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SEGPTHPITVFPARKVLTMTPSLPEASAVAVADGRIVAVGSLDSMRPWLNRHEYVVDERLSDKVVLPGFI DPHVHPSLPAVLTQFPFLAPEDWNLPTGRFAGATTPDAFRTRLRELVDAHPDWSVPFVAWGYHPLWHGPI GRPELTAMFGTRPVILWHRSFHELIANDGAIDWMGLSEQQFADLPEVDWERGRFWENGAMALVGASRLPQ LLFDPARYGEGMANFFRMVHLAGVTTCLDMGVGSMGNPENEIRLINRISREIDAPSRIVLTPLISDFLAR GVTPQEAVAVVAEWAQMTSGRVGFDHHFKLMMDGAIFSGMAQFGYPGYLDGHTGMWMAPLQVTRTWAEVF WREGYQLHAHTVGDLSAEALIDLVRHLQWIHPRIGHRTVLEHFGYTTEEQNLQMRELGMVVSANPYYHYL LSDIYSSEWLGSDRGAELVRLGSLERLGVPFGLHSDCPMAPLAPLTLAWVAARRITINGNLNCAQERISL HAALRAITIDAAWIMRKENDLGSIRAGKYADFTVLEDDPYQVGVDGLKDLPIWGTVFEGQVRSLPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1579 | - | - | 100% (557) | hypothetical protein MMAR_1579 |
| M. marinum M | MMAR_0898 | - | 5e-38 | 25.81% (554) | hypothetical protein MMAR_0898 |
| M. marinum M | MMAR_1131 | - | 2e-17 | 26.19% (252) | metal-dependent hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 2e-43 | 27.72% (552) | hypothetical protein Mb0567 |
| M. gilvum PYR-GCK | Mflv_2885 | - | 1e-34 | 27.07% (569) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv0552 | - | 2e-43 | 27.72% (552) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1868c | - | 5e-32 | 25.71% (564) | hypothetical protein MAB_1868c |
| M. avium 104 | MAV_4591 | - | 7e-40 | 26.80% (556) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_1102 | - | 8e-38 | 26.42% (564) | twin-arginine translocation pathway signal |
| M. thermoresistible (build 8) | TH_0643 | - | 4e-06 | 28.67% (143) | amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_0651 | - | 3e-37 | 25.63% (554) | hypothetical protein MUL_0651 |
| M. vanbaalenii PYR-1 | Mvan_3625 | - | 4e-36 | 28.57% (560) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0567|M.bovis_AF2122/97 -----------------------------------MADADLVMTG-TVLT
Rv0552|M.tuberculosis_H37Rv -----------------------------------MADADLVMTG-TVLT
MUL_0651|M.ulcerans_Agy99 -----------------------------------MADADVVITG-TVLT
MAV_4591|M.avium_104 ---------------------------------MHMGQADLVLTG-TVLT
MSMEG_1102|M.smegmatis_MC2_155 -----------------------------------MPAADLVFYG-TVMT
MAB_1868c|M.abscessus_ATCC_199 MSINRRQFVVGGAAATAATTGLAALAGCGHDTTDPDTGADLIFVGGPVVT
Mflv_2885|M.gilvum_PYR-GCK -------------------------------------MADVILTAKTIIT
Mvan_3625|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1579|M.marinum_M -------------------------------MSEGPTHPITVFPARKVLT
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mb0567|M.bovis_AF2122/97 VDDARPTAEAIAVADGRVIAVGDRSEVAGLVGANTRVIDL--GAGCVMPG
Rv0552|M.tuberculosis_H37Rv VDDARPTAEAIAVADGRVIAVGDRSEVAGLVGANTRVIDL--GAGCVMPG
MUL_0651|M.ulcerans_Agy99 VDDTRPTAEAIAVTDGRVVAVGDRSEVAGLIGEGTRTIDL--GSGCLMPG
MAV_4591|M.avium_104 VDEARPTAEALAVADGRIVAVGTRAEIAAHVGPHTQTVDI--GDGCVMPG
MSMEG_1102|M.smegmatis_MC2_155 VDPARPTAEALAVSGGQIVAVGDRADVAQWVGPDTDVREL--GNSCVAPG
MAB_1868c|M.abscessus_ATCC_199 VDGHGTTTEALAVAQGKIAAVGSRQDVMRLRGAQTDVIEL--DGLALLPA
Mflv_2885|M.gilvum_PYR-GCK MNADVPRAEAVAVSGDTIAAVGSVEECRRAL-PGAEVVDT--GATVLAPG
Mvan_3625|M.vanbaalenii_PYR-1 MADGAPRAQAVAVSGEKIVAVGSVDDCRAAL-PDAEVVDT--GAAALAPG
MMAR_1579|M.marinum_M MTPSLPEASAVAVADGRIVAVGSLDSMRPWLNRHEYVVDERLSDKVVLPG
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mb0567|M.bovis_AF2122/97 FVEAHGHPLLEAVVLSDRFVDIRPVTMRDA--------DDVVAAIRGEVA
Rv0552|M.tuberculosis_H37Rv FVEAHGHPLLEAVVLSDRFVDIRPVTMRDA--------DDVVAAIRGEVA
MUL_0651|M.ulcerans_Agy99 FVEAHGHPLMEAIVLSGRIVDIRPVTVRDS--------ERVVAEICREAG
MAV_4591|M.avium_104 FVEAHGHPLMEAVALSDRIVDIRPVTLANA--------DDVVAAVKSEVG
MSMEG_1102|M.smegmatis_MC2_155 FVEAHGHPLMEAVAVSDRIVDIRPVTLGTA--------DAVVDAIHAEVA
MAB_1868c|M.abscessus_ATCC_199 FVEAHSHPSQIAATLGPPAVDVRPFVVPTG--------QQVMQKLADTVR
Mflv_2885|M.gilvum_PYR-GCK FVEPHGHPLISGIATQAPARSIAPWDCPSW--------ADVLDVFAETLA
Mvan_3625|M.vanbaalenii_PYR-1 FIEPHGHPLISGVATQAPARSIAPWDCPTW--------ADVQTVFTDALA
MMAR_1579|M.marinum_M FIDPHVHPSLPAVLTQFPFLAPEDWNLPTGRFAGATTPDAFRTRLRELVD
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mb0567|M.bovis_AF2122/97 RRGP--AGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAY
Rv0552|M.tuberculosis_H37Rv RRGP--AGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAY
MUL_0651|M.ulcerans_Agy99 ERGS--AGAYLIGWDPLLQPGLPEPTLAWLDDIAPNGPLVIIHNSGHKAY
MAV_4591|M.avium_104 KRGE--AGAYLNGWDPLLQQGLPQPTLAWLDDIAPDGPLVIIHNSGHKAF
MSMEG_1102|M.smegmatis_MC2_155 KRGA--AGAYLNGWDPLLQTGLPEPTLAWLDGIAPEHPLVILHNSGHKAF
MAB_1868c|M.abscessus_ATCC_199 STPKG-TQVLLYGIDVLLQPDLQLPTRTILDALAPDHPVIIVANSGHAAY
Mflv_2885|M.gilvum_PYR-GCK TSDPD-TPLLFAGFDALLH-GHPKPHAAELDEIFGDRVALVTDNSGHGVY
Mvan_3625|M.vanbaalenii_PYR-1 TTDPD-TPLWFAGYDALLH-GHPAPDAEELDGIFGDRVALLTDNSGHGIY
MMAR_1579|M.marinum_M AHPDWSVPFVAWGYHPLWHGPIGRP---ELTAMFGTRPVILWHRSFHELI
TH_0643|M.thermoresistible__bu ------------------------------------VPVRVQHRSGVLWT
: .*
Mb0567|M.bovis_AF2122/97 FNSHAAWLNGLTRDTA-DPKGAKYGRDGNGELDGTAEEIGAI----LPLL
Rv0552|M.tuberculosis_H37Rv FNSHAAWLNGLTRDTA-DPKGAKYGRDGNGELDGTAEEIGAI----LPLL
MUL_0651|M.ulcerans_Agy99 FNTHAAWLNGLTRDTP-DPKGAKYGRDANGELDGTAEETGAV----LPLL
MAV_4591|M.avium_104 FNSRAAQRHGLNRDTP-DPKGARYGRDADGELDGTAEETGAV----FPLL
MSMEG_1102|M.smegmatis_MC2_155 FNSAAARAAGLTRDTP-DPKGAKYGRDANGDLDGTAEESAAV----FTLL
MAB_1868c|M.abscessus_ATCC_199 ANTASFRLAGITRDTP-NPVGAEYVHGPDGELTGEVREAAALTTLAMPYL
Mflv_2885|M.gilvum_PYR-GCK FNSALMRSYGWDTNPPADPVASHFGRNPDGSLDGQGFELPVVTAVTGPLM
Mvan_3625|M.vanbaalenii_PYR-1 FNSALIRSYGWDSEPPADPVASHYGRNADGSLTGQGFELPVVTAVTGPLM
MMAR_1579|M.marinum_M ANDGAIDWMGLSEQQFADLPEVDWERGRFWENGAMALVGASR------LP
TH_0643|M.thermoresistible__bu LNSAGLARIGMPDHPD----GRLRSADPDWSNSLQRRETRIA--------
* * . . .
Mb0567|M.bovis_AF2122/97 AGVADPSNFGAMLRAECARLNRAGLTTCSEMAFDPG-----YRPMVEAVR
Rv0552|M.tuberculosis_H37Rv AGVADPSNFGAMLRAECARLNRAGLTTCSEMAFDPG-----YRPMVEAVR
MUL_0651|M.ulcerans_Agy99 AGVTDPSNYPAMLRAECARLNRAGLTTCLEMAFDPG-----FRPLVEQLR
MAV_4591|M.avium_104 DGAIDTAGYPRMLHAECARLNRAGLTTCSEMAFDPR-----FRPMVEQLR
MSMEG_1102|M.smegmatis_MC2_155 GGAISVADYPAMLRAECARLNRAGLTTCSEMAFDPM-----FRPLLANLH
MAB_1868c|M.abscessus_ATCC_199 RNVAEPNAFQN-LHWAFGQLAAVGIATASEHSYSAAQQGDLYRRMAADP-
Mflv_2885|M.gilvum_PYR-GCK ATLGNPLVAAALYYAVMARG---GYTSTSDMTYDPKFAAG-YEALAAAP-
Mvan_3625|M.vanbaalenii_PYR-1 AKMGNPLVSAAHYFALMARG---GYTSTSDMTYDPKFAAG-YEALAAAP-
MMAR_1579|M.marinum_M QLLFDPARYGEGMANFFRMVHLAGVTTCLDMGVGSMGNPENEIRLINRIS
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mb0567|M.bovis_AF2122/97 --AELTVRLCTYEISNARMCTDATPGQG-----DDMLRQVGIKIWVDGSP
Rv0552|M.tuberculosis_H37Rv --AELTVRLCTYEISNARMCTDATPGQG-----DDMLRQVGIKIWVDGSP
MUL_0651|M.ulcerans_Agy99 --DELTVRLRTYEISNAQLSTEASPGDG-----DDMLRQVGIKIWVDGSP
MAV_4591|M.avium_104 --GQLTVRLRSYEISNPQLRTDATPGEG-----DDMLRQVGIKIWVDGSP
MSMEG_1102|M.smegmatis_MC2_155 --DHLTVRLRTYEMSTAALHTDAQPFEG-----DDVVRQVGIKIWVDGSP
MAB_1868c|M.abscessus_ATCC_199 ---GVKLRIRAYEMGAPELAKDPTHVAGPAAGADQLFAQIGMKLWADGSP
Mflv_2885|M.gilvum_PYR-GCK ---SCPLRVSMWEVSTSDTYSEAVTFAAG----EASLTKTGVKLWTDGSP
Mvan_3625|M.vanbaalenii_PYR-1 ---SCPLRVSMWEMSITDTYSDPATFAAG----EAWLTKAGVKLWTDGSP
MMAR_1579|M.marinum_M REIDAPSRIVLTPLISDFLARGVTPQEA------VAVVAEWAQMTSGRVG
TH_0643|M.thermoresistible__bu ---DLSAELTRYGVTG---VTDATPGLD-----------VGDVVRLTGMN
.: : :
Mb0567|M.bovis_AF2122/97 WVGNIDLTFPYLDTPATRAIGVPPGSRG---CANYTREQLAEIVGAYFPR
Rv0552|M.tuberculosis_H37Rv WVGNIDLTFPYLDTPATRAIGVPPGSRG---CANYTREQLAEIVGAYFPR
MUL_0651|M.ulcerans_Agy99 WIGNIDLSFPYLDTAATRTIGVTPGSCG---CANYTREQLAETVGAYFPL
MAV_4591|M.avium_104 WIGNIALSFPYLDTEATRTIGVTPGSCG---CANYTTEQLREIVGAYFPL
MSMEG_1102|M.smegmatis_MC2_155 WIGNIDLTFPYLDTDATRTIGVVPGSCG---HANYTPEQLAEIVDTYYPQ
MAB_1868c|M.abscessus_ATCC_199 WQGNIFTSFPYLDTAATRRMGLEPHHHG---GMNYTPAQVTELATAFIEQ
Mflv_2885|M.gilvum_PYR-GCK WVGNIAISFPYLDSEATRTAGIDPATAGGAHSMNYSREQLDAILDKAAPA
Mvan_3625|M.vanbaalenii_PYR-1 WVGNIAISFPYLDTEATRTAGIDPATAGGTQSMNYSREQLDAILDRAAPA
MMAR_1579|M.marinum_M FDHHFKLMMDGAIFSGMAQFGYPGYLDGHTGMWMAPLQVTRTWAEVFWRE
TH_0643|M.thermoresistible__bu RRGNLSQRVNCLAPGKRILHDDR-----------LDLTELTEWIATRHAA
:: . .
Mb0567|M.bovis_AF2122/97 GWQIACHVHGDGGVDTILDVYEEALRRN--PRDDHRLRLEHVGAIRPDQL
Rv0552|M.tuberculosis_H37Rv GWQIACHVHGDGGVDTILDVYEEALRRN--PRDDHRLRLEHVGAIRPDQL
MUL_0651|M.ulcerans_Agy99 GWPIACHVQGDAGVDTTLDVYEEALRSN--PRPDHRLRLEHVGAIRPEQL
MAV_4591|M.avium_104 GWQLACHVQGDAGVDTILDVYEEALKRH--PRDDHRLRLEHVGAIRPDQL
MSMEG_1102|M.smegmatis_MC2_155 GWQMACHVHGDAGVDTILDVYEKALRRW--PRDDHRLRLEHVGAITPEQL
MAB_1868c|M.abscessus_ATCC_199 GWQLACHVHGDRAIDVVLDAYEKAQSP-----ASLRSRLEHVGAMTPAQF
Mflv_2885|M.gilvum_PYR-GCK GWQMAFHANGDLALDLALDAYEDALTRHDLLGTDHRWRLEHCGAGTREHF
Mvan_3625|M.vanbaalenii_PYR-1 GWQMAFHANGDLALDLALDAYEDALTRHGLLGSDHRWRLEHCGAGTRAQF
MMAR_1579|M.marinum_M GYQLHAHTVGDLSAEALIDLVRHLQWIH--PRIGHRTVLEHFGYTTEEQN
TH_0643|M.thermoresistible__bu GGAVAIHCVTAAQLVVTLTALRAVGTHP-------QDRIEHAAVVPDDSL
* : * : . : :** .
Mb0567|M.bovis_AF2122/97 RRAAELGVTCSIFVDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRI
Rv0552|M.tuberculosis_H37Rv RRAAELGVTCSIFVDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRI
MUL_0651|M.ulcerans_Agy99 RRAADLGVTCSIFVDQIHYWGDAIVDGLFGPERGSRWMPAGSAVATGMRI
MAV_4591|M.avium_104 QRAADLGVTCSIFVDQIHYWGDVLVDGLFGEERGSRWMPAGSAVATGMRI
MSMEG_1102|M.smegmatis_MC2_155 QRAHDLGVTCSLFVDQIHYWGDIIVDGLFGAERGERWMPVGSAVATGMRV
MAB_1868c|M.abscessus_ATCC_199 QRAARLGVHPSLFIEHVYFWGDPLIDELFGQDHGAHWMSAKSALDAGLRI
Mflv_2885|M.gilvum_PYR-GCK DRAARLGVHVSLAPFQYYYWGDLLDGAIFDHEHGSRWAAFGDAVASGACV
Mvan_3625|M.vanbaalenii_PYR-1 DRAARLGVHVSLAPFQYYYWGDLLDGAMFDPEHGARWAAFGDAVASGACV
MMAR_1579|M.marinum_M LQMRELGMVVSANPYYHYLLSDIYSSEWLGSDRGAELVRLGSLERLGVPF
TH_0643|M.thermoresistible__bu EEIAALGLTVVTQPNFIAERGDQYRTDVPADEHHELWR-LKSLLDAGIPT
. **: .* :: . *
Mb0567|M.bovis_AF2122/97 SLHNDPPVTPEEPLRNISVAATRVAP-SGRVLAPEERLTVEQAIRAQTID
Rv0552|M.tuberculosis_H37Rv SLHNDPPVTPEEPLRNISVAATRVAP-SGRVLAPEERLTVEQAIRAQTID
MUL_0651|M.ulcerans_Agy99 SLHNDPPVTPEEPLRNISVAATRVAP-SDRVLAPEERLTVEQAIRAQTID
MAV_4591|M.avium_104 SLHNDPPVTPEEPLRNISVAATRKAP-SGRVLAPEERLTVEQAIRAQTLD
MSMEG_1102|M.smegmatis_MC2_155 SLHNDPPVTPEEPLRNIAVAATRTAP-SGRVLAPEQRITVEQAIRAQTID
MAB_1868c|M.abscessus_ATCC_199 SFHNDGNVSPPNPLGNIATAVTRTAKGSGRVLAPEQRISVTQAVRAQTID
Mflv_2885|M.gilvum_PYR-GCK SLHNDGSVSPPTPVVSIATTVTRRTR-GGGVHRPDQAITLDQAWRAQTID
Mvan_3625|M.vanbaalenii_PYR-1 SLHNDGSVSPPTPVINIATAVTRRTR-DGGVHRPDQAITLDQAWRAQTID
MMAR_1579|M.marinum_M GLHSDCPMAPLAPLT-LAWVAARRITINGNLNCAQERISLHAALRAITID
TH_0643|M.thermoresistible__bu ALSTDAPFGDADPWAAMRAAVHRTTG-SGAVLGADERIDAGTALRMFFGT
.: .* . * : .. * .. : .:: : * *
Mb0567|M.bovis_AF2122/97 AAWQLFAEDAIGSLQVGKYADMVVLSADPRTVPPEQIAD-LAVRATFLAG
Rv0552|M.tuberculosis_H37Rv AAWQLFAEDAIGSLQVGKYADMVVLSADPRTVPPEQIAD-LAVRATFLAG
MUL_0651|M.ulcerans_Agy99 AAWQMFADDIIGSLEVGKYADMVVLSADPRTVPPEEIAD-LEVRATFLAG
MAV_4591|M.avium_104 AAWQLFADDVIGSLEVGKYADLVVLSADPRAVPPERIAD-LQVRATYLAG
MSMEG_1102|M.smegmatis_MC2_155 AAWQLFSDDVIGSLEVGKYADLVVLSADPRATEPARIAD-LDVQATFLAG
MAB_1868c|M.abscessus_ATCC_199 AAWQLHLDNEVGSLEVGKYADLVVLSADPHAVDPQALRD-ISVRATYLAG
Mflv_2885|M.gilvum_PYR-GCK AARTLRREHLIGSIEAGKLADFVELSADPWAVAPESLIESVQVQGTWVGG
Mvan_3625|M.vanbaalenii_PYR-1 AARTLHRDHLVGSVEVGKLADFVELSADPWAVDPDALIDTVTVTGTWLGG
MMAR_1579|M.marinum_M AAWIMRKENDLGSIRAGKYADFTVLEDDPYQVGVDGLKD-LPIWGTVFEG
TH_0643|M.thermoresistible__bu ADRPTRPR----TVEPGQPADLCVLSAPPDRVLRELSAE--LVSATIVGG
* ::. *: **: *. * . : : .* . *
Mb0567|M.bovis_AF2122/97 RQVYRR--------------------------
Rv0552|M.tuberculosis_H37Rv RQVYRR--------------------------
MUL_0651|M.ulcerans_Agy99 RQVYRK--------------------------
MAV_4591|M.avium_104 RRVYPQ--------------------------
MSMEG_1102|M.smegmatis_MC2_155 RQVYPALG------------------------
MAB_1868c|M.abscessus_ATCC_199 RQTYAAPVG-----------------------
Mflv_2885|M.gilvum_PYR-GCK RRVDLDEFLTEVGGADAAVHTHLGQRTTKNCC
Mvan_3625|M.vanbaalenii_PYR-1 RRIDLDEFLAAVGGADNAAHAHLAERNAKSCC
MMAR_1579|M.marinum_M QVRSLPS-------------------------
TH_0643|M.thermoresistible__bu KPVYQKPV------------------------
: