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MSVVGTPKSAEQIQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLWEQLHDMDFVNALG ALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALLRADEIAKVEND RSVDNWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLT SARLAADVADVPTVVIARTDAEAATLITSDVDERDRPFITGERTKEGFYRIKNGLEPCIARAKAYAPFSD LIWMETGTPDLKLAKQFAEGVKAEFPDQMLAYNCSPSFNWKKHLDDETIAKFQKELGAMGFKFQFITLAG FHALNYSMFDLAYGYARNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAG STEEGQFH
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0792 | icl | - | 100% (428) | isocitrate lyase Icl |
M. marinum M | MMAR_2821 | aceAb | 3e-39 | 36.63% (243) | isocitrate lyase AceAb |
M. marinum M | MMAR_1380 | - | 1e-08 | 28.32% (173) | methylisocitrate lyase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0476 | icl | 0.0 | 91.36% (428) | isocitrate lyase |
M. gilvum PYR-GCK | Mflv_0107 | - | 0.0 | 94.86% (428) | isocitrate lyase |
M. tuberculosis H37Rv | Rv0467 | icl | 0.0 | 91.36% (428) | isocitrate lyase |
M. leprae Br4923 | MLBr_01985 | aceA | 2e-40 | 36.73% (245) | isocitrate lyase |
M. abscessus ATCC 19977 | MAB_4095c | - | 0.0 | 84.19% (430) | isocitrate lyase (AceA) |
M. avium 104 | MAV_4682 | aceA | 0.0 | 92.29% (428) | isocitrate lyase |
M. smegmatis MC2 155 | MSMEG_0911 | aceA | 0.0 | 95.56% (428) | isocitrate lyase |
M. thermoresistible (build 8) | TH_4509 | - | 0.0 | 89.95% (428) | PUTATIVE isocitrate lyase |
M. ulcerans Agy99 | MUL_4536 | icl | 0.0 | 99.53% (428) | isocitrate lyase Icl |
M. vanbaalenii PYR-1 | Mvan_0801 | - | 0.0 | 95.33% (428) | isocitrate lyase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_0792|M.marinum_M ----------------------MSVVGTPKSAEQ---------------- MUL_4536|M.ulcerans_Agy99 ----------------------MSVVGTPKCAEQ---------------- Mflv_0107|M.gilvum_PYR-GCK ----------------------MSTVGMPKSPEQ---------------- Mvan_0801|M.vanbaalenii_PYR-1 ----------------------MSTVGTPKSPEQ---------------- MSMEG_0911|M.smegmatis_MC2_155 ----------------------MSTVGTPKSPEQ---------------- Mb0476|M.bovis_AF2122/97 ----------------------MSVVGTPKSAEQ---------------- Rv0467|M.tuberculosis_H37Rv ----------------------MSVVGTPKSAEQ---------------- MAV_4682|M.avium_104 ----------------------MSVVGTPKSAEE---------------- TH_4509|M.thermoresistible__bu ----------------------MSNVGTPRSAEQ---------------- MAB_4095c|M.abscessus_ATCC_199 ----------------------MSNVGKPRTAAE---------------- MLBr_01985|M.leprae_Br4923 MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLF * :* . MMAR_0792|M.marinum_M -----IQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLW MUL_4536|M.ulcerans_Agy99 -----IQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLW Mflv_0107|M.gilvum_PYR-GCK -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW Mvan_0801|M.vanbaalenii_PYR-1 -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW MSMEG_0911|M.smegmatis_MC2_155 -----IQHDWDHNPRWKGIKRDYTPEDVVALQGTVVEEHTLARRGAEVLW Mb0476|M.bovis_AF2122/97 -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW Rv0467|M.tuberculosis_H37Rv -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW MAV_4682|M.avium_104 -----IQKDWDTNPRWKDVTRTYTAEDVVALQGTVVEENTLARRGAEVLW TH_4509|M.thermoresistible__bu -----IKKDWETNPRWKNVKRDYTAEDVVALQGTVVEEHTLARRGAEILW MAB_4095c|M.abscessus_ATCC_199 -----IQQDWDTNPRWKGITRDYTAAQVEELQGSVVEENTLARRGAEILW MLBr_01985|M.leprae_Br4923 TQEVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFY ::: :**: .: * *:. :* :* : : *:** .: :: MMAR_0792|M.marinum_M EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG MUL_4536|M.ulcerans_Agy99 EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG Mflv_0107|M.gilvum_PYR-GCK EQLH----DMDFVNSLGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG Mvan_0801|M.vanbaalenii_PYR-1 DQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG MSMEG_0911|M.smegmatis_MC2_155 EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG Mb0476|M.bovis_AF2122/97 EQLH----DLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG Rv0467|M.tuberculosis_H37Rv EQLH----DLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG MAV_4682|M.avium_104 EQLH----DLEYINALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG TH_4509|M.thermoresistible__bu NQLH----DMEFVNALGALTGNQAVQQVRAGLKAIYLSGWQVAGDANLSG MAB_4095c|M.abscessus_ATCC_199 DAVSKD--DDSYINALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG MLBr_01985|M.leprae_Br4923 ARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITE : . :.::*. : . **. * *::****.** .:....:: MMAR_0792|M.marinum_M HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------NDRSVD MUL_4536|M.ulcerans_Agy99 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------NDRSVD Mflv_0107|M.gilvum_PYR-GCK HTYPDQSLYPANSVPQVIRRINNALLRADEIAKVE---------GDTSVE Mvan_0801|M.vanbaalenii_PYR-1 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------GDTSVE MSMEG_0911|M.smegmatis_MC2_155 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------GDTSVE Mb0476|M.bovis_AF2122/97 HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE Rv0467|M.tuberculosis_H37Rv HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE MAV_4682|M.avium_104 HTYPDQSLYPANSVPTVVRRINNALLRADQIAKVE---------GDTSVK TH_4509|M.thermoresistible__bu HTYPDQSLYPANSVPQVVRRINNALMRADQIAKVE---------GDTSVE MAB_4095c|M.abscessus_ATCC_199 HTYPDQSLYPANSVPAVVRRINNALLRADEIARVE---------GDTSVD MLBr_01985|M.leprae_Br4923 DPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAY .. ** : ** ..** : .** **. : .. MMAR_0792|M.marinum_M NWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL MUL_4536|M.ulcerans_Agy99 NWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL Mflv_0107|M.gilvum_PYR-GCK NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL Mvan_0801|M.vanbaalenii_PYR-1 NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL MSMEG_0911|M.smegmatis_MC2_155 NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL Mb0476|M.bovis_AF2122/97 NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL Rv0467|M.tuberculosis_H37Rv NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL MAV_4682|M.avium_104 NWLAPIVADGEAGFGGALNVFELQKAMIAAGVAGSHWEDQLASEKKCGHL TH_4509|M.thermoresistible__bu NWLVPIVADGEAGFGGALNVYELQKAMITAGVAGSHWEDQLASEKKCGHL MAB_4095c|M.abscessus_ATCC_199 NWLVPIVADGEAGFGGALNVYELQKAMIAAGAAGTHWEDQLASEKKCGHL MLBr_01985|M.leprae_Br4923 DYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGTKKCGHQ :: *:**.::*.** :* :* : :: *..* * *** .. ***** MMAR_0792|M.marinum_M GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER MUL_4536|M.ulcerans_Agy99 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER Mflv_0107|M.gilvum_PYR-GCK GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER Mvan_0801|M.vanbaalenii_PYR-1 GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER MSMEG_0911|M.smegmatis_MC2_155 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER Mb0476|M.bovis_AF2122/97 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER Rv0467|M.tuberculosis_H37Rv GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER MAV_4682|M.avium_104 GGKVLIPTQQHIRTLTSARLAADVCDVPTVVIARTDAEAATLITSDVDER TH_4509|M.thermoresistible__bu GGKVLIPTQQHIRTLTAARLAADVADVPTVIIARTDAEAATLITSDVDER MAB_4095c|M.abscessus_ATCC_199 GGKVLIPTQQHIRTLTSARLAADVANTPTVVIARTDAEAATLITSDVDER MLBr_01985|M.leprae_Br4923 GGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADER *****:*::::*: *.:**: *: .* :::********.** * .*** MMAR_0792|M.marinum_M DRPFITGER----------------------------------------- MUL_4536|M.ulcerans_Agy99 DRPFITGEP----------------------------------------- Mflv_0107|M.gilvum_PYR-GCK DQPFITGDR----------------------------------------- Mvan_0801|M.vanbaalenii_PYR-1 DRPFITGER----------------------------------------- MSMEG_0911|M.smegmatis_MC2_155 DQPFITGER----------------------------------------- Mb0476|M.bovis_AF2122/97 DQPFITGER----------------------------------------- Rv0467|M.tuberculosis_H37Rv DQPFITGER----------------------------------------- MAV_4682|M.avium_104 DQPFITGER----------------------------------------- TH_4509|M.thermoresistible__bu DRPFITGER----------------------------------------- MAB_4095c|M.abscessus_ATCC_199 DKPFVTGER----------------------------------------- MLBr_01985|M.leprae_Br4923 DQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAA *:**: * MMAR_0792|M.marinum_M -------------------------------------------------- MUL_4536|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0107|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0911|M.smegmatis_MC2_155 -------------------------------------------------- Mb0476|M.bovis_AF2122/97 -------------------------------------------------- Rv0467|M.tuberculosis_H37Rv -------------------------------------------------- MAV_4682|M.avium_104 -------------------------------------------------- TH_4509|M.thermoresistible__bu -------------------------------------------------- MAB_4095c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01985|M.leprae_Br4923 ASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGL MMAR_0792|M.marinum_M -------------------------------------------------- MUL_4536|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0107|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0911|M.smegmatis_MC2_155 -------------------------------------------------- Mb0476|M.bovis_AF2122/97 -------------------------------------------------- Rv0467|M.tuberculosis_H37Rv -------------------------------------------------- MAV_4682|M.avium_104 -------------------------------------------------- TH_4509|M.thermoresistible__bu -------------------------------------------------- MAB_4095c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01985|M.leprae_Br4923 MTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVD MMAR_0792|M.marinum_M ---------TKEGFYRIKNGLEPCIARAKAYAPFSDLIWMETGTPDLKLA MUL_4536|M.ulcerans_Agy99 ---------TKEGFYRIKNGLEPCIARAKAYAPFSDLIWMETGTPDLKLA Mflv_0107|M.gilvum_PYR-GCK ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA Mvan_0801|M.vanbaalenii_PYR-1 ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA MSMEG_0911|M.smegmatis_MC2_155 ---------TKEGFFRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA Mb0476|M.bovis_AF2122/97 ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA Rv0467|M.tuberculosis_H37Rv ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA MAV_4682|M.avium_104 ---------TKEGFYRVRNGLEPCIARAKAYAPYSDLIWMETGTPDLELA TH_4509|M.thermoresistible__bu ---------TKEGFYRVQNGIEPCIARAKAYAPYADLIWMETGTPDLELA MAB_4095c|M.abscessus_ATCC_199 ---------TSEGFYNVQKGIEPCIARAKAYAPYADLIWMETGVPDLEVA MLBr_01985|M.leprae_Br4923 PGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTADLADA * **::. : *:: .**:: * **::*::**** ..** * MMAR_0792|M.marinum_M KQFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDETIAKFQKELGAMGFKF MUL_4536|M.ulcerans_Agy99 KQFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDETIAKFQKELGAMGFKF Mflv_0107|M.gilvum_PYR-GCK KKFAEGVKSEFPDQMLAYNCSPSFNWKQH-LDDATIAKFQKELGAMGFKF Mvan_0801|M.vanbaalenii_PYR-1 KKFAEGVKSEFPDQMLAYNCSPSFNWRKH-LDDATIAKFQKELGAMGFKF MSMEG_0911|M.smegmatis_MC2_155 KKFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELGAMGFKF Mb0476|M.bovis_AF2122/97 RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF Rv0467|M.tuberculosis_H37Rv RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF MAV_4682|M.avium_104 AKFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF TH_4509|M.thermoresistible__bu KRFAEAVKAEFPDQMLAYNCSPSFNWRKH-LDDATIARFQKELGAMGYKF MAB_4095c|M.abscessus_ATCC_199 RKFAEAVKADFPDQLLSYNCSPSFNWKQH-LDDSTIAKFQKELGAMGFKF MLBr_01985|M.leprae_Br4923 RQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVF :*:*.:::::*:*:*:** ****** :.* : :* :**. **: * MMAR_0792|M.marinum_M QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ---------------- MUL_4536|M.ulcerans_Agy99 QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ---------------- Mflv_0107|M.gilvum_PYR-GCK QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ---------------- Mvan_0801|M.vanbaalenii_PYR-1 QFITLAGFHALNYSMFDLAHGYARNQMTAYVELQ---------------- MSMEG_0911|M.smegmatis_MC2_155 QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ---------------- Mb0476|M.bovis_AF2122/97 QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ---------------- Rv0467|M.tuberculosis_H37Rv QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ---------------- MAV_4682|M.avium_104 QFITLAGFHALNYSMFDLAYGYARNQMTAYVELQ---------------- TH_4509|M.thermoresistible__bu QFITLAGFHALNYSMFDLAYGYARNQMTAYVDLQ---------------- MAB_4095c|M.abscessus_ATCC_199 QFITLAGFHALNYSMFDLAYGYAREGMTAYVDLQ---------------- MLBr_01985|M.leprae_Br4923 NFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTL :*** .*.: . : ::* . :: * * . ** MMAR_0792|M.marinum_M ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS MUL_4536|M.ulcerans_Agy99 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS Mflv_0107|M.gilvum_PYR-GCK ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS Mvan_0801|M.vanbaalenii_PYR-1 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS MSMEG_0911|M.smegmatis_MC2_155 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALAGS Mb0476|M.bovis_AF2122/97 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS Rv0467|M.tuberculosis_H37Rv ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS MAV_4682|M.avium_104 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALTGS TH_4509|M.thermoresistible__bu ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALKGS MAB_4095c|M.abscessus_ATCC_199 ------EREFASEARGYTATKHQREVGAGYFDKIATTVDPNTSTAALKGS MLBr_01985|M.leprae_Br4923 VGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALW : :*:. ::** : .: : . : * * . * MMAR_0792|M.marinum_M TEEGQFH------------------------------------------- MUL_4536|M.ulcerans_Agy99 TEEGQFH------------------------------------------- Mflv_0107|M.gilvum_PYR-GCK TEEGQFH------------------------------------------- Mvan_0801|M.vanbaalenii_PYR-1 TEEGQFH------------------------------------------- MSMEG_0911|M.smegmatis_MC2_155 TEEGQFH------------------------------------------- Mb0476|M.bovis_AF2122/97 TEEGQFH------------------------------------------- Rv0467|M.tuberculosis_H37Rv TEEGQFH------------------------------------------- MAV_4682|M.avium_104 TEEGQFH------------------------------------------- TH_4509|M.thermoresistible__bu TEEDQFH------------------------------------------- MAB_4095c|M.abscessus_ATCC_199 TEEGQFH------------------------------------------- MLBr_01985|M.leprae_Br4923 SEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGR :*. *: MMAR_0792|M.marinum_M -------------------------------------------------- MUL_4536|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0107|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0801|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0911|M.smegmatis_MC2_155 -------------------------------------------------- Mb0476|M.bovis_AF2122/97 -------------------------------------------------- Rv0467|M.tuberculosis_H37Rv -------------------------------------------------- MAV_4682|M.avium_104 -------------------------------------------------- TH_4509|M.thermoresistible__bu -------------------------------------------------- MAB_4095c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01985|M.leprae_Br4923 SILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTEDNLYQT MMAR_0792|M.marinum_M ------------------------------------------------ MUL_4536|M.ulcerans_Agy99 ------------------------------------------------ Mflv_0107|M.gilvum_PYR-GCK ------------------------------------------------ Mvan_0801|M.vanbaalenii_PYR-1 ------------------------------------------------ MSMEG_0911|M.smegmatis_MC2_155 ------------------------------------------------ Mb0476|M.bovis_AF2122/97 ------------------------------------------------ Rv0467|M.tuberculosis_H37Rv ------------------------------------------------ MAV_4682|M.avium_104 ------------------------------------------------ TH_4509|M.thermoresistible__bu ------------------------------------------------ MAB_4095c|M.abscessus_ATCC_199 ------------------------------------------------ MLBr_01985|M.leprae_Br4923 SKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG