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MIKNASGQTAWTVEAVKQVRYHVIKSDGLFDLGNNQLFSACSDAPLKVGDRRLVIIDGTVDALHGSKVRA FFAHHGVEAEFVVIPIDETLKHWDTVTRIVDAMNAFGIDRRREPMLVIGGGVLTDVAGFAASLYRRGTPY IRIPTTLIGLVDAGVGVKTGVNYQLGKNRLGTYAPPTVTFLDKSFLRTLDQRHLSNGLAEILKIALIKSG ALFDVLETSGRDVRDDHFQGSTSALDVATEYILDESIHLMLEELQPNLWESTLERCVDYGHTFSPTIEMH AQPALLHGEAVNLDMAVTTAIGELRGYVSEDEANRIYRVMVDLGLPLWDDTLATPELLIEALIDTVRHRD GQQRLPLPVGIGHHRFVNDVTPEEIQCAVAMLRRHHETLTGSVAASSGVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0578 | aroB_1 | - | 100% (400) | 3-dehydroquinate synthase AroB_1 |
| M. marinum M | MMAR_2177 | aroB | 3e-36 | 32.08% (293) | 3-dehydroquinate synthase AroB |
| M. marinum M | MMAR_2329 | aroB_2 | 3e-23 | 30.58% (278) | 3-dehydroquinate synthase AroB_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2567c | aroB | 1e-35 | 30.58% (327) | 3-dehydroquinate synthase |
| M. gilvum PYR-GCK | Mflv_3756 | aroB | 3e-36 | 28.71% (317) | 3-dehydroquinate synthase |
| M. tuberculosis H37Rv | Rv2538c | aroB | 1e-35 | 30.58% (327) | 3-dehydroquinate synthase |
| M. leprae Br4923 | MLBr_00518 | aroB | 7e-37 | 28.75% (327) | 3-dehydroquinate synthase |
| M. abscessus ATCC 19977 | MAB_2841c | aroB | 1e-33 | 30.00% (290) | 3-dehydroquinate synthase |
| M. avium 104 | MAV_3415 | aroB | 1e-35 | 30.21% (331) | 3-dehydroquinate synthase |
| M. smegmatis MC2 155 | MSMEG_3033 | aroB | 8e-37 | 29.22% (332) | 3-dehydroquinate synthase |
| M. thermoresistible (build 8) | TH_0108 | aroB | 5e-37 | 31.72% (290) | 3-DEHYDROQUINATE SYNTHASE AROB |
| M. ulcerans Agy99 | MUL_1761 | aroB | 4e-36 | 32.08% (293) | 3-dehydroquinate synthase |
| M. vanbaalenii PYR-1 | Mvan_2647 | aroB | 5e-38 | 28.69% (373) | 3-dehydroquinate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2567c|M.bovis_AF2122/97 ---MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRH---------
Rv2538c|M.tuberculosis_H37Rv ---MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRH---------
MLBr_00518|M.leprae_Br4923 ---MTNIDAPVTVQVAVDPPYPVVIGTGLSDQLDELLANRH---------
MUL_1761|M.ulcerans_Agy99 ---MSDNKEPVTVQVAVDPPYPVVIGTGLLTELEELLAGRH---------
MAV_3415|M.avium_104 ----------MTVQVAVDPPYPVIIGTGLLGELDELLGARH---------
Mflv_3756|M.gilvum_PYR-GCK ------MTEPVTVDVRTDPPYPVIIGRGLLGDLGRVLDGRH---------
Mvan_2647|M.vanbaalenii_PYR-1 ------MTQPVTVEVRTDPPYPVIIGTGLLDDLARVLDGRH---------
MSMEG_3033|M.smegmatis_MC2_155 ----------MIVEVKVDRPYPVVIGTGLLEDLGRTLEGRH---------
TH_0108|M.thermoresistible__bu ------MTEPVTVDVQVDPPYPVIIGTGLLGELDRLLGGRH---------
MAB_2841c|M.abscessus_ATCC_199 ----MTSANPTTITVEVNPPYPVIVGTGLLGELVDNLKGSQGLA------
MMAR_0578|M.marinum_M MIKNASGQTAWTVEAVKQVRYHVIKSDGLFDLGNNQLFSACSDAPLKVGD
: . : * *: . ** *
Mb2567c|M.bovis_AF2122/97 -KVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIW
Rv2538c|M.tuberculosis_H37Rv -KVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIW
MLBr_00518|M.leprae_Br4923 -RVAILHQPVLTQTAEAIRSHLAGKGVDAHRIEIPDAEAGKDLSVMDFIW
MUL_1761|M.ulcerans_Agy99 -KVAILHQPVLTETAEAIRNHLADKGIDAHRIEIPDAEAGKELPVVVFIW
MAV_3415|M.avium_104 -KVAVVHQPVLAETAEVIRKRLADKGVDAHRIEIPDAEDGKDLPVVGFLW
Mflv_3756|M.gilvum_PYR-GCK -KVAILHQPTLTQTAEAIRTHLSEKGIDAHRIEIPDAEGGKELPVVGFIW
Mvan_2647|M.vanbaalenii_PYR-1 -KVAILHQPTLTQTAEVIRNHLADKGIDAHRIEIPDAEGGKELPVVGFIW
MSMEG_3033|M.smegmatis_MC2_155 -KVAVLHQPVLNQTAEAIRSHLADKGIDAHRIELPDAEAGKELPVVGFIW
TH_0108|M.thermoresistible__bu -KVAVLHQPVLAQTAEAIRSRLADSGVDAHRIEIPDAEAGKDLPVVGFVW
MAB_2841c|M.abscessus_ATCC_199 -KVAILHQPTLAVTAEEIRKTLADSGIDAHRVEIPDAEAGKDLAVLGFIW
MMAR_0578|M.marinum_M RRLVIIDGTVDALHGSKVRAFFAHHGVEAEFVVIPIDETLKHWDTVTRIV
::.::. . .. :* :: *::*. : :* * *. .: :
Mb2567c|M.bovis_AF2122/97 EVLGRIGIGRK-DALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGM
Rv2538c|M.tuberculosis_H37Rv EVLGRIGIGRK-DALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGM
MLBr_00518|M.leprae_Br4923 EVLGRIGIGRK-DALVSFGGGAATDVAGFAAATWLRGVSIVHVPTTLLGM
MUL_1761|M.ulcerans_Agy99 EVLGRIGIGRK-DALVSLGGGAATDVAGFAAATWLRGVSIVHVPTTLLGM
MAV_3415|M.avium_104 EVLGRIGIGRK-DALVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGM
Mflv_3756|M.gilvum_PYR-GCK QVLGRIGVGRK-DAIVSLGGGAATDVAGFAAATWLRGIDIVHVPTTLLGM
Mvan_2647|M.vanbaalenii_PYR-1 EVLGRIGLGRK-DAIVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGM
MSMEG_3033|M.smegmatis_MC2_155 EVLGRIGIGRK-DALVSLGGGAATDVAGFAAATWLRGVDIVHVPTTLLGM
TH_0108|M.thermoresistible__bu EVLGRIGLGRK-DAIVSLGGGAATDVAGFVAATWLRGVDIVHIPTTLLGM
MAB_2841c|M.abscessus_ATCC_199 EVLGRIGIGRK-DAVVSLGGGAATDTAGFAAATWLRGIKVVHVPTTLLAM
MMAR_0578|M.marinum_M DAMNAFGIDRRREPMLVIGGGVLTDVAGFAASLYRRGTPYIRIPTTLIGL
:.:. :*:.*: :.:: :***. **.***.*: : ** :::****:.:
Mb2567c|M.bovis_AF2122/97 VDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMICGMAE
Rv2538c|M.tuberculosis_H37Rv VDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMICGMAE
MLBr_00518|M.leprae_Br4923 VDAAVGGKTGINTEAGKNLVGAFHQPLAVLADLATLETLPRKEIASGMAE
MUL_1761|M.ulcerans_Agy99 VDAAVGGKTGINTDAGKNLVGAFHQPLGVLADLATLQTLPQNEIVCGMAE
MAV_3415|M.avium_104 VDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLHTLPPNELVAGMAE
Mflv_3756|M.gilvum_PYR-GCK VDAAVGGKTGINTDAGKNLVGAFHQPAAVLIDLATLESLPRNEIVAGMAE
Mvan_2647|M.vanbaalenii_PYR-1 VDAAVGGKTGINTDAGKNLVGAFHQPAAVLIDLATLESLPRNEIVAGMAE
MSMEG_3033|M.smegmatis_MC2_155 VDAAVGGKTGINTDAGKNLVGAFHQPAAVLVDLATLETLPRNEIVAGMAE
TH_0108|M.thermoresistible__bu VDAAVGGKTGINTDAGKNLVGAFHQPIGVLIDLATMETLPRNEIVAGMAE
MAB_2841c|M.abscessus_ATCC_199 VDAAVGGKTGINTEAGKNLVGAFHQPGAVLVDLATLESLPRNEIIAGMAE
MMAR_0578|M.marinum_M VDAGVGVKTGVNYQLGKNRLGTYAPPTVTFLDKSFLRTLDQRHLSNGLAE
***.** ***:* : *** :*:: * .: * : :.:* .: *:**
Mb2567c|M.bovis_AF2122/97 VVKAGFIADPVILDLIEADP--------QAALDPAGDVLPELIRRAITVK
Rv2538c|M.tuberculosis_H37Rv VVKAGFIADPVILDLIEADP--------QAALDPAGDVLPELIRRAITVK
MLBr_00518|M.leprae_Br4923 VVKAGFIADPIILDLIEADP--------QASLDPMGGVLPELIRRAVTVK
MUL_1761|M.ulcerans_Agy99 VVKAGFIADPVILDLIEADP--------QAALDPSGDVMPELIRRSIAVK
MAV_3415|M.avium_104 VVKAGFIADPAILDLIEADP--------RAAVDPSGEVLAELVQRAIAVK
Mflv_3756|M.gilvum_PYR-GCK IVKAGFIADPVILDMIEADP--------EAALDPSGAVLPELIRRAVVVK
Mvan_2647|M.vanbaalenii_PYR-1 IVKAGFIADPVILDMIEADP--------QAALDPTGQVLPELIRRAVVVK
MSMEG_3033|M.smegmatis_MC2_155 IVKAGFIADPVILDLIEADP--------EAAIDPTGSVLPELIRRAVAVK
TH_0108|M.thermoresistible__bu VVKAGFIADPKILDLIEANP--------QAALDPAGDVLPELIRRAVAVK
MAB_2841c|M.abscessus_ATCC_199 VVKAGFIADPVILDLIEADP--------ETAIDPSKPVLRELVERSIAVK
MMAR_0578|M.marinum_M ILKIALIKSGALFDVLETSGRDVRDDHFQGSTSALDVATEYILDESIHLM
::* .:* . ::*::*:. . : .. . :: .:: :
Mb2567c|M.bovis_AF2122/97 AEVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAE
Rv2538c|M.tuberculosis_H37Rv AEVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAE
MLBr_00518|M.leprae_Br4923 AGVVSADEKESELREILNYGHTLAHAIERRERYEWRHGAAVSVGLVFAAE
MUL_1761|M.ulcerans_Agy99 AEVVAADEKESELREILNYGHTLAHAIERRERYQWQHGAAVSVGLVFAAE
MAV_3415|M.avium_104 ADVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAE
Mflv_3756|M.gilvum_PYR-GCK AEVVAADEKESQLREILNYGHTLAHAIERRERYQWRHGAAVSVGLVFAAE
Mvan_2647|M.vanbaalenii_PYR-1 AEVVAADEKESQLREILNYGHTLAHAIERRERYQWRHGAAVSVGLVFAAE
MSMEG_3033|M.smegmatis_MC2_155 ADVVAADEKESALREILNYGHTLAHAIERRERYKWRHGAAVSVGLVFAAE
TH_0108|M.thermoresistible__bu AEVVAADEKESQLREILNYGHTLAHAIERRERYQWRHGAAVSVGLVYAAE
MAB_2841c|M.abscessus_ATCC_199 ATVVAADEKEAELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAE
MMAR_0578|M.marinum_M LEELQPNLWESTLERCVDYGHTFSPTIEMHAQPALLHGEAVNLDMAVTTA
: .: *: *.. ::****:. :** : : ** **.:.:. ::
Mb2567c|M.bovis_AF2122/97 LARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAGD-KKTRA
Rv2538c|M.tuberculosis_H37Rv LARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAGD-KKTRA
MLBr_00518|M.leprae_Br4923 LARVAGRLDDATAQRHHTILTSLGLPVSYDADALPQLLEYMAGD-KKTRA
MUL_1761|M.ulcerans_Agy99 LARLSGRLDDAMALRHRTILSALGLPVSYDADALPQLLEFMTGD-KKTRA
MAV_3415|M.avium_104 LARLAGRLDDATARRHRTILSALGLPVSYDADALPQLLEYMAGD-KKSRA
Mflv_3756|M.gilvum_PYR-GCK LGRLAGRLDDDTTERHRAILTSLGLPVTYDADALPQLMESMLGD-KKTRA
Mvan_2647|M.vanbaalenii_PYR-1 LGRLAGRLDDATAERHRAILISLGLPVTYDADALPQLMEAMLGD-KKTRA
MSMEG_3033|M.smegmatis_MC2_155 LGRLAGGLGDQTADRHRSVLTALGLPITYDADALPQLLEYMAGD-KKNRS
TH_0108|M.thermoresistible__bu LGRLAGRLDDATADRHRSVLTALGLPVSYDADALPELLEFMRGD-KKTRS
MAB_2841c|M.abscessus_ATCC_199 LGRLAGRLDDETADRHARVLSALGLPVSYDADALGQLVEYMQGD-KKTRS
MMAR_0578|M.marinum_M IGELRGYVSEDEANRIYRVMVDLGLPLWDDTLATPELLIEALIDTVRHRD
:..: * :.: : * :: ****: *. * :*: * : *
Mb2567c|M.bovis_AF2122/97 GVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP---------------
Rv2538c|M.tuberculosis_H37Rv GVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP---------------
MLBr_00518|M.leprae_Br4923 GVLRFVILDGLAKPGRLVGPDPGLLVTAYAGLSA----------------
MUL_1761|M.ulcerans_Agy99 GVLRFVVLDGLAKPGRMAGPDPGLLVTAYAGICAP---------------
MAV_3415|M.avium_104 GVLRFVVLDGLAKPGRLAGPDPSLLAAAYAALADEDAS------------
Mflv_3756|M.gilvum_PYR-GCK GVLRFVVLDGLAKPGRLEGPDPSLLAAAYAEVARD---------------
Mvan_2647|M.vanbaalenii_PYR-1 GVLRFVVLDGLGKPGRLEGPDPSLLAAAYAEVARS---------------
MSMEG_3033|M.smegmatis_MC2_155 GVLRFVVLDGLAKPGRLEGPDPSLLAAAYAECAGLSPALPQQLSFVKLSP
TH_0108|M.thermoresistible__bu GVLRFVVLDGLAKPGRLEGPDPSLLTAAYSEIAAQGSKA-----------
MAB_2841c|M.abscessus_ATCC_199 GILRFVVLDGLAKPGRLEGPDPSLLAAAYSVVAGEARGEGVLL-------
MMAR_0578|M.marinum_M GQQRLPLPVGIGHHRFVNDVTPEEIQCAVAMLRRHHETLTGSVAASSGVA
* *: : *:.: : . * : * :
Mb2567c|M.bovis_AF2122/97 ---
Rv2538c|M.tuberculosis_H37Rv ---
MLBr_00518|M.leprae_Br4923 ---
MUL_1761|M.ulcerans_Agy99 ---
MAV_3415|M.avium_104 ---
Mflv_3756|M.gilvum_PYR-GCK ---
Mvan_2647|M.vanbaalenii_PYR-1 ---
MSMEG_3033|M.smegmatis_MC2_155 DQL
TH_0108|M.thermoresistible__bu ---
MAB_2841c|M.abscessus_ATCC_199 ---
MMAR_0578|M.marinum_M ---