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WGGNCVDTALHRLLNVPTDKGGRLAAARAYGSRLLGDAGVPPKRRWIRIRTMSTVAILGINLIGICVMLV LLTLAVPEPNVLSEAPAWLNYGVGPAYNVIALTLGTWWITALAKRALRWYIEGRRPSLTEATETFRIPSR VAAVNFFLWGLGTLTMTTLYGLIDTRFIAKYLFSVSFCGILVCTGSYLLTEFWLRPMTAQALETGPPHRR IGSGIIGRTLLIWLLGSGVPLIGISLFAAFEVALLHLTVVEFAVGVMIASSATLVFGLLLIAISAWLTAT PVRLVRAALKQVEQGDLRGDVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPP QLGGEERYVAVVFVDIIGSTQLVSNRPATDVVQLLNRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPNP LECPEVAALSAARAIAGRLCTEVPECRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEAARLCELAKSY SARLVASSETVAGATETERAHWNLAETVTLRGRDRPTHLAIPASAPGQPPQSGLARIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3795 | - | - | 100% (549) | adenylate cyclase |
| M. marinum M | MMAR_4080 | - | 0.0 | 81.80% (533) | adenylate cyclase |
| M. marinum M | MMAR_4078 | - | 0.0 | 64.24% (523) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1352c | - | 0.0 | 62.91% (523) | adenylate cyclase |
| M. gilvum PYR-GCK | Mflv_2336 | - | 1e-175 | 60.42% (523) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1318c | - | 0.0 | 62.91% (523) | adenylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 3e-85 | 39.76% (503) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 1e-157 | 53.70% (527) | hypothetical protein MAB_1459c |
| M. avium 104 | MAV_1540 | - | 0.0 | 65.53% (528) | HAMP domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4924 | - | 1e-162 | 57.74% (530) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_3474 | - | 0.0 | 63.36% (524) | PUTATIVE putative adenylate/guanylate cyclase |
| M. ulcerans Agy99 | MUL_3944 | - | 0.0 | 80.86% (533) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 1e-178 | 62.02% (524) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3795|M.marinum_M MWGG--NCVDTALHRLLNVPTDKGGRLAA-ARAYGSRLLGDAGVPPKRRW
MUL_3944|M.ulcerans_Agy99 MVAT--NTVVQRLRRALEKITQQSDQLTE-NYAYGSRLLGQLTETPQRRR
Mb1352c|M.bovis_AF2122/97 MSAK--KSTAQRLGRVLETVTRQSGRLPE-TPAYGSWLLGRVSESQRRRR
Rv1318c|M.tuberculosis_H37Rv MSAK--KSTAQRLGRVLETVTRQSGRLPE-TPAYGSWLLGRVSESQRRRR
MAV_1540|M.avium_104 MSAT--QSTAQRIGRVLEKITRQSGRLPE-TPAYGSLLLGRVTESQHRRR
Mflv_2336|M.gilvum_PYR-GCK MNAT--KSVPYRLGRVLERVTRQSGRLDT--PGYGSWLLGRPAESQSRRR
Mvan_4309|M.vanbaalenii_PYR-1 MNAT--KSVPYRLGRVLERVTRQSGRLET--PDYGSWLLGKPEESQARRR
MSMEG_4924|M.smegmatis_MC2_155 MNAD--NSLARQLGRVLETVTRQNSRLPSGTPEYGSWILGRVTESQSRRR
TH_3474|M.thermoresistible__bu MTPN--NRLARRLGHLLETLTRQSGRLSG-ANEYGSWLLGRVSESQRRRR
MAB_1459c|M.abscessus_ATCC_199 MANESIRAVSRRVGRALGAITGQTGNINT-GNGYGSWLLGTADESTFIQR
MLBr_00201|M.leprae_Br4923 -------------------MATQAAGLPGRIGAFVRWGIRTPWPLFSLSM
: : : : :
MMAR_3795|M.marinum_M IRIRTMSTVAILGINLIGICVMLVLLTLAVPEPNVLSEAPAWLNYGVGPA
MUL_3944|M.ulcerans_Agy99 VRIQLMLTSSIMAANLVAIGVALLLVFVAIPEPNVITEAPRWLTFGVGAG
Mb1352c|M.bovis_AF2122/97 VRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPG
Rv1318c|M.tuberculosis_H37Rv VRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPG
MAV_1540|M.avium_104 IRIQIIMTVMVLGANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPA
Mflv_2336|M.gilvum_PYR-GCK VRIQIILTFFILFTNIMGIAVSLLLNTIAIPVPSVFSDAPAWLTFGVTPA
Mvan_4309|M.vanbaalenii_PYR-1 IRIQVILTFLLLFTNILGIAVSLLLNTVAIPVPSVFSDAPAWLTFGVVPA
MSMEG_4924|M.smegmatis_MC2_155 IRIQLILTTFVVIANLLGIAVSFLVLTVLFPSPSVFDARVAPYTYIVAPA
TH_3474|M.thermoresistible__bu LRIQTILTTFIVGANVVGIAVAVTLVSFVFPVPSIFSDAPAWLTFGVSPA
MAB_1459c|M.abscessus_ATCC_199 IRIQLILTVFVVAANLIGIGVVILLVTVAFPTPNVF-DAPAWVNFVIVPV
MLBr_00201|M.leprae_Br4923 LQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVAFSTGF
:: : : :: .: : .* .:
MMAR_3795|M.marinum_M YNVIALTLGTWWITALAKRALRWYIEGRRPSLTEATETFRIPSRVAAVNF
MUL_3944|M.ulcerans_Agy99 YDVTAFVVGSFWITSNTVRALRWYIEGRPPNRAVSRETFLVPSRIAAVHL
Mb1352c|M.bovis_AF2122/97 YVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHL
Rv1318c|M.tuberculosis_H37Rv YVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHL
MAV_1540|M.avium_104 YVASALAVGTYWITRRTVLALRWAIEERKPTPTDERNTFLAPWRIALVDL
Mflv_2336|M.gilvum_PYR-GCK YMLVALFFGTAWITSRTVRSLRWAIEERQPTSTDQRNVFLAPARVAQKLL
Mvan_4309|M.vanbaalenii_PYR-1 YMVVALVLGTAWITSRTVGSLRWAIEERSPTRTDQRNVFVAPSRVAQMLL
MSMEG_4924|M.smegmatis_MC2_155 YVVGALVVGVIWATNRVIGNVRWALEERPPTPQDQRNTFFAPFRLTRVLL
TH_3474|M.thermoresistible__bu LVGVALVVGTTWITRGIVRNLRWAIEERPPSRTDQRNTFLAPWRVARAHL
MAB_1459c|M.abscessus_ATCC_199 YIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQRNAFAVPWRLTVIQS
MLBr_00201|M.leprae_Br4923 AVNLKLLMPVFRWQR---RDNRLAEADPAATELARSRALRMPFYHTIISL
. . * .. ..: * :
MMAR_3795|M.marinum_M FLWGLGTLTMTTLYGLIDTRFIAKYLFSVSFCGILVCTGSYLLTEFWLRP
MUL_3944|M.ulcerans_Agy99 FLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCGILVATGSYLLTEFALRP
Mb1352c|M.bovis_AF2122/97 MFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRP
Rv1318c|M.tuberculosis_H37Rv MFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRP
MAV_1540|M.avium_104 VLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCGVLVATACYLLAEFALRP
Mflv_2336|M.gilvum_PYR-GCK LLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPGIVVATACYMITEFALRP
Mvan_4309|M.vanbaalenii_PYR-1 LFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPGIVVATACYMITEFALRP
MSMEG_4924|M.smegmatis_MC2_155 ILWAAGTALLTTLYGMVDTNFIPKVLLGISFPGIVVSVSCHLFTEFALRP
TH_3474|M.thermoresistible__bu VLWGAGTAVLTTLYGLVDPAFIPRYLFTVSFAGIVVATICYLFTEFALRP
MAB_1459c|M.abscessus_ATCC_199 VLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAVVCAANYLFTEFAMRP
MLBr_00201|M.leprae_Br4923 VTWGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVLRP
. *. * : . : .: . .. :: :* :**
MMAR_3795|M.marinum_M MTAQALETGPPHRRIGSGIIGRTLLIWLLGSGVPLIGISLFAAFE-VALL
MUL_3944|M.ulcerans_Agy99 LTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPVVDIALLAVFE-IALL
Mb1352c|M.bovis_AF2122/97 FAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFE-MVLL
Rv1318c|M.tuberculosis_H37Rv FAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFE-MVLL
MAV_1540|M.avium_104 VAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLALFE-IWLR
Mflv_2336|M.gilvum_PYR-GCK IAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAVFS-LSLK
Mvan_4309|M.vanbaalenii_PYR-1 VAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAIFT-LSLR
MSMEG_4924|M.smegmatis_MC2_155 VAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPILGILLAGVFA-VTLE
TH_3474|M.thermoresistible__bu VAAQALEAGPPPRRLAHGIMGRTMTVWLLGSGVPLLGIMIAAAVS-LTQR
MAB_1459c|M.abscessus_ATCC_199 VAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPAAGIVITGIGA-LVLH
MLBr_00201|M.leprae_Br4923 VAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIALL
.:. **.:* *: * : * .:*** * : :
MMAR_3795|M.marinum_M HLTVVEFAVGVMIASSATLVFGLLLIAISAWLTATPVRLVRAALKQVEQG
MUL_3944|M.ulcerans_Agy99 HLSEVEFAVGVLIASSATLVFGLLLIAISAWLTATPVRVVRAALKRVERG
Mb1352c|M.bovis_AF2122/97 NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERG
Rv1318c|M.tuberculosis_H37Rv NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERG
MAV_1540|M.avium_104 NLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERG
Mflv_2336|M.gilvum_PYR-GCK NLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATPVRVVRSALKQVEDG
Mvan_4309|M.vanbaalenii_PYR-1 NLSATQFAVAVMIISVVALMFGLILMWLLSWLIATPVRVVRSALKHVEDG
MSMEG_4924|M.smegmatis_MC2_155 NLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATPIRVVRAALNRVEQG
TH_3474|M.thermoresistible__bu HLSLVQFTIATMVLAAVALVFGFVLMWLVSWLTATPVRVVREALKQVENG
MAB_1459c|M.abscessus_ATCC_199 NLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMATPVKEVQTAIKRVAQN
MLBr_00201|M.leprae_Br4923 HAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQRG
: :: : : .* : : * *:: :: *: .* .
MMAR_3795|M.marinum_M DLRGDVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAA
MUL_3944|M.ulcerans_Agy99 DLRGDVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAA
Mb1352c|M.bovis_AF2122/97 ELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
Rv1318c|M.tuberculosis_H37Rv ELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
MAV_1540|M.avium_104 DLRGDLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAA
Mflv_2336|M.gilvum_PYR-GCK DLDCNLVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVALAA
Mvan_4309|M.vanbaalenii_PYR-1 DLDCNVVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVARAA
MSMEG_4924|M.smegmatis_MC2_155 DLDTNLVVFDGTELGQLQRGFNSMVHGLRERERVRDLFGRHVGREVAVLA
TH_3474|M.thermoresistible__bu NLDCNVVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVARAA
MAB_1459c|M.abscessus_ATCC_199 DLDIDLVVYDGTELGELQAGFNTMVEGLRERERVRDLFGKHVGREVAAAA
MLBr_00201|M.leprae_Br4923 NYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVARRA
: .: ::*.:*** ** *** ** * **:*:*****::**.:** *
MMAR_3795|M.marinum_M ERKPPQLGGEERYVAVVFVDIIGSTQLVSNRPATDVVQLLNRFFAVIVDE
MUL_3944|M.ulcerans_Agy99 ERKPPQLGGEERYVAVVFVDIIGSTQLVSNRPATDVVQLLDRFFAVIVDE
Mb1352c|M.bovis_AF2122/97 ERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDE
Rv1318c|M.tuberculosis_H37Rv ERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDE
MAV_1540|M.avium_104 ERERPKLGGEERHVAVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEE
Mflv_2336|M.gilvum_PYR-GCK EKQQVELGGEERRAAVIFVDIIGSTKLVTSRPAAEVVELLNRFFDVVVDE
Mvan_4309|M.vanbaalenii_PYR-1 EKQKIELGGEERHAAVIFVDIIGSTQLVTSRPAVEVVELLNRFFDVVVEE
MSMEG_4924|M.smegmatis_MC2_155 EQQKFTLGGEERHAAVVFVDVIGSTQLVTSRPAVEVVELLNRFFAVIVDE
TH_3474|M.thermoresistible__bu EEQQLELGGEERHVAVIFVDIVGSTQLVTTRPAAEVVSLLNRFFAVIVEE
MAB_1459c|M.abscessus_ATCC_199 EQQQPELGGEERHIAVLFADIVGSTRLAATRPAVEVVALLNRFFTVVVEE
MLBr_00201|M.leprae_Br4923 LEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVVDT
.. ***:** **:* *::***:*. :*...** :*:.** ::*:
MMAR_3795|M.marinum_M VERHRGLVNKFEGDASLAIFGAPNPLECPEVAALSAARAIAGRLCTEVPE
MUL_3944|M.ulcerans_Agy99 VERHRGLVNKFEGDASLAIFGAPNPLECPEVAALSAARAIAGRLCTEVPE
Mb1352c|M.bovis_AF2122/97 VDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPE
Rv1318c|M.tuberculosis_H37Rv VDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPE
MAV_1540|M.avium_104 VDRHCGLVNKFEGDATLAIFGAPNHLDCPEDAALTAARAIADRLANEMPQ
Mflv_2336|M.gilvum_PYR-GCK VDKHHGLVNKFEGDAVLAVFGAPVSLDNAEAEALAAARAMSRRLAAEVPE
Mvan_4309|M.vanbaalenii_PYR-1 VDNHHGLVNKFEGDAVLAVFGAPVSLDSAETEALSAARAMARRLRTEVPE
MSMEG_4924|M.smegmatis_MC2_155 VDAHRGLVNKFEGDAVLAVFGAPVALDNAEDEALGAARGIARRLREEVPE
TH_3474|M.thermoresistible__bu VDRHRGLVNKFEGDATLAIFGAPNRLDNPEDAALAAARAIAARLRTEVPE
MAB_1459c|M.abscessus_ATCC_199 IDRYEGMVNKFEGDATLAVFGAPVRQDRPESQALAAARAIARRLRTEVPE
MLBr_00201|M.leprae_Br4923 VGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPVLGS
: : *:****:*** *::**** . ** *** : .* : .
MMAR_3795|M.marinum_M CRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEAARLCELAKSYSARLV
MUL_3944|M.ulcerans_Agy99 CPAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEAARLCELAKSYSTRLV
Mb1352c|M.bovis_AF2122/97 CQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLL
Rv1318c|M.tuberculosis_H37Rv CQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLL
MAV_1540|M.avium_104 CRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNEAARLCELAKSHSGRLL
Mflv_2336|M.gilvum_PYR-GCK CTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNEAARLCELSKKIDGHLV
Mvan_4309|M.vanbaalenii_PYR-1 CPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAARLCELAKNVPALLV
MSMEG_4924|M.smegmatis_MC2_155 LDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAARLCEFAKSVPGHVV
TH_3474|M.thermoresistible__bu VRAGIGVASGQVVAGNVGARERFEYTVIGEPVNEGARLCELAKTKPGLLV
MAB_1459c|M.abscessus_ATCC_199 CQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEAARLCELSKTVPGHLV
MLBr_00201|M.leprae_Br4923 AEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDGHVL
****::*:.:**::**. ******** ****.*** *::* ::
MMAR_3795|M.marinum_M ASSETVAGATETERAHWNLAETVTLRGRDRPTHLAIPASAPGQPPQSGLA
MUL_3944|M.ulcerans_Agy99 ASSETVAGATETERAHWNLAETVTLRGRDRPTRLAIPASSP-RP------
Mb1352c|M.bovis_AF2122/97 ASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR-----
Rv1318c|M.tuberculosis_H37Rv ASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR-----
MAV_1540|M.avium_104 ATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAGAADRPAGTD--
Mflv_2336|M.gilvum_PYR-GCK ASADAVHNATETERRHWELGETVTLRGHAEPTTLATPVDRD---------
Mvan_4309|M.vanbaalenii_PYR-1 ASADAVGGATESERALWKLGETVTLRGHDQPTRLATPAGEL---------
MSMEG_4924|M.smegmatis_MC2_155 ASSDTLANASESERARWSLGESVTLRGLDEPTRLAVPV------------
TH_3474|M.thermoresistible__bu ASADAVANAGEQERAHWVLGETVTLRGHNQPTRLALPA------------
MAB_1459c|M.abscessus_ATCC_199 ASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELAVPV------------
MLBr_00201|M.leprae_Br4923 ASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQITSEV
*: :: * . * * . * *** *. ** *
MMAR_3795|M.marinum_M RIG
MUL_3944|M.ulcerans_Agy99 ---
Mb1352c|M.bovis_AF2122/97 ---
Rv1318c|M.tuberculosis_H37Rv ---
MAV_1540|M.avium_104 ---
Mflv_2336|M.gilvum_PYR-GCK ---
Mvan_4309|M.vanbaalenii_PYR-1 ---
MSMEG_4924|M.smegmatis_MC2_155 ---
TH_3474|M.thermoresistible__bu ---
MAB_1459c|M.abscessus_ATCC_199 ---
MLBr_00201|M.leprae_Br4923 TG-