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TQDRMIIKSEQGDYPVDFVGEVKLVPEFIDVGPETLVIIDEALVDLYGDALGPLSERPTYRVAADEESKT LSGVSLFVDWLLENKATRSAHVVAIGGGVIQDIATFACHIYYRGVGWTFVPTTLLSQADSCIGAKSSINV LPLKNQLGVFHSPSHVIVCSEFLTSLPQIEVDSGYGEIYKLALTNEGAFFDQLAEALTHGGHRNPRVLEM IRNALESKRLVIEQDEHESDLRRVLNYGHSFGHALEALTHNEVPHGLAVMWGMDLINFLGVKWGLTSPAT AARVRTVLDANTDYAIGAIPSARELVDTLKRDKKVRKGVMYFAVLHDEGDLRIVPKPLDEALVAEVAEYL DGDPLFAAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2329 | aroB_2 | - | 100% (360) | 3-dehydroquinate synthase AroB_2 |
| M. marinum M | MMAR_2177 | aroB | 5e-33 | 36.73% (245) | 3-dehydroquinate synthase AroB |
| M. marinum M | MMAR_0578 | aroB_1 | 3e-23 | 30.58% (278) | 3-dehydroquinate synthase AroB_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2567c | aroB | 7e-33 | 36.73% (245) | 3-dehydroquinate synthase |
| M. gilvum PYR-GCK | Mflv_3756 | aroB | 2e-32 | 35.92% (245) | 3-dehydroquinate synthase |
| M. tuberculosis H37Rv | Rv2538c | aroB | 7e-33 | 36.73% (245) | 3-dehydroquinate synthase |
| M. leprae Br4923 | MLBr_00518 | aroB | 2e-32 | 34.47% (264) | 3-dehydroquinate synthase |
| M. abscessus ATCC 19977 | MAB_2841c | aroB | 6e-33 | 35.54% (242) | 3-dehydroquinate synthase |
| M. avium 104 | MAV_3415 | aroB | 2e-33 | 34.25% (292) | 3-dehydroquinate synthase |
| M. smegmatis MC2 155 | MSMEG_3033 | aroB | 2e-31 | 37.14% (245) | 3-dehydroquinate synthase |
| M. thermoresistible (build 8) | TH_0108 | aroB | 3e-33 | 36.33% (245) | 3-DEHYDROQUINATE SYNTHASE AROB |
| M. ulcerans Agy99 | MUL_1761 | aroB | 1e-32 | 36.33% (245) | 3-dehydroquinate synthase |
| M. vanbaalenii PYR-1 | Mvan_2647 | aroB | 4e-34 | 36.19% (268) | 3-dehydroquinate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2567c|M.bovis_AF2122/97 MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRH---KVAVVHQPG
Rv2538c|M.tuberculosis_H37Rv MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRH---KVAVVHQPG
MLBr_00518|M.leprae_Br4923 MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRH---RVAILHQPV
MUL_1761|M.ulcerans_Agy99 MSDNKEPVTVQVAVDPPYPVVIGTGLLTELEELLAGRH---KVAILHQPV
MAV_3415|M.avium_104 -------MTVQVAVDPPYPVIIGTGLLGELDELLGARH---KVAVVHQPV
Mflv_3756|M.gilvum_PYR-GCK ---MTEPVTVDVRTDPPYPVIIGRGLLGDLGRVLDGRH---KVAILHQPT
Mvan_2647|M.vanbaalenii_PYR-1 ---MTQPVTVEVRTDPPYPVIIGTGLLDDLARVLDGRH---KVAILHQPT
MSMEG_3033|M.smegmatis_MC2_155 -------MIVEVKVDRPYPVVIGTGLLEDLGRTLEGRH---KVAVLHQPV
TH_0108|M.thermoresistible__bu ---MTEPVTVDVQVDPPYPVIIGTGLLGELDRLLGGRH---KVAVLHQPV
MAB_2841c|M.abscessus_ATCC_199 -MTSANPTTITVEVNPPYPVIVGTGLLGELVDNLKGSQGLAKVAILHQPT
MMAR_2329|M.marinum_M ---MTQDRMIIKSEQGDYPVDF-VGEVKLVPEFIDVGP---ETLVIIDEA
: : *** . * : : .. :: :
Mb2567c|M.bovis_AF2122/97 LAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGR
Rv2538c|M.tuberculosis_H37Rv LAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGR
MLBr_00518|M.leprae_Br4923 LTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDLSVMDFIWEVLGRIGIGR
MUL_1761|M.ulcerans_Agy99 LTETAEAIRNHLADKGIDAHRIEIPDAEAGKELPVVVFIWEVLGRIGIGR
MAV_3415|M.avium_104 LAETAEVIRKRLADKGVDAHRIEIPDAEDGKDLPVVGFLWEVLGRIGIGR
Mflv_3756|M.gilvum_PYR-GCK LTQTAEAIRTHLSEKGIDAHRIEIPDAEGGKELPVVGFIWQVLGRIGVGR
Mvan_2647|M.vanbaalenii_PYR-1 LTQTAEVIRNHLADKGIDAHRIEIPDAEGGKELPVVGFIWEVLGRIGLGR
MSMEG_3033|M.smegmatis_MC2_155 LNQTAEAIRSHLADKGIDAHRIELPDAEAGKELPVVGFIWEVLGRIGIGR
TH_0108|M.thermoresistible__bu LAQTAEAIRSRLADSGVDAHRIEIPDAEAGKDLPVVGFVWEVLGRIGLGR
MAB_2841c|M.abscessus_ATCC_199 LAVTAEEIRKTLADSGIDAHRVEIPDAEAGKDLAVLGFIWEVLGRIGIGR
MMAR_2329|M.marinum_M LVDLYGDALGPLSER----PTYRVAADEESKTLSGVSLFVDWLLENKATR
* *: .:. * .* *. : :. : * . *
Mb2567c|M.bovis_AF2122/97 KDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGI
Rv2538c|M.tuberculosis_H37Rv KDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGI
MLBr_00518|M.leprae_Br4923 KDALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGI
MUL_1761|M.ulcerans_Agy99 KDALVSLGGGAATDVAGFAAATWLRGVSIVHVPTTLLGMVDAAVGGKTGI
MAV_3415|M.avium_104 KDALVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGMVDAAVGGKTGI
Mflv_3756|M.gilvum_PYR-GCK KDAIVSLGGGAATDVAGFAAATWLRGIDIVHVPTTLLGMVDAAVGGKTGI
Mvan_2647|M.vanbaalenii_PYR-1 KDAIVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGMVDAAVGGKTGI
MSMEG_3033|M.smegmatis_MC2_155 KDALVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGMVDAAVGGKTGI
TH_0108|M.thermoresistible__bu KDAIVSLGGGAATDVAGFVAATWLRGVDIVHIPTTLLGMVDAAVGGKTGI
MAB_2841c|M.abscessus_ATCC_199 KDAVVSLGGGAATDTAGFAAATWLRGIKVVHVPTTLLAMVDAAVGGKTGI
MMAR_2329|M.marinum_M SAHVVAIGGGVIQDIATFACHIYYRGVGWTFVPTTLLSQADSCIGAKSSI
. :*::***. * * *.. : **: ..:*****. .*:.:*.*:.*
Mb2567c|M.bovis_AF2122/97 NTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPV
Rv2538c|M.tuberculosis_H37Rv NTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPV
MLBr_00518|M.leprae_Br4923 NTEAGKNLVGAFHQPLAVLADLATLETLPRKEIASGMAEVVKAGFIADPI
MUL_1761|M.ulcerans_Agy99 NTDAGKNLVGAFHQPLGVLADLATLQTLPQNEIVCGMAEVVKAGFIADPV
MAV_3415|M.avium_104 NTDAGKNLVGAFHQPLAVLVDLATLHTLPPNELVAGMAEVVKAGFIADPA
Mflv_3756|M.gilvum_PYR-GCK NTDAGKNLVGAFHQPAAVLIDLATLESLPRNEIVAGMAEIVKAGFIADPV
Mvan_2647|M.vanbaalenii_PYR-1 NTDAGKNLVGAFHQPAAVLIDLATLESLPRNEIVAGMAEIVKAGFIADPV
MSMEG_3033|M.smegmatis_MC2_155 NTDAGKNLVGAFHQPAAVLVDLATLETLPRNEIVAGMAEIVKAGFIADPV
TH_0108|M.thermoresistible__bu NTDAGKNLVGAFHQPIGVLIDLATMETLPRNEIVAGMAEVVKAGFIADPK
MAB_2841c|M.abscessus_ATCC_199 NTEAGKNLVGAFHQPGAVLVDLATLESLPRNEIIAGMAEVVKAGFIADPV
MMAR_2329|M.marinum_M NVLPLKNQLGVFHSPSHVIVCSEFLTSLPQIEVDSGYGEIYKLALTNEGA
*. . ** :*.**.* *: : :** *: .* .*: * .: :
Mb2567c|M.bovis_AF2122/97 ILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESELREILNY
Rv2538c|M.tuberculosis_H37Rv ILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESELREILNY
MLBr_00518|M.leprae_Br4923 ILDLIEADPQASLDPMGGVLPELIRRAVTVKAGVVSADEKESELREILNY
MUL_1761|M.ulcerans_Agy99 ILDLIEADPQAALDPSGDVMPELIRRSIAVKAEVVAADEKESELREILNY
MAV_3415|M.avium_104 ILDLIEADPRAAVDPSGEVLAELVQRAIAVKADVVAADEKESELREILNY
Mflv_3756|M.gilvum_PYR-GCK ILDMIEADPEAALDPSGAVLPELIRRAVVVKAEVVAADEKESQLREILNY
Mvan_2647|M.vanbaalenii_PYR-1 ILDMIEADPQAALDPTGQVLPELIRRAVVVKAEVVAADEKESQLREILNY
MSMEG_3033|M.smegmatis_MC2_155 ILDLIEADPEAAIDPTGSVLPELIRRAVAVKADVVAADEKESALREILNY
TH_0108|M.thermoresistible__bu ILDLIEANPQAALDPAGDVLPELIRRAVAVKAEVVAADEKESQLREILNY
MAB_2841c|M.abscessus_ATCC_199 ILDLIEADPETAIDPSKPVLRELVERSIAVKATVVAADEKEAELREILNY
MMAR_2329|M.marinum_M FFDQLAEALTHGGHRNPRVL-EMIRNALESKRLVIEQDEHESDLRRVLNY
::* : . . *: *::..:: * *: **:*: **.:***
Mb2567c|M.bovis_AF2122/97 GHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTI
Rv2538c|M.tuberculosis_H37Rv GHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTI
MLBr_00518|M.leprae_Br4923 GHTLAHAIERRERYEWRHGAAVSVGLVFAAELARVAGRLDDATAQRHHTI
MUL_1761|M.ulcerans_Agy99 GHTLAHAIERRERYQWQHGAAVSVGLVFAAELARLSGRLDDAMALRHRTI
MAV_3415|M.avium_104 GHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATARRHRTI
Mflv_3756|M.gilvum_PYR-GCK GHTLAHAIERRERYQWRHGAAVSVGLVFAAELGRLAGRLDDDTTERHRAI
Mvan_2647|M.vanbaalenii_PYR-1 GHTLAHAIERRERYQWRHGAAVSVGLVFAAELGRLAGRLDDATAERHRAI
MSMEG_3033|M.smegmatis_MC2_155 GHTLAHAIERRERYKWRHGAAVSVGLVFAAELGRLAGGLGDQTADRHRSV
TH_0108|M.thermoresistible__bu GHTLAHAIERRERYQWRHGAAVSVGLVYAAELGRLAGRLDDATADRHRSV
MAB_2841c|M.abscessus_ATCC_199 GHTLGHAIERRERYRWRHGAAVSVGLVFAAELGRLAGRLDDETADRHARV
MMAR_2329|M.marinum_M GHSFGHALEALTHNEVPHGLAVMWGMDLINFLGVKWGLTSPATAARVRTV
**::.**:* : . ** ** *: *. * . : * :
Mb2567c|M.bovis_AF2122/97 LSSLGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAKPGRMVGP
Rv2538c|M.tuberculosis_H37Rv LSSLGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAKPGRMVGP
MLBr_00518|M.leprae_Br4923 LTSLGLPVSYDADALPQLLEYMAGDKKTRAGVLRFVILDGLAKPGRLVGP
MUL_1761|M.ulcerans_Agy99 LSALGLPVSYDADALPQLLEFMTGDKKTRAGVLRFVVLDGLAKPGRMAGP
MAV_3415|M.avium_104 LSALGLPVSYDADALPQLLEYMAGDKKSRAGVLRFVVLDGLAKPGRLAGP
Mflv_3756|M.gilvum_PYR-GCK LTSLGLPVTYDADALPQLMESMLGDKKTRAGVLRFVVLDGLAKPGRLEGP
Mvan_2647|M.vanbaalenii_PYR-1 LISLGLPVTYDADALPQLMEAMLGDKKTRAGVLRFVVLDGLGKPGRLEGP
MSMEG_3033|M.smegmatis_MC2_155 LTALGLPITYDADALPQLLEYMAGDKKNRSGVLRFVVLDGLAKPGRLEGP
TH_0108|M.thermoresistible__bu LTALGLPVSYDADALPELLEFMRGDKKTRSGVLRFVVLDGLAKPGRLEGP
MAB_2841c|M.abscessus_ATCC_199 LSALGLPVSYDADALGQLVEYMQGDKKTRSGILRFVVLDGLAKPGRLEGP
MMAR_2329|M.marinum_M LDANTDYAIGAIPSARELVDTLKRDKKVRKGVMYFAVLHDEGDLRIVPKP
* : : :*:: : *** * *:: *.:*.. .. : *
Mb2567c|M.bovis_AF2122/97 DPGLLVTAYAGVCAP------------------
Rv2538c|M.tuberculosis_H37Rv DPGLLVTAYAGVCAP------------------
MLBr_00518|M.leprae_Br4923 DPGLLVTAYAGLSA-------------------
MUL_1761|M.ulcerans_Agy99 DPGLLVTAYAGICAP------------------
MAV_3415|M.avium_104 DPSLLAAAYAALADEDAS---------------
Mflv_3756|M.gilvum_PYR-GCK DPSLLAAAYAEVARD------------------
Mvan_2647|M.vanbaalenii_PYR-1 DPSLLAAAYAEVARS------------------
MSMEG_3033|M.smegmatis_MC2_155 DPSLLAAAYAECAGLSPALPQQLSFVKLSPDQL
TH_0108|M.thermoresistible__bu DPSLLTAAYSEIAAQGSKA--------------
MAB_2841c|M.abscessus_ATCC_199 DPSLLAAAYSVVAGEARGEGVLL----------
MMAR_2329|M.marinum_M LDEALVAEVAEYLDGDPLFAAR-----------
*.: :