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SAENTSTDADPTAHWSFETKQIHAGQQPDSATNARALPIYQTTSYTFENTAHAAALFGLEVPGNIYTRLG NPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVS FVDDPDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGIPLIVDNTIATPYLIRPFTQGA DIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQGRFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDL GSAASPFNAFLVAQGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKLSPKGTGA VLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLSTGVSPGLVRLAVGIEG IEDILADLELGFAAARKFSGDSQAVAAI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1185 | metC | - | 100% (449) | O-acetylhomoserine sulfhydrylase MetC |
| M. marinum M | MMAR_0688 | metZ | 4e-61 | 35.15% (404) | O-succinylhomoserine sulfhydrylase, MetZ |
| M. marinum M | MMAR_4388 | metB | 6e-58 | 34.06% (411) | cystathionine gamma-synthase MetB (cgs) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3372 | metC | 0.0 | 91.07% (448) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. gilvum PYR-GCK | Mflv_4875 | - | 0.0 | 82.43% (444) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. tuberculosis H37Rv | Rv3340 | metC | 0.0 | 91.07% (448) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. leprae Br4923 | MLBr_02394 | metB | 6e-58 | 33.58% (411) | cystathionine gamma-synthase |
| M. abscessus ATCC 19977 | MAB_3687 | - | 0.0 | 75.11% (442) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. avium 104 | MAV_4315 | - | 0.0 | 88.57% (455) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. smegmatis MC2 155 | MSMEG_1652 | - | 0.0 | 82.81% (442) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. thermoresistible (build 8) | TH_1970 | metC | 0.0 | 81.17% (446) | PROBABLE O-ACETYLHOMOSERINE SULFHYDRYLASE METC (HOMOCYSTEINE |
| M. ulcerans Agy99 | MUL_1438 | metC | 0.0 | 99.55% (449) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1554 | - | 0.0 | 83.33% (438) | O-acetylhomoserine aminocarboxypropyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1185|M.marinum_M -----MSAENTSTDADPTAHWSFETKQIHAGQQPDSATNARALPIYQTTS
MUL_1438|M.ulcerans_Agy99 -----MSAENTSTDADPTAHWSFETKQIHAGQQPDSATNARALPIYQTTS
Mb3372|M.bovis_AF2122/97 -----MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTS
Rv3340|M.tuberculosis_H37Rv -----MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTS
MAV_4315|M.avium_104 -----MSSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTS
Mflv_4875|M.gilvum_PYR-GCK --------MTDPDLT---AGWAFETKQVHAGQTPDSATNARALPIYQTTS
Mvan_1554|M.vanbaalenii_PYR-1 --------MTDTTAAN--ASWAFETKQVHAGQTPDIATNARALPIYQTTS
TH_1970|M.thermoresistible__bu --------MTNSEQDDPTAKWSFETKQVHAGQTPDPATNARALPIYQTTS
MSMEG_1652|M.smegmatis_MC2_155 --------MTTPDPT---ENWSFETKQIHAGQSPDSATHARALPIYQTTS
MAB_3687|M.abscessus_ATCC_1997 MTDIDPTTADSRSDKPRSAQWAFETKQIHAGQSADAATNARALPIYQTTS
MLBr_02394|M.leprae_Br4923 ---------MSEDYRGHHGITGLATKAIHAGYRPDPATGAVNVPIYASST
.: ** :*** .* :* * :*** :::
MMAR_1185|M.marinum_M YTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALEGGVAALFLS
MUL_1438|M.ulcerans_Agy99 YTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALEGGVAALFLS
Mb3372|M.bovis_AF2122/97 YTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
Rv3340|M.tuberculosis_H37Rv YTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
MAV_4315|M.avium_104 YTFDDTTHAAALFGLEVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
Mflv_4875|M.gilvum_PYR-GCK YIFDSTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALFLS
Mvan_1554|M.vanbaalenii_PYR-1 YTFNSTDHAAALFGLAEPGNIYTRIMNPTTDVVEQRIAALEGGVAALFLA
TH_1970|M.thermoresistible__bu YTFDSTEHAAALFGLSEPGNIYTRIMNPTQDVVEKRIAALEGGVAALFLA
MSMEG_1652|M.smegmatis_MC2_155 YTFDDTSHAAALFGLEVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
MAB_3687|M.abscessus_ATCC_1997 YVFNDTAHAAALFGLSEEGNIYTRIGNPTQDVVEQRIAALEGGVAALLLA
MLBr_02394|M.leprae_Br4923 FAQDG-------VGELRGGFEYARTGNPMRAALEASLATVEEGVFARAFS
: :. .* * *:* ** .:* :*::* ** * ::
MMAR_1185|M.marinum_M SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
MUL_1438|M.ulcerans_Agy99 SGQAAETFGILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
Mb3372|M.bovis_AF2122/97 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
Rv3340|M.tuberculosis_H37Rv SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
MAV_4315|M.avium_104 SGQAAETFAILNLASAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVED
Mflv_4875|M.gilvum_PYR-GCK SGQAAETLAILNIAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVED
Mvan_1554|M.vanbaalenii_PYR-1 SGQAAETFAILNLANHGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEN
TH_1970|M.thermoresistible__bu SGQAAETFAILNLANAGDHIVASPRLYGGTYNLFQHTLPKLGIETTFVEN
MSMEG_1652|M.smegmatis_MC2_155 SGQAAETFAILNIAKAGDHIVSSPRLYGGTYNLLHYTLPKLGIETTFVEN
MAB_3687|M.abscessus_ATCC_1997 SGQAAATLAIVNIAQAGDNIVSSPRLYGGTYNLLHYTLPRLGISTTFVED
MLBr_02394|M.leprae_Br4923 SGMAASDCALRVMLRPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVP-
** ** .: : **::: . :****:.*:. :.: .:. : *
MMAR_1185|M.marinum_M PDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGIPLIVD
MUL_1438|M.ulcerans_Agy99 PDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGIPLIVD
Mb3372|M.bovis_AF2122/97 PDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVD
Rv3340|M.tuberculosis_H37Rv PDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVD
MAV_4315|M.avium_104 PDDLDSWQAAVRPNTKAFFAETISNPQIDILDIPGVSGVAHANGVPLIVD
Mflv_4875|M.gilvum_PYR-GCK PDDLESWRAASRPNTKAFFAETISNPKIDVLDIPGVSGVAHDIGVPLIVD
Mvan_1554|M.vanbaalenii_PYR-1 PDDLESWRAAARPNTKAFFGETISNPQIDILDIPGVAGVAHEVGVPLIVD
TH_1970|M.thermoresistible__bu PDDLDSWRAAVRPNTKAFFGESISNPKIDILDIPNVAAVAHEAGVPLIVD
MSMEG_1652|M.smegmatis_MC2_155 PDDLESWRAAVRPNTKAFFAETISNPQIDILDIPNVAAIAHEAGVPLIVD
MAB_3687|M.abscessus_ATCC_1997 PDDLESWRNAITPDTKALFAESISNPQNDILDIAGLSEIAHAAGIPLIVD
MLBr_02394|M.leprae_Br4923 LSDLDAVRAAITSRTRLIWVETPTNPLLSIADITSIGELGKKHSVKVLVD
.:*:: : * . *: :: *: :** .: * . :. :.: .: ::**
MMAR_1185|M.marinum_M NTIATPYLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQ-G
MUL_1438|M.ulcerans_Agy99 NTIATPYLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQ-G
Mb3372|M.bovis_AF2122/97 NTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-G
Rv3340|M.tuberculosis_H37Rv NTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-G
MAV_4315|M.avium_104 NTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTQ-G
Mflv_4875|M.gilvum_PYR-GCK NTIATPYLIQPLSHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTASG
Mvan_1554|M.vanbaalenii_PYR-1 NTIATPYLIQPLSHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTAGG
TH_1970|M.thermoresistible__bu NTIATPYLIQPLSHGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTN-G
MSMEG_1652|M.smegmatis_MC2_155 NTIATPYLIQPIAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTN-G
MAB_3687|M.abscessus_ATCC_1997 NTVATPYLIQPLAHGADVVVHSATKYLGGHGNAIGGVIIDGGTFDWTQ-G
MLBr_02394|M.leprae_Br4923 NTFASPALQQPLMLGADVVLHSTTKYIGGHSDVVGGALVTND--------
**.*:* * :*: ***:*:**:***:***. .:.*.:: ..
MMAR_1185|M.marinum_M RFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAASPFNAFLVA
MUL_1438|M.ulcerans_Agy99 RFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAASPFNAFLVA
Mb3372|M.bovis_AF2122/97 RFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVA
Rv3340|M.tuberculosis_H37Rv RFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVA
MAV_4315|M.avium_104 RFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVA
Mflv_4875|M.gilvum_PYR-GCK RFPGFTEPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLIA
Mvan_1554|M.vanbaalenii_PYR-1 RFPGFTSPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAASPFNAFLIA
TH_1970|M.thermoresistible__bu KFPGFTEPDPSYHGVVFAELGPPAFALKARVQLLRDLGSAAAPFNAFLIA
MSMEG_1652|M.smegmatis_MC2_155 KFPGFTEPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAAAPFNAFLIA
MAB_3687|M.abscessus_ATCC_1997 RHPGFTTPDPSYHGVVFADLGAPAYALKARVQLLRDLGPAISPFNAFLIA
MLBr_02394|M.leprae_Br4923 -----EELDQAFG---FLQNGA---------------GAVPSPFDAYLTM
* :: * : *. *.. :**:*:*
MMAR_1185|M.marinum_M QGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKL
MUL_1438|M.ulcerans_Agy99 QGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKL
Mb3372|M.bovis_AF2122/97 QGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRL
Rv3340|M.tuberculosis_H37Rv QGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRL
MAV_4315|M.avium_104 QGIETLSLRMERHVANAQRVAEFLASHDGVLSVNYAGLPGSPWHERAKKL
Mflv_4875|M.gilvum_PYR-GCK QGLETLSLRIERHVQNAQRVAEFLEAHPDVVSVNYAGLPSSPWYGLGKKL
Mvan_1554|M.vanbaalenii_PYR-1 QGLETLSLRIERHVQNARQVAEFLDAHPDVVSVNYAGLPSSPWYDLGKKL
TH_1970|M.thermoresistible__bu QGLETLSLRVERHVENAQKVAEYLEAHPDVVSVNYAGLPSSPWYDLGKKL
MSMEG_1652|M.smegmatis_MC2_155 QGLETLSLRVERHVANAQKVAEFLENHPDVSSVNYAGLPSSPWYELGRKL
MAB_3687|M.abscessus_ATCC_1997 QGLETLSLRVERHVANAQRVAEFLVAQPEVTRVNYAGLPTSPWYERAKAL
MLBr_02394|M.leprae_Br4923 RGLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEVAARQ
:*::** **::** ** ***:* : * * *.*** * : .
MMAR_1185|M.marinum_M SPKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTT
MUL_1438|M.ulcerans_Agy99 SPKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTT
Mb3372|M.bovis_AF2122/97 APKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTT
Rv3340|M.tuberculosis_H37Rv APKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTT
MAV_4315|M.avium_104 APKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTT
Mflv_4875|M.gilvum_PYR-GCK APKGTGAVLAFELSGGIDAGKAFVNALSLHSHVANIGDVRSLVIHPASTT
Mvan_1554|M.vanbaalenii_PYR-1 APKGTGAVLAFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTT
TH_1970|M.thermoresistible__bu APKGTGAVLAFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTT
MSMEG_1652|M.smegmatis_MC2_155 APKGTGAVLAFELSGGLEAGKAFVNALTLHSHVANIGDVRSLVIHPASTT
MAB_3687|M.abscessus_ATCC_1997 APKGAGAVLAFELDGGVEAATTFIDSLTLHSQVANIGDVRSLVIHPATTT
MLBr_02394|M.leprae_Br4923 MR-GFGGMVSLRMRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPSAMT
* *.::::.: .* *. : .:.: . .:*.*.**: :*:: *
MMAR_1185|M.marinum_M HAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILADLELGFAAARKFSG---
MUL_1438|M.ulcerans_Agy99 HAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILADLELGFAAAREFSG---
Mb3372|M.bovis_AF2122/97 HAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSA---
Rv3340|M.tuberculosis_H37Rv HAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSA---
MAV_4315|M.avium_104 HAQLSPAEQLSTGVSPGLVRLAVGIEGIDDILADLELGFAAAAKFGANAG
Mflv_4875|M.gilvum_PYR-GCK HQQLSPEEQLASGVTPGLVRLAVGIEGIDDILADLELGFAAAKPSAAAT-
Mvan_1554|M.vanbaalenii_PYR-1 HQQLSAEEQLASGVTPGLVRLAVGIEGIEDILTDLERGFAAAKPFSAAA-
TH_1970|M.thermoresistible__bu HAQLSPEDQLATGVTPGLVRLAVGIEGIDDIIADLEQGFAAAKPFTASAG
MSMEG_1652|M.smegmatis_MC2_155 HQQLSPEEQLSTGVTPGLVRLAVGLEGIDDIIADLEQGFAAARPFSGAA-
MAB_3687|M.abscessus_ATCC_1997 HGQLSPAEQVASGVTPGLVRLAVGIEGIDDILADLESGFTAVRRLKQ---
MLBr_02394|M.leprae_Br4923 HASTTGS---QLEVPDDLVRLSVGIEDVGDLLCDLKQALN----------
* . : *. .****:**:*.: *:: **: .:
MMAR_1185|M.marinum_M ----DSQAVAAI
MUL_1438|M.ulcerans_Agy99 ----DSQAVAAI
Mb3372|M.bovis_AF2122/97 ----DPQSVAAF
Rv3340|M.tuberculosis_H37Rv ----DPQSVAAF
MAV_4315|M.avium_104 TSGADPHAVAAF
Mflv_4875|M.gilvum_PYR-GCK ----DPNAVASF
Mvan_1554|M.vanbaalenii_PYR-1 ----DPNTVASF
TH_1970|M.thermoresistible__bu ---GDPQTVASF
MSMEG_1652|M.smegmatis_MC2_155 ------QTAQTV
MAB_3687|M.abscessus_ATCC_1997 -----PAAVASS
MLBr_02394|M.leprae_Br4923 ------------