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MTQLYIQDVTLRDGMHAIRHQISPTAVARIASALEAAGVNAIEVAHGDGLAGGSVNYGPGSNTDWEWIEA AADAVTTAKLTTLLLPGIGTVAELKRAYSLGVRSIRVAAHCTEADITAQHITMARELGMDVSGFLMLSHM ASAETLAEQAKLMETFGAHCVYVTDSGGRLTMPMVRDRVRAYRDVLDSHTEIGIHAHENLSLSVANSVVA VEEGATRIDASLAGHGAGAGNCPLEAFVAVADLHGWGHSCDLFALQDAADDLVRPLHDRPVRVDRETLTL GYAGVYSSFLRHAEAAAQRYDVDVRSILIEAGRRRLVGGQEDMLVDIALSLST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4375 | - | - | 100% (333) | 4-hydroxy-2-ketovalerate aldolase |
| M. abscessus ATCC 19977 | MAB_0626 | - | 1e-82 | 47.85% (326) | 4-hydroxy-2-ketovalerate aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3564c | - | 2e-84 | 48.34% (331) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_1522 | - | 1e-83 | 48.15% (324) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv3534c | - | 2e-84 | 48.34% (331) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1506 | - | 1e-120 | 66.46% (328) | 4-hydroxy-2-oxovalerate aldolase |
| M. avium 104 | MAV_0627 | - | 4e-84 | 47.73% (331) | 4-hydroxy-2-ketovalerate aldolase |
| M. smegmatis MC2 155 | MSMEG_4150 | - | 1e-116 | 61.75% (332) | 4-hydroxy-2-ketovalerate aldolase |
| M. thermoresistible (build 8) | TH_0371 | - | 1e-83 | 48.16% (326) | PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) |
| M. ulcerans Agy99 | MUL_2435 | - | 1e-119 | 66.16% (328) | 4-hydroxy-2-ketovalerate aldolase |
| M. vanbaalenii PYR-1 | Mvan_4391 | - | 1e-148 | 78.85% (331) | 4-hydroxy-2-ketovalerate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1522|M.gilvum_PYR-GCK MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIVAALDAAGVP
MAV_0627|M.avium_104 -MTTDIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIVAALDVAGVP
TH_0371|M.thermoresistible__bu -MTTDIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIVAALDTAGVP
Mb3564c|M.bovis_AF2122/97 -------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVP
Rv3534c|M.tuberculosis_H37Rv -------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVP
MAB_4375|M.abscessus_ATCC_1997 ----------MTQLYIQDVTLRDGMHAIRHQISPTAVARIASALEAAGVN
Mvan_4391|M.vanbaalenii_PYR-1 ---------MTTTVYVQDVTLRDGMHAIRHRISPRNVARIAAALDRAGVD
MMAR_1506|M.marinum_M ---------MIRDLYISDVTLRDGMHAVRHQYSIAQAVAIARALDDAGVD
MUL_2435|M.ulcerans_Agy99 ---------MIGDLYISDVTLRDGMHAVRHQDGIAQAVAIARALDDAGVD
MSMEG_4150|M.smegmatis_MC2_155 --------MTMTRLFITDVTLRDGMHAIGHRYDRGQVREIAAALDEAGVD
: : *.:**** * *: . *. **: ***
Mflv_1522|M.gilvum_PYR-GCK VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIAFLMLPGVGT
MAV_0627|M.avium_104 VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIAFLMLPGVGT
TH_0371|M.thermoresistible__bu VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIAFLMLPGVGT
Mb3564c|M.bovis_AF2122/97 VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGT
Rv3534c|M.tuberculosis_H37Rv VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGT
MAB_4375|M.abscessus_ATCC_1997 AIEVAHGDGLAGGSVNYGPGSNTDWEWIEAAADAVTTAKLTTLLLPGIGT
Mvan_4391|M.vanbaalenii_PYR-1 AIEVAHGDGLAGSSLSYGPGSHTDWEWIDAVAGAVTNATVTTLLLPGIGT
MMAR_1506|M.marinum_M SIEVAHGDGLGGSSCCYGFGAHTDLQWIEAVAGAVDRARVATLLLPGIGS
MUL_2435|M.ulcerans_Agy99 SIEVAHGDGLGGSSCCYGFGAHTDLEWIEAVAGAVDRARVATLLLPGIGG
MSMEG_4150|M.smegmatis_MC2_155 AIEVGHGDGLNGSSLAYGFSRHSDLSYIHEAASVTRRAKLACVLLPGIGT
*** ***** *.* ** . .: . *. .* .. : :: ::***:*
Mflv_1522|M.gilvum_PYR-GCK KEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHT
MAV_0627|M.avium_104 KEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHT
TH_0371|M.thermoresistible__bu KDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
Mb3564c|M.bovis_AF2122/97 KDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
Rv3534c|M.tuberculosis_H37Rv KDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
MAB_4375|M.abscessus_ATCC_1997 VAELKRAYSLGVRSIRVAAHCTEADITAQHITMARELGMDVSGFLMLSHM
Mvan_4391|M.vanbaalenii_PYR-1 VAQLDEAYRRGVRSVRVATHCTEADIAAQHIAHARELGMDVSGFLMMSHM
MMAR_1506|M.marinum_M VANLEDAHRAGASVVRVGTHCTEADLAARYLGAARDLGMDAVGFLMMSHL
MUL_2435|M.ulcerans_Agy99 VAHLEDAHRAGATVVRVGTHCTEADLAARYLGAARDLGMDAVGFLMMSHL
MSMEG_4150|M.smegmatis_MC2_155 IEDLKRARDSGIELVRIATHCTEADVSAQHISAAVELGFHVSGFLMMSSA
.:. * * *:.:******:: ::: * :**:.. ****::
Mflv_1522|M.gilvum_PYR-GCK ISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSALVAELGDDA
MAV_0627|M.avium_104 IPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDA
TH_0371|M.thermoresistible__bu IPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDA
Mb3564c|M.bovis_AF2122/97 IAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDA
Rv3534c|M.tuberculosis_H37Rv IAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDA
MAB_4375|M.abscessus_ATCC_1997 ASAETLAEQAKLMETFGAHCVYVTDSGGRLTMPMVRDRVRAYRDVLDSHT
Mvan_4391|M.vanbaalenii_PYR-1 AQPADLAAQAKLMESFGAQSVYVTDSGGRLTMHDVRDRVLAYRDVLAPST
MMAR_1506|M.marinum_M TTPKRLAEQAKLLEGYGASCVYVVDSGGALTGAAVAQRFDALRQNLDPAT
MUL_2435|M.ulcerans_Agy99 TTPKLLAEQAKLLEGYGASCVYVVDSGGAMTGAAVAQRFDALRQNLDPAT
MSMEG_4150|M.smegmatis_MC2_155 TTPENIGVQAAKMESYGAQCVYIADSAGNLTPAGTTARFQALEAALDGAT
. :. ** : *. .**:.**.* :. . *. * * :
Mflv_1522|M.gilvum_PYR-GCK QVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
MAV_0627|M.avium_104 QVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
TH_0371|M.thermoresistible__bu QVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
Mb3564c|M.bovis_AF2122/97 QVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
Rv3534c|M.tuberculosis_H37Rv QVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
MAB_4375|M.abscessus_ATCC_1997 EIGIHAHENLSLSVANSVVAVEEGATRIDASLAGHGAGAGNCPLEAFVAV
Mvan_4391|M.vanbaalenii_PYR-1 QIGIHAHENLSLAVANSVAAVEAGATRVDASLAGQGAGAGNCPIEPFVAV
MMAR_1506|M.marinum_M ELGIHAHHNLSLGVANSVVAVEHGARRIDASLAGMGAGAGNAPLEVLIAV
MUL_2435|M.ulcerans_Agy99 ELGIHAHHNLSLGVANSVVAVEHGARRIDASLAGMGAGAGNVPLEVLIAV
MSMEG_4150|M.smegmatis_MC2_155 QRGIHAHENLSLSVANTVVAVENGARRVDAALAGMGAGAGNCPIEAFIAV
: *:*.*.**.*.***:: **. ** ::*.: ****** *:* ::.*
Mflv_1522|M.gilvum_PYR-GCK FDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
MAV_0627|M.avium_104 FDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
TH_0371|M.thermoresistible__bu FDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMGYSGVYSSFL
Mb3564c|M.bovis_AF2122/97 FDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFL
Rv3534c|M.tuberculosis_H37Rv FDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFL
MAB_4375|M.abscessus_ATCC_1997 ADLHGWGHSCDLFALQDAADDLVRPLHDRPVRVDRETLTLGYAGVYSSFL
Mvan_4391|M.vanbaalenii_PYR-1 ADLFGWKHGCDLFALQDAADDIVRPLRDRPVRVDRETLTLGFAGVYSSFL
MMAR_1506|M.marinum_M VNRLGWTHGCELNALEDAADDLVRPLQDRPVRIDRETLTLGYAGVYSSFL
MUL_2435|M.ulcerans_Agy99 VNRLGWTHGCELNALEDAADDLVRPLQDRPVRIDRETLTLGYAGVYSSFL
MSMEG_4150|M.smegmatis_MC2_155 ANKYGWEHGCELFKLQDAAEDLVRPLQDRPVRVDRQTLTLGYAGVYSSFL
: * . :: : ***:::* * :**::* :*::*******
Mflv_1522|M.gilvum_PYR-GCK KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQEAEAT
MAV_0627|M.avium_104 KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQESGAA
TH_0371|M.thermoresistible__bu KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKRELEEQAG
Mb3564c|M.bovis_AF2122/97 KHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAA
Rv3534c|M.tuberculosis_H37Rv KHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAA
MAB_4375|M.abscessus_ATCC_1997 RHAEAAAQRYDVDVRSILIEAGRRRLVGGQEDMLVDIALSLST-------
Mvan_4391|M.vanbaalenii_PYR-1 RHAEDASARYGVDTRAILVEVGRRGLIGGQEDMIVDIALSLSAGVP----
MMAR_1506|M.marinum_M RHAEVTAGRYGVDARSLLEEAGRRGLIGGQEDLLVDIALDLVGPAEPLAH
MUL_2435|M.ulcerans_Agy99 RHAEITAGRYGVDARSLLEEAGRRGLIGGQEDLLVDIALDLVGPAEPLAH
MSMEG_4150|M.smegmatis_MC2_155 RHAERAANEFDIDVREIILEIGRRELIGGQEDMIIDVALDLAAHQSAQSP
:** : .:.: . :: . *:* *:***** ::*:**.:
Mflv_1522|M.gilvum_PYR-GCK RA--
MAV_0627|M.avium_104 AAR-
TH_0371|M.thermoresistible__bu STA-
Mb3564c|M.bovis_AF2122/97 VTH-
Rv3534c|M.tuberculosis_H37Rv VTH-
MAB_4375|M.abscessus_ATCC_1997 ----
Mvan_4391|M.vanbaalenii_PYR-1 ----
MMAR_1506|M.marinum_M GAP-
MUL_2435|M.ulcerans_Agy99 GAP-
MSMEG_4150|M.smegmatis_MC2_155 NRTG