGVESLIEYPG
TH_2171|M.thermoresistible__bu AARQMSGFGGMVSVRMRGGAEAARKFCARTELFILAESLGGVESLIEHPG
Mflv_2046|M.gilvum_PYR-GCK AARQMSGFGGMISVRLAGGPQAARDFCARTEIFILAESLGGVESLIEYPG
Mvan_4670|M.vanbaalenii_PYR-1 AARQMSGFGGMVSVRLRGGPQAARDFCARTEIFILAESLGGVESLIEYPG
MAB_1197|M.abscessus_ATCC_1997 AARQMRGFGGMVSVRLAGGRQAALDLCSRTELFILAESLGGVESLIEHPG
***** *****:*:*: .* ** .:*:.*.:* ******.****** *.
MMAR_4388|M.marinum_M AMTHASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG---
MUL_0201|M.ulcerans_Agy99 AMTHASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG---
Mb1108|M.bovis_AF2122/97 AMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG---
Rv1079|M.tuberculosis_H37Rv AMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG---
MLBr_02394|M.leprae_Br4923 AMTHASTTGSQLEVPDDLVRLSVGIEDVGDLLCDLKQALN---
MAV_1203|M.avium_104 AMTHASTAGSQLEVPDDLVRLSVGIEDVDDLLADLDRALS---
MSMEG_5265|M.smegmatis_MC2_155 AMTHASTAGSQLEVPDDLVRLSVGIEHSADLLADLEQALG---
TH_2171|M.thermoresistible__bu AMTHASTAGSQLEVPDDLVRLSVGIEDSADLLADLDQALADI-
Mflv_2046|M.gilvum_PYR-GCK AMTHASTAGSQLEVPDDLVRLSVGIEDVADLVGDVEQALG---
Mvan_4670|M.vanbaalenii_PYR-1 AMTHASTAGSQLEVPDDLVRLSVGIEDVADLLGDVEQALGAPG
MAB_1197|M.abscessus_ATCC_1997 AMTHASTAGSLLEVPDDLVRLSVGIEEVGDLIGDLEQALR---
*******:** ***************. **: *:.:**