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ATHKAVQIGAAGGLLQLVDVDTAPPGDGEVRISVSACGICGTDRAFVHGAFPGLGWPLTPGHEIAGRIAE IGNGVEDFAVGDRVAVGWFGGNCNHCDPCRKGMFIHCAKMKVPGWQYPGGYAESVTVPATALARIPAELS DAEAAPMGCAGVTTYNALRHTRARPGDRVAVLGVGGLGHLGLQFCRAMGFETVAIARGSAKAEDARQLGA HHYIDSTTGDVAEALRRIGGAAVVLATAGNSAAMAETVGGLLPRGELVVIGVTADPLPISPVQLINPGLS VTGHPSGTAKDVEETMHFAVLSGVRAWIEERPLAQAADGYEAMEQGRTRYRTVLAM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2782 | adhC | - | 100% (337) | NADP-dependent alcohol dehydrogenase AdhC |
| M. marinum M | MMAR_4911 | adhX | 8e-48 | 33.43% (332) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. marinum M | MMAR_1649 | adh | 3e-44 | 32.70% (318) | NADP-dependent alcohol dehydrogenase Adh |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3071 | adhC | 5e-43 | 31.49% (343) | NADP-dependent alcohol dehydrogenase ADHC |
| M. gilvum PYR-GCK | Mflv_0236 | - | 1e-142 | 72.11% (337) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3045 | adhC | 5e-43 | 31.49% (343) | NADP-dependent alcohol dehydrogenase ADHC |
| M. leprae Br4923 | MLBr_01730 | adhA | 3e-45 | 31.78% (343) | alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 9e-47 | 33.44% (317) | NADP-dependent alcohol dehydrogenase C |
| M. avium 104 | MAV_2812 | - | 1e-150 | 78.26% (322) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3464 | - | 1e-137 | 69.05% (336) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_2673 | - | 3e-42 | 33.64% (321) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2965 | adhC | 0.0 | 98.22% (337) | NADP-dependent alcohol dehydrogenase AdhC |
| M. vanbaalenii PYR-1 | Mvan_0669 | - | 1e-141 | 71.81% (337) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3071|M.bovis_AF2122/97 ----------------MSTVAAYAAMSAT----EPLTKTTITRRDPGPHD
Rv3045|M.tuberculosis_H37Rv ----------------MSTVAAYAAMSAT----EPLTKTTITRRDPGPHD
MLBr_01730|M.leprae_Br4923 MKSHVSKHRRKRRLGAMTTVSAYAATSAT----EPLTKVTINRRAPGPHD
MAB_3400|M.abscessus_ATCC_1997 ----------------MVTVSAYAATSGK----DPLVPTTIERREVGPHD
MMAR_2782|M.marinum_M ----------------MATHKAVQIGAAG----GLLQLVDVDTAPPGDGE
MUL_2965|M.ulcerans_Agy99 ----------------MATHKAVQIGAAG----GPLQLVDVDTAPPADGE
MAV_2812|M.avium_104 -----------------------------------MELVDTETRPPGRDE
Mflv_0236|M.gilvum_PYR-GCK ----------------MPTHKAVHVAGAN----EDLTLVEVETAPPPPGH
Mvan_0669|M.vanbaalenii_PYR-1 ----------------MPTHKAVQVPSAN----EALTHVEVDTLPPPAGH
MSMEG_3464|M.smegmatis_MC2_155 ----------------MPTHRAVHVKSTG----GTLELTDVETPPPDRGQ
TH_2673|M.thermoresistible__bu -LWTTGAVARDDDRMSASMMSAWRVREPGPMRTRPLEWVRTPVPEPGPGE
: . .
Mb3071|M.bovis_AF2122/97 VAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYR
Rv3045|M.tuberculosis_H37Rv VAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYR
MLBr_01730|M.leprae_Br4923 VAIQIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGTEVTKHK
MAB_3400|M.abscessus_ATCC_1997 VFIDIKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVGSEVTKFK
MMAR_2782|M.marinum_M VRISVSACGICGTDRAFVHGAFPGLGWPLTPGHEIAGRIAEIGNGVEDFA
MUL_2965|M.ulcerans_Agy99 VRISVSACGICGTDRAFVHGAFPGLDWPLTPGHEIAGRIAEIGNGVEDFA
MAV_2812|M.avium_104 VRLTVGACGICGTDAHFVNGAFPGLSWPLTPGHEIAGRIAELGEGVEGFA
Mflv_0236|M.gilvum_PYR-GCK VRLAVKACGVCGTDREFRAGHFPGLQWPLTLGHEIAGAVAEVGDGVEDFS
Mvan_0669|M.vanbaalenii_PYR-1 VRIDVAACGVCGTDREFRAGHFPGLQWPITLGHEIAGTVAELGDGVEEFA
MSMEG_3464|M.smegmatis_MC2_155 VRIDVAACGVCGTDRGIVNGVFPVASWPVTPGHEIAGTVAEIGPGVEDFA
TH_2673|M.thermoresistible__bu LLVAVRACGVCRTDLHVAEGDLPVHRPGVTPGHEVVGEVVATADG-TDFR
: : : .*:* :* :. ***:.* :. . .
Mb3071|M.bovis_AF2122/97 QGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGY
Rv3045|M.tuberculosis_H37Rv QGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGY
MLBr_01730|M.leprae_Br4923 VGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQGGY
MAB_3400|M.abscessus_ATCC_1997 PGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQGGY
MMAR_2782|M.marinum_M VGDRVAVGWFGGNCNHCDPCRKGMFIHCAKMKVPGWQYP--------GGY
MUL_2965|M.ulcerans_Agy99 VGDRVAVGWFGGNCNHCDPCRKGMFIHCSKMKVPGWQYP--------GGY
MAV_2812|M.avium_104 VGQRVAVGWFGGCCYRCDPCRAGLFIHCVNGKVPSWHYP--------GGY
Mflv_0236|M.gilvum_PYR-GCK VGDRVAVGWFGGNCNRCIPCRRGSFMQCERMQVPSWHYP--------GGY
Mvan_0669|M.vanbaalenii_PYR-1 VGDRVAVGWFGGNCNRCVPCRRGFFMQCERMQVPSWQYP--------GGY
MSMEG_3464|M.smegmatis_MC2_155 VGDRVAIGWFGGHCGTCVPCRKGLFIHCVNGQVPSLSYP--------GGY
TH_2673|M.thermoresistible__bu VGDRVGIAWLRHTCGQCRYCRRGQENLCPESRYTGWDAD--------GGY
*::..:. : * * * * * ***
Mb3071|M.bovis_AF2122/97 SEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAI
Rv3045|M.tuberculosis_H37Rv SEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAI
MLBr_01730|M.leprae_Br4923 SQAIVVDENFVVHIPDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAI
MAB_3400|M.abscessus_ATCC_1997 SQAIVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGKRVAV
MMAR_2782|M.marinum_M AESVTVPATALARIPAELSDAEAAPMGCAGVTTYNALRHTRARPGDRVAV
MUL_2965|M.ulcerans_Agy99 AESVTVPATALARIPAELSDAEAAPMGCAGVTTYNALRHTRARPGDRVAV
MAV_2812|M.avium_104 AESVTVPTSALARIPEELTDAEAAPMGCAGVTTYNALRHTKALPGDRVAI
Mflv_0236|M.gilvum_PYR-GCK AESVTVPWTALARIPDGLSFVEAAPMGCAGVTTFNGLRQTRAKAGDVVAV
Mvan_0669|M.vanbaalenii_PYR-1 AESVTAPATALARIPDGLSFVEAAPMGCAGVTTFNGLRRTRAKAGDLVAV
MSMEG_3464|M.smegmatis_MC2_155 AESVTAPANALARIPDELSFVEAAPMGCAGVTTYNALRHTRAVAGDVVAI
TH_2673|M.thermoresistible__bu AEFATVPAAYAHRLPAGYSDAELAPLLCAGIIGYRALRRAELPPGGRLGI
:: .. ::* . **: ***: : **: . .. :.:
Mb3071|M.bovis_AF2122/97 IGLGGLGHMGVKLGAAMGADVTVLSQSLK-KMEDGLRLGAKSYYATADPD
Rv3045|M.tuberculosis_H37Rv IGLGGLGHMGVKLGAAMGADVTVLSQSLK-KMEDGLRLGAKSYYATADPD
MLBr_01730|M.leprae_Br4923 IGLGGLGHMGVKLGRKMGCEVTVLSQSLK-KMEDGLQLGASNYYATADPD
MAB_3400|M.abscessus_ATCC_1997 VGLGGLGHMAVKLGKAMGAEVTVLSQSLK-KMEDGLRLGASHYYATADPD
MMAR_2782|M.marinum_M LGVGGLGHLGLQFCRAMGFETVAIARGSA-KAEDARQLGAHHYIDSTTGD
MUL_2965|M.ulcerans_Agy99 LGVGGLGHLGLQFCRAMGFETVAIARGSA-KAEDARQLGAHHYIDSTTGD
MAV_2812|M.avium_104 LGVGGLGHLGVQFAAAMGFETIAINRGTG-KADDARKLGAHHYIDSTAED
Mflv_0236|M.gilvum_PYR-GCK LGVGGLGHLGVQWSRAMGFETVAIARGTG-KAEEARELGAHHYIDSTGQD
Mvan_0669|M.vanbaalenii_PYR-1 LGVGGLGHLGVQWARAMGFETVAIGRGTG-KAEEATQFGAHHYIDSTGQD
MSMEG_3464|M.smegmatis_MC2_155 IGLGGLGHLGVQFAAAMGFDTVVIARGRGDREQDARALGARHYIDSTSED
TH_2673|M.thermoresistible__bu YGFGGSAHLTAQVALAQGAEVHVMTRGAQ-ARELALALGAASAQGAADPP
*.** .*: : * :. .: :. : . :** ::
Mb3071|M.bovis_AF2122/97 TFRKLR--GGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVP
Rv3045|M.tuberculosis_H37Rv TFRKLR--GGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVP
MLBr_01730|M.leprae_Br4923 TFRKLR--GSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVP
MAB_3400|M.abscessus_ATCC_1997 TFKSLR--NSFDLILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVP
MMAR_2782|M.marinum_M VAEALRRIGGAAVVLATAGNSAAMAETVGGLLPRGELVVIGVTADPLPIS
MUL_2965|M.ulcerans_Agy99 VAEGLRRIGGAAVVLATAGNSAAMAETVGGLLPRGELVVIGVTADPLPIS
MAV_2812|M.avium_104 PAEALRALGGAAVVLATAGNSQAMAATVGGLAPQGELVTIGVTPEPLPIS
Mflv_0236|M.gilvum_PYR-GCK VAAELKKLGGAAVVLATANNAEAMAATVGGLGPAGELVVVGVSADNLPIS
Mvan_0669|M.vanbaalenii_PYR-1 VAAELTKLGGASVVLATANNAAAMAAAVGGLGPAGELVVVGVTAENLPIS
MSMEG_3464|M.smegmatis_MC2_155 VAAALQDLGGAAVVLGTAGNSQAMADTIGGLAPRGELVAVGVSAEPLGVS
TH_2673|M.thermoresistible__bu P-------VPLDAAILFAPVGHLVLPALEALDRGGTLSIAGIHLTDIPTL
: . : : * * * *: :
Mb3071|M.bovis_AF2122/97 AFALALMR-RSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDA
Rv3045|M.tuberculosis_H37Rv AFALALMR-RSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDA
MLBr_01730|M.leprae_Br4923 AFALALMR-RSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDYINEA
MAB_3400|M.abscessus_ATCC_1997 GFPLLTNR-RSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDASYINEA
MMAR_2782|M.marinum_M PVQLINPG-LSVTGHPSGTAKDVEETMHFAVLSGVRAWIEERPLAQAADG
MUL_2965|M.ulcerans_Agy99 PVQLINPG-LSVTGHPSGTAKDVEDTMHFAVLSGVRAWIEERPLAQAADG
MAV_2812|M.avium_104 PLQLITPG-LSIVGHPSGTAKDVEDTMQFAVLSGVRAWIEELPLSRAADG
Mflv_0236|M.gilvum_PYR-GCK PLHLINDG-LSVTGHPSGTSRDVEETLHFAMLSGVRARVEEVPLAQPAEA
Mvan_0669|M.vanbaalenii_PYR-1 PLDLINAG-RSVTGHPSGTSRDVEETMHFALLSGVRAKVEEVPLARAAEA
MSMEG_3464|M.smegmatis_MC2_155 PAQLIQPA-VSISGHPSGTAREVEETMHFAVVAGVRARVEERPLDDAAEA
TH_2673|M.thermoresistible__bu DYQRHLFQERQVRSVTANTRDDARAFLDFAAQHRIEVTTPEYPLDRADDA
.: . . :.. :.*. : :.
Mb3071|M.bovis_AF2122/97 YERVLASDVRYRFVIDISAL
Rv3045|M.tuberculosis_H37Rv YERVLASDVRYRFVIDISAL
MLBr_01730|M.leprae_Br4923 YERVLASDVRYRFVINISSL
MAB_3400|M.abscessus_ATCC_1997 YERVVASDVRYRFVIDTQTL
MMAR_2782|M.marinum_M YEAMEQGRTRYRTVLAM---
MUL_2965|M.ulcerans_Agy99 YEAMEQGRTRYRTVLAM---
MAV_2812|M.avium_104 YAALEGGRAHYRTVLTM---
Mflv_0236|M.gilvum_PYR-GCK YEAMDSSRARYRMVLTV---
Mvan_0669|M.vanbaalenii_PYR-1 YESMDSGRARYRMVLTM---
MSMEG_3464|M.smegmatis_MC2_155 YGAMADGRARYRFVLTT---
TH_2673|M.thermoresistible__bu LTDLSEGRIAGAAVLRV---
: . *: