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M. leprae Br4923 MLBr_02688 (ponA)

annotation: penicillin-bonding protein
coordinates: 3236528 - 3238654
length: 708

PGSRLNRTWLLHLNRQVNWRWVRYSLYLAVVVLLLLPIVTFTMTYFMVKVPRPGDIRTNQVSTILANNGL
EIAKIVPPEGNRVDVNLSQVPVHVRQAVIAAEDRNFYSNPGFDFRASVRAVQNNLFGSGDLQGGSTITQQ
YVKNALVGSAQHGFDGLMRKTKELVIAIKMSDAWSKDDVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQ
LTCSEGALLAALIRRPSVLDPAINLKGVTARWNWVLDGMVDINALSPNDRSVQLFPATVPPDQARAQNQT
TGPNGLIERQVVKELFELFNIDRQTLNTQGLQVITTIDPQAQRIVEKAVSKYLDGQDPDMRAAIVSIDPH
NGAIRAYYGGADANGFDFAQAGLQTGSSFKVFALIAALEQGIGLGYRVDSSPLTVDGIKITNNGDESCGN
CNIAEALKLSLNTSYYRLMLKLKNGPQAVADAAHQAGIVSSFPGVAHTLSEDGKGGPPNNGIVLGQYETR
VIDMASAYATLAASGVYHRPHLVQKVVNAEGRVLFDASTADNSGDQRIAKAVADNVTAAMQPIAGYSRGH
NLAGGRPSAAKTGTVQLGDTTANKDAWMVGYTPSLSTAVWVGTVKDNVPLITASGEAIYGSGLPSDIWKS
TMDGALEGTPNEGFPKPTEVGGYAGVPTLAPPPPLKKVIQPTIEVAPGIIIPVGPPTTVTVPPTQALPDL
TTSTTPP*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02688ponA-100% (708)penicillin-bonding protein
M. leprae Br4923MLBr_02308pon14e-4525.76% (691) penicillin binding protein (class A)
M. leprae Br4923MLBr_00018pbpA1e-1323.56% (399) putative penicillin-binding protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0051ponA10.082.38% (681) bifunctional penicillin-binding protein 1A/1B
M. gilvum PYR-GCKMflv_0871-0.071.83% (703) glycosyl transferase family protein
M. tuberculosis H37RvRv0050ponA10.082.77% (679) bifunctional penicillin-binding protein 1A/1B
M. abscessus ATCC 19977MAB_4901c-0.067.83% (690) penicillin-binding protein
M. marinum MMMAR_0069ponA10.081.77% (691) bifunctional penicillin-binding protein 1A/1B PonA1
M. avium 104MAV_0071-0.081.49% (697) transglycosylase
M. smegmatis MC2 155MSMEG_6900-0.072.81% (695) penicillin-binding protein 1
M. thermoresistible (build 8)TH_3201-0.070.17% (714) PUTATIVE glycosyl transferase, family 51
M. ulcerans Agy99MUL_0068ponA10.081.50% (681) bifunctional penicillin-binding protein 1A/1B PonA1
M. vanbaalenii PYR-1Mvan_6036-0.072.34% (705) glycosyl transferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0871|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6036|M.vanbaalenii_PYR-1       ---------------------------MGARNPQHRKDDPVRRPGEGGVR
MSMEG_6900|M.smegmatis_MC2_155      --------------------------------------------------
TH_3201|M.thermoresistible__bu      --------------------------------------------MRLSTL
MMAR_0069|M.marinum_M               --------------------------------------------------
MUL_0068|M.ulcerans_Agy99           --------------------------------------------------
MAV_0071|M.avium_104                MSSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRNGPSTSSRR
Mb0051|M.bovis_AF2122/97            --------------------------------------------------
Rv0050|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02688|M.leprae_Br4923          --------------------------------------------------
MAB_4901c|M.abscessus_ATCC_199      ---------------------------------MVGEENSVAPNSGPDSP
                                                                                      

Mflv_0871|M.gilvum_PYR-GCK          --MPPDDRHTAVLPPFRDGPPPPTRDPIDAVKSALDSRDRR---------
Mvan_6036|M.vanbaalenii_PYR-1       RAPAPDDRHTTVIPPVRDGAPPPLRDPIDAVKRALDGGAR----------
MSMEG_6900|M.smegmatis_MC2_155      --MPPDDRLTAVLPPVRDGDIAP---PIDVVRAALE--------------
TH_3201|M.thermoresistible__bu      ATTAAAVALTGTVGGLATGPAARSRWFARLKKPGFQPPAQ----------
MMAR_0069|M.marinum_M               --------------------------------------------------
MUL_0068|M.ulcerans_Agy99           --------------------------------------------------
MAV_0071|M.avium_104                RQAPPDDRLTTILPPVDDDRAPRRSDPIEEVKAALAGPPSTPLRRDALDE
Mb0051|M.bovis_AF2122/97            --------------------------------------------------
Rv0050|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02688|M.leprae_Br4923          --------------------------------------------------
MAB_4901c|M.abscessus_ATCC_199      RTPSTDDRPTSILDPIEDLPLYRRDDDAVAAARAALERDED---------
                                                                                      

Mflv_0871|M.gilvum_PYR-GCK          ----------RRDGDRRREGDQRRGS-GPPPPPPGPPRHGGGGPTGGDGP
Mvan_6036|M.vanbaalenii_PYR-1       -------------GERKNFGPPKQPPPSQPPPPPGRP-PGGGGPPGGGGP
MSMEG_6900|M.smegmatis_MC2_155      ------------------------GSPPPKPPPPPPPGRGGGGPSGPGGP
TH_3201|M.thermoresistible__bu      -------------------AFPIVWPILYTDIAGVSAATIDRLXXXPGEP
MMAR_0069|M.marinum_M               --------------------------------------------------
MUL_0068|M.ulcerans_Agy99           --------------------------------------------------
MAV_0071|M.avium_104                VKAALDSRGPASGRQQRAGLGGRPPVGPPPPPPRRGWSGGPGGPGGRGSG
Mb0051|M.bovis_AF2122/97            --------------------------------------------------
Rv0050|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02688|M.leprae_Br4923          ------------------------------------------MPGSRLNR
MAB_4901c|M.abscessus_ATCC_199      -----------------------GGRGHEPPPPPGTP-----GRPGGSSR
                                                                                      

Mflv_0871|M.gilvum_PYR-GCK          SGPPRSLREQINWTWVRRGSLIAAVVLIVLPLLTFGMAYMIVDVPKPGDI
Mvan_6036|M.vanbaalenii_PYR-1       AGPRRSLREQINWKWVRRGSIIAAAVLILLPLLTFGMAYMIVDVPKPGDI
MSMEG_6900|M.smegmatis_MC2_155      SGPGRQFR--INWKWVRRGSAIAVAVMVLLPLITFGMAYMIVDVPEPGDI
TH_3201|M.thermoresistible__bu      PEEPANWFDRINWRWVRRGLFAGAVALLVLPIITFVMAYLIVDVPRPGDI
MMAR_0069|M.marinum_M               ---------------MRRSAYLAAAVVILLPIVTFTMAYFIVDVPRPGDI
MUL_0068|M.ulcerans_Agy99           -------------------------MVILLPIVTFTVAYFIVDVPRPGDI
MAV_0071|M.avium_104                PWRDWSWTQQINWLWVRRAAYLCAAVLVLLPIVTFAMAYFIVDIPKPGDL
Mb0051|M.bovis_AF2122/97            -------------------------MVILLLMVTFTMAYLIVDVPKPGDI
Rv0050|M.tuberculosis_H37Rv         -------------------------MVILLPMVTFTMAYLIVDVPKPGDI
MLBr_02688|M.leprae_Br4923          TWLLHLN-RQVNWRWVRYSLYLAVVVLLLLPIVTFTMTYFMVKVPRPGDI
MAB_4901c|M.abscessus_ATCC_199      PPQRRRKRKSNGWKIFRNVMIALVLLAIVIPLATFALAYSVVDIPKPGDI
                                                               ::: : ** ::* :*.:*.***:

Mflv_0871|M.gilvum_PYR-GCK          RTAQVSTILASDGS-EIAKIVPPEGNRIDVNIDQIPVHVRDAVMAAEDRD
Mvan_6036|M.vanbaalenii_PYR-1       RTAQVSTILASDGS-EIAKIVPPEGNRVDVDIDQIPVHVRDAVMAAEDRD
MSMEG_6900|M.smegmatis_MC2_155      RTPQVSTILASDGS-EIARIVPPEGNRVDVKIDQIPVHVRDAVMAAEDRD
TH_3201|M.thermoresistible__bu      RTNQVSTILASDGS-ELARIVPPEGNRIDVNINQIPVHVRDAVMAAEDRD
MMAR_0069|M.marinum_M               RTNQVSTILASDGS-EIAKIVPPEGNRVDVNLSQVPEHVRAAVIAAEDRG
MUL_0068|M.ulcerans_Agy99           RTNQVSTILASDGS-EIAKIVPPEGNRVDVNLSQVPEHVRAAVIAAEDRG
MAV_0071|M.avium_104                RTNQVSTILASDGS-EIAKIIPPEGNRVDVNLNQVPVHVRQAVIAAEDRN
Mb0051|M.bovis_AF2122/97            RTNQVSTILASDGS-EIAKIVPPEGNRVDVNLSQVPMHVRQAVIAAEDRN
Rv0050|M.tuberculosis_H37Rv         RTNQVSTILASDGS-EIAKIVPPEGNRVDVNLSQVPMHVRQAVIAAEDRN
MLBr_02688|M.leprae_Br4923          RTNQVSTILANNGL-EIAKIVPPEGNRVDVNLSQVPVHVRQAVIAAEDRN
MAB_4901c|M.abscessus_ATCC_199      RTSQVSTILASDGTTELAKVVPPEGNRVDIKIDQVPQHVRAAVMAAEDRD
                                    ** *******.:*  *:*:::******:*:.:.*:* *** **:*****.

Mflv_0871|M.gilvum_PYR-GCK          FYSNPGFSFTGFLRAFKNNIFGG-DLQGGSTITQQYVKNALVGDARSGVG
Mvan_6036|M.vanbaalenii_PYR-1       FYSNPGFSFTGFLRAAKNNIFGG-DLQGGSTITQQYVKNALVGDARSGVG
MSMEG_6900|M.smegmatis_MC2_155      FYSNPGFSWTGFLRAIKNNLFGGGGLQGGSTITQQYVKNALVGDERSGIG
TH_3201|M.thermoresistible__bu      FYSNPGFSFTGFARAIGNNIFGG-DVQGGSTITQQYVKNALVGSERVGVR
MMAR_0069|M.marinum_M               FYSNPGFSFSGFARAIKNNLFG-GDLQGGSTITQQYVKNALVGSAQHGWS
MUL_0068|M.ulcerans_Agy99           FYSNPGFSFSGFARAIKNNLFG-GDLQGGSTITQQYVKNALVGSAQHGWS
MAV_0071|M.avium_104                FYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVS
Mb0051|M.bovis_AF2122/97            FYSNPGFSFTGFARAVKNNLFG-GDLQGGSTITQQYVKNALVGSAQHGWS
Rv0050|M.tuberculosis_H37Rv         FYSNPGFSFTGFARAVKNNLFG-GDLQGGSTITQQYVKNALVGSAQHGWS
MLBr_02688|M.leprae_Br4923          FYSNPGFDFRASVRAVQNNLFGSGDLQGGSTITQQYVKNALVGSAQHGFD
MAB_4901c|M.abscessus_ATCC_199      FYGNPGFSFSGLLRAVKNNMFG-GDTQGGSTITQQYVKNAMVGSQRAGLG
                                    **.****.: .  **  **:**  . **************:**. : *  

Mflv_0871|M.gilvum_PYR-GCK          GVIRKAKELVISTKMSSEWSKDQVLQSYLNIIYFGRGAYGVAAAAKAYFG
Mvan_6036|M.vanbaalenii_PYR-1       GLIRKAKELVISTKMSSEWSKDQVLQSYLNIIYFGRGAYGVAAAAQAYFG
MSMEG_6900|M.smegmatis_MC2_155      GLIRKAKELVISTKMSGEWSKDAVLQAYLNIIYFGRGAYGISAASKAYFD
TH_3201|M.thermoresistible__bu      GLIRKAKELVISTKMSRQWSKDQVMQSYLNIIYFGRGAYGVAAASRAYFD
MMAR_0069|M.marinum_M               GLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFD
MUL_0068|M.ulcerans_Agy99           GLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFD
MAV_0071|M.avium_104                GLMRKAKELVIATKMSGEWSKDEVLQSYLNIIYFGRGAYGISAAAKAYFD
Mb0051|M.bovis_AF2122/97            GLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFD
Rv0050|M.tuberculosis_H37Rv         GLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFD
MLBr_02688|M.leprae_Br4923          GLMRKTKELVIAIKMSDAWSKDDVLQSYLNIIYFGRGAYGISAAAKAYFD
MAB_4901c|M.abscessus_ATCC_199      GLTRKAKEIVISTKMSQSWSKDQVMEAYLNIIYFGRGAYGISAASKAYFD
                                    *: **:**:**: ***  **** *:::*************::**::***.

Mflv_0871|M.gilvum_PYR-GCK          KPIEEVTVSEGALLAALIQRPSVLDPAVDPDASAVRWSWVLDGMVEIGAL
Mvan_6036|M.vanbaalenii_PYR-1       KPVEQLNVSEGALLAALIQRPSVLDPAVDPDASAVRWSWVLDGMVEIGAL
MSMEG_6900|M.smegmatis_MC2_155      KPVEQLDVAEGALLAALIQRPSTLDPAVDPEGAADRWNWVLDGMVDIGAL
TH_3201|M.thermoresistible__bu      KPVEELNVAEGALLAALIQRPSTLDPAADPQGAETRWNWVLDGMVEIGAL
MMAR_0069|M.marinum_M               KPVEQLTVSEGALLAALIRRPSTLDPAVDPDGALARWNWVLDGMVDTKAL
MUL_0068|M.ulcerans_Agy99           KPVEQLTVSEGALLAALIRRPSTLDPAVDPDGALARWNWVLDGMVDTKAL
MAV_0071|M.avium_104                KPVEQLTVSEGALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKAL
Mb0051|M.bovis_AF2122/97            KPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKAL
Rv0050|M.tuberculosis_H37Rv         KPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKAL
MLBr_02688|M.leprae_Br4923          KPVEQLTCSEGALLAALIRRPSVLDPAINLKGVTARWNWVLDGMVDINAL
MAB_4901c|M.abscessus_ATCC_199      KPVEQLTVSEGALLAALIQRPSRLDPAVDLPESTNRWNWVLDGMVTIGAL
                                    **:*::  :*********:*** **** :      **.*******   **

Mflv_0871|M.gilvum_PYR-GCK          SEQDRAAQIFPPTIPPDQASTQNQTTGPNGLIERQVVSELMEIFDINEQA
Mvan_6036|M.vanbaalenii_PYR-1       SPEDRAGQVFPPTIPPDQAFTQNQTTGPNGLIERQVVNELMEIFDINEQT
MSMEG_6900|M.smegmatis_MC2_155      SQADRDAQVFPPTVPPDYAFQQNQTTGPNGLIERQVTNELLDLFDINEQT
TH_3201|M.thermoresistible__bu      SPQERAAQVFPPTVPPELARSQNQTTGPNGLIERQVTRELLELFNISEQA
MMAR_0069|M.marinum_M               SAKDRAEQVFPRTVPPDQARAANQTTGPNGLIERQVTKELLELFNIDEQT
MUL_0068|M.ulcerans_Agy99           SAKDRAEQAFPRTVPPDQARAANQTTGPNGLIERQVTKELLELFNIDEQT
MAV_0071|M.avium_104                PAKDRAAQVFPQTVPPDQARAQNQTTGPNGLIERQVTKELMELFNIDERT
Mb0051|M.bovis_AF2122/97            SPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQT
Rv0050|M.tuberculosis_H37Rv         SPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQT
MLBr_02688|M.leprae_Br4923          SPNDRSVQLFPATVPPDQARAQNQTTGPNGLIERQVVKELFELFNIDRQT
MAB_4901c|M.abscessus_ATCC_199      SAQDRAGQVYPATVPPEQAAAQNATTGPNGLIKRQVMAELTDLFNIDEQT
                                    .  :*  * :* *:**: *   * *.******:***  ** ::*:*..::

Mflv_0871|M.gilvum_PYR-GCK          LNTEGLQITTTIDPKAQSAAQDAVEDYLDGQDPDMRSAVVSIDPKTGGIK
Mvan_6036|M.vanbaalenii_PYR-1       LNTEGLQITTTIDPQMQAAAVDAVEEYMDGQDPDMRTAVVSIDPRTGGVR
MSMEG_6900|M.smegmatis_MC2_155      LNTEGLQITTTIDPKAQEAAVDAVDKYLEGQDPDMRAAVVSIDPRTGGIK
TH_3201|M.thermoresistible__bu      LNTEGLQITTTIDPQAQQAAVDAVETYLEGQDPDMRAAVVSIDPRTGAVK
MMAR_0069|M.marinum_M               LNTQGLQVTTTIDAQAQQAAEKAVAKYLDGQDPEMRAAVVSIDPHNGAVR
MUL_0068|M.ulcerans_Agy99           LNTQGLQVTTTIDAQAQQAAEKAVAKYLDGQDPEMRAAVVSIDPHNGAVR
MAV_0071|M.avium_104                LNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQDPDMRAAVVSVDPHDGAIR
Mb0051|M.bovis_AF2122/97            LNTQGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVR
Rv0050|M.tuberculosis_H37Rv         LNTQGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVR
MLBr_02688|M.leprae_Br4923          LNTQGLQVITTIDPQAQRIVEKAVSKYLDGQDPDMRAAIVSIDPHNGAIR
MAB_4901c|M.abscessus_ATCC_199      LNTEGLQITTTIDTKAQQAAENAVNTTLQSENPDLRTAVVSIDPRTGAVK
                                    ***:** : ****.: *  . .**   ::.::*::*:*:**:**: *.::

Mflv_0871|M.gilvum_PYR-GCK          AYYGGSDAAGFDFAQAGLPTGSSFKVFALIAALEQGMGLGYQVDSSPLEV
Mvan_6036|M.vanbaalenii_PYR-1       AYYGGSDANGFDFAQAGLPTGSSFKVFALVAALQQGMGLGYQVDSSPVEV
MSMEG_6900|M.smegmatis_MC2_155      AYYGGSDANGFDFAQAGLPTGSSFKVFALVAALQQGIGLGYQIDSGPLEV
TH_3201|M.thermoresistible__bu      AYYGGSDANGYDFAQAAVPTGSSFKVFALVAALEQGMGLGYQVDSSPLTV
MMAR_0069|M.marinum_M               AYYGGDNANGFDFAQAGLQTGSSFKVFALVAALEQGIGLGYDVDSSPLTV
MUL_0068|M.ulcerans_Agy99           AYYGGDNANGFDFAQAGLQTGSSFKVFALVAALEQGIGLGYDVDSSPLTV
MAV_0071|M.avium_104                AYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGYQVDSSPLTV
Mb0051|M.bovis_AF2122/97            AYYGGDNANGFDFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTV
Rv0050|M.tuberculosis_H37Rv         AYYGGDNANGFDFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTV
MLBr_02688|M.leprae_Br4923          AYYGGADANGFDFAQAGLQTGSSFKVFALIAALEQGIGLGYRVDSSPLTV
MAB_4901c|M.abscessus_ATCC_199      AYYGGSNAQGLDYAQQGLQTGSSFKVFALVAALQQGIGLGYQLDSSELTY
                                    ***** :* * *:** .: ********.*:***:**:**** :**. :  

Mflv_0871|M.gilvum_PYR-GCK          NGIKISNVEGSSCGSCNIAEALKRSLNTSYYRLMLKLKNGPQDVADAAHQ
Mvan_6036|M.vanbaalenii_PYR-1       NGIKISNVEGNSCGTCNIAEALKRSLNTSYYRLMLQLENGPQDVADAAHA
MSMEG_6900|M.smegmatis_MC2_155      NGIKIGNVEGEGCGTCSIAEALKRSLNTSYYRLMLKLENGPADVAEAAHD
TH_3201|M.thermoresistible__bu      NGIEITNVEGSSCGRCNIAEALKRSLNTSFYRLMLELKNGPEDVADAAHR
MMAR_0069|M.marinum_M               DGIKITNVEGESCGTCNIAQALKMSLNTSYYRLMLKLKGGPEAVADAAHQ
MUL_0068|M.ulcerans_Agy99           DGIKITNVEGESCGTCNIAQALKMSLNTPYYRLMLKLKGGPEAVADAAHQ
MAV_0071|M.avium_104                DGIKITNVEGESCGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQ
Mb0051|M.bovis_AF2122/97            DGIKITNVEGEGCGTCNIAEALKMSLNTSYYRLMLKLNGGPQAVADAAHQ
Rv0050|M.tuberculosis_H37Rv         DGIKITNVEGEGCGTCNIAEALKMSLNTSYYRLMLKLNGGPQAVADAAHQ
MLBr_02688|M.leprae_Br4923          DGIKITNNGDESCGNCNIAEALKLSLNTSYYRLMLKLKNGPQAVADAAHQ
MAB_4901c|M.abscessus_ATCC_199      QGITIKNSEDASCGTCSVAEALKRSLNTSFYRLMLKLKNGPEDVAAAAHN
                                    :** * *  . .** *.:*:*** ****.:*****:*:.**  ** *** 

Mflv_0871|M.gilvum_PYR-GCK          AGIAESIPGIEHTLSEDGQGGPPNNGIVLGQYQSRVLDMASAYATIAASG
Mvan_6036|M.vanbaalenii_PYR-1       AGIAESFPGVEHTLSEDGQGGPPNNGVVLGQYQSRVIDMASAYATLAASG
MSMEG_6900|M.smegmatis_MC2_155      AGVAESFPGVEHTLSEDGKGGPPNNGVVLGQYQSRVLDMASAYATLAASG
TH_3201|M.thermoresistible__bu      AGIAESIPGIEHTLSEDGKGGPPNNGIVLGQYQSRPIDMASAYATLANSG
MMAR_0069|M.marinum_M               AGIATSFPGVPHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASG
MUL_0068|M.ulcerans_Agy99           AGIATSFPGVPHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASG
MAV_0071|M.avium_104                AGVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASG
Mb0051|M.bovis_AF2122/97            AGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASG
Rv0050|M.tuberculosis_H37Rv         AGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASG
MLBr_02688|M.leprae_Br4923          AGIVSSFPGVAHTLSEDGKGGPPNNGIVLGQYETRVIDMASAYATLAASG
MAB_4901c|M.abscessus_ATCC_199      AGIAENFPGVSHTLSEDGQGGPPNNGVVLGQYQTRVLDMASAYATLAASG
                                    **:. .:**: *******:*******:*****::* :********:* **

Mflv_0871|M.gilvum_PYR-GCK          VYHKPHFVQKVVNSDGQVLFDATQEDNSGEQRIDQAVAENVIAAMQPIAG
Mvan_6036|M.vanbaalenii_PYR-1       VYHKPHFVQKVVNAEGTVLFDASQEDNTGEQRIDKAVADNVTAAMQPIAA
MSMEG_6900|M.smegmatis_MC2_155      VYHKPHFVEKVVNSSGQVLFDASKEDN-GEERIDKAVADNVTSAMQPIAG
TH_3201|M.thermoresistible__bu      VYHRPHFVQKVVNSEGQVLFDADQRDDDGEQRIEKDVADNVTAAMQPIAA
MMAR_0069|M.marinum_M               IYHRPHFVQKVVNADGRVLFDASTEDNTGDQRIPKAVADNVTAAMEPIAG
MUL_0068|M.ulcerans_Agy99           IYHRPHFVQKVVDADGRVLFDASTEDNTGDQRIPKAVADNVTAAMEPIAG
MAV_0071|M.avium_104                VYHRPHFVQKVVNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAG
Mb0051|M.bovis_AF2122/97            IYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPKAVADNVTAAMEPIAG
Rv0050|M.tuberculosis_H37Rv         IYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPKAVADNVTAAMEPIAG
MLBr_02688|M.leprae_Br4923          VYHRPHLVQKVVNAEGRVLFDASTADNSGDQRIAKAVADNVTAAMQPIAG
MAB_4901c|M.abscessus_ATCC_199      TYRKPHFIQKVVNADGQVLFDAGSSDNTGEKRISDDVANNAISAMKPIAA
                                     *: **:::***.:.* *****   *: *::** . **:*. :**:***.

Mflv_0871|M.gilvum_PYR-GCK          YS-GRALAGGRPSAAKTGTNQLGDTGENRDAWMVGFTPSLSTAVWVGTVD
Mvan_6036|M.vanbaalenii_PYR-1       YSNGHALAGGRPSAAKTGTNQLGDTGANRDAWMVGFTPSLSTAVWVGTTD
MSMEG_6900|M.smegmatis_MC2_155      WSRGHNLAGGRPSAAKTGTVQLGDTGDNRDAWMVGYTPSLSTAVWVGTTE
TH_3201|M.thermoresistible__bu      YSNGHALAGGRPSAAKTGTHQLGDTGENRDAWMVGYTPSLSTAVWVGTVD
MMAR_0069|M.marinum_M               YSRGHNLAGGRPSASKTGTVQLGDTSANRDAWMVGYTPSLSTAVWVGTVK
MUL_0068|M.ulcerans_Agy99           YSRGHNLAGGRPSASKTGTVQLGDTSANRDAWMVGYTPSLSTAVWVGTVK
MAV_0071|M.avium_104                YSRGHALAGGRPSAAKTGTTQLGDTTSNKDAWMVGYTPSLSTAVWLGTAK
Mb0051|M.bovis_AF2122/97            YSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTAVWVGTVK
Rv0050|M.tuberculosis_H37Rv         YSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTAVWVGTVK
MLBr_02688|M.leprae_Br4923          YSRGHNLAGGRPSAAKTGTVQLGDTTANKDAWMVGYTPSLSTAVWVGTVK
MAB_4901c|M.abscessus_ATCC_199      YSRGHALAGGRESASKTGTAQLGDTKDNKDAWMVGFTPSLSTAVWVGTDD
                                    :* *: ***** **:**** *:***  *:******:*********:** .

Mflv_0871|M.gilvum_PYR-GCK          GTKPLVTSGGASVYGSGLPGQIWKSTMDNALDGTDNETFPKPEEIGGYAG
Mvan_6036|M.vanbaalenii_PYR-1       GTKPLENKWGSPVYGSGLPSDIWKATMDGALDGTDNESFPKPEEIGGYAG
MSMEG_6900|M.smegmatis_MC2_155      GVKPLVNKWGSPIYGSGLPSDIWKATMDGALEGTDVESFPKPTEIGGYAG
TH_3201|M.thermoresistible__bu      GNKPLRTKWGGKIYGSGLPSDIWKATMDGALKGTERESFPKPGEIGGYAG
MMAR_0069|M.marinum_M               GDEPLVTASGAPIYGSGLPSDIWKATMDGALKGTEVESFPKPTEIGGYAG
MUL_0068|M.ulcerans_Agy99           GDEPLVTASGAPIYGSGLPSDIWKATMDGALKGTEVESFPKPTEIGGYAG
MAV_0071|M.avium_104                GDQPLVTASGGPVYGSGLPSDIWKATMDGALKGTPNESFPKPAEVGGYAG
Mb0051|M.bovis_AF2122/97            GDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAG
Rv0050|M.tuberculosis_H37Rv         GDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAG
MLBr_02688|M.leprae_Br4923          DNVPLITASGEAIYGSGLPSDIWKSTMDGALEGTPNEGFPKPTEVGGYAG
MAB_4901c|M.abscessus_ATCC_199      G-KPIKTSWGGPIYGSGLPSDIWKKTMDGALDGTAKETFPKPGPIGGYAG
                                    .  *: .  *  :******.:*** ***.**.**  * ****  :*****

Mflv_0871|M.gilvum_PYR-GCK          VPQ-APPPPPSS-----TAPPTPSETVIQPTLEIAPGITIPWG-------
Mvan_6036|M.vanbaalenii_PYR-1       VPQ-APPPPPSPS---VTVPPPPSETVIQPTLEIAPGITIPWG-------
MSMEG_6900|M.smegmatis_MC2_155      VPQ-APAAPPPSAGP-PTDPGQPSVTVIQPTIEVAPGITIPIG-------
TH_3201|M.thermoresistible__bu      VPQ-APSPQRTSDDDGTTTVTPPSETVIQPSVEVAPGITIPLGXAVSAVV
MMAR_0069|M.marinum_M               VPA-PPPPPPEAP--------PPSETVIQPTVEIAPGITIPVG-------
MUL_0068|M.ulcerans_Agy99           VPA-PPPPPPEAP--------PPAETVIQPTVEIVPGITIPVG-------
MAV_0071|M.avium_104                VPA-PPPPP--KA--------PPSETVIQPTIEVAPGITIPVG-------
Mb0051|M.bovis_AF2122/97            VPP-PPPPPPSEV--------PPSETVIQPTVEIAPGITIPIG-------
Rv0050|M.tuberculosis_H37Rv         VPP-PPPPP--EV--------PPSETVIQPTVEIAPGITIPIG-------
MLBr_02688|M.leprae_Br4923          VPT-LAPPP-------------PLKKVIQPTIEVAPGIIIPVG-------
MAB_4901c|M.abscessus_ATCC_199      VPTYVPPPPVPNGPPAPAPTGGGEVTVIQPTIEIAPGITIPVG-------
                                    **   ...                 .****::*:.*** ** *       

Mflv_0871|M.gilvum_PYR-GCK          --------------PPTT--------------------------------
Mvan_6036|M.vanbaalenii_PYR-1       --------------PPTT--------------------------------
MSMEG_6900|M.smegmatis_MC2_155      --------------PPTT--------------------------------
TH_3201|M.thermoresistible__bu      RVRDAVVRPHLVAEPPLTGRPDGTSRPGRRAPVRRCRNVDFRRDIGAPCA
MMAR_0069|M.marinum_M               --------------PPTT--------------------------------
MUL_0068|M.ulcerans_Agy99           --------------PPTT--------------------------------
MAV_0071|M.avium_104                --------------PPTT--------------------------------
Mb0051|M.bovis_AF2122/97            --------------PPTT--------------------------------
Rv0050|M.tuberculosis_H37Rv         --------------PPTT--------------------------------
MLBr_02688|M.leprae_Br4923          --------------PPTT--------------------------------
MAB_4901c|M.abscessus_ATCC_199      --------------PPTT--------------------------------
                                                  ** *                                

Mflv_0871|M.gilvum_PYR-GCK          --------------------------------------------VPVGP-
Mvan_6036|M.vanbaalenii_PYR-1       --------------------------------------------VPVAPP
MSMEG_6900|M.smegmatis_MC2_155      --------------------------------------------VPVGPP
TH_3201|M.thermoresistible__bu      FHRDRRWLPADAVRAEPLGRGSPQRTGPGRAGGLLSGAAVRGTGVPSEPA
MMAR_0069|M.marinum_M               --------------------------------------------ITLAP-
MUL_0068|M.ulcerans_Agy99           --------------------------------------------ITLAP-
MAV_0071|M.avium_104                --------------------------------------------VTLAP-
Mb0051|M.bovis_AF2122/97            --------------------------------------------ITLAP-
Rv0050|M.tuberculosis_H37Rv         --------------------------------------------ITLAP-
MLBr_02688|M.leprae_Br4923          --------------------------------------------VTVPP-
MAB_4901c|M.abscessus_ATCC_199      --------------------------------------------VPVGP-
                                                                                :.  * 

Mflv_0871|M.gilvum_PYR-GCK          -PGAPP--VPETAPPVPPPGAPVPPGAPPPPGA-------PVPPGAPPGP
Mvan_6036|M.vanbaalenii_PYR-1       VPGAPP--APGAPPPAGAPGAPVPPGAPPP------------------GP
MSMEG_6900|M.smegmatis_MC2_155      -PGAPG--APVGP---GAPEVPVAPGAPGVP-----------------GA
TH_3201|M.thermoresistible__bu      HGGSVPRRAGGADDGADAPGAGRAPGAQRRVR--------HHPGGPDGGP
MMAR_0069|M.marinum_M               -----------------PPPPGAPP-----------------------AD
MUL_0068|M.ulcerans_Agy99           -----------------PPPPGAPP-----------------------AD
MAV_0071|M.avium_104                -----------------APPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAP
Mb0051|M.bovis_AF2122/97            -----------------PPP--APP---------------------AATP
Rv0050|M.tuberculosis_H37Rv         -----------------PPP--APP---------------------AATP
MLBr_02688|M.leprae_Br4923          -----------------TQALPDLT-----------------------TS
MAB_4901c|M.abscessus_ATCC_199      ----------------AAPPAGDVP------------------------P
                                                     .      .                         

Mflv_0871|M.gilvum_PYR-GCK          LPPP----------
Mvan_6036|M.vanbaalenii_PYR-1       LPPP----------
MSMEG_6900|M.smegmatis_MC2_155      PPPP----------
TH_3201|M.thermoresistible__bu      RQPAAVSPLRGTTR
MMAR_0069|M.marinum_M               NPPP----------
MUL_0068|M.ulcerans_Agy99           NPPP----------
MAV_0071|M.avium_104                PPPP----------
Mb0051|M.bovis_AF2122/97            TPPP----------
Rv0050|M.tuberculosis_H37Rv         TPPP----------
MLBr_02688|M.leprae_Br4923          TTPP----------
MAB_4901c|M.abscessus_ATCC_199      PGP-----------
                                      *