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TTSRTTPATPLLQQHHELGARFTDFAGWQMPVRYGSELTEHHTVRSAAGLFDLSHMGEIEVLGPGAAAAL DYALVGAFSGLKVGKAKYSLLCREDGGVIDDLVAYRLAEDNFLVVANAANAAAVYEALVQRAAGFDATVT DRSQDTALIALQGPVAERVLCKVVAEADRATVTELKYYAATQIQLGEIPVLLARTGYTGEDGFELYVDNA HAAPVWHLLLDAGRADGVIPAGLACRDTLRLEAGMALYGHELSLETSPYDAGLGRTVRLEKYFVGRDALA ELAAQGPRRTLIGLQGLGKRAARAGYAVYTEDGQRQIGTVTSGALSPTLGYPIAISYVEAGTVDTDSIVA VDIRGSMEHFRVVATPFYVRPRPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0210 | gcvT | - | 100% (375) | aminomethyltransferase GcvT_1ne |
| M. marinum M | MMAR_3256 | gcvT | 1e-68 | 43.06% (360) | aminomethyltransferase GcvT |
| M. marinum M | MMAR_4420 | gcvT_2 | 2e-31 | 30.13% (385) | aminomethyltransferase GcvT_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2234c | gcvT | 3e-69 | 42.78% (360) | glycine cleavage system aminomethyltransferase T |
| M. gilvum PYR-GCK | Mflv_2939 | gcvT | 7e-71 | 43.25% (363) | glycine cleavage system aminomethyltransferase T |
| M. tuberculosis H37Rv | Rv2211c | gcvT | 3e-69 | 42.78% (360) | glycine cleavage system aminomethyltransferase T |
| M. leprae Br4923 | MLBr_00865 | gcvT | 6e-67 | 42.11% (361) | glycine cleavage system aminomethyltransferase T |
| M. abscessus ATCC 19977 | MAB_1949 | gcvT | 5e-66 | 42.50% (360) | glycine cleavage system aminomethyltransferase T |
| M. avium 104 | MAV_2280 | gcvT | 2e-67 | 42.50% (360) | glycine cleavage system aminomethyltransferase T |
| M. smegmatis MC2 155 | MSMEG_4278 | gcvT | 2e-71 | 43.89% (360) | glycine cleavage system aminomethyltransferase T |
| M. thermoresistible (build 8) | TH_1298 | gcvT | 5e-67 | 41.67% (360) | Probable aminomethyltransferase GcvT (Glycine cleavage |
| M. ulcerans Agy99 | MUL_3571 | gcvT | 6e-68 | 42.78% (360) | glycine cleavage system aminomethyltransferase T |
| M. vanbaalenii PYR-1 | Mvan_3574 | gcvT | 4e-72 | 43.37% (362) | glycine cleavage system aminomethyltransferase T |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2234c|M.bovis_AF2122/97 MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGT
Rv2211c|M.tuberculosis_H37Rv MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGT
MUL_3571|M.ulcerans_Agy99 ------------MSDAPELMQGPLEDRHRALGASFAEFGGWLMPVSYTGT
MLBr_00865|M.leprae_Br4923 ------------MTDAPELLKGPLEDRHRELGANFAEFGGWLMPVSYAGT
MAV_2280|M.avium_104 ------------MSNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGT
Mflv_2939|M.gilvum_PYR-GCK ----------MWIVVSDNLLAGPLENRHRELGATFAEFGGWSMPVSYAGT
Mvan_3574|M.vanbaalenii_PYR-1 ----------MWFAVTDNLLAGPLENRHRELGASFAEFGGWLMPVSYAGT
MSMEG_4278|M.smegmatis_MC2_155 --------------MSDELLQGPLEDRHRELGAAFAEFGGWLMPVSYAGT
TH_1298|M.thermoresistible__bu ------------VTGVSDIQHGPLEERHRQLGANFAEFGGWLMPVSYAGT
MAB_1949|M.abscessus_ATCC_1997 ---------------MTDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGT
MMAR_0210|M.marinum_M ------------MTTSRTTPATPLLQQHHELGARFTDFAGWQMPVRYGSE
** ::* ** *::*.** *** * .
Mb2234c|M.bovis_AF2122/97 VSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQ
Rv2211c|M.tuberculosis_H37Rv VSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQ
MUL_3571|M.ulcerans_Agy99 VSEHNATRNAAGLFDVSHLGKALVRGPGAAEFVNSALTNDLRRIGPGKAQ
MLBr_00865|M.leprae_Br4923 VSEHSATRNAVGLFDVSHLGKALVRGPGAAQFVNSVLTNDLGRIRPGKAQ
MAV_2280|M.avium_104 VSEHNATRNAVGLFDVSHLGKALVRGTGAARFVNSALTNDLNRIGPGKAQ
Mflv_2939|M.gilvum_PYR-GCK VAEHTATRTTVGLFDVSHLGKALVTGPGAAEFVNSAFTNDLRRIGPGKAQ
Mvan_3574|M.vanbaalenii_PYR-1 VAEHTATRTTVGLFDVSHLGKALVKGPGAAEFVNSAFTNDLRRIGPGQAQ
MSMEG_4278|M.smegmatis_MC2_155 VAEHNATRSTVGLFDVSHLGKALVKGPGAAAYVNSALTNDLGKIGPGKAQ
TH_1298|M.thermoresistible__bu VSEHTATRTTVGLFDVSHLGKARVRGPGAADFVNSAFTNDLRRIGPGSAQ
MAB_1949|M.abscessus_ATCC_1997 VGEHTATRAAVGLFDVSHLGKALVRGPGAAAFVNACFTNDLNKVGPGKAQ
MMAR_0210|M.marinum_M LTEHHTVRSAAGLFDLSHMGEIEVLGPGAAAALDYALVGAFSGLKVGKAK
: ** :.* :.****:**:*: * *.*** :: :.. : : *.*:
Mb2234c|M.bovis_AF2122/97 YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAP-GGL
Rv2211c|M.tuberculosis_H37Rv YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAP-GGL
MUL_3571|M.ulcerans_Agy99 YTLCCNESGGVIDDLIAYYVADDEIFLVPNAANTAAVVAALQAAAP-SGL
MLBr_00865|M.leprae_Br4923 YTLCCSESGGVIDDLIAYYVDDDEIFLVSNAANTAAVVDALQAVVP-AGL
MAV_2280|M.avium_104 YTLCCNESGGVIDDLIAYYVDDDEIFLVPNAANTAAVVEALQGAAP-AGV
Mflv_2939|M.gilvum_PYR-GCK YTLCCTEDGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALQDRAP-DGI
Mvan_3574|M.vanbaalenii_PYR-1 YTLCCTEDGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALQQRAP-GGL
MSMEG_4278|M.smegmatis_MC2_155 YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTATVVEELQRHAP-DGL
TH_1298|M.thermoresistible__bu YTLCCTESGGVVDDLIAYYISDDEIFLVPNAANNATVVDLLRRHAP-AGV
MAB_1949|M.abscessus_ATCC_1997 YTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTSAVVAALQEQAP-EGI
MMAR_0210|M.marinum_M YSLLCREDGGVIDDLVAYRLAEDNFLVVANAANAAAVYEALVQRAAGFDA
*:* * * ***:***:** : :*::::*.**** ::* * .. .
Mb2234c|M.bovis_AF2122/97 SITNLHRSYAVLAVQGPCSTDVLTALGLP------TEMDYMGYADASYSG
Rv2211c|M.tuberculosis_H37Rv SITNLHRSYAVLAVQGPCSTDVLTALGLP------TEMDYMGYADASYSG
MUL_3571|M.ulcerans_Agy99 TITDLHRSYAVLAVQGPRSTEVLAALGLP------TEMDYMGYADSSYNG
MLBr_00865|M.leprae_Br4923 TIINQHRSHAVLAVQGPRSTDVLGELGLP------TGIDYMGYVDASYAG
MAV_2280|M.avium_104 TVSNLHRSYAVLAVQGPRSADVLAELGLP------SDMDYMAYADTSFRQ
Mflv_2939|M.gilvum_PYR-GCK TITDEHRSRAVLAVQGPRSADVVGGLGLP------TDMDYMGFADGEVGG
Mvan_3574|M.vanbaalenii_PYR-1 TITDEHRSRAVLAVQGPVSADVVGGLGLP------TDMDYMGYADAEFRG
MSMEG_4278|M.smegmatis_MC2_155 TITNEHRSYAVLAVQGPKSAEVLDKLGLP------TDMDYMGYADAEFDG
TH_1298|M.thermoresistible__bu EVIDEHRAHAVFAVQGPRSADVLSGLGLP------VDMDYMAFTDATLNG
MAB_1949|M.abscessus_ATCC_1997 AVTNQHRDYAVLAVQGPRSADVLQRLGLP------TDMEYMAYADATLAG
MMAR_0210|M.marinum_M TVTDRSQDTALIALQGPVAERVLCKVVAEADRATVTELKYYAATQIQLGE
: : : *::*:*** : *: : :.* . .:
Mb2234c|M.bovis_AF2122/97 VPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARD
Rv2211c|M.tuberculosis_H37Rv VPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARD
MUL_3571|M.ulcerans_Agy99 VSVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVAEVGGSPAGLGARD
MLBr_00865|M.leprae_Br4923 VPVRVCRTGYTGEQGYELLPPWESADVVFDALVAAVVDARGEPAGLGARD
MAV_2280|M.avium_104 VPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARD
Mflv_2939|M.gilvum_PYR-GCK VETRVCRTGYTGEHGYELLPAWDQAEVVFDALVESVRAAGGEPAGLGARD
Mvan_3574|M.vanbaalenii_PYR-1 VEVRVCRTGYTGEHGYELLPPWDQAAVVFDALVEAVQSAGGEPAGLGARD
MSMEG_4278|M.smegmatis_MC2_155 VFVRVCRTGYTGEHGYELLPAWDRAGVVFDALVAAVRAAGGEPAGLGARD
TH_1298|M.thermoresistible__bu VEVRVCRTGYTGEHGYEVLPPWESALPVFDALVDAVQAAGGQLAGLGARD
MAB_1949|M.abscessus_ATCC_1997 LPVRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARD
MMAR_0210|M.marinum_M IPVLLARTGYTGEDGFELYVDNAHAAPVWHLLLDAGRADGVIPAGLACRD
: . :.*******.*:*: * *:. * ***..**
Mb2234c|M.bovis_AF2122/97 TLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAG
Rv2211c|M.tuberculosis_H37Rv TLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAG
MUL_3571|M.ulcerans_Agy99 TLRTEMGYPLHGHELSLDISPLQARCGWAIGWKKDAFFGREALLAEKAAG
MLBr_00865|M.leprae_Br4923 TLRTEMGYPLYGHELSLDISPLQARCGWAIGWKKDAFLGRDALLAEKAAG
MAV_2280|M.avium_104 TLRTEMGYPLHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAG
Mflv_2939|M.gilvum_PYR-GCK TLRTEMGYPLHGHELSLDISPLQARCGWAIGWKKDAFWGRDALLAEKEAG
Mvan_3574|M.vanbaalenii_PYR-1 TLRTEMGYPLHGHELSLDISPLQARCGWAIGWKKDAFWGRDALLAEKAAG
MSMEG_4278|M.smegmatis_MC2_155 TLRTEMGYPLHGHELSLDISPLQARCGWAVGWKKDAFWGRDALLAEKADG
TH_1298|M.thermoresistible__bu TLRTEMGYPLHGHELSPDISPLEARCGWAVGWKKERFWGRDALLAEKQAG
MAB_1949|M.abscessus_ATCC_1997 TLRTEMGYPLHGHELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDG
MMAR_0210|M.marinum_M TLRLEAGMALYGHELSLETSPYDAGLGRTVRLEK-YFVGRDALAELAAQG
*** * * .*:***** : ** :* * :: .* * ** ** *
Mb2234c|M.bovis_AF2122/97 PRRLLRGLRMVGRGVLRPGLAVLV--GDETVGVTTSGTFSPTLQVGIGLA
Rv2211c|M.tuberculosis_H37Rv PRRLLRGLRMVGRGVLRPGLAVLV--GDETVGVTTSGTFSPTLQVGIGLA
MUL_3571|M.ulcerans_Agy99 PRRLPRGLRMVGRGVLRPGLTVLN--GSTPVGVTTSGTFSPTLQIGIALA
MLBr_00865|M.leprae_Br4923 PRRLLRGLRMAGRGVLRPGLTVCA--GDIPIGVTTSGTFSPTLQVGVALA
MAV_2280|M.avium_104 PRRLLRGLRMVGRGVLRAGLTVLV--GDTPVGVTTSGTFSPTLQAGIALA
Mflv_2939|M.gilvum_PYR-GCK PRRTLRGLRAVGRGVLRADLSVLT--DDTPVGFTTSGTFSPTLKVGIALA
Mvan_3574|M.vanbaalenii_PYR-1 PRRTLRGLRAVGRGVLRQDLTVLD--GENRVGVTTSGTFSPTLKVGIALA
MSMEG_4278|M.smegmatis_MC2_155 PKRVLRGLKALGRGVLRADLAVLD--GDTRVGVTTSGTFSPTLKVGIALA
TH_1298|M.thermoresistible__bu PRRLLRGLRAVDRGVLRAGLSVYD--GDTVVGTTTSGTFSPTLKVGIALA
MAB_1949|M.abscessus_ATCC_1997 PRRTLRGLRATGRGVLRPDLTVLS--DGQSIGVTTSGTFSPTLKTGIALA
MMAR_0210|M.marinum_M PRRTLIGLQGLGKRAARAGYAVYTEDGQRQIGTVTSGALSPTLGYPIAIS
*:* **: .: . * . :* . :* .***::**** :.::
Mb2234c|M.bovis_AF2122/97 LIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR-
Rv2211c|M.tuberculosis_H37Rv LIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR-
MUL_3571|M.ulcerans_Agy99 LIDTDAGVEDGQQITVDVRGRAVECEVVRPPFVEAKTR-
MLBr_00865|M.leprae_Br4923 LIDSEAAVQDGQQIIVDVRGRAVECEVVRPPFIEVKTR-
MAV_2280|M.avium_104 LIDTDADVRDGQKVTVDVRGRAATCEVVRPPFVAVKTR-
Mflv_2939|M.gilvum_PYR-GCK LIDTAAGIADGDHVTVDVRGRRVECEVVKPPFVDTRTR-
Mvan_3574|M.vanbaalenii_PYR-1 LIDTEADITDGAHVDVDVRGRRIECEVVKPPFVDTRTR-
MSMEG_4278|M.smegmatis_MC2_155 LIDTEYDIADGTTVTVDVRGRAVECEVVKPPFVTPSTR-
TH_1298|M.thermoresistible__bu LIDTEHGIPDGARVSVDVRGRRIGCEVVKPPFVEVKTR-
MAB_1949|M.abscessus_ATCC_1997 LLDTAAQIPDGASVVVDVRGREIECEVVKPPFVDVNVG-
MMAR_0210|M.marinum_M YVEAGT-VDTDSIVAVDIRGSMEHFRVVATPFYVRPRPA
::: : . : **:** .** .**