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TGAGSGSNDGRENVLIVHWHDLGRYLGAYGHRDVDSPRLDRLAGEAILFTRAHATAPLCSPSRGSLFTGR YPQSNGLVGLAHHGWEYRSGVRTLPQLLGEHGWHSALFGMQHETSQPSRLGFDELDVSNSYCDYVVDKVQ NWLHEGVAALAGQPFLLTAGFFETHRPYPHERYEPADSSSVDLPDYLPDTPEVRQDLADFYGAITTADAA VGRILDTLEQTGLDASTWVVFLTDHGPAFPRAKSTLYDAGTGIAMIVRPPKRLAVPPRVYDELFSGVDLL PTLLSLLGIDIPADVEGLSHAHALISPEADADGRPVREHVYAMKTYHDSFDPIRAIRTKEYSYIENYVSR PMLDLPKDIEESPSGLAVAPLVSSPRPAQELYDLRSDPTETANLLAGEGAASADTVAAELAALLNDWRQS TGDVIPSDFAGSHIAARYTETYLKSHQPTPREDSSAAADRDIEG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0554 | - | - | 100% (465) | sulfatase |
M. marinum M | MMAR_2840 | atsD_2 | 5e-10 | 22.46% (325) | arylsulfatase AtsD_2 |
M. marinum M | MMAR_1232 | atsB | 5e-10 | 21.69% (498) | arylsulfatase AtsB (aryl-sulfate sulphohydrolase) |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0304c | - | 0.0 | 76.65% (454) | sulfatase |
M. gilvum PYR-GCK | Mflv_5039 | - | 3e-06 | 30.28% (109) | sulfatase |
M. tuberculosis H37Rv | Rv0296c | - | 0.0 | 76.65% (454) | sulfatase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_1547c | - | 1e-179 | 66.45% (453) | sulfatase |
M. avium 104 | MAV_4858 | - | 0.0 | 76.77% (465) | sulfatase family protein |
M. smegmatis MC2 155 | MSMEG_1228 | - | 1e-14 | 25.88% (371) | sulfatase |
M. thermoresistible (build 8) | TH_0315 | - | 3e-09 | 31.86% (113) | arylsulfatase |
M. ulcerans Agy99 | MUL_1217 | - | 0.0 | 98.89% (451) | sulfatase |
M. vanbaalenii PYR-1 | Mvan_1317 | - | 1e-05 | 30.28% (109) | sulfatase |
CLUSTAL 2.0.9 multiple sequence alignment Mb0304c|M.bovis_AF2122/97 -----------------------MTSERATGQRENLLIVHWHDLGRYLGV Rv0296c|M.tuberculosis_H37Rv -----------------------MTSERATGQRENLLIVHWHDLGRYLGV MMAR_0554|M.marinum_M -------------------MTGAGSGSNDG--RENVLIVHWHDLGRYLGA MUL_1217|M.ulcerans_Agy99 -----------------------------------MLIVHWHDLGRYLGA MAV_4858|M.avium_104 ---------------MTQLTPGDAGDRNDAGRKDNVLIVHWHDLGRYLGA MAB_1547c|M.abscessus_ATCC_199 ---------------------------MAAASRDNVLIVHWHDLGRYLGV Mflv_5039|M.gilvum_PYR-GCK -MTTEFNGKIALDIRDSEPDWGPFAAPTAQPEAPNVLYLVWDDIGIATWD Mvan_1317|M.vanbaalenii_PYR-1 MATTEFNGKIAVDIRDSEPDWGPFAAPTAQPDAPNVLYLVWDDIGIATWD TH_0315|M.thermoresistible__bu --MADFGGKIELDIRDSEPDWGPFAAPTAPEGAPNILYVVWDDVGIGTWD MSMEG_1228|M.smegmatis_MC2_155 -----------------------------MPEKPNIVYFHVDNLGMGELG :: . .::* Mb0304c|M.bovis_AF2122/97 YHHP----DVYSPRLDRLAAEGILFTRAHATAPLCTPSRGSLFTGRYPQS Rv0296c|M.tuberculosis_H37Rv YHHP----DVYSPRLDRLAAEGILFTRAHATAPLCTPSRGSLFTGRYPQS MMAR_0554|M.marinum_M YGHR----DVDSPRLDRLAGEAILFTRAHATAPLCSPSRGSLFTGRYPQS MUL_1217|M.ulcerans_Agy99 YGHR----DVDSPRLDRLAGEAILFTRAHATAPLCSPSRGSLFTGRYPQS MAV_4858|M.avium_104 YGHR----DVSSPRLDRLAAEGILFTRAHATAPLCSPSRGSLFTGRYPQT MAB_1547c|M.abscessus_ATCC_199 YGHP----DVSSPHLDRLAAEGILFTRAHATAPLCSPSRGSLFTGRYPQS Mflv_5039|M.gilvum_PYR-GCK CFGG----LVDMPAMSRIAERGVRLSQFHTTA-LCSPTRASLLTGRNATT Mvan_1317|M.vanbaalenii_PYR-1 CFGG----LVNMPAMSRIAERGVRLSQFHTTA-LCSPTRASLLTGRNATT TH_0315|M.thermoresistible__bu CFGG----LVEMPTMSRIAEQGVRLSQFHTTA-LCSPTRAALLTGRNPTT MSMEG_1228|M.smegmatis_MC2_155 CYGGGILRGADTVRMDAFAAESLKLTHFVVEP-QCTPTRSALMTGRYPIR . :. :* ..: ::: . . *:*:*.:*:*** . Mb0304c|M.bovis_AF2122/97 NGLVGLAHHGWEYRTG-------VQTLPQLLSESGWYSALFGMQHETSY- Rv0296c|M.tuberculosis_H37Rv NGLVGLAHHGWEYRTG-------VQTLPQLLSESGWYSALFGMQHETSY- MMAR_0554|M.marinum_M NGLVGLAHHGWEYRSG-------VRTLPQLLGEHGWHSALFGMQHETSQ- MUL_1217|M.ulcerans_Agy99 NGLVGLAHHGWEYRSG-------VRTLPQLLGEHGWHSALFGMQHETSQ- MAV_4858|M.avium_104 NGLIGLAHHGWEYRSG-------IRTLPQILSEAGWYSALFGMQHETSY- MAB_1547c|M.abscessus_ATCC_199 NGLIGLAHHGWEYRAG-------VRTLPHILSGSGWHTALFGMQHESAY- Mflv_5039|M.gilvum_PYR-GCK VGMATIEEFTDGFPNCNGRIPFDTALLSEVLSENGYNTYCIGKWHLTPLE Mvan_1317|M.vanbaalenii_PYR-1 VGMATIEEFTDGFPNCSGRIPFDTALISEVLAENGYNTYCVGKWHLTPLE TH_0315|M.thermoresistible__bu VGMATIEEFTDGFPNCSGRIPVDTGLISEVLAEHGWNTYCVGKWHLTPLE MSMEG_1228|M.smegmatis_MC2_155 SGNHTIALGGNGGGIVS-----WERTMGDILSEAGYATACFGKWHIGAED * : : .:*. *: : .* * . Mb0304c|M.bovis_AF2122/97 -----------PKRLGFDEFD----------------------------V Rv0296c|M.tuberculosis_H37Rv -----------PKRLGFDEFD----------------------------V MMAR_0554|M.marinum_M -----------PSRLGFDELD----------------------------V MUL_1217|M.ulcerans_Agy99 -----------PSRLGFDELD----------------------------V MAV_4858|M.avium_104 -----------PKRLGFDEFD----------------------------V MAB_1547c|M.abscessus_ATCC_199 -----------PATLGFDEYD----------------------------V Mflv_5039|M.gilvum_PYR-GCK ESNLAATKRHWPLSRGFERFYGFMGGETDQWYPDLMYDNHPVAPPATPEE Mvan_1317|M.vanbaalenii_PYR-1 ESNLAATKRHWPLSRGFERFYGFMGGETDQWYPDLVYDNHPVPPPAGPEE TH_0315|M.thermoresistible__bu ESNMAATKRHWPVSRGFERFYGFLGGETDQWYPDLVHDNHPVAPPATPED MSMEG_1228|M.smegmatis_MC2_155 G--------RWPTDHGFDEWYG-----PARTYDECLWPDDPWYDGERDGY * **:. Mb0304c|M.bovis_AF2122/97 SNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFETHRPYP-------- Rv0296c|M.tuberculosis_H37Rv SNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFETHRPYP-------- MMAR_0554|M.marinum_M SNSYCDYVVDKVQNWLHEGVAALAGQPFLLTAGFFETHRPYP-------- MUL_1217|M.ulcerans_Agy99 SSSYCDYVVDKVQNWLHEGVAALAGQPFLLTAGFFETHRPYP-------- MAV_4858|M.avium_104 SNSYCDYVAQRADEWLRQSAEGVVGQPFLLTAGFFETHRPYP-------- MAB_1547c|M.abscessus_ATCC_199 SNSYCEYVVEHATRWLRNSPQ----SPFLLTAGFFETHRPFP-------- Mflv_5039|M.gilvum_PYR-GCK GYHLSKDLADKTIEFIRDSKVIAPDKPWFSYVCPGAGHAPHHVFKEWADR Mvan_1317|M.vanbaalenii_PYR-1 GYHLSKDLADKTIEFIRDSKVIAPDKPWFSYVCPGAGHAPHHVFKEWADR TH_0315|M.thermoresistible__bu GYHLSKDLADKTIEFIRDAKVIAPDKPWFTYLCPGAGHAPHHAPRDWADR MSMEG_1228|M.smegmatis_MC2_155 SYMYEGTKADGVHATDQQLTVKLKGEMDGEYDRRAKAFMKRS-------- . . . :: . . Mb0304c|M.bovis_AF2122/97 --------HERYRPADSAAVELPDYLPDTPEVR----------------- Rv0296c|M.tuberculosis_H37Rv --------HERYRPADSAAVELPDYLPDTPEVR----------------- MMAR_0554|M.marinum_M --------HERYEPADSSSVDLPDYLPDTPEVR----------------- MUL_1217|M.ulcerans_Agy99 --------HERYEPADSSTVDLPDYLPDTPEVR----------------- MAV_4858|M.avium_104 --------EDRYPPADSAEVQPPDYLPDTPEVR----------------- MAB_1547c|M.abscessus_ATCC_199 --------RERYAPSDASSVDVPDYLPDTPEVR----------------- Mflv_5039|M.gilvum_PYR-GCK YAGRFDMGYEAYREIVLENQKRLGLVPPDTELSAVNPYLDVKGPDGQDWP Mvan_1317|M.vanbaalenii_PYR-1 YSGVFDMGYERYREIVLENQKRLGIVPPETELSPVNPYLDVKGPDGQEWP TH_0315|M.thermoresistible__bu YAGRFDMGYERYREVVLENQKKLGIVPPDTELPPINPYQDVKGPHGEPWP MSMEG_1228|M.smegmatis_MC2_155 --------VEADKPFFLYHNHSLMHFPMEVREEFKGK------------- : . .* . Mb0304c|M.bovis_AF2122/97 --------------------QDVAEFYGSIATADEAVGRLLDTLADTGLD Rv0296c|M.tuberculosis_H37Rv --------------------QDVAEFYGSIATADEAVGRLLDTLADTGLD MMAR_0554|M.marinum_M --------------------QDLADFYGAITTADAAVGRILDTLEQTGLD MUL_1217|M.ulcerans_Agy99 --------------------QDLADFYAAITTADAAVGRILDTLEQTGLD MAV_4858|M.avium_104 --------------------GDLAAFYGAISTADAAVGRLLDTLADTGLD MAB_1547c|M.abscessus_ATCC_199 --------------------DDLAEFYGSITVADAKVGELLEVLTETGLD Mflv_5039|M.gilvum_PYR-GCK AQDTVRPWDSLSEDEKRLFARMAEVFAGFLSYTDAQIGRVLDYLEESGQL Mvan_1317|M.vanbaalenii_PYR-1 AQDTVRPWDSLSEEEKRLFARMAEVFAGFLSYTDAQIGRVLDYLDESGQL TH_0315|M.thermoresistible__bu LQDTVRPWDSLSDAEKRLFCRMAEVFAGFLSYTDHQIGRVLDYLEESDQL MSMEG_1228|M.smegmatis_MC2_155 --------------------STNGQWGDSLLMLDYDFGSILDYLAELGIE : : * .* :*: * : . Mb0304c|M.bovis_AF2122/97 ASTWVVFVTDHGP------------------------------------- Rv0296c|M.tuberculosis_H37Rv ASTWVVFVTDHGP------------------------------------- MMAR_0554|M.marinum_M ASTWVVFLTDHGP------------------------------------- MUL_1217|M.ulcerans_Agy99 GSTWVVFLTDHGP------------------------------------- MAV_4858|M.avium_104 ASTWVVFFTDHGP------------------------------------- MAB_1547c|M.abscessus_ATCC_199 QNTWVIFMTDHGP------------------------------------- Mflv_5039|M.gilvum_PYR-GCK DNTVIVVISDNGASGEGGPNGSVNEVKFFNGYIDSAEESLKVFDELGGPQ Mvan_1317|M.vanbaalenii_PYR-1 DNTIIVVISDNGASGEGGPNGSVNEVKFFNGYIDSVEESLKAFDELGGTQ TH_0315|M.thermoresistible__bu DNTLIVVLSDNGASGEGGPDGSVNEVKFFNGYVDTVEESMRFYDQLGGPQ MSMEG_1228|M.smegmatis_MC2_155 DNTIVIMAGDNGAEDHLAGRGTAG-------------------------- .* ::. *:*. Mb0304c|M.bovis_AF2122/97 ---AFPR-------------AKSTLYDAGTGIALIIRPPTRRAMAPRVYD Rv0296c|M.tuberculosis_H37Rv ---AFPR-------------AKSTLYDAGTGIALIIRPPTRRAMAPRVYD MMAR_0554|M.marinum_M ---AFPR-------------AKSTLYDAGTGIAMIVRPPKRLAVPPRVYD MUL_1217|M.ulcerans_Agy99 ---AFPR-------------AKSTLYDAGTGIAMIVRPPKRLAVPPRVYD MAV_4858|M.avium_104 ---AFPR-------------AKSTLYDAGTGIGMIVRPPTGRGLPPRVYD MAB_1547c|M.abscessus_ATCC_199 ---ALPR-------------AKSTLYDAGTGIALIVRPPRGRTTEPLRYE Mflv_5039|M.gilvum_PYR-GCK TYNHYPIGWAMAFNTPYKLFKRYASHEGGIADTAIISWPKGIAAHGEIRD Mvan_1317|M.vanbaalenii_PYR-1 TYNHYPIGWAMAFNTPYKLFKRYASHEGGIADTAIISWPNGIAAHGEVRD TH_0315|M.thermoresistible__bu TYNHYPTGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGITARDAVCD MSMEG_1228|M.smegmatis_MC2_155 ---FFDG-------------SYFSSAEGGIRTPCLIRWPG--KVVPRESN : :.* :: * : Mb0304c|M.bovis_AF2122/97 ELFSGVDLVPTLLDLLRLEVPADVEGVS---------------------- Rv0296c|M.tuberculosis_H37Rv ELFSGVDLVPTLLDLLRLEVPADVEGVS---------------------- MMAR_0554|M.marinum_M ELFSGVDLLPTLLSLLGIDIPADVEGLS---------------------- MUL_1217|M.ulcerans_Agy99 ELFSGVDLLPTLLSLLGIDIPADVEGLS---------------------- MAV_4858|M.avium_104 ELFSAVDLVPTLLGLLGISVPPDVDGVS---------------------- MAB_1547c|M.abscessus_ATCC_199 ELFSGVDLLPTLLELLGVEIPEEVQGVS---------------------- Mflv_5039|M.gilvum_PYR-GCK NYVNVADITPTVYDLLDITPPATVRGVAQKPLDGVSFKVALENPNAPTGK Mvan_1317|M.vanbaalenii_PYR-1 NYVNVCDITPTVFDLLDITPPATVRGVAQKPMDGVSFKVALDNPTAPTGK TH_0315|M.thermoresistible__bu RYINVVDVTPTVYELIGLTPPDTVRGVRQRPLEGVSFRAALADPDADTGK MSMEG_1228|M.smegmatis_MC2_155 EMVHVTDMFPTLLRWVGCDIPDDRIIDG---------------------- . . *: **: : * Mb0304c|M.bovis_AF2122/97 --------------------HAPALLAPDTENA--AVRDHVYTAKTYHDS Rv0296c|M.tuberculosis_H37Rv --------------------HAPALLAPDTENA--AVRDHVYTAKTYHDS MMAR_0554|M.marinum_M --------------------HAHALISPEADADGRPVREHVYAMKTYHDS MUL_1217|M.ulcerans_Agy99 --------------------HAHALISPEADADGRPVREHVYAMKTYHDS MAV_4858|M.avium_104 --------------------HASALLRPDPDAA--PVREHVYTMKTYHDS MAB_1547c|M.abscessus_ATCC_199 --------------------HAGNIQKQSGELE--EVRSEVFTTKTYHDS Mflv_5039|M.gilvum_PYR-GCK ETQFYTMLGTRGIWHRGWFANTVHAASPAGWSHFDDDRWELYHVDADRSQ Mvan_1317|M.vanbaalenii_PYR-1 ETQFYTMLGTRGIWHKGWFASAVHAASPSGWSHFDDDRWELFHIEADRSQ TH_0315|M.thermoresistible__bu RTQFYSMLGTRGIWSDGWFANTVHAASPAGWSNFDADRWELYHLESDRSQ MSMEG_1228|M.smegmatis_MC2_155 -----------------------------------IDQREFFSGAEESNR : ..: . Mb0304c|M.bovis_AF2122/97 --------FDPIRAIRTKEYSYIENYAPRPLLDL---------------- Rv0296c|M.tuberculosis_H37Rv --------FDPIRAIRTKEYSYIENYAPRPLLDL---------------- MMAR_0554|M.marinum_M --------FDPIRAIRTKEYSYIENYVSRPMLDL---------------- MUL_1217|M.ulcerans_Agy99 --------FDPIRAIRTKEYSYIENYVSRPMLDL---------------- MAV_4858|M.avium_104 --------FDPIRAIRTKDYSYIENYASRPLLEL---------------- MAB_1547c|M.abscessus_ATCC_199 --------FDPIRAIRTKNYSYIENYAPRPVLDL---------------- Mflv_5039|M.gilvum_PYR-GCK VHDLAAEYPEKLDELKALWFSEAQKYNGLPLGDLDIFETMSRWRPTLSGE Mvan_1317|M.vanbaalenii_PYR-1 CHDLAAEHPDKVEELKALWFAEAAKYNGLPLGDLDILETITRWRPYLTGE TH_0315|M.thermoresistible__bu SRDLAAEHPEKLEELKQLWFDEAAKYNGLPLGDLNLFETLGRWRPHLSRG MSMEG_1228|M.smegmatis_MC2_155 -------------DGCMVWLNEELHAVKWSQFKIN--------------- : . .: Mb0304c|M.bovis_AF2122/97 --PWDIQESPAGMAVAPLVKAP-RPQRELYDLRADPTETNNLLAGDDS-- Rv0296c|M.tuberculosis_H37Rv --PWDIQESPAGMAVAPLVKAP-RPQRELYDLRADPTETNNLLAGDDS-- MMAR_0554|M.marinum_M --PKDIEESPSGLAVAPLVSSP-RPAQELYDLRSDPTETANLLAGEG--- MUL_1217|M.ulcerans_Agy99 --PKDIEESPSGLAVAPLVSSP-RPAQELYDLRSDPTETANLLAGEG--- MAV_4858|M.avium_104 --PWDIEESPSGMAVAPLVTAP-RPERELYDLRADPTEITNLLAGD---- MAB_1547c|M.abscessus_ATCC_199 --PWDIADSPPGRAVATHITGP-RAHRELYDLRTDPEEAHNLLGLDA--- Mflv_5039|M.gilvum_PYR-GCK RSAYVYYPGTADVGIGAVVELRGRSFAVLAEVEVDPGGANGVVVKHGGAH Mvan_1317|M.vanbaalenii_PYR-1 RNSYAYYPGTADVGMGAVVELRGRSFAVLAEVAVDPDGADGVVVKHGGAH TH_0315|M.thermoresistible__bu RTSYTYYPGTAEVGLGAAVDIRGQSFTVLADVTVDAAGAQGVIVKHGAGH MSMEG_1228|M.smegmatis_MC2_155 -FKRQQHFHDPEVPLG---------FARITNLLEDPKERE---------- . :. : :: *. Mb0304c|M.bovis_AF2122/97 -------------------TQGVAAIAADLAVRLHDWRQRTADVIPSDFA Rv0296c|M.tuberculosis_H37Rv -------------------TQGVAAIAADLAVRLHDWRQRTADVIPSDFA MMAR_0554|M.marinum_M -------------------AASADTVAAELAALLNDWRQSTGDVIPSDFA MUL_1217|M.ulcerans_Agy99 -------------------AASADPVAAELAALLNDWRQSTGDVIPSDFA MAV_4858|M.avium_104 -------------------DADADEVAANLAVLLHDWRQRTGDVIPSEFA MAB_1547c|M.abscessus_ATCC_199 -------------------DEASEAVANDLALRLNDWREKTLDVIPSDFA Mflv_5039|M.gilvum_PYR-GCK GGYVMYLQGGRLHFCYNFLGEYEQTLAAPDPVPPGLHTLGFTYTVTGTAE Mvan_1317|M.vanbaalenii_PYR-1 GGYVMYVQGGRLHFCYNFLGEYEQTLASADPVSAGLHTLGFTFTLTGTAE TH_0315|M.thermoresistible__bu GGYVLFLQDGRLHFVYNFMGEEEQRVSSADPIPAGRHILGVSYHRTGTVD MSMEG_1228|M.smegmatis_MC2_155 ---------------------------PVNQTWVRWWVMQHAYRFIQEFE Mb0304c|M.bovis_AF2122/97 GSRIAERYTETYLRIHR-KTPTGRSAIAADRGIDEHCS------------ Rv0296c|M.tuberculosis_H37Rv GSRIAERYTETYLRIHR-KTPTGRSAIAADRGIDEHCS------------ MMAR_0554|M.marinum_M GSHIAARYTETYLKSHQ-PTPREDSSAAADRDIEG--------------- MUL_1217|M.ulcerans_Agy99 GSHIAARYTETYLKSHQ-PTPREDSSAAADRDIEG--------------- MAV_4858|M.avium_104 GTRIAARYTETYLQIHHGARPTARSAIAADRGIEEEGNPAQR-------- MAB_1547c|M.abscessus_ATCC_199 GTRISERYTETFLRIHG-RPGANRSAIADERGIEQ--------------- Mflv_5039|M.gilvum_PYR-GCK GSHTPIGDAELFLDTERVASLAEMRSQPGTFGLAGASLSVGRNNGSPVSE Mvan_1317|M.vanbaalenii_PYR-1 GSHTPVGDAALFIDSAQVASLAEMRVHPGTFGLAGATLSVGRNSGSPVSQ TH_0315|M.thermoresistible__bu GSHTPLGEVALYVDGTVVATRPDVRAHPANFGLAGGGIAVGRNTGQPVSS MSMEG_1228|M.smegmatis_MC2_155 ASVEKEQLIPAGAPLDFVPARNP--------------------------- .: Mb0304c|M.bovis_AF2122/97 --------------------------------------- Rv0296c|M.tuberculosis_H37Rv --------------------------------------- MMAR_0554|M.marinum_M --------------------------------------- MUL_1217|M.ulcerans_Agy99 --------------------------------------- MAV_4858|M.avium_104 --------------------------------------- MAB_1547c|M.abscessus_ATCC_199 --------------------------------------- Mflv_5039|M.gilvum_PYR-GCK AYHPPFAFAGGRIARVNIDTSGAPYVDLERDFARAFARD Mvan_1317|M.vanbaalenii_PYR-1 AYQAPYPFTGGTIARVNIDVSGAPYLDLEREFARAFARD TH_0315|M.thermoresistible__bu AYRAPFAFTGGSIAKVIVDISGTPYRDVEREAAMAFARD MSMEG_1228|M.smegmatis_MC2_155 ---------------------------------------