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TSAFDEAAVRRWLVDYLVTNNGCSPEHIERGASMHDLGVGSRDAVVLTGVLSEYLGRAVSPVDFWQYPTV DALAKFLTGGEVEPVDPGPGVRPAATNEPIAVIGLGLRLPGGADLDSNIEGPEAFWEFLTEGRSSVREVP EDRWEWCEDGTPEGAAALADTTRWGSFLRDLDAFDAEYFEIIPREATRMDPQQRLLLEVTHEALENAGIA ADSLAETQTGVFAGASAADYAQLGATDLSGIDAWYSTGGALSIIANRVSYYFDLRGPSVTVDTACSSSLV AIHLACQSLRSGDSELALAAGVNLLLSPAPTRSFDRAKAMSPTGQCHAFDAGADGFVRGEGCGVAVLKRL SDAQRDGDRVLAVIRGSAVNQDGRSNGLMAPNPSAQMAVLRAAYAAAGVDPREVDYVEAHGTGTLLGDPI EARALGTVLGKGRAADAPLLLGAVKSNLGHLEAAAGIAGFAKAVLALQHNMIPANLGYQSPNPHIPFEKL RLKVVAEHTDWAPAGRPRRAGISSFGFGGTNAHVVIEQAPVFAPSPVEEPEAVTTLVVSGKSPERIASQA AALAEWMAGAGSDASLVEVAHSLNHHRAQHAKFATVVARDRDQAIAGLQALAAGQSAPGVVGVAAGNPQP GTVFVYSGQGSQWPGMARQLLVDEPAFANALAEIEPVFVEQVGFSLRDVIAGGETVSGDAQVQPVLMGLQ LALTELWRSYDVHPDAVIGHSMGEVTAAVVAGALSLADGLKVIAARSSIMSRLAGQGAVALLNLDADAAR SLIADHPSVEIAGYLSPRQTVVAGLPEQVDAVIAAVTAQNTFARRVNMVVASHTALMDPVLPDIRAALAG IEPNIPTLPFLSTVTGADSAPVLDADYWVANVRQPVKFSQAIVAAAADNGTFIEISPHSTLGQAIGNTLG DGPDHHMLGTLARDTDDTVTFHANLNATHTSRPPHTAHHGEPHIVLPTTPWHRSRHWVDVRPLRRGGGVR AGALPADSAVPPEWFCGLTWPAKPLVAQDGPVDPGASWLVVGDDALAAEMGKLLGRPVATGDGADLSSAT HVLYAPTSGDELGYELFEAGRAIATTASRVSQPPKLFLLTRNAQPVSEGDRANPGQAVLWGLGRTLALEH PDIWGALIDTDESVPAVVAARWVLAEAHAGDGEDQLVYRAGIRRVARLVHALPPAPTGSGTLDADGAHLV IGATGNIGPRLVEQLAAMGAKTVVAVSRNPGSRLDELTARLAASGTTVVTAAADASDASSLRAVFDRFGA DLPPLKGVYLAAMSGGPVTLDEMTHDDVVAMFRSKMDAAALLHQLSAGHPVEQFVLFSSISGVLGSRWLA HYAATTTFLDTFAFARRAAGLPACAINWGLWKSLADAQTGFERQATQESGLEPMDDAVAITALRSFIGPQ APARATVVAADWPRLAAAYHTRAQLHILDDLLATEGTAATGLTPTGDTRFRQELKECEPQRRVELLTDHV LSQIAAAMGLASTHTLDPTVGFFQFGMDSLMSVTLQRSLSESLGEALPASVVFDYPTVEALTDYLASVLP EIIETAGTDNDVDGGPSVIEDAYDDLAEDELLARLSERLS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_3126 | - | - | 100% (1581) | beta-ketoacyl synthase |
M. vanbaalenii PYR-1 | Mvan_3128 | - | 0.0 | 78.38% (976) | beta-ketoacyl synthase |
M. vanbaalenii PYR-1 | Mvan_3125 | - | 0.0 | 52.83% (1380) | beta-ketoacyl synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2957 | ppsB | 0.0 | 54.47% (1531) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
M. gilvum PYR-GCK | Mflv_3393 | - | 0.0 | 82.43% (1582) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2932 | ppsB | 0.0 | 54.41% (1531) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
M. leprae Br4923 | MLBr_02356 | - | 0.0 | 53.55% (1535) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 38.98% (1016) | polyketide synthase |
M. marinum M | MMAR_1776 | ppsA | 0.0 | 54.80% (1615) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. avium 104 | MAV_1763 | - | 0.0 | 34.68% (1560) | tylactone synthase modules 4 & 5 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 33.76% (1567) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 41.68% (931) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2019 | ppsA | 0.0 | 54.80% (1615) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
CLUSTAL 2.0.9 multiple sequence alignment MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR MAV_1763|M.avium_104 MSTVEGLRDPASSFAIVGYAARFPGAADADEFWRVLAEGRDAVSEVPKDR Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH MAV_1763|M.avium_104 WDADEFFDPDPDAPGKVVTRRAGFVDDVTGFDAPFFGMSAREARLLDPQH Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI MAV_1763|M.avium_104 RLLLETAWRAVEHSGTAPTDLANTNTGVFIGISTHDYLGMASDELTYDQI Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL MAV_1763|M.avium_104 EAYTAIGTSSAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG MAV_1763|M.avium_104 GECDLALAGGANVLLTPATMITFSQAHMLAPDGRCKTFDAAADGYVRGEG Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA MAV_1763|M.avium_104 CGVLVVKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI MAV_1763|M.avium_104 EALQRAGIAPGDVDYLEAHGTGTSLGDPIEVQAAGAVLGAGREASRPLLI Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP MAV_1763|M.avium_104 GSVKTNIGHLEAAAGIAGVIKVILALEHGMLPQHLHFRDPSPHIPWDRLA Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRNGRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPA MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRNGKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATTEPV MAV_1763|M.avium_104 VQVVKEATAWQRNGRPRVAGVSSFGFAGTNAHVILEEAPDGTGRAAVPPA Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PAGG---RKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAG MSMEG_0408|M.smegmatis_MC2_155 EDP----RRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG MAV_1763|M.avium_104 AVRPPGQRRFHVLPLSARTPAALVQIAGEYRDWLSAHPDTALADLCLTAG Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGRAHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWL MSMEG_0408|M.smegmatis_MC2_155 TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL MAV_1763|M.avium_104 AGRAHFEHRAALVVDSTGSAGELLAALADDRPAPGLLRGVCEDAPKTAWL Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FTGQGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVDG MSMEG_0408|M.smegmatis_MC2_155 FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDADE MAV_1763|M.avium_104 FTGQGSQYAGMARELFDTEPVFAETLTRCATVLADVLEKPLLDVIFDTDD Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PE--AEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSA MSMEG_0408|M.smegmatis_MC2_155 LDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSA MAV_1763|M.avium_104 PA--SEATLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSA Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFP MSMEG_0408|M.smegmatis_MC2_155 ACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYP MAV_1763|M.avium_104 ACVAGVLRVEDGARLIAERGRLFGSLPAGGRMVAAFAAAARVEGLTDEFP Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SLSVAAYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLD MSMEG_0408|M.smegmatis_MC2_155 SLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLD MAV_1763|M.avium_104 SLSVAAYNGANTVLSGPGQELEQAVARLTAEKVRCDWLDTSHAFHSALLD Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPV MSMEG_0408|M.smegmatis_MC2_155 PILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPV MAV_1763|M.avium_104 PILDEFESYANQFDFGPPQRILICNRTGSALGRSVKLDGAYWRRHARQPV Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRN MSMEG_0408|M.smegmatis_MC2_155 EFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPT MAV_1763|M.avium_104 EFAKSVHTLADLGCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRN Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TADHRQITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSD MSMEG_0408|M.smegmatis_MC2_155 TADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSD MAV_1763|M.avium_104 TADHRQITEALAEAYIVGHLPDFGAAVG-PARKLDLPTYPFQHRQYWFSE Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 KRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLN MSMEG_0408|M.smegmatis_MC2_155 NRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLR MAV_1763|M.avium_104 QRVPPGSQQTS-------TQTTAVRLLEDGRIAELAELLDGASADQHTLD Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVAD MSMEG_0408|M.smegmatis_MC2_155 VLNKLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAA--ADWILVGD MAV_1763|M.avium_104 VLTKLAAQHNQQRKSRSIAEDRYEIRWEKSTVPGPEAEAT----WLVVGD Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRI MSMEG_0408|M.smegmatis_MC2_155 DTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYV MAV_1763|M.avium_104 DDDAVAPLVDALTARGHQHRILVLPASDADEERLEIVLRAAAAEEAPLRI Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VHVAALAGQGSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTRG MSMEG_0408|M.smegmatis_MC2_155 VHIAAGDG-AAAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRD MAV_1763|M.avium_104 ALVAALDSGTAPSMRSLLRMQHRVLAGTRRLFRAAAAAELRQPIWLVTRG Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEWAQFI MSMEG_0408|M.smegmatis_MC2_155 GQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT-EWPRLI MAV_1763|M.avium_104 AQRVTDADTVFPDQSCLWGFGRAASLEYPQLWGGLADLAQGSAEEWSRLV Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYLV MSMEG_0408|M.smegmatis_MC2_155 ARITSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYLV MAV_1763|M.avium_104 RVASAPRDPAVGEDQIALRGSDIYVPRLTRRSGQPAAAALTLRADATYLV Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQ-GCEV MSMEG_0408|M.smegmatis_MC2_155 TGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQYACDV MAV_1763|M.avium_104 TGGLGSIGLEIAGHLAAQGARHLVLTGRRAPGEAAQRRIDALSQQHGCEV Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEV MSMEG_0408|M.smegmatis_MC2_155 RVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEV MAV_1763|M.avium_104 RVIAADVADAHHVARLLGAVRAELPPVAGIVHAAGEIGTTPLSDLEDAEI Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAAN MSMEG_0408|M.smegmatis_MC2_155 DRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAAN MAV_1763|M.avium_104 DRVFAGKVWGAWHLSEAAADLR--LDFFVSTSSIASVWGGLGQTAYGAAN Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTD MSMEG_0408|M.smegmatis_MC2_155 AFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAE MAV_1763|M.avium_104 AFLDGLAWRLREQGVNGISVNFGPWAAGMADENARARLAQRGIKTLSPAD Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVP MSMEG_0408|M.smegmatis_MC2_155 ALAGMADVVAG----PVQGVVAKIDWSRFLPLYQQAGRRAFLSELESELP MAV_1763|M.avium_104 ALAGLADVMAT---AAAQGVVARIDWTRFLPLYQQAGQRSLLAELAREIP Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SHLAGVAG--AQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDV MSMEG_0408|M.smegmatis_MC2_155 AAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDA MAV_1763|M.avium_104 DFAPAPTP----SGKTGLVERLAGAPVQQRRKLMTEFLRNAVAEVTRVDA Mvan_3126|M.vanbaalenii_PYR-1 ------------------------MTSAFDEAAVRRWLVDYLVTNNGCSP Mflv_3393|M.gilvum_PYR-GCK ------------------------MTSASDEAAVRRWLIDYLVTNNGCSP MMAR_1776|M.marinum_M -----------------------MTPSIGGEADLRHWLVDYLVTNIGCPP MUL_2019|M.ulcerans_Agy99 -----------------------MTPSIGGEADLRHWLVDYLVTNIGCPP Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVAD MSMEG_0408|M.smegmatis_MC2_155 DEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAAD MAV_1763|M.avium_104 AEIREDAGFFDLGMDSLMAIELRRHIEQGVGKQIPATLAMDYPRLSDVAE Mvan_3126|M.vanbaalenii_PYR-1 EHIERGASMHDLGVGSRDAVVLTGVLSEYLGRAVSPVDFWQYPTVDALAK Mflv_3393|M.gilvum_PYR-GCK EHIERGASMHDLGVGSRDAVVLTGVLSEYLGRTVSPVDFWQYPTVDSLAK MMAR_1776|M.marinum_M DEVDPNLSLADLGVSSRDAVVLSGELTELLGRTVSPIDFWEHPTINDLAA MUL_2019|M.ulcerans_Agy99 DEVDPNLSLADLGVSSRDAVVLSGELTELLGRTVSPIDFWEHPTINDLAA Mb2957|M.bovis_AF2122/97 --------------------MMRTAFSRISG------------------- Rv2932|M.tuberculosis_H37Rv --------------------MMRTAFSRISG------------------- MLBr_02356|M.leprae_Br4923 ---------------------MRTAFSRISG------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YLLGDVLGLAEQAKPAAQLAS---AVTGRTDEPIAIVAVSCRFPG----- MSMEG_0408|M.smegmatis_MC2_155 YLLVEVLGLGEQTN--VRQAS---TVTARTDDPIAVVAVSCRFPG----- MAV_1763|M.avium_104 YLLGDVLDLRGQPDAKPAPPAGTPAPAGRTDEPIAIVAMACRFPG----- Mvan_3126|M.vanbaalenii_PYR-1 --FLTGGEVEPVDPGPGVRPA-------ATNEPIAVIGLGLRLPGGADLD Mflv_3393|M.gilvum_PYR-GCK --FLTGGEVEPIEVGGAARPA-------GMDEPIAVIGLGLRLPGGDDLD MMAR_1776|M.marinum_M YLTAPEPSTGAEAAVSRTVRG-------SLEEPIAVVGMGCRFPG----- MUL_2019|M.ulcerans_Agy99 YLTAPEPSTGAEAAVSRTVRG-------SLEEPIAVVGMGCRFPG----- Mb2957|M.bovis_AF2122/97 --MTAQQRTSLADEFDRVSRI-------AVAEPVAVVGIGCRFPG----- Rv2932|M.tuberculosis_H37Rv --MTAQQRTSLADEFDRVSRI-------AVAEPVAVVGIGCRFPG----- MLBr_02356|M.leprae_Br4923 --MTTQQRAALIEEFTKLSRI-------AVAEPIAVVGIGCRFPG----- TH_2454|M.thermoresistible__bu ----------MSVDVTAKARP---------DDPIAIIGIGCRLAG----- :*:*::.:. *:.* MAB_0939|M.abscessus_ATCC_1997 --APDPEAFWDVLSGGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGG MSMEG_0408|M.smegmatis_MC2_155 --APDPESFWELLAGGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGG MAV_1763|M.avium_104 --AADPEAFWELLSGGVDAIREVPEDRFDIDEFYDPDPETPGKMYSRFGG Mvan_3126|M.vanbaalenii_PYR-1 SNIEGPEAFWEFLTEGRSSVREVPEDRWEWCEDGTPEGAAALADTTRWGS Mflv_3393|M.gilvum_PYR-GCK GNIEGPDAYWDFLTEGRSSVREVPEDRWSWFNDGTPEGAAALAATTRWGS MMAR_1776|M.marinum_M -GISGPEALWQFLCDRKSSIGRVPDERWAQFDDGSPAVKALLARTTRWGS MUL_2019|M.ulcerans_Agy99 -GISGPEALWQFLCDRKSSIGRVPDERWAQFDDGSPAVKALLARTTRWGS Mb2957|M.bovis_AF2122/97 -DVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGG Rv2932|M.tuberculosis_H37Rv -DVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGG MLBr_02356|M.leprae_Br4923 -DVTGPDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGG TH_2454|M.thermoresistible__bu -RITSPEEFWGFLLAGGSNVREIPAERWEPYLRRDPRNAAVLREITPWGT .*: * .* . : :* :*: * . : :* MAB_0939|M.abscessus_ATCC_1997 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRG MSMEG_0408|M.smegmatis_MC2_155 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRG MAV_1763|M.avium_104 YLDQIDEFDPEFFGISPREAVWIDPQQRLVLETVWEGLERAGYSPAALRG Mvan_3126|M.vanbaalenii_PYR-1 FLRDLDAFDAEYFEIIPREATRMDPQQRLLLEVTHEALENAGIAADSLAE Mflv_3393|M.gilvum_PYR-GCK YLRDLDAFDAEFFEIMPREATRMDPQQRLLLEVTHEALENAGIAADALAE MMAR_1776|M.marinum_M YLTDIDAFDADFFEISASEADKMDPQQRLLLEVAWEALEHAGIPPSSLRR MUL_2019|M.ulcerans_Agy99 YLTDIDAFDADFFEISASEADKMDPQQRLLLEVAWEALEHAGIPPSSLRR Mb2957|M.bovis_AF2122/97 FVPDVAGFDAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGG Rv2932|M.tuberculosis_H37Rv FVPDVAGFDAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGG MLBr_02356|M.leprae_Br4923 FVSDIAGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGN TH_2454|M.thermoresistible__bu FLDDLAGFDAEFFGVSPREAELTDPQQRLALEVSWEALEHAGVPPRSLAG :: : **. :* : . ** :****: **. *.**.** .. * MAB_0939|M.abscessus_ATCC_1997 SRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFE MSMEG_0408|M.smegmatis_MC2_155 SRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFE MAV_1763|M.avium_104 SRSGIFVGVGANEYSHLLSAESVDKIEPHFITGNALNAISGRVAFALGLE Mvan_3126|M.vanbaalenii_PYR-1 TQTGVFAGASAADYAQLGATD-LSGIDAWYSTGGALSIIANRVSYYFDLR Mflv_3393|M.gilvum_PYR-GCK TRTGVFAGASAGDYAQMGATD-LGGIDAWYGTGGSISIIANRVSYFFDLR MMAR_1776|M.marinum_M SQTGVFAGSCLSEYGAIASTD-LTQVDGWSNTGGAMSIIANRLSYFLDLR MUL_2019|M.ulcerans_Agy99 SQTGVFAGSCLSEYGAIASTD-LTQVDGWSNTGGAMSIIANRLSYFLDLR Mb2957|M.bovis_AF2122/97 TRTAVMMGVYFNEYQSMLAAS-PQNVDAYSGTGNAHSITVGRISYLLGLR Rv2932|M.tuberculosis_H37Rv TRTAVMMGVYFNEYQSMLAAS-PQNVDAYSGTGNAHSITVGRISYLLGLR MLBr_02356|M.leprae_Br4923 SRTGVMIGVYFNEYQSMLASS-LENVDAYSGTGNAHSITVGRISYLLGLR TH_2454|M.thermoresistible__bu TDTAVLMGVNSDDYGRLLMED-LPGIEAWTGIGTSLCGIANRVSHLLDLR : :.:: * :* : . :: * : .*::. :.:. MAB_0939|M.abscessus_ATCC_1997 GPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAAS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAAS MAV_1763|M.avium_104 GPAVAVDTACSSSLVAVHQACQALHSGDCDLALAGGVNVLLSPVSNIAAS Mvan_3126|M.vanbaalenii_PYR-1 GPSVTVDTACSSSLVAIHLACQSLRSGDSELALAAGVNLLLSPAPTRSFD Mflv_3393|M.gilvum_PYR-GCK GPSVTIDTACSSSLVAVHLAAQSLRTGDSDLALAAGVNLLLSPAGTRGLD MMAR_1776|M.marinum_M GPSVAVDTACSSSLVAIHLACQSLRMQDSNLAIAAGVNLLLSPAVFRGFD MUL_2019|M.ulcerans_Agy99 GPSVAVDTACSSSLVAIHLACQSLRMQDSNLAIAAGVNLLLSPAVFRGFD Mb2957|M.bovis_AF2122/97 GPAVAVDTACSSSLVAVHLACQSLRLRETDLALAGGVSITLRPETQIAIS Rv2932|M.tuberculosis_H37Rv GPAVAVDTACSSSLVAVHLACQSLRLRETDLALAGGVSITLRPETQIAIS MLBr_02356|M.leprae_Br4923 GPSLAVDTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAIS TH_2454|M.thermoresistible__bu GPSVALDAACAASLVAVHNACQLLRAGETGLAIAGGVSALIGPGLTRVLD **::::*:**:::***:* * * *: : *.:*.**. : * . MAB_0939|M.abscessus_ATCC_1997 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIP MSMEG_0408|M.smegmatis_MC2_155 RARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIP MAV_1763|M.avium_104 RARMLSPVGRCKTFDATADGYVRSEGCGILVLKRMSDAVRDGDRVCAVIP Mvan_3126|M.vanbaalenii_PYR-1 RAKAMSPTGQCHAFDAGADGFVRGEGCGVAVLKRLSDAQRDGDRVLAVIR Mflv_3393|M.gilvum_PYR-GCK QAEALSPTGQCHAFDASADGFVRGEGCGVAVLKRLSDAQRDGDRVLAVIR MMAR_1776|M.marinum_M QVGALSPTGNCRAFDAAADGFVRGEGAGVVVLKRLTDAQQDGDRVLAVIC MUL_2019|M.ulcerans_Agy99 QVGALSPTGNCRAFDAAADGFVRGEGAGVVVLKRLTDAQQDGDRVLAVIC Mb2957|M.bovis_AF2122/97 AWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDQVLAVVR Rv2932|M.tuberculosis_H37Rv AWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDQVLAVVR MLBr_02356|M.leprae_Br4923 AWGLLSPHGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDLVLAVVR TH_2454|M.thermoresistible__bu KAGATAPDGRCKSFDASADGYGRGEGAAVVILKRLPDALRDGDRVIAVIR :* *.* :*** ***: *.**..: :***:.** :*** * **: MAB_0939|M.abscessus_ATCC_1997 GSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTP MSMEG_0408|M.smegmatis_MC2_155 ASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTP MAV_1763|M.avium_104 ASAVNQDGASSGLTVPNGGAQQRLIATALSRAGLSGDDVDYLEAHGTGTA Mvan_3126|M.vanbaalenii_PYR-1 GSAVNQDGRSNGLMAPNPSAQMAVLRAAYAAAGVDPREVDYVEAHGTGTL Mflv_3393|M.gilvum_PYR-GCK GSAVNQDGRSNGLMAPNPSAQIAVLRAAYAAAGVNPREVDYVEAHGTGTL MMAR_1776|M.marinum_M GSAINQDGRSNGLMAPNPAAQQAVLRAAYTNAGMQPSEVDYVEAHGTGTL MUL_2019|M.ulcerans_Agy99 GSAINQDGRSNGLMAPNPAAQQAVLRAAYTNAGMQPSEVDYVEAHGTGTL Mb2957|M.bovis_AF2122/97 GSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAHGTGTV Rv2932|M.tuberculosis_H37Rv GSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAHGTGTV MLBr_02356|M.leprae_Br4923 GSAVNQDGRSNGVTAPNTAAQCDVITDALRSSDVAPESVNYVESHGTGTV TH_2454|M.thermoresistible__bu GGAVAQDGRTVGIMSPNGAAQRDLFRHTCEITGTSPATVDFVEAHGTGTP ..:: *** : *: ** .** :: . . *:::*:***** MAB_0939|M.abscessus_ATCC_1997 LGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVL MSMEG_0408|M.smegmatis_MC2_155 LGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVL MAV_1763|M.avium_104 LGDPIEVQAAGAVYGATRDTDRPLLIGSVKTNIGHLEAASGVAGLIKVVL Mvan_3126|M.vanbaalenii_PYR-1 LGDPIEARALGTVLGKGRAADAPLLLGAVKSNLGHLEAAAGIAGFAKAVL Mflv_3393|M.gilvum_PYR-GCK LGDPIEARALGTVLGKGRPADAPLMIGAVKSNLGHLEAAAGIAGFAKAVL MMAR_1776|M.marinum_M LGDPIEARALGSVLGRGRPEESPLLIGAVKTNLGHTEAAAGIAGFIKAVL MUL_2019|M.ulcerans_Agy99 LGDPIEARALGSVLGRGRPEESPLLIGAVKTNLGHTEAAAGIAGFIKAVL Mb2957|M.bovis_AF2122/97 LGDPIEFEALAATYGHG---GDACALGAVKTNIGHLEAAAGIAGFIKATL Rv2932|M.tuberculosis_H37Rv LGDPIEFEALAATYGHG---GDACALGAVKTNIGHLEAAAGIAGFIKATL MLBr_02356|M.leprae_Br4923 LGDPIEFEALAATYGRG---ESACALGAVKTNLGHLEAAAGIAGFIKTVL TH_2454|M.thermoresistible__bu TGDPVELDALAAVYGAAHGPDDPCRVGSVKPNTGHLEGGAGVVGLIKAAL ***:* * .:. * . :*:**.* ** *..:* .*: *..* MAB_0939|M.abscessus_ATCC_1997 SLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQANGR---PRRAGV MSMEG_0408|M.smegmatis_MC2_155 SLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTNGR---VRRAGV MAV_1763|M.avium_104 SLQHEMLPQSLHFETPSPHIPWDSLPLRVVDKAVPWQTNGR---PRRAGV Mvan_3126|M.vanbaalenii_PYR-1 ALQHNMIPANLGYQSPNPHIPFEKLRLKVVAEHTDWAPAGR---PRRAGI Mflv_3393|M.gilvum_PYR-GCK ALQHNRIPGNRGWQTPNPHIPFDKLRLRVIDEHTDWAPAGR---PRRAGI MMAR_1776|M.marinum_M AVQHGRIPPNQRFESPNPHIAFADLRMKVVDELTDWPDTGH---PRRAGV MUL_2019|M.ulcerans_Agy99 AVQHGRIPPNQRFESPNPHIAFADLRMKVVDELTDWPDTGH---PRRAGV Mb2957|M.bovis_AF2122/97 AVQRATIPPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEG---PRRAAV Rv2932|M.tuberculosis_H37Rv AVQRATIPPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEG---PRRAAV MLBr_02356|M.leprae_Br4923 AVQRGQIPPNLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRAAV TH_2454|M.thermoresistible__bu ALQHGVIPPTAGIRELTPAVDWATNGLHVPTTVEPFPRRAD--SPRRAAV ::*. :* . .* : . * : ***.: MAB_0939|M.abscessus_ATCC_1997 SSFGFTGTNAHVLIEEAPQPQATPDEDDASTPQSAPVS------VLPLSA MSMEG_0408|M.smegmatis_MC2_155 SSFGFTGTNAHVLVEEAPPQLHTADAAPVEPAATAEAGTDDSPQVLALSA MAV_1763|M.avium_104 SSFGFTGTNAHVLIEEAPQPVTTQDATPAAESDARPVD------VLPLSA Mvan_3126|M.vanbaalenii_PYR-1 SSFGFGGTNAHVVIEQAPVFAPSPVEEPE-AVTTLVVS-----------G Mflv_3393|M.gilvum_PYR-GCK SSFGFGGTNAHVVIEQAPVLPPTPGEAPEGAVTTLVVS-----------G MMAR_1776|M.marinum_M SSFGFGGTNAHVVIEQGQEAASSPEAGLTPALSTLVVA-----------G MUL_2019|M.ulcerans_Agy99 SSFGFGGTNAHVVIEQGQEAASSPEADLTPALSTLVVA-----------G Mb2957|M.bovis_AF2122/97 SSFGLGGTNAHVIIEQGSELAPVSEGGEDTGVSTLVVT-----------G Rv2932|M.tuberculosis_H37Rv SSFGLGGTNAHVIIEQGSELAPVSEGGEDTGVSTLVVT-----------G MLBr_02356|M.leprae_Br4923 SSFGLGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVT-----------G TH_2454|M.thermoresistible__bu CSYGYGGTIAHLLLEEAPAVDETPAAAPAPAADAADANS----PRFHVIP .*:* ** **:::*:. : . MAB_0939|M.abscessus_ATCC_1997 RSPEALAAVAQRYESWLA-AHPDVDLEDVCLTAGRGRSHFEHRAALVVDS MSMEG_0408|M.smegmatis_MC2_155 RSPEALVELARRYDDWLS-ATPGLDIADVCHTAGVGRSHFEYRAALVVDS MAV_1763|M.avium_104 RSPEALLALAQRYGEWLH-AHPDADIGDLCFTVGAGRAHFEHRAALVVDS Mvan_3126|M.vanbaalenii_PYR-1 KSPERIASQAAALAEWMAGAGSDASLVEVAHSLNHHRAQHAKFATVVARD Mflv_3393|M.gilvum_PYR-GCK KSAERIATHAAALAVWMD--GTDASLTEVAHTLNHHRTQHPRFATVTARD MMAR_1776|M.marinum_M KTPARVAATAGMLADWMEGPGAEVALADVAHTLNHHRSRQARFGTVVARE MUL_2019|M.ulcerans_Agy99 KTPARVAATAGMLADWMEGPGAEVALADVAHTLNHHRSRQARFGTVVARE Mb2957|M.bovis_AF2122/97 KTAQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRARQATFGTVVARD Rv2932|M.tuberculosis_H37Rv KTAQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRARQATFGTVVARD MLBr_02356|M.leprae_Br4923 KTASRVAAMAGMLADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVARD TH_2454|M.thermoresistible__bu VSARSGARLARHAAALRGHLSAGADLTAVAATMWQRRSHEPVRAAVIARH :. * . : :. : *:: .:: . MAB_0939|M.abscessus_ATCC_1997 IQTAREGLLELAQNRLRPGVVRG-EHTNHPT-TAWLFTGQGSQYPGMARE MSMEG_0408|M.smegmatis_MC2_155 VERAREGLAALAEGRTPAGVVRG-EHVHRPT-TAWLFTGQGSQYPGMARE MAV_1763|M.avium_104 VRSAREALADLADNRTRPGVARG-ECTDPPT-TAWLFTGQGSQYPGMARE Mvan_3126|M.vanbaalenii_PYR-1 RDQAIAGLQALAAGQSAPGVVGVAAGNPQPG-TVFVYSGQGSQWPGMARQ Mflv_3393|M.gilvum_PYR-GCK KAQAVAGLSALAAGQTVPGVVAAATATPKPG-TVFVYSGQGSQWPGMARR MMAR_1776|M.marinum_M RAQAVAGLRALAANQHAPGVVNPADAPPEPG-TVFVYSGRGSQWAGMGRQ MUL_2019|M.ulcerans_Agy99 RAQAVAGLRALAANQHAPGVVNPADAPPEPG-TVFVYSGRGSQWAGMGRQ Mb2957|M.bovis_AF2122/97 RAQAIAGLRALAAGQHAPGVVSHQDGSPGPG-TVFVYSGRGSQWAGMGRQ Rv2932|M.tuberculosis_H37Rv RAQAIAGLRALAAGQHAPGVVSHQDGSPGPG-TVFVYSGRGSQWAGMGRQ MLBr_02356|M.leprae_Br4923 RIQAVAGLRALAAGKQAPGVVGQQDGTPGSG-TVFVYSGRGSQWAGMGRQ TH_2454|M.thermoresistible__bu PGELVAGLDAIATDTRHPAVVAGSVLPAAEAGAVWVFSGHGSHWPGMGRE .* :* . ..*. :.::::*:**::.**.*. MAB_0939|M.abscessus_ATCC_1997 LFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTS MSMEG_0408|M.smegmatis_MC2_155 LFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTS MAV_1763|M.avium_104 LFDAEPVFAETVTRCADAVDGLLPRPLTEVIFATDKDTGGEAGKTLRNTA Mvan_3126|M.vanbaalenii_PYR-1 LLVDEPAFANALAEIEPVFVEQVGFSLRDVIAG---------GETVSGDA Mflv_3393|M.gilvum_PYR-GCK LLADEPVFAEALDEIEPLFAEHVGFSLRDVIAG---------GREVSGDA MMAR_1776|M.marinum_M LLADEPVFAAAVAELEPVFLAEAGFSLHDVLAN---------GTELVGIE MUL_2019|M.ulcerans_Agy99 LLADEPAFAAAVAELEPVFLAEAGFSLHDVLAN---------GTELVGIE Mb2957|M.bovis_AF2122/97 LLADEPAFAAAVAELEPVFVEQAGFSLRDVIAT---------GKELVGIE Rv2932|M.tuberculosis_H37Rv LLADEPAFAAAVAELEPVFVEQAGFSLRDVIAT---------GKELVGIE MLBr_02356|M.leprae_Br4923 LLADEPAFTAAVAELEPVFVVHAGFSLHDVLAN---------GKELVGIE TH_2454|M.thermoresistible__bu LLEHEPVFAAVIDEIEPVFRAELGFSPRQALQS----------GELGGTD *: :*.*: .: . . . :.: : MAB_0939|M.abscessus_ATCC_1997 FAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGA MSMEG_0408|M.smegmatis_MC2_155 FAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGA MAV_1763|M.avium_104 FAQPALFAVEMGLARLWQSWGVEPDVVLGHSVGQYAAACVAGVFSLEDGA Mvan_3126|M.vanbaalenii_PYR-1 QVQPVLMGLQLALTELWRSYDVHPDAVIGHSMGEVTAAVVAGALSLADGL Mflv_3393|M.gilvum_PYR-GCK EVQPVLMGVQLALTQLWRSYGVHPDAVIGHSMGEVTAAVVAGALDVADGL MMAR_1776|M.marinum_M QIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEGL MUL_2019|M.ulcerans_Agy99 QIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEGL Mb2957|M.bovis_AF2122/97 QIQLGLIGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGL Rv2932|M.tuberculosis_H37Rv QIQLGLIGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGL MLBr_02356|M.leprae_Br4923 QIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGL TH_2454|M.thermoresistible__bu RVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAACVAAGVFDLARGA * :.:: *: : :. :.* *:***:*: :*. .**.: * MAB_0939|M.abscessus_ATCC_1997 RLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPRVSVGAYNGP-NT MSMEG_0408|M.smegmatis_MC2_155 RLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSVGAYNGP-NT MAV_1763|M.avium_104 RLMAERGRLFGGLPDGGRMVAVFADAQYVEELANDCPRVSVAAYNGP-NT Mvan_3126|M.vanbaalenii_PYR-1 KVIAARSSIMSRLAGQGAVALLNLDADAARSLIADHPSVEIAGYLSPRQT Mflv_3393|M.gilvum_PYR-GCK KVIAARSTIMSRLAGQGAVALLNVDADECAALIGGHPSVEIAGYLSPHQT MMAR_1776|M.marinum_M RVTAVRSRLMAPLSGQGGMALLELDASQTEALIADYPQVTLGIYNSPRQT MUL_2019|M.ulcerans_Agy99 RVTAVRSRLMAPLSGQGGMALLGLDASQTEALIADYPQVTLGIYNSPRQT Mb2957|M.bovis_AF2122/97 RVTATRARLMAPLSGQGGMALLGLDAAATEALIADYPQVTVGIYNSPRQT Rv2932|M.tuberculosis_H37Rv RVTATRARLMAPLSGQGGMALLGLDAAATEALIADYPQVTVGIYNSPRQT MLBr_02356|M.leprae_Br4923 RVTATRSRLMAPLSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQT TH_2454|M.thermoresistible__bu AVACYRARGFRSVAGKGAMALVGLPFEDARQRLGERTDVVAAISASPLST : . *. : :. * :. : . * . .* .* MAB_0939|M.abscessus_ATCC_1997 VLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQ MSMEG_0408|M.smegmatis_MC2_155 VLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQ MAV_1763|M.avium_104 VLSGPGADLEQIVARGASDGIRCSWLETSHAFHSELLDPVLDEFESYAAH Mvan_3126|M.vanbaalenii_PYR-1 VVAGLPEQVDAVIAAVTAQNTFARRVNMVVASHTALMDPVLPDIRAALAG Mflv_3393|M.gilvum_PYR-GCK VVAGLPEEVDAVIATVTSLNTFARRVNMVVASHTALMDPVLDDIRSALSD MMAR_1776|M.marinum_M VISGPTDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSELAD MUL_2019|M.ulcerans_Agy99 VISGPTDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSELAD Mb2957|M.bovis_AF2122/97 VIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELAD Rv2932|M.tuberculosis_H37Rv VIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELAD MLBr_02356|M.leprae_Br4923 VIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELAD TH_2454|M.thermoresistible__bu VISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALTAELARLTST *::* : . : * *. :*.: : : MAB_0939|M.abscessus_ATCC_1997 VQFAAPTLPLVCNRTGAVLT---AQTPIDGQYWRRHSRQPVQFAESVRTV MSMEG_0408|M.smegmatis_MC2_155 FQFAAPTLPLVCNRTGAVLT---GQTPLDAQYWRRHSRQPVQFAESVRTV MAV_1763|M.avium_104 LDFAVPTLPLVCNRTGTVLT---TETPLDARYWRRHSRQPVQFAESVRTV Mvan_3126|M.vanbaalenii_PYR-1 IEPNIPTLPFLSTVTGADS-----APVLDADYWVANVRQPVKFSQAIVAA Mflv_3393|M.gilvum_PYR-GCK VDPNIPSLPFLSTVTDPGV-----TPEFDADYWVSNVRQPVRFSQAVSAA MMAR_1776|M.marinum_M LAPRTPTIPIISTTYADLGSARESGPTFDAEHWAINMRNPVHFQQAITAA MUL_2019|M.ulcerans_Agy99 LAPRTPTIPIISTTYADLGAARESGPTFDAEHWAINMRNPVHFQQAITAA Mb2957|M.bovis_AF2122/97 LTPRTPTIGIISTTYADLH----TQPIFDAEHWATNMRNPVRFQQAIASA Rv2932|M.tuberculosis_H37Rv LTPRTPTIGIISTTYADLH----TQPIFDAEHWATNMRNPVRFQQAIASA MLBr_02356|M.leprae_Br4923 VAPRTPTIPILSTTYADLG----SCPVFDAQHWATNMRNPVHFQQAIMTA TH_2454|M.thermoresistible__bu LTPKPAAVPLYSTALADPRS----TAARDEHYWVANLRGRVRFAEAVTAA . .:: : .. . * :* : * *:* ::: :. MAB_0939|M.abscessus_ATCC_1997 AALG---CSVLMEIGPQPVLTGAAVQVWPEHLAPP--RAIVSLRKGVEDR MSMEG_0408|M.smegmatis_MC2_155 AALG---CSVLMEIGPQPVLTGAAVQVWPEHMAAP--RAVASLRKGVADR MAV_1763|M.avium_104 AALG---CTVLMEIGPQPVLTGAAVQVWPEHLAAP--RAIVSLRKGVGDR Mvan_3126|M.vanbaalenii_PYR-1 AA----DNGTFIEISPHSTLGQAIGNTLGDGP-------DHHMLGTLARD Mflv_3393|M.gilvum_PYR-GCK AT----EYGTFVEISPHPTLGQSIRDTLGDGA-------DHLVVGTLARD MMAR_1776|M.marinum_M AT----DKHNFIEISAHPLLTQAILETLHTVQ----PGSKYTSLGTLQRD MUL_2019|M.ulcerans_Agy99 AT----DKHNFIEISAHPLLTQAILETLHTVQ----PGSKYTSLGTLQRD Mb2957|M.bovis_AF2122/97 GSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYLSIGTLQRD Rv2932|M.tuberculosis_H37Rv GSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYLSIGTLQRD MLBr_02356|M.leprae_Br4923 GT----DHRTFIEISAHPLLTQAITDTLHGTR--------CISIGTLQRD TH_2454|M.thermoresistible__bu AEDG---HRLFLEVSAHPVVCHSMAETLALAEVG--EHAVLPVLRREQPE . ::*:..:. : : :. MAB_0939|M.abscessus_ATCC_1997 RQIADALASAYVSGHRPNFAALQRHPRRTVELPTYPFQRRRFWPKSSGTA MSMEG_0408|M.smegmatis_MC2_155 RQIADALASAYVGGHRPDFAAVHRQPRRPVELPTYPFQRRRFWPKASSIA MAV_1763|M.avium_104 RQIAEGLAAAYVSGHRPEFAALHRRPRRKLELPTYPFQRRRFWPKASGIA Mvan_3126|M.vanbaalenii_PYR-1 TDDTVTFHANLNATHTSRPPHTAHHGEPHIVLPTTPWHRSRHWVDVRPLR Mflv_3393|M.gilvum_PYR-GCK ADDTVAFHASVNATHTSRPPHTPHGPEPHLVLPATPWHHTRHWIDVRPAR MMAR_1776|M.marinum_M SDDTIVFRTNLNTVRTA-PPQTPHPPEPHPQIPTTPWHHTHHWIDTPAVA MUL_2019|M.ulcerans_Agy99 SDDTIVFRTNLDTVRTA-PPQTPHPPEPHPQIPTTPWHHTHHWIDTPAVA Mb2957|M.bovis_AF2122/97 ADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATTHPS Rv2932|M.tuberculosis_H37Rv ADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATTHPS MLBr_02356|M.leprae_Br4923 ADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWITTPLAS TH_2454|M.thermoresistible__bu LPAVAAVVGALYCHGAPVRPAFPPGTRWATGLPGTQWQHRRFWRTPGTPP . . . . :* ::: :.* MAB_0939|M.abscessus_ATCC_1997 -IEGGGGLPSGILGRGEDLASGDSVYISRLSVRSQPWLSDHVIYGTVVVP MSMEG_0408|M.smegmatis_MC2_155 -VDGG-TAASGILGSGKDLASGDTIYTSRLSVKSQPWLADHVIYGTVVVP MAV_1763|M.avium_104 GIDGQGAAASGLLGSAKELASGDSVYTSRLSVKSQPWLADHVIYGTVVVP Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------RGGGVRA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------RSGGVRA MMAR_1776|M.marinum_M -------------------------------------------SRSASTP MUL_2019|M.ulcerans_Agy99 -------------------------------------------SRSASTP Mb2957|M.bovis_AF2122/97 -------------------------------------------TAAPEDP Rv2932|M.tuberculosis_H37Rv -------------------------------------------TAAPEDP MLBr_02356|M.leprae_Br4923 -------------------------------------------TTALQHL TH_2454|M.thermoresistible__bu GGVGVHDVDSHTLLGGRIDVAG---AVPARVWQTRLDLSTRPYPGDHPVQ MAB_0939|M.abscessus_ATCC_1997 GATYAAMALAAVGTPARAKDVFFYEPIILPEKSSREVQLTLHPLEDGSGS MSMEG_0408|M.smegmatis_MC2_155 GATYAAMALAAVGTPARLKDVFFYEPIILPEKASREVQLTLHPADGGSVL MAV_1763|M.avium_104 GATYAAMALAAVGPPARVQNVYFYEPIILPDKASREVQLSLHPLQEG-GW Mvan_3126|M.vanbaalenii_PYR-1 GALPADS----------AVPPEWFCGLTWPAK------------------ Mflv_3393|M.gilvum_PYR-GCK GAVPAGS----------PVPPEWFCELTWPAK------------------ MMAR_1776|M.marinum_M DKDAAGSSEPSVSGDSDDAVDSCHYRVGWPTK------------------ MUL_2019|M.ulcerans_Agy99 DKDAAGSSEPSVSGDSDDAVDSCHYRVGWPTK------------------ Mb2957|M.bovis_AF2122/97 GSNKVVVNGQSTSE--SRALEDWCHQLAWPIR------------------ Rv2932|M.tuberculosis_H37Rv GSNKVVVNGQSTSE--SRALEDWCHQLAWPIR------------------ MLBr_02356|M.leprae_Br4923 DRNRVTTHATGIG---NTELDDWIYQLDWPTR------------------ TH_2454|M.thermoresistible__bu GTEIVPAAVLLNTFLTAAGSDIADVRLRTPVAPARTRDVQVVLQDRALAL . . : * MAB_0939|M.abscessus_ATCC_1997 KFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIE MSMEG_0408|M.smegmatis_MC2_155 SFQIHSRPYGERGADWSLNAEGTVDT---AGSDPDAAADEQSDPVDEVIE MAV_1763|M.avium_104 SFRVDSRPYGVPDAEWSLNADGTVVAG-----IEDEPAADPADHIDAVIE Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu ASRIVGEDTTARATAGRDTTDRDTTACDTTDRDTTACDDPGVWLTHCTAR MAB_0939|M.abscessus_ATCC_1997 RMERMRPMELFEIFADLELAWGPTWSGSLKSLWLGEGEAIGDVLVGEELA MSMEG_0408|M.smegmatis_MC2_155 RLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVGDILVGAELA MAV_1763|M.avium_104 RLDRNRPQLLFDSFAESELEWGTTWSTSLKSLWMGDGEAVGDVTVGDELA Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu VADDHVGAEGVLDEEAIRARCPQPLPAGHVVDTLAGLGVAAMGFGWEVLE MAB_0939|M.abscessus_ATCC_1997 EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKE MSMEG_0408|M.smegmatis_MC2_155 EQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAE MAV_1763|M.avium_104 EHLGTEPMHPVLLDLCTGVVFPAFPALLAAEQGFNDLLLPLRYGQVSLRE Mvan_3126|M.vanbaalenii_PYR-1 ---------PLVAQ--DGPVDPGASWLVVGDDALAAEMGKL--------- Mflv_3393|M.gilvum_PYR-GCK ---------PLAAH--HDPEGT-AKWLVVGDDALADQMRR---------- MMAR_1776|M.marinum_M ---------PLADAKASTETASGTRWLVFADAELGAELGLA--------- MUL_2019|M.ulcerans_Agy99 ---------PLADAKASTETASGTRWLVFADAELGAELGLA--------- Mb2957|M.bovis_AF2122/97 ---------PAVS---ADPPSTAA-WLVVADNELCHELAR---------- Rv2932|M.tuberculosis_H37Rv ---------PAVS---ADPPSTAA-WLVVADNELCHELAR---------- MLBr_02356|M.leprae_Br4923 ---------PLTSEPGATWASSGS-WLVVSDAGLSDELARLVV------- TH_2454|M.thermoresistible__bu LHRGEGELFARVAAEPDKSAPATWAGLIDAATSTASTIFDGPP------- . . *: . : MAB_0939|M.abscessus_ATCC_1997 KMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPRE MSMEG_0408|M.smegmatis_MC2_155 KMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPRE MAV_1763|M.avium_104 KMPRRFYCRGKWRPSALDSETQVFDIDFIDRDGRHLGGIREFTVKRAPRE Mvan_3126|M.vanbaalenii_PYR-1 ----------------LGRPVATGD-------GADLSSATHVLYAPTSG- Mflv_3393|M.gilvum_PYR-GCK ----------------LGAAVTTGG-------PDDLADATHVLYAPSTS- MMAR_1776|M.marinum_M -------AGAQTRVDVIDPSALTEE----SELLAALAGVEHVVYAPPAG- MUL_2019|M.ulcerans_Agy99 -------AGAQTRVDVIDPSALTEG----SELLAALAGVEHVVYAPPAG- Mb2957|M.bovis_AF2122/97 --------AADSRVDSLSPPALAAG-SDPAALLDALRGVDNVLYAPPVPG Rv2932|M.tuberculosis_H37Rv --------AADSRVDSLSPPALAAG-SDPAALLDALRGVDNVLYAPPVPG MLBr_02356|M.leprae_Br4923 ------LADPASRVEYLAPSALDHDVSTLHDLHNALRGVDNVLYAPSVST TH_2454|M.thermoresistible__bu ------RLRMPARIERVHVRDKPPAIALLHVRRRPEGTVTDVTIAEESGA : .. MAB_0939|M.abscessus_ATCC_1997 ALLRGL---------------GGDATRLLYTLGWHEVAVPPVAGEGEESA MSMEG_0408|M.smegmatis_MC2_155 ALLRGL---------------GGDATRLLYTLGWHEVPPPPSADD----- MAV_1763|M.avium_104 ALLRGL---------------GGDATRLLYTLGWHEVPPQPSNDG---VA Mvan_3126|M.vanbaalenii_PYR-1 ---D-------------------ELGYELFEAGRAIATTASRVS------ Mflv_3393|M.gilvum_PYR-GCK ---D-------------------ELGYELFETGRALARAAAQDP------ MMAR_1776|M.marinum_M KSLD------------------VNAAYQLFHQVRRLVTVMTKAS------ MUL_2019|M.ulcerans_Agy99 KSLD------------------VNAAYQLFHQVRRLVAVMTKAS------ Mb2957|M.bovis_AF2122/97 ELLD------------------IESAYQVFHATRRLAAAMVASSA----- Rv2932|M.tuberculosis_H37Rv ELLD------------------IESAYQVFHATRRLAAAMVASSA----- MLBr_02356|M.leprae_Br4923 ESVDPV---------------DPESGYRLFHAVRRLAAAMVAG------- TH_2454|M.thermoresistible__bu VSVTLTGMGFEELENPGGGGSSGDLTGMLHHLRWHPVDWPDTDPP----- : :. . MAB_0939|M.abscessus_ATCC_1997 ASIGTWLIAGFDELAAKVPGCIPLNRETDPELLGEVLVAAKERGVPFSGV MSMEG_0408|M.smegmatis_MC2_155 -AVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGEVLSQAHARGAGFSGV MAV_1763|M.avium_104 NPSGTWLIAGFDELGAQLPGCIPFDRNTDPESFGQLLARAEDRGGPVTGI Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu --------------------------------------AAVVLVGGDART MAB_0939|M.abscessus_ATCC_1997 VWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGL MSMEG_0408|M.smegmatis_MC2_155 VWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ---GPSVKLPGGL MAV_1763|M.avium_104 VWRATQSGGRES--SAESVARLETEIAGLLTAVHALQNADGSAVKLPGGL Mvan_3126|M.vanbaalenii_PYR-1 ---------------------------------------------QPPKL Mflv_3393|M.gilvum_PYR-GCK ---------------------------------------------TPPKL MMAR_1776|M.marinum_M ---------------------------------------------LTAKL MUL_2019|M.ulcerans_Agy99 ---------------------------------------------LTAKL Mb2957|M.bovis_AF2122/97 ------------------------------------------TAISPPKL Rv2932|M.tuberculosis_H37Rv ------------------------------------------TAISPPKL MLBr_02356|M.leprae_Br4923 --------------------------------------------TSKPKL TH_2454|M.thermoresistible__bu RAFVTRDLDEARVAHRSYADPAALPPDLTAGTVVLVLPRTAARPAASAQL * MAB_0939|M.abscessus_ATCC_1997 WIVTERAVATESG------------EPVDPVQAALWGFGRTTINEEPALR MSMEG_0408|M.smegmatis_MC2_155 WIVTEHGVACESG------------EPVDPVQAALWGFGRTTINEEPALH MAV_1763|M.avium_104 WIVTERGVATESG------------EPVDPVQAALWGLGRTIVNEEPALR Mvan_3126|M.vanbaalenii_PYR-1 FLLTRNAQPVSEG------------DRANPGQAVLWGLGRTLALEHPDIW Mflv_3393|M.gilvum_PYR-GCK FLLTRNAQPVEAG------------DRADPAQAVLWGLGRTLALEHPEIW MMAR_1776|M.marinum_M LLVTRNAQPIAEG------------DRANPAHGVLWGLGRTIALEHPEIW MUL_2019|M.ulcerans_Agy99 LLVTRNAQPIAEG------------DRANPAHGVLWGLGRTIALEHPEIW Mb2957|M.bovis_AF2122/97 FIMTRNAQPISEG------------DRANPGHAVLWGLGRSLALEHPEIW Rv2932|M.tuberculosis_H37Rv FIMTRNAQPISEG------------DRANPGHAVLWGLGRSLALEHPEIW MLBr_02356|M.leprae_Br4923 VVVTRNAQPVAVG------------ERANPAHAVLWGFGRTLALEHPEIW TH_2454|M.thermoresistible__bu VLHTLQRLSATNSGARLWVLTRGVHEGTDPGHGPLWGLARVAAAEHPQLW : * . . . : .:* :. ***:.* *.* : MAB_0939|M.abscessus_ATCC_1997 AKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGH MSMEG_0408|M.smegmatis_MC2_155 CRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGH MAV_1763|M.avium_104 CRLVDSDGSEQAVRSLAGLLGAP-LDEPELAVRQGKLLASRLLPWARSGH Mvan_3126|M.vanbaalenii_PYR-1 GALIDTDESVPAVVAARWVLAEAHAG------------------------ Mflv_3393|M.gilvum_PYR-GCK GGVLDVDASVPAVVAARWALAEAHAG------------------------ MMAR_1776|M.marinum_M RGIIDLDESMPAELAAPKILGEVTG------------------------- MUL_2019|M.ulcerans_Agy99 RGIIDLDESMPAELAAPKILGEVTG------------------------- Mb2957|M.bovis_AF2122/97 GGIIDLDDSMPAELAVRHVLTAAHG------------------------- Rv2932|M.tuberculosis_H37Rv GGIIDLDDSMPAELAVRHVLTAAHG------------------------- MLBr_02356|M.leprae_Br4923 GSVIDLDASMPPELAARCILDEVASQDE---------------------- TH_2454|M.thermoresistible__bu GGLLDIGEDRLPVRALTALTGHG--------------------------- ::* . . . MAB_0939|M.abscessus_ATCC_1997 LTVPRGSDYVLAPTERGAIDNLRITEKEVPAPDEGYVQVRVEAAGLNFRD MSMEG_0408|M.smegmatis_MC2_155 LTLPRGGDFVLAPTERGAIDNLRLTETDVPEPDEGYVQVRVEAAGLNFRD MAV_1763|M.avium_104 LAVPRGTDYVLAPTERGAIDNLRLIEQEAPPPAEGCVQVRVEAGGLNFRE Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFGSR MSMEG_0408|M.smegmatis_MC2_155 VLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFASR MAV_1763|M.avium_104 VLNVLGLYPGDPGPLGGDFAGTVTQLGSGVTGLEVGTRVYGFMQGAFASR Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FNVPAQFLAPIPDGISGVEAATIPAAALTVRLSFDWAQLKPGDKVLIHAA MSMEG_0408|M.smegmatis_MC2_155 FNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAFDWAQLKPGDKVLIHAA MAV_1763|M.avium_104 FNVPVQLLAPIPDGVSAVDAATIPAAALTARLAFDWAQLKPGDRVLIHAA Mvan_3126|M.vanbaalenii_PYR-1 ----------------------------------------DGEDQLVYRA Mflv_3393|M.gilvum_PYR-GCK ----------------------------------------DGEDQVVYRA MMAR_1776|M.marinum_M ---------------------------------------TDGEDQVVYRC MUL_2019|M.ulcerans_Agy99 ---------------------------------------TDGEDQVVYRC Mb2957|M.bovis_AF2122/97 ---------------------------------------TDGEDQVVYRS Rv2932|M.tuberculosis_H37Rv ---------------------------------------TDGEDQVVYRS MLBr_02356|M.leprae_Br4923 ---------------------------------------KDREDQVVYRA TH_2454|M.thermoresistible__bu --------------------------------------------VVVVRD :: MAB_0939|M.abscessus_ATCC_1997 SGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLGVKYVYDSRTTDFADQ MSMEG_0408|M.smegmatis_MC2_155 SGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLGVKYVYDSRTTDFADQ MAV_1763|M.avium_104 SGGVGLAAIQLAQRHGATVFATASTYKRATLRKLGVEYVYDSRSTDFADQ Mvan_3126|M.vanbaalenii_PYR-1 G------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK G------------------------------------------------- MMAR_1776|M.marinum_M G------------------------------------------------- MUL_2019|M.ulcerans_Agy99 G------------------------------------------------- Mb2957|M.bovis_AF2122/97 G------------------------------------------------- Rv2932|M.tuberculosis_H37Rv G------------------------------------------------- MLBr_02356|M.leprae_Br4923 C------------------------------------------------- TH_2454|M.thermoresistible__bu G------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTTEQM MSMEG_0408|M.smegmatis_MC2_155 ILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSHEQM MAV_1763|M.avium_104 ILADTDGAGVDVVLNSLTNEGFIEATVRATAQHGRFVEIAKRDIWTREQM Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPAEIYP MSMEG_0408|M.smegmatis_MC2_155 AEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPAEIYP MAV_1763|M.avium_104 AAARPDIAYEIVALDWACVEQPEHIHALLTEVSDGLASGEWRPLPAEIYP Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LTEARTAFRRMQQARHIGKIVCQMP-NPLAPRPDRTYLITGGLGAIGLHT MSMEG_0408|M.smegmatis_MC2_155 ITEARSAFRRMQQARHIGKIVLQVP-KPLQPQQDRSYLITGGLGAIGLHT MAV_1763|M.avium_104 LAEAKTAFRRMQQARHIGKIVLQMP-KPLQPRGDRSYLITGGLGAIGLHL Mvan_3126|M.vanbaalenii_PYR-1 -------IRRVARLVHALPPAPTGS-GTLD--ADGAHLVIGATGNIGPRL Mflv_3393|M.gilvum_PYR-GCK -------IRRVARLVHALPPAPTGP-TTLA--RDGAHLVIGATGNIGPGL MMAR_1776|M.marinum_M -------GRHVPRLQRRTAPAVAP--VTLD--PNSSQLVIGATGNIGPYL MUL_2019|M.ulcerans_Agy99 -------SRHVPRLQRRTAPAVAP--VTLD--PNSSQLVIGATGNIGPYL Mb2957|M.bovis_AF2122/97 -------ARHVPRLQRRTLPGKP---VTLN--ADASQLVIGATGNIGPHL Rv2932|M.tuberculosis_H37Rv -------ARHVPRLQRRTLPGKP---VTLN--ADASQLVIGATGNIGPHL MLBr_02356|M.leprae_Br4923 -------LRRAPRLQRRTASAVSS--VKLSSGQDTTQLVIGATGNIGPHL TH_2454|M.thermoresistible__bu -------VAHTARLAPAGPGARDSAGEGLRCSPGGTYLITGGTGALGLRL : : * . : *: *. * :* MAB_0939|M.abscessus_ATCC_1997 AAYLAQLGAGDIVLTSRRAPDT---------DAQRVIGEITERSKTRIHV MSMEG_0408|M.smegmatis_MC2_155 AAYLAQLGAGDIVLTSRRDPDE---------SAQRAIDEITERHKCRIHT MAV_1763|M.avium_104 AAYLAQLGAGEIVLTSRRAPDA---------AAWRAIDDITERYRCRVHT Mvan_3126|M.vanbaalenii_PYR-1 VEQLAAMGAKTVVAVSRNPG-----------SRLDELTARLAASGTTVVT Mflv_3393|M.gilvum_PYR-GCK IEQLAAMGAGTVVAVSRNPG-----------TRLDELTARLAATGTTVVT MMAR_1776|M.marinum_M IRQLAQMGAKTVVAVSRNPG-----------QRLQELAESLAAEGTNLVI MUL_2019|M.ulcerans_Agy99 IRQLAQMGAKTVVAVSRNPG-----------QRLQELAESLAAEGTNLVI Mb2957|M.bovis_AF2122/97 IRQLARMGAKTIVAMARKP------------GALDELTQCLAATGTDLIA Rv2932|M.tuberculosis_H37Rv IRQLARMGAKTIVAMARKP------------GALDELTQCLAATGTDLIA MLBr_02356|M.leprae_Br4923 IRQLAAMGATTIVAVSRNPS-----------TRLLELDKNLAATGTNLIS TH_2454|M.thermoresistible__bu AHRLADLGARRLVLVSRSGMPARDSWGRAGDSDTVAAITALEERGVSVRV ** :** :* :* : MAB_0939|M.abscessus_ATCC_1997 FTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRT MSMEG_0408|M.smegmatis_MC2_155 YAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRT MAV_1763|M.avium_104 FAADVGDAAQVEQLLARIRAELPPLAGVAHLAGVLDDALLSQQSPERFRV Mvan_3126|M.vanbaalenii_PYR-1 AAADASDASSLRAVFDRFGADLPPLKGVYLAAMSGGPVTLDEMTHDDVVA Mflv_3393|M.gilvum_PYR-GCK VAADASDESSLRPVFERFGADLPPLKGVYLAAMAGGPVTLAEMTHEDVVA MMAR_1776|M.marinum_M EAADATDEAAMTALFDRFGADLPPLEGIYLAAFAGGPVLLNEMTDADVRA MUL_2019|M.ulcerans_Agy99 EAADATDEAAMTALFDRFGADLPPLDGIYLAAFAGGPVLLNEMTDADVRA Mb2957|M.bovis_AF2122/97 VAADATDPAAMQTLFDRFGTELPPLEGIYLAAFAGRPALLSEMTDDDVTT Rv2932|M.tuberculosis_H37Rv VAADATDPAAMQTLFDRFGTELPPLEGIYLAAFAGRPALLSEMTDDDVTT MLBr_02356|M.leprae_Br4923 VAADATDPTAMTALFDRFGVDLPPLEGIYLAAFAGRPVLLSDMTDNDVVA TH_2454|M.thermoresistible__bu AALDIGAPG-AAARLREVLADLPDVRGVIHAAGVEAGALLTNTTAEDIEA : * : .. .:** : *: * . * . . . MAB_0939|M.abscessus_ATCC_1997 TLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLD MSMEG_0408|M.smegmatis_MC2_155 TLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLD MAV_1763|M.avium_104 ALAPKAFGASYLDHATRTDDLDFFIVSSSVSSLLGSPGQANYSTANAWLD Mvan_3126|M.vanbaalenii_PYR-1 MFRSKMDAAALLHQLSAGHPVEQFVLFSSISGVLGSRWLAHYAATTTFLD Mflv_3393|M.gilvum_PYR-GCK MFRPKLDAAAAVHTLSLSHPVEQFVLFSSISGVLGSRWLAHYAATTTFLD MMAR_1776|M.marinum_M MFAPKLDAAALLHRLSLKVPARHFVLFSSISGLIGSRWLAHYTATSGYLD MUL_2019|M.ulcerans_Agy99 MFAPKLDAAALLHRLSLKVPARHFVLFSSISGLIGSRWLAHYTATSGYLD Mb2957|M.bovis_AF2122/97 MFRPKLDALALLHRLSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAFLD Rv2932|M.tuberculosis_H37Rv MFRPKLDALALLHRRSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAFLD MLBr_02356|M.leprae_Br4923 MFRPKLDVASLLHRLSLKQPVKYFLLFSSISGLIGSRWLAHYTATSAFLD TH_2454|M.thermoresistible__bu TMRPKVDGVLALHEVFPPGRLDWLVLFSSCGYLGGFPGQGAYACGNAYLD : .* :. ::: ** . : * . *: . ** MAB_0939|M.abscessus_ATCC_1997 GLIAQRRAQGLPATGINFGPWGQG-GMASSEAATANISAQGLIPLDPSAA MSMEG_0408|M.smegmatis_MC2_155 GLVAKRRAQGLVATGINFGPWGQG-GMASSEAATANITAQGLIPLDPSAA MAV_1763|M.avium_104 GLVAARQARGLPATGVNLGPWAQG-GMASSEAARANIGAQGLIPLEPTAA Mvan_3126|M.vanbaalenii_PYR-1 TFAFARRAAGLPACAINWGLWKSL-ADAQTGFERQATQESGLEPMDDAVA Mflv_3393|M.gilvum_PYR-GCK TFAFARRAAGLPASAINWGLWKSL-ADAQTGFEAQATHESGLEPMDDAVA MMAR_1776|M.marinum_M ALAYARHALGLPATTVNWGLWKSL-ADAEHDAS-QVSVGSGLLPMQDEVA MUL_2019|M.ulcerans_Agy99 ALAYARHALGLPATTVNWGLWKSL-ADAEHDAS-QVSVGSGLLPMQDEVA Mb2957|M.bovis_AF2122/97 SFAGARRTMGLPATVVDWGLWKSL-ADVQKDAT-QISAESGLQPMADEVA Rv2932|M.tuberculosis_H37Rv SFAGARRTMGLPATVVDWGLWKSL-ADVQKDAT-QISAESGLQPMADEVA MLBr_02356|M.leprae_Br4923 ILGYARRLVGLPATVVAWGLWKSL-ADAQQDAT-QVSAESGLQPMTDDVA TH_2454|M.thermoresistible__bu AFARYRRASGDATTSVAWTAWRGLGMGSASDFVAAQLDALGMGTVDVDDA : *: * : : * *: .: * MAB_0939|M.abscessus_ATCC_1997 LAALAEVVANGT-GQATILKANWQRAAKVLGS-SRPPILDLVLPSAVGEV MSMEG_0408|M.smegmatis_MC2_155 LHALAEVIANGS-GQATVLKANWQRAAKVLGS-ARPPILDLVLPSAAGEA MAV_1763|M.avium_104 LAALAEVVANGT-GQATVIKANWQRAAKLLGG-ARPPILDLVLPSAVGEA Mvan_3126|M.vanbaalenii_PYR-1 ITALRSFIGPQAPARATVVAADWPRLAAAYHTRAQLHILDDLLATEGTAA Mflv_3393|M.gilvum_PYR-GCK ITALQAFVGPQAPVRGTVVAADWPRLAAAYHTRAQLHILDDLLAEEGTAA MMAR_1776|M.marinum_M IGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRGSLHIVDDLLRDFAEAS MUL_2019|M.ulcerans_Agy99 IGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRWSLHIVDDLLRDFAEAS Mb2957|M.bovis_AF2122/97 IGALPLVMNPDAAVATVVVAADWPLLAAAYRTRGALRIVDDLLPAPEDVG Rv2932|M.tuberculosis_H37Rv IGALPLVMNPDAAVATVVVAADWPLLAAAYRTRGALRIVDDLLPAPEDVG MLBr_02356|M.leprae_Br4923 IGALPLVMSPDAPVHSVVAAADWPLLAAAYQTRGVLRMVDDLLPAPGEVL TH_2454|M.thermoresistible__bu MRALDAAIRDGD---PNVVVLPLSPAAAAVPMFADVAPADPDADAPGGEV : :* : : * * MAB_0939|M.abscessus_ATCC_1997 T-----GDSELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPP--AAT MSMEG_0408|M.smegmatis_MC2_155 T-----GDSELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPP--AAS MAV_1763|M.avium_104 S-----GDSELLKQLQEIPVAQRAAFITEFLQREVQGFLRLAQPP--AAT Mvan_3126|M.vanbaalenii_PYR-1 TGLTPTGDTRFRQELKECEPQRRVELLTDHVLSQIAAAMGLASTHTLDPT Mflv_3393|M.gilvum_PYR-GCK SGPALTGDTKFRQELKDRDPEQRRDMLTDFVISQVAAAMGLASAHTLDPG MMAR_1776|M.marinum_M T-----IPARDWSHLS---AQEVRTEFEAGLRRIVARELRVSESD-LETD MUL_2019|M.ulcerans_Agy99 T-----IPARDWSHLS---AQEVRTEFEAGLRRIVARELRVSESD-LETD Mb2957|M.bovis_AF2122/97 K-----GESEFRTSLRSCPAEKRRDMLFDHVGALAATVMGMPPTEPLDPS Rv2932|M.tuberculosis_H37Rv K-----GESEFRTSLRSCPAEKRRDMLFDHVGALAATVMGMPPTEPLDPS MLBr_02356|M.leprae_Br4923 M-----QESEFRKALRTCQAERRHNMLFDHVSALVAKAMGLLPAETLDPS TH_2454|M.thermoresistible__bu P----DGLSDGFPADGFPDDGDLAEWVHRRVIAAVAGELGLAETD-VDPR : . : : : . . MAB_0939|M.abscessus_ATCC_1997 SRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVG MSMEG_0408|M.smegmatis_MC2_155 SRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVG MAV_1763|M.avium_104 SRFLDLGTDSLMAVELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYLAG Mvan_3126|M.vanbaalenii_PYR-1 VGFFQFGMDSLMSVTLQRSLSESLG--EALPASVVFDYPTVEALTDYLAS Mflv_3393|M.gilvum_PYR-GCK VGFFQFGMDSLMSVTLQRSLSESLG--ETLPASVVFDYPTVEALTDYLAS MMAR_1776|M.marinum_M RPLAELGLNSLMAMAIRREAEMFVG--IELSATMLFNHPTVASLASYLAN MUL_2019|M.ulcerans_Agy99 RPLAELGLNSLMAMAIRREAEMFVG--IELSATMLFNHPTVASLASYLAN Mb2957|M.bovis_AF2122/97 AGFFQLGMDSLMSVTLQRALSESLG--EFLPASVVFDYPTVYSLTDYLAT Rv2932|M.tuberculosis_H37Rv AGFFQLGMDSLMSVTLQRALSESLG--EFLPASVVFDYPTVYSLTDYLAT MLBr_02356|M.leprae_Br4923 AGFFQLGMDSLMSVTLQRALSDSLG--EFLPASVVFDYPTVYSLTDYLAT TH_2454|M.thermoresistible__bu LPLVEIGVDSIMTVALRRQLERQTG--LTLPPTLLWEHPTAGAVSDRIVE : ::* :*:*:: ::. * : .: ::::** .::. :. MAB_0939|M.abscessus_ATCC_1997 QLPDADAESAEAPPAVESAEAESGAGPAAASDAVSELKE------- MSMEG_0408|M.smegmatis_MC2_155 QLPDAEAPETA----------------------------------- MAV_1763|M.avium_104 QLPDAESEPGAAVAANPNPGSETGTGEAEPEREAAPEPS------- Mvan_3126|M.vanbaalenii_PYR-1 VLPEIIETAGTDNDVDGGPSVIEDAYDDLAEDELLARLSERLS--- Mflv_3393|M.gilvum_PYR-GCK VLPEIIETAGTE-GGDVISDEADDTYDDLAEDELLARLSERLS--- MMAR_1776|M.marinum_M RVAPQDNSSNDQMAELSAS----AGSTLDSLFDRIESSSLLPEGPG MUL_2019|M.ulcerans_Agy99 RVAPQDNSSNDQMAELSAS----AGSTLDSLFDRIESSSLLPEGPG Mb2957|M.bovis_AF2122/97 VLPELLEIGATAVATQQAT----DSYHELTEAELLEQLSERLRGTQ Rv2932|M.tuberculosis_H37Rv VLPELLEIGATAVATQQAT----DSYHELTEAELLEQLSERLRGTQ MLBr_02356|M.leprae_Br4923 ILPEFLEP--EAPSGRTTA----DAYDEFTESELLDQLSERLRGTQ TH_2454|M.thermoresistible__bu MLRARG---------------------------------------- :