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TDTTAANASWAFETKQVHAGQTPDIATNARALPIYQTTSYTFNSTDHAAALFGLAEPGNIYTRIMNPTTD VVEQRIAALEGGVAALFLASGQAAETFAILNLANHGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVENP DDLESWRAAARPNTKAFFGETISNPQIDILDIPGVAGVAHEVGVPLIVDNTIATPYLIQPLSHGADIVVH SATKYLGGHGSAIAGVIVDGGTFDWTAGGRFPGFTSPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAA SPFNAFLIAQGLETLSLRIERHVQNARQVAEFLDAHPDVVSVNYAGLPSSPWYDLGKKLAPKGTGAVLAF ELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHQQLSAEEQLASGVTPGLVRLAVGIEGIEDI LTDLERGFAAAKPFSAAADPNTVASF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1554 | - | - | 100% (447) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0688 | - | 9e-64 | 36.07% (402) | O-succinylhomoserine sulfhydrylase |
| M. vanbaalenii PYR-1 | Mvan_4670 | - | 2e-59 | 35.49% (417) | cystathionine gamma-synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3372 | metC | 0.0 | 83.60% (439) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. gilvum PYR-GCK | Mflv_4875 | - | 0.0 | 90.38% (447) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. tuberculosis H37Rv | Rv3340 | metC | 0.0 | 83.60% (439) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. leprae Br4923 | MLBr_00275 | metZ | 8e-58 | 34.00% (400) | O-succinylhomoserine sulfhydrylase |
| M. abscessus ATCC 19977 | MAB_3687 | - | 0.0 | 77.22% (439) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. marinum M | MMAR_1185 | metC | 0.0 | 83.33% (438) | O-acetylhomoserine sulfhydrylase MetC |
| M. avium 104 | MAV_4315 | - | 0.0 | 84.15% (448) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. smegmatis MC2 155 | MSMEG_1652 | - | 0.0 | 87.44% (430) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. thermoresistible (build 8) | TH_1970 | metC | 0.0 | 89.34% (441) | PROBABLE O-ACETYLHOMOSERINE SULFHYDRYLASE METC (HOMOCYSTEINE |
| M. ulcerans Agy99 | MUL_1438 | metC | 0.0 | 83.11% (438) | O-acetylhomoserine aminocarboxypropyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3372|M.bovis_AF2122/97 -----MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTS
Rv3340|M.tuberculosis_H37Rv -----MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTS
MMAR_1185|M.marinum_M -----MSAENTSTDADPTAHWSFETKQIHAGQQPDSATNARALPIYQTTS
MUL_1438|M.ulcerans_Agy99 -----MSAENTSTDADPTAHWSFETKQIHAGQQPDSATNARALPIYQTTS
MAV_4315|M.avium_104 -----MSSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTS
Mvan_1554|M.vanbaalenii_PYR-1 --------MTDTTAAN--ASWAFETKQVHAGQTPDIATNARALPIYQTTS
Mflv_4875|M.gilvum_PYR-GCK --------MTDPDLT---AGWAFETKQVHAGQTPDSATNARALPIYQTTS
TH_1970|M.thermoresistible__bu --------MTNSEQDDPTAKWSFETKQVHAGQTPDPATNARALPIYQTTS
MSMEG_1652|M.smegmatis_MC2_155 --------MTTPDPT---ENWSFETKQIHAGQSPDSATHARALPIYQTTS
MAB_3687|M.abscessus_ATCC_1997 MTDIDPTTADSRSDKPRSAQWAFETKQIHAGQSADAATNARALPIYQTTS
MLBr_00275|M.leprae_Br4923 -----MTDDRSVRTPKALPDGVTAATVGVRGGLLRSRFEETAETMYLTSG
:. * . * .:* *:.
Mb3372|M.bovis_AF2122/97 YTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
Rv3340|M.tuberculosis_H37Rv YTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
MMAR_1185|M.marinum_M YTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALEGGVAALFLS
MUL_1438|M.ulcerans_Agy99 YTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALEGGVAALFLS
MAV_4315|M.avium_104 YTFDDTTHAAALFGLEVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
Mvan_1554|M.vanbaalenii_PYR-1 YTFNSTDHAAALFGLAEPGNIYTRIMNPTTDVVEQRIAALEGGVAALFLA
Mflv_4875|M.gilvum_PYR-GCK YIFDSTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALFLS
TH_1970|M.thermoresistible__bu YTFDSTEHAAALFGLSEPGNIYTRIMNPTQDVVEKRIAALEGGVAALFLA
MSMEG_1652|M.smegmatis_MC2_155 YTFDDTSHAAALFGLEVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS
MAB_3687|M.abscessus_ATCC_1997 YVFNDTAHAAALFGLSEEGNIYTRIGNPTQDVVEQRIAALEGGVAALLLA
MLBr_00275|M.leprae_Br4923 YVYESAVVAEKSFTGELDHFVYSRYGNPTVTMFEERLRLIEGAPAAFVTA
* ::.: * * :*:* *** :.*:*: :**. **:. :
Mb3372|M.bovis_AF2122/97 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
Rv3340|M.tuberculosis_H37Rv SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
MMAR_1185|M.marinum_M SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
MUL_1438|M.ulcerans_Agy99 SGQAAETFGILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDD
MAV_4315|M.avium_104 SGQAAETFAILNLASAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVED
Mvan_1554|M.vanbaalenii_PYR-1 SGQAAETFAILNLANHGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEN
Mflv_4875|M.gilvum_PYR-GCK SGQAAETLAILNIAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVED
TH_1970|M.thermoresistible__bu SGQAAETFAILNLANAGDHIVASPRLYGGTYNLFQHTLPKLGIETTFVEN
MSMEG_1652|M.smegmatis_MC2_155 SGQAAETFAILNIAKAGDHIVSSPRLYGGTYNLLHYTLPKLGIETTFVEN
MAB_3687|M.abscessus_ATCC_1997 SGQAAATLAIVNIAQAGDNIVSSPRLYGGTYNLLHYTLPRLGISTTFVED
MLBr_00275|M.leprae_Br4923 SGMAAVFTSLGALLASGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDG
** ** .: : **.:*:: *:*. : : : *.: *:.. **:.
Mb3372|M.bovis_AF2122/97 PDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVD
Rv3340|M.tuberculosis_H37Rv PDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVD
MMAR_1185|M.marinum_M PDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGIPLIVD
MUL_1438|M.ulcerans_Agy99 PDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGIPLIVD
MAV_4315|M.avium_104 PDDLDSWQAAVRPNTKAFFAETISNPQIDILDIPGVSGVAHANGVPLIVD
Mvan_1554|M.vanbaalenii_PYR-1 PDDLESWRAAARPNTKAFFGETISNPQIDILDIPGVAGVAHEVGVPLIVD
Mflv_4875|M.gilvum_PYR-GCK PDDLESWRAASRPNTKAFFAETISNPKIDVLDIPGVSGVAHDIGVPLIVD
TH_1970|M.thermoresistible__bu PDDLDSWRAAVRPNTKAFFGESISNPKIDILDIPNVAAVAHEAGVPLIVD
MSMEG_1652|M.smegmatis_MC2_155 PDDLESWRAAVRPNTKAFFAETISNPQIDILDIPNVAAIAHEAGVPLIVD
MAB_3687|M.abscessus_ATCC_1997 PDDLESWRNAITPDTKALFAESISNPQNDILDIAGLSEIAHAAGIPLIVD
MLBr_00275|M.leprae_Br4923 -EDLVQWEQALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLD
::* *. * *:*.* *: *** .::* . :: :** * :::*
Mb3372|M.bovis_AF2122/97 NTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-G
Rv3340|M.tuberculosis_H37Rv NTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-G
MMAR_1185|M.marinum_M NTIATPYLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQ-G
MUL_1438|M.ulcerans_Agy99 NTIATPYLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQ-G
MAV_4315|M.avium_104 NTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTQ-G
Mvan_1554|M.vanbaalenii_PYR-1 NTIATPYLIQPLSHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTAGG
Mflv_4875|M.gilvum_PYR-GCK NTIATPYLIQPLSHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTASG
TH_1970|M.thermoresistible__bu NTIATPYLIQPLSHGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTN-G
MSMEG_1652|M.smegmatis_MC2_155 NTIATPYLIQPIAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTN-G
MAB_3687|M.abscessus_ATCC_1997 NTVATPYLIQPLAHGADVVVHSATKYLGGHGNAIGGVIIDGGTFDWTQ-G
MLBr_00275|M.leprae_Br4923 NAFATPLLQHGLPLGVDVVIYSGTKHIDGQGRVLGGAILGDR--------
*:.*** * : :. *.*:*::*.**::.*:* .:.*.*:..
Mb3372|M.bovis_AF2122/97 RFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVA
Rv3340|M.tuberculosis_H37Rv RFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVA
MMAR_1185|M.marinum_M RFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAASPFNAFLVA
MUL_1438|M.ulcerans_Agy99 RFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAASPFNAFLVA
MAV_4315|M.avium_104 RFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVA
Mvan_1554|M.vanbaalenii_PYR-1 RFPGFTSPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAASPFNAFLIA
Mflv_4875|M.gilvum_PYR-GCK RFPGFTEPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLIA
TH_1970|M.thermoresistible__bu KFPGFTEPDPSYHGVVFAELGPPAFALKARVQLLRDLGSAAAPFNAFLIA
MSMEG_1652|M.smegmatis_MC2_155 KFPGFTEPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAAAPFNAFLIA
MAB_3687|M.abscessus_ATCC_1997 RHPGFTTPDPSYHGVVFADLGAPAYALKARVQLLRDLGPAISPFNAFLIA
MLBr_00275|M.leprae_Br4923 -----------------------DYIDGPVQKLMRHTGPAMSAFNAWILL
: . :*:*. *.* :.***:::
Mb3372|M.bovis_AF2122/97 QGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRL
Rv3340|M.tuberculosis_H37Rv QGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRL
MMAR_1185|M.marinum_M QGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKL
MUL_1438|M.ulcerans_Agy99 QGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKL
MAV_4315|M.avium_104 QGIETLSLRMERHVANAQRVAEFLASHDGVLSVNYAGLPGSPWHERAKKL
Mvan_1554|M.vanbaalenii_PYR-1 QGLETLSLRIERHVQNARQVAEFLDAHPDVVSVNYAGLPSSPWYDLGKKL
Mflv_4875|M.gilvum_PYR-GCK QGLETLSLRIERHVQNAQRVAEFLEAHPDVVSVNYAGLPSSPWYGLGKKL
TH_1970|M.thermoresistible__bu QGLETLSLRVERHVENAQKVAEYLEAHPDVVSVNYAGLPSSPWYDLGKKL
MSMEG_1652|M.smegmatis_MC2_155 QGLETLSLRVERHVANAQKVAEFLENHPDVSSVNYAGLPSSPWYELGRKL
MAB_3687|M.abscessus_ATCC_1997 QGLETLSLRVERHVANAQRVAEFLVAQPEVTRVNYAGLPTSPWYERAKAL
MLBr_00275|M.leprae_Br4923 KGLETLAIRVDHCNSSAHRIAEFLEKHPAVSWVRYPFLVSHPQYDLAKRQ
:*:***::*::: .*:::**:* : * *.*. * * : .:
Mb3372|M.bovis_AF2122/97 APKGTGAVLSFELAGGIEAGKA----FVNALKLHSHVANIGDVRSLVIHP
Rv3340|M.tuberculosis_H37Rv APKGTGAVLSFELAGGIEAGKA----FVNALKLHSHVANIGDVRSLVIHP
MMAR_1185|M.marinum_M SPKGTGAVLSFELAGGVEAGKA----FVNALKLHSHVANIGDVRSLVIHP
MUL_1438|M.ulcerans_Agy99 SPKGTGAVLSFELAGGVEAGKA----FVNALKLHSHVANIGDVRSLVIHP
MAV_4315|M.avium_104 APKGTGAVLSFELAGGVEAGKA----FVNALKLHSHVANIGDVRSLVIHP
Mvan_1554|M.vanbaalenii_PYR-1 APKGTGAVLAFELAGGVEAGKA----FVNALTLHSHVANIGDVRSLVIHP
Mflv_4875|M.gilvum_PYR-GCK APKGTGAVLAFELSGGIDAGKA----FVNALSLHSHVANIGDVRSLVIHP
TH_1970|M.thermoresistible__bu APKGTGAVLAFELAGGVEAGKA----FVNALTLHSHVANIGDVRSLVIHP
MSMEG_1652|M.smegmatis_MC2_155 APKGTGAVLAFELSGGLEAGKA----FVNALTLHSHVANIGDVRSLVIHP
MAB_3687|M.abscessus_ATCC_1997 APKGAGAVLAFELDGGVEAATT----FIDSLTLHSQVANIGDVRSLVIHP
MLBr_00275|M.leprae_Br4923 MS-GGGTVVTFALNSPEDAAKQRAFEVLDRLRLIDISNNFGDVKSLITHP
. * *:*::* * . :*.. .:: * * . *:***:**: **
Mb3372|M.bovis_AF2122/97 ASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFS
Rv3340|M.tuberculosis_H37Rv ASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFS
MMAR_1185|M.marinum_M ASTTHAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILADLELGFAAARKFS
MUL_1438|M.ulcerans_Agy99 ASTTHAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILADLELGFAAAREFS
MAV_4315|M.avium_104 ASTTHAQLSPAEQLSTGVSPGLVRLAVGIEGIDDILADLELGFAAAAKFG
Mvan_1554|M.vanbaalenii_PYR-1 ASTTHQQLSAEEQLASGVTPGLVRLAVGIEGIEDILTDLERGFAAAKPFS
Mflv_4875|M.gilvum_PYR-GCK ASTTHQQLSPEEQLASGVTPGLVRLAVGIEGIDDILADLELGFAAAKPSA
TH_1970|M.thermoresistible__bu ASTTHAQLSPEDQLATGVTPGLVRLAVGIEGIDDIIADLEQGFAAAKPFT
MSMEG_1652|M.smegmatis_MC2_155 ASTTHQQLSPEEQLSTGVTPGLVRLAVGLEGIDDIIADLEQGFAAARPFS
MAB_3687|M.abscessus_ATCC_1997 ATTTHGQLSPAEQVASGVTPGLVRLAVGIEGIDDILADLESGFTAVRRLK
MLBr_00275|M.leprae_Br4923 ATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIADIDQALS------
*:*** :.. : : *: *:**:::*:*. *:::*:: .::
Mb3372|M.bovis_AF2122/97 A-------DPQSVAAF
Rv3340|M.tuberculosis_H37Rv A-------DPQSVAAF
MMAR_1185|M.marinum_M G-------DSQAVAAI
MUL_1438|M.ulcerans_Agy99 G-------DSQAVAAI
MAV_4315|M.avium_104 ANAGTSGADPHAVAAF
Mvan_1554|M.vanbaalenii_PYR-1 AAA-----DPNTVASF
Mflv_4875|M.gilvum_PYR-GCK AAT-----DPNAVASF
TH_1970|M.thermoresistible__bu ASAG---GDPQTVASF
MSMEG_1652|M.smegmatis_MC2_155 GAA-------QTAQTV
MAB_3687|M.abscessus_ATCC_1997 Q--------PAAVASS
MLBr_00275|M.leprae_Br4923 ----------------