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NSPIKRVAISTGGGDAPGLNAVIHAATLAARNRGWDVVGIRDGLNGLLLPEDYPEGGLIELTRDRVRGII HQGGTIIGTTNRGNPTAYPVRQSDGSWAEVDRTEELLGRFAQHQIDALILVGGDGSMSIGQHLHQSGLPL VGVPKTIDNDLDKTTSTFGFDSAVDFASECIDRLFTTATSHGRIIVVEVMGRYAGWIALNAGMASGVHAI LIPEIPFSLEPVAAVITDREQRGAKFSIVCVAEGAKPIGGEVTILGKSVGQAERLGGIGAKVAAELERMT GREARTVVLGHLLRGGSPTSFDRLLGLRFGAAAVRALDEGHYGVMVALNPPTVDYVPLADATHRQKVVPL DCDSILTARDMGINFGDEMPTHSTID*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3411 | pfkA_1 | - | 100% (377) | 6-phosphofructokinase PfkA_1 |
| M. marinum M | MMAR_1703 | pfkA | 5e-71 | 43.97% (348) | 6-phosphofructokinase PfkA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3035c | pfkA | 2e-72 | 43.39% (348) | 6-phosphofructokinase |
| M. gilvum PYR-GCK | Mflv_4245 | - | 1e-73 | 45.69% (348) | 6-phosphofructokinase |
| M. tuberculosis H37Rv | Rv3010c | pfkA | 2e-72 | 43.39% (348) | 6-phosphofructokinase |
| M. leprae Br4923 | MLBr_01701 | pfkA | 2e-72 | 44.25% (348) | 6-phosphofructokinase |
| M. abscessus ATCC 19977 | MAB_3335c | - | 1e-74 | 45.40% (348) | 6-phosphofructokinase |
| M. avium 104 | MAV_3858 | - | 1e-73 | 45.11% (348) | 6-phosphofructokinase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_0059 | pfkA | 1e-74 | 46.55% (348) | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) |
| M. ulcerans Agy99 | MUL_1940 | pfkA | 3e-71 | 43.97% (348) | 6-phosphofructokinase |
| M. vanbaalenii PYR-1 | Mvan_2116 | - | 1e-72 | 44.83% (348) | 6-phosphofructokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3035c|M.bovis_AF2122/97 -----MRIGVLTGGGDCPGLNAVIRAVVRTCHARYGSSVVGFQNGFRGLL
Rv3010c|M.tuberculosis_H37Rv -----MRIGVLTGGGDCPGLNAVIRAVVRTCHARYGSSVVGFQNGFRGLL
MUL_1940|M.ulcerans_Agy99 -----MRIGVLTGGGDCPGLNAVIRAVVRTCDARYGSSVVGFQDGWRGLL
MLBr_01701|M.leprae_Br4923 -----MRIGILTGGGDCPGLNAVIRAIVRTCDARYGSSVVGFQDGWRGLL
MAV_3858|M.avium_104 -----MRIGVLTGGGDCPGLNAVIRAVVRTCDSRYGSSVVGFQDGWRGLL
Mflv_4245|M.gilvum_PYR-GCK -----MRIGVLTGGGDCPGLNAVIRAVVRTCDARYGSSVVGFLDGWRGLL
Mvan_2116|M.vanbaalenii_PYR-1 -----MRIGVLTGGGDCPGLNAVIRAVVRTSYVRYGSSVVGFQDGWRGLL
TH_0059|M.thermoresistible__bu -----MRIGVLTGGGDCPGLNAVIRAVVRTCDVRYGSSVVGFRDGWRGLL
MAB_3335c|M.abscessus_ATCC_199 -----MRIGVLTGGGDCPGLNAVIRAVVRTCANRYNSQVVGFQDGWRGLL
MMAR_3411|M.marinum_M MNSPIKRVAISTGGGDAPGLNAVIHAATLAARNR-GWDVVGIRDGLNGLL
*:.: *****.*******:* . :. * . .***: :* .***
Mb3035c|M.bovis_AF2122/97 ------ENRRVQLHNDDRNDRLLAKGGTMLGTAR-----VHPDKLRAG--
Rv3010c|M.tuberculosis_H37Rv ------ENRRVQLHNDDRNDRLLAKGGTMLGTAR-----VHPDKLRAG--
MUL_1940|M.ulcerans_Agy99 ------ENRRLQLRNDDRNDRLLAKGGTMLGTAR-----VHPDKLRAG--
MLBr_01701|M.leprae_Br4923 ------ENRRMQLCNDDRNDRLLAKGGTMLGTAH-----VHPDKLRAG--
MAV_3858|M.avium_104 ------ENRRIQLHNDDRNDRLLAKGGTMLGTAR-----VHPDKLRAG--
Mflv_4245|M.gilvum_PYR-GCK ------EDRRVQLKNDDRNDRLLAKGGTMLGTAR-----TNPDKLRAG--
Mvan_2116|M.vanbaalenii_PYR-1 ------EDRRIQLSNDDRNDRLLAKGGTMLGTAR-----VNPDKLRAG--
TH_0059|M.thermoresistible__bu ------ENRRVQLRNDDRNDRLLAKGGTILGTAR-----VHPEKLRAG--
MAB_3335c|M.abscessus_ATCC_199 ------ENRRIHLHNDDRNDRLLTKGGTVLGTAR-----TNPDRLRAG--
MMAR_3411|M.marinum_M LPEDYPEGGLIELTR-DRVRGIIHQGGTIIGTTNRGNPTAYPVRQSDGSW
*. :.* . ** :: :***::**:. . * : *
Mb3035c|M.bovis_AF2122/97 --LPQIMQTLD---DNGIDVLIPIGGEGTLTAASWLSEENVPVVGVPKTI
Rv3010c|M.tuberculosis_H37Rv --LPQIMQTLD---DNGIDVLIPIGGEGTLTAASWLSEENVPVVGVPKTI
MUL_1940|M.ulcerans_Agy99 --LPQIKQTLD---DNGIDVLIPIGGEGTLTAAHWLSEENVPVVGVPKTI
MLBr_01701|M.leprae_Br4923 --LHQIKQTLD---DNGIDVLIPIGGEGTLTAAHWLSQEDVPVVGVPKTI
MAV_3858|M.avium_104 --LNQIKQTLD---DNGIDVLIPIGGEGTLTAAHWLSEENVPVVGVPKTI
Mflv_4245|M.gilvum_PYR-GCK --LDQIKQTLE---DNGIDVLIPIGGEGTLTAAHWLSEEGVPVVGVPKTI
Mvan_2116|M.vanbaalenii_PYR-1 --LDQIKQTLE---DNGIDVLIPIGGEGTLTAAHWLSEENVPVVGVPKTI
TH_0059|M.thermoresistible__bu --LDQIKQTLD---ENGIDVLIPIGGEGTLTAARWLSDENVPVVGVPKTI
MAB_3335c|M.abscessus_ATCC_199 --LDQIKQTLD---DNGIDVLIPIGGEGTLTAASWLADENVPVVGVPKTI
MMAR_3411|M.marinum_M AEVDRTEELLGRFAQHQIDALILVGGDGSMSIGQHLHQSGLPLVGVPKTI
: : : * :: **.** :**:*::: . * :..:*:*******
Mb3035c|M.bovis_AF2122/97 DNDIDCTDVTFGHDTALTVATEAIDRLHSTAESHERVMLVEVMGRHAGWI
Rv3010c|M.tuberculosis_H37Rv DNDIDCTDVTFGHDTALTVATEAIDRLHSTAESHERVMLVEVMGRHAGWI
MUL_1940|M.ulcerans_Agy99 DNDIDCTDVTFGHDTALMVATEAIDRLHSTAESHQRVMLVEVMGRHAGWI
MLBr_01701|M.leprae_Br4923 DNDIDCTDVTFGHDTALTVATEAIDRLHSTAESHQRVMLVEVMGRHAGWI
MAV_3858|M.avium_104 DNDIDCTDVTFGHDTALTVATDAIDRLHSTAESHQRVMLVEVMGRHAGWI
Mflv_4245|M.gilvum_PYR-GCK DNDIDCTDVTFGHDTALTIATEAIDRLHSTAESHQRVMLVEVMGRHAGWI
Mvan_2116|M.vanbaalenii_PYR-1 DNDIDCTDVTFGHDTALTVATEAIDRLHSTAESHQRVMLVEVMGRHAGWI
TH_0059|M.thermoresistible__bu DNDIDCTDQTFGHDTAVTVASEAIDRLHSTAESHQRVMLVEVMGRHAGWI
MAB_3335c|M.abscessus_ATCC_199 DNDIDCTDVTFGFDTALTIATEAIDRLHSTAESHQRVMLVEVMGRHAGWI
MMAR_3411|M.marinum_M DNDLDKTTSTFGFDSAVDFASECIDRLFTTATSHGRIIVVEVMGRYAGWI
***:* * ***.*:*: .*::.****.:** ** *:::******:****
Mb3035c|M.bovis_AF2122/97 ALNAGLASGAHMTLIPEQPFDIEEVCRLVKGRFQRGDSHFICVVAEGAKP
Rv3010c|M.tuberculosis_H37Rv ALNAGLASGAHMTLIPEQPFDIEEVCRLVKGRFQRGDSHFICVVAEGAKP
MUL_1940|M.ulcerans_Agy99 ALNSGLASGAHMTLIPEQPFDIEEVCRLVKQRFQRGDSHFICVVAEGAKP
MLBr_01701|M.leprae_Br4923 ALSSGLASGAHMTLIPEQPFDVEEVCCLVKRRFQRGDSHFICVVAEGAKP
MAV_3858|M.avium_104 ALNAGLASGAHMTLIPEQPFDVEEVCRLVKRRFQRGDSHFICVVAEGAKP
Mflv_4245|M.gilvum_PYR-GCK ALNAGMASGAHMTLIPEQPFDVEEVCRLVKQRFQRGDSHFICVVAEGAKP
Mvan_2116|M.vanbaalenii_PYR-1 ALNAGLASGAHMTLIPEQPFDVEEVCRLVKQRFVRGDSHFICVVAEGAKP
TH_0059|M.thermoresistible__bu ALNAGLASGAHLILIPEQPFDVEEVCRLIRQRFVRGDSHFICVVAEGAKP
MAB_3335c|M.abscessus_ATCC_199 ALHAGLASGAHMTLIPEVPFDVDEVCRLIKGRFQRGDSHFICVVAEGAKP
MMAR_3411|M.marinum_M ALNAGMASGVHAILIPEIPFSLEPVAAVITDREQRGAKFSIVCVAEGAKP
** :*:***.* **** **.:: *. :: * ** .. * *******
Mb3035c|M.bovis_AF2122/97 APGTIMLREGGLDEFGHERFTGVAAQLAVEVEKRINKDVRVTVLGHIQRG
Rv3010c|M.tuberculosis_H37Rv APGTIMLREGGLDEFGHERFTGVAAQLAVEVEKRINKDVRVTVLGHIQRG
MUL_1940|M.ulcerans_Agy99 VSGSMQLREGGLDEFGHERFTGVAAQLGWEVEKRINKDVRVTVLGHVQRG
MLBr_01701|M.leprae_Br4923 VPGSITLRQGGMDEFGHERFTGVAAQLGAEVEKRINKDVRVTVLGHVQRG
MAV_3858|M.avium_104 IPGSISLREGGIDEFGHERFTGVAAQLGAEVEKRINKEVRVTVLGHVQRG
Mflv_4245|M.gilvum_PYR-GCK AEGSMQLRQGGMDEFGHEKFTGVAAQLAIEVEKRIKKDVRVTVLGHVQRG
Mvan_2116|M.vanbaalenii_PYR-1 AEGSMQLRQGGIDEFGHEKFTGVAQQLAIEVEKRINKEVRVTVLGHVQRG
TH_0059|M.thermoresistible__bu APGSMQLREGGVDEFGHERFTGVAQQLALEVEKRINKEVRVTVLGHVQRG
MAB_3335c|M.abscessus_ATCC_199 AEGSMELRDGGIDEFGHQRFTGVAQQLGVEIEKRINKEVRTTVLGHVQRG
MMAR_3411|M.marinum_M IGGEVTILGKSVGQA--ERLGGIGAKVAAELERMTGREARTVVLGHLLRG
* : : .:.: ::: *:. ::. *:*: ::.*..****: **
Mb3035c|M.bovis_AF2122/97 GTPTAYDRVLATRFGVNAADAAHAGEYGQMVTLRGQDIGRVPLADAVRKL
Rv3010c|M.tuberculosis_H37Rv GTPTAYDRVLATRFGVNAADAAHAGEYGQMVTLRGQDIGRVPLADAVRKL
MUL_1940|M.ulcerans_Agy99 GQPTAYDRVLATRFGVNAADAAHAGEYGQMVSLRGQDIGRVPLADAVRQL
MLBr_01701|M.leprae_Br4923 GTPTAFDRVLATRFGVNAADASHAGEYGQMVSLRGQDIGRVPLEDAVRQL
MAV_3858|M.avium_104 GTPTAYDRVLATRFGVNAADAAHAGEYGQMVSLRGQDIGRVPLADAVRQL
Mflv_4245|M.gilvum_PYR-GCK GTPTAFDRVLATRFGVNAADAAHAGEYGMMVSARGTEIGRVPLADAVRQL
Mvan_2116|M.vanbaalenii_PYR-1 GTPTAYDRVLATRFGVNAADAAHAGEYGMMVSLRGQEIGRVPLADAVRQL
TH_0059|M.thermoresistible__bu GTPTAFDRVLATRFGVNAADAAHAGEYGMMVALRGQEIVRVSLADATRNL
MAB_3335c|M.abscessus_ATCC_199 GTPTPFDRVLATRFGVNAADAAHAGEFGVMVSLRGQDIGRVPLAEATRQL
MMAR_3411|M.marinum_M GSPTSFDRLLGLRFGAAAVRALDEGHYGVMVALNPPTVDYVPLADATHRQ
* **.:**:*. ***. *. * . *.:* **: . : *.* :*.:.
Mb3035c|M.bovis_AF2122/97 KLVPQS-----RYDDAAAFFG----------
Rv3010c|M.tuberculosis_H37Rv KLVPQS-----RYDDAAAFFG----------
MUL_1940|M.ulcerans_Agy99 KLVPQS-----RYDDAAEFFG----------
MLBr_01701|M.leprae_Br4923 KLVPES-----RYDDAAAFFG----------
MAV_3858|M.avium_104 KLVPES-----RYDDAAAFFG----------
Mflv_4245|M.gilvum_PYR-GCK KLVPQT-----RYDDAAEFFG----------
Mvan_2116|M.vanbaalenii_PYR-1 KLVPQS-----RYDDAAEFFG----------
TH_0059|M.thermoresistible__bu KLVPQS-----RYDDAAEFFG----------
MAB_3335c|M.abscessus_ATCC_199 KLVPKN-----RYEDAAAFFG----------
MMAR_3411|M.marinum_M KVVPLDCDSILTARDMGINFGDEMPTHSTID
*:** * . **