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WFAVTDNLLAGPLENRHRELGASFAEFGGWLMPVSYAGTVAEHTATRTTVGLFDVSHLGKALVKGPGAAE FVNSAFTNDLRRIGPGQAQYTLCCTEDGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALQQRAPGGLTI TDEHRSRAVLAVQGPVSADVVGGLGLPTDMDYMGYADAEFRGVEVRVCRTGYTGEHGYELLPPWDQAAVV FDALVEAVQSAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAIGWKKDAFWGRDALLAEKA AGPRRTLRGLRAVGRGVLRQDLTVLDGENRVGVTTSGTFSPTLKVGIALALIDTEADITDGAHVDVDVRG RRIECEVVKPPFVDTRTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3574 | gcvT | - | 100% (369) | glycine cleavage system aminomethyltransferase T |
| M. vanbaalenii PYR-1 | Mvan_1202 | - | 1e-41 | 35.33% (368) | glycine cleavage T protein (aminomethyl transferase) |
| M. vanbaalenii PYR-1 | Mvan_2290 | - | 3e-22 | 30.86% (337) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2234c | gcvT | 1e-174 | 80.81% (370) | glycine cleavage system aminomethyltransferase T |
| M. gilvum PYR-GCK | Mflv_2939 | gcvT | 0.0 | 89.97% (369) | glycine cleavage system aminomethyltransferase T |
| M. tuberculosis H37Rv | Rv2211c | gcvT | 1e-174 | 80.81% (370) | glycine cleavage system aminomethyltransferase T |
| M. leprae Br4923 | MLBr_00865 | gcvT | 1e-167 | 78.47% (367) | glycine cleavage system aminomethyltransferase T |
| M. abscessus ATCC 19977 | MAB_1949 | gcvT | 1e-164 | 77.93% (358) | glycine cleavage system aminomethyltransferase T |
| M. marinum M | MMAR_3256 | gcvT | 1e-174 | 81.72% (361) | aminomethyltransferase GcvT |
| M. avium 104 | MAV_2280 | gcvT | 1e-168 | 80.11% (362) | glycine cleavage system aminomethyltransferase T |
| M. smegmatis MC2 155 | MSMEG_4278 | gcvT | 0.0 | 84.93% (365) | glycine cleavage system aminomethyltransferase T |
| M. thermoresistible (build 8) | TH_1298 | gcvT | 1e-171 | 80.45% (358) | Probable aminomethyltransferase GcvT (Glycine cleavage |
| M. ulcerans Agy99 | MUL_3571 | gcvT | 1e-173 | 80.89% (361) | glycine cleavage system aminomethyltransferase T |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3574|M.vanbaalenii_PYR-1 ----------MWFAVTDNLLAGPLENRHRELGASFAEFGGWLMPVSYAGT
Mflv_2939|M.gilvum_PYR-GCK ----------MWIVVSDNLLAGPLENRHRELGATFAEFGGWSMPVSYAGT
MSMEG_4278|M.smegmatis_MC2_155 --------------MSDELLQGPLEDRHRELGAAFAEFGGWLMPVSYAGT
MMAR_3256|M.marinum_M ------------MSDAPELMQGPLEDRHRALGASFAEFGGWLMPVSYAGT
MUL_3571|M.ulcerans_Agy99 ------------MSDAPELMQGPLEDRHRALGASFAEFGGWLMPVSYTGT
Mb2234c|M.bovis_AF2122/97 MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGT
Rv2211c|M.tuberculosis_H37Rv MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGT
MLBr_00865|M.leprae_Br4923 ------------MTDAPELLKGPLEDRHRELGANFAEFGGWLMPVSYAGT
MAV_2280|M.avium_104 ------------MSNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGT
TH_1298|M.thermoresistible__bu ------------VTGVSDIQHGPLEERHRQLGANFAEFGGWLMPVSYAGT
MAB_1949|M.abscessus_ATCC_1997 ---------------MTDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGT
:: ***.:** ** ******* *****:**
Mvan_3574|M.vanbaalenii_PYR-1 VAEHTATRTTVGLFDVSHLGKALVKGPGAAEFVNSAFTNDLRRIGPGQAQ
Mflv_2939|M.gilvum_PYR-GCK VAEHTATRTTVGLFDVSHLGKALVTGPGAAEFVNSAFTNDLRRIGPGKAQ
MSMEG_4278|M.smegmatis_MC2_155 VAEHNATRSTVGLFDVSHLGKALVKGPGAAAYVNSALTNDLGKIGPGKAQ
MMAR_3256|M.marinum_M VSEHNATRNAAGLFDVSHLGKALVRGPGAAEFVNSALTNDLRRIGPGKAQ
MUL_3571|M.ulcerans_Agy99 VSEHNATRNAAGLFDVSHLGKALVRGPGAAEFVNSALTNDLRRIGPGKAQ
Mb2234c|M.bovis_AF2122/97 VSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQ
Rv2211c|M.tuberculosis_H37Rv VSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQ
MLBr_00865|M.leprae_Br4923 VSEHSATRNAVGLFDVSHLGKALVRGPGAAQFVNSVLTNDLGRIRPGKAQ
MAV_2280|M.avium_104 VSEHNATRNAVGLFDVSHLGKALVRGTGAARFVNSALTNDLNRIGPGKAQ
TH_1298|M.thermoresistible__bu VSEHTATRTTVGLFDVSHLGKARVRGPGAADFVNSAFTNDLRRIGPGSAQ
MAB_1949|M.abscessus_ATCC_1997 VGEHTATRAAVGLFDVSHLGKALVRGPGAAAFVNACFTNDLNKVGPGKAQ
*.**.*** :.*********** * *.*** :**: :**** :: **.**
Mvan_3574|M.vanbaalenii_PYR-1 YTLCCTEDGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALQQRAPGGLT
Mflv_2939|M.gilvum_PYR-GCK YTLCCTEDGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALQDRAPDGIT
MSMEG_4278|M.smegmatis_MC2_155 YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTATVVEELQRHAPDGLT
MMAR_3256|M.marinum_M YTLCCNESGGVIDDLIAYYVADDEIFLVPNAANTAAVVAALQAAAPSGLT
MUL_3571|M.ulcerans_Agy99 YTLCCNESGGVIDDLIAYYVADDEIFLVPNAANTAAVVAALQAAAPSGLT
Mb2234c|M.bovis_AF2122/97 YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLS
Rv2211c|M.tuberculosis_H37Rv YTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLS
MLBr_00865|M.leprae_Br4923 YTLCCSESGGVIDDLIAYYVDDDEIFLVSNAANTAAVVDALQAVVPAGLT
MAV_2280|M.avium_104 YTLCCNESGGVIDDLIAYYVDDDEIFLVPNAANTAAVVEALQGAAPAGVT
TH_1298|M.thermoresistible__bu YTLCCTESGGVVDDLIAYYISDDEIFLVPNAANNATVVDLLRRHAPAGVE
MAB_1949|M.abscessus_ATCC_1997 YTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTSAVVAALQEQAPEGIA
*****.* ***:*******: *******.****.::** *: .* *:
Mvan_3574|M.vanbaalenii_PYR-1 ITDEHRSRAVLAVQGPVSADVVGGLGLPTDMDYMGYADAEFRGVEVRVCR
Mflv_2939|M.gilvum_PYR-GCK ITDEHRSRAVLAVQGPRSADVVGGLGLPTDMDYMGFADGEVGGVETRVCR
MSMEG_4278|M.smegmatis_MC2_155 ITNEHRSYAVLAVQGPKSAEVLDKLGLPTDMDYMGYADAEFDGVFVRVCR
MMAR_3256|M.marinum_M ITDLHRSYAVLAVQGPRSTEVLAALGLPTEMDYMGYADSSYNGVSVRVCR
MUL_3571|M.ulcerans_Agy99 ITDLHRSYAVLAVQGPRSTEVLAALGLPTEMDYMGYADSSYNGVSVRVCR
Mb2234c|M.bovis_AF2122/97 ITNLHRSYAVLAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCR
Rv2211c|M.tuberculosis_H37Rv ITNLHRSYAVLAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCR
MLBr_00865|M.leprae_Br4923 IINQHRSHAVLAVQGPRSTDVLGELGLPTGIDYMGYVDASYAGVPVRVCR
MAV_2280|M.avium_104 VSNLHRSYAVLAVQGPRSADVLAELGLPSDMDYMAYADTSFRQVPVRVCR
TH_1298|M.thermoresistible__bu VIDEHRAHAVFAVQGPRSADVLSGLGLPVDMDYMAFTDATLNGVEVRVCR
MAB_1949|M.abscessus_ATCC_1997 VTNQHRDYAVLAVQGPRSADVLQRLGLPTDMEYMAYADATLAGLPVRVCR
: : ** **:***** *::*: **** ::**.:.* : .****
Mvan_3574|M.vanbaalenii_PYR-1 TGYTGEHGYELLPPWDQAAVVFDALVEAVQSAGGEPAGLGARDTLRTEMG
Mflv_2939|M.gilvum_PYR-GCK TGYTGEHGYELLPAWDQAEVVFDALVESVRAAGGEPAGLGARDTLRTEMG
MSMEG_4278|M.smegmatis_MC2_155 TGYTGEHGYELLPAWDRAGVVFDALVAAVRAAGGEPAGLGARDTLRTEMG
MMAR_3256|M.marinum_M TGYTGEHGYELLPPWESAGVVFDALAAAVAEVGGEPAGLGARDTLRTEMG
MUL_3571|M.ulcerans_Agy99 TGYTGEHGYELLPPWESAGVVFDALAAAVAEVGGSPAGLGARDTLRTEMG
Mb2234c|M.bovis_AF2122/97 TGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARDTLRTEMG
Rv2211c|M.tuberculosis_H37Rv TGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARDTLRTEMG
MLBr_00865|M.leprae_Br4923 TGYTGEQGYELLPPWESADVVFDALVAAVVDARGEPAGLGARDTLRTEMG
MAV_2280|M.avium_104 TGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMG
TH_1298|M.thermoresistible__bu TGYTGEHGYEVLPPWESALPVFDALVDAVQAAGGQLAGLGARDTLRTEMG
MAB_1949|M.abscessus_ATCC_1997 TGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMG
******:***:**.*: * ***** : . *. **************
Mvan_3574|M.vanbaalenii_PYR-1 YPLHGHELSLDISPLQARCGWAIGWKKDAFWGRDALLAEKAAGPRRTLRG
Mflv_2939|M.gilvum_PYR-GCK YPLHGHELSLDISPLQARCGWAIGWKKDAFWGRDALLAEKEAGPRRTLRG
MSMEG_4278|M.smegmatis_MC2_155 YPLHGHELSLDISPLQARCGWAVGWKKDAFWGRDALLAEKADGPKRVLRG
MMAR_3256|M.marinum_M YPLHGHELSLDISPLQARCGWAIGWKKDAFFGREALLAEKAAGPRRLLRG
MUL_3571|M.ulcerans_Agy99 YPLHGHELSLDISPLQARCGWAIGWKKDAFFGREALLAEKAAGPRRLPRG
Mb2234c|M.bovis_AF2122/97 YPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRG
Rv2211c|M.tuberculosis_H37Rv YPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRG
MLBr_00865|M.leprae_Br4923 YPLYGHELSLDISPLQARCGWAIGWKKDAFLGRDALLAEKAAGPRRLLRG
MAV_2280|M.avium_104 YPLHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRG
TH_1298|M.thermoresistible__bu YPLHGHELSPDISPLEARCGWAVGWKKERFWGRDALLAEKQAGPRRLLRG
MAB_1949|M.abscessus_ATCC_1997 YPLHGHELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRG
***:***** ****::**.***:**:*: * ** ** ** **:* **
Mvan_3574|M.vanbaalenii_PYR-1 LRAVGRGVLRQDLTVLDGENRVGVTTSGTFSPTLKVGIALALIDTEADIT
Mflv_2939|M.gilvum_PYR-GCK LRAVGRGVLRADLSVLTDDTPVGFTTSGTFSPTLKVGIALALIDTAAGIA
MSMEG_4278|M.smegmatis_MC2_155 LKALGRGVLRADLAVLDGDTRVGVTTSGTFSPTLKVGIALALIDTEYDIA
MMAR_3256|M.marinum_M LRMVGRGVLRPGLTVLNGSTPVGVTTSGTFSPTLQIGIALALIDTDAGVE
MUL_3571|M.ulcerans_Agy99 LRMVGRGVLRPGLTVLNGSTPVGVTTSGTFSPTLQIGIALALIDTDAGVE
Mb2234c|M.bovis_AF2122/97 LRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIE
Rv2211c|M.tuberculosis_H37Rv LRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIE
MLBr_00865|M.leprae_Br4923 LRMAGRGVLRPGLTVCAGDIPIGVTTSGTFSPTLQVGVALALIDSEAAVQ
MAV_2280|M.avium_104 LRMVGRGVLRAGLTVLVGDTPVGVTTSGTFSPTLQAGIALALIDTDADVR
TH_1298|M.thermoresistible__bu LRAVDRGVLRAGLSVYDGDTVVGTTTSGTFSPTLKVGIALALIDTEHGIP
MAB_1949|M.abscessus_ATCC_1997 LRATGRGVLRPDLTVLSDGQSIGVTTSGTFSPTLKTGIALALLDTAAQIP
*: .***** .*:* . :* **********: *:.***:*: :
Mvan_3574|M.vanbaalenii_PYR-1 DGAHVDVDVRGRRIECEVVKPPFVDTRTR
Mflv_2939|M.gilvum_PYR-GCK DGDHVTVDVRGRRVECEVVKPPFVDTRTR
MSMEG_4278|M.smegmatis_MC2_155 DGTTVTVDVRGRAVECEVVKPPFVTPSTR
MMAR_3256|M.marinum_M DGQQITVDVRGRAVECEVVRPPFVEAKTR
MUL_3571|M.ulcerans_Agy99 DGQQITVDVRGRAVECEVVRPPFVEAKTR
Mb2234c|M.bovis_AF2122/97 DGQQINVDVRGRAVECQVVCPPFVAVKTR
Rv2211c|M.tuberculosis_H37Rv DGQQINVDVRGRAVECQVVCPPFVAVKTR
MLBr_00865|M.leprae_Br4923 DGQQIIVDVRGRAVECEVVRPPFIEVKTR
MAV_2280|M.avium_104 DGQKVTVDVRGRAATCEVVRPPFVAVKTR
TH_1298|M.thermoresistible__bu DGARVSVDVRGRRIGCEVVKPPFVEVKTR
MAB_1949|M.abscessus_ATCC_1997 DGASVVVDVRGREIECEVVKPPFVDVNVG
** : ****** *:** ***: .