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M. leprae Br4923 MLBr_02425 (-)

MTVPLEAEGLIGKHYRQLDHFQVGREKIREFAIAVKDDHPTHYNETAAFEAGYPALVAPLTFLAIAGRRV
QLEIFTKFNIPINVARVFHRDQKFRFYRTILAQDKLYFDTYLDSVIESHGTVIAEVRSEVTDTEGKAVVT
SIVTMLGELARQDATAEETVAAIASI

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_02425	-	-	100% (166)	hypothetical protein MLBr_02425
M. leprae Br4923	MLBr_01910	-	1e-28	40.71% (140)	(3R)-hydroxyacyl-ACP dehydratase subunit HadA
M. leprae Br4923	MLBr_01908	-	3e-25	38.69% (137)	(3R)-hydroxyacyl-ACP dehydratase subunit HadC

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb0516c	-	2e-75	83.13% (166)	hypothetical protein Mb0516c
M. gilvum PYR-GCK	Mflv_0070	-	4e-52	61.64% (159)	MaoC-like dehydratase
M. tuberculosis H37Rv	Rv0504c	-	3e-75	83.13% (166)	hypothetical protein Rv0504c
M. abscessus ATCC 19977	MAB_3996	-	2e-43	55.06% (158)	hypothetical protein MAB_3996
M. marinum M	MMAR_0832	-	2e-69	77.11% (166)	hypothetical protein MMAR_0832
M. avium 104	MAV_4646	-	6e-71	75.90% (166)	hypothetical protein MAV_4646
M. smegmatis MC2 155	MSMEG_0948	-	6e-54	65.54% (148)	hypothetical protein MSMEG_0948
M. thermoresistible (build 8)	TH_3830	-	4e-55	65.41% (159)	PUTATIVE MaoC-like dehydratase
M. ulcerans Agy99	MUL_4576	-	2e-69	77.11% (166)	hypothetical protein MUL_4576
M. vanbaalenii PYR-1	Mvan_0842	-	4e-53	64.78% (159)	MaoC-like dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0516c|M.bovis_AF2122/97           --MTVPEEAQTLIGKHYRAPDHFLVGREKIREFAVAVKDDHPTHYSEPDA
Rv0504c|M.tuberculosis_H37Rv        --MTVPEEAQTLIGKHYRAPDHFLVGREKIREFAVAVKDDHPTHYSEPDA
MAV_4646|M.avium_104                --MTVPKEAEGLIGSHYRAPDYFEVGREKIREFALAVKDDHPAHFDESES
MLBr_02425|M.leprae_Br4923          --MTVPLEAEGLIGKHYRQLDHFQVGREKIREFAIAVKDDHPTHYNETAA
MMAR_0832|M.marinum_M               --MTVPPEAAGLIGKHYQAPDYFVVGREKIREFATAIQDEHPSHSDEAAA
MUL_4576|M.ulcerans_Agy99           --MTVPPEAAGLIGKHYQAPDYFVVGREKIREFATAIQDEHPSHSDEAAA
Mflv_0070|M.gilvum_PYR-GCK          MATSI---AADIIGTHYRYPDYFQVDREKIREFARAVKDEHPAHHDEDAA
Mvan_0842|M.vanbaalenii_PYR-1       --MAI---AEEIIGTHYRYPDYFAVDREKIREFARAVKDEHPAHYTEEAA
MSMEG_0948|M.smegmatis_MC2_155      --MSI---AANIIGTHYRYPDYFEVGREKVREFSAAVKDDHPAHFDEAAA
TH_3830|M.thermoresistible__bu      --MSI---AADIIGTHYRYPDYFEVDREKIREFARAVKNDHPAHFTEEAA
MAB_3996|M.abscessus_ATCC_1997      --MAI---RQDIVGTHYRYPDYFEVGREKMREFAAAIKDECEVN------
                                       ::      ::*.**:  *:* *.***:***: *::::   :      

Mb0516c|M.bovis_AF2122/97           AAAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINIARVFHRDQKFRFHR
Rv0504c|M.tuberculosis_H37Rv        AAAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINIARVFHRDQKFRFHR
MAV_4646|M.avium_104                AAAGYPDMVAPLTFLAIAGRRVQLEIFTKFSIPINIARVIHRDQKFKFHR
MLBr_02425|M.leprae_Br4923          FEAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINVARVFHRDQKFRFYR
MMAR_0832|M.marinum_M               AELGYPELVAPLTFLAIAGRRVQLEIFNKFNIPINIARVFHRDQKFRFYR
MUL_4576|M.ulcerans_Agy99           TELGYPELVAPLTFLAIAGRRVQLEIFNKFNIPINIARVFHRDQKFRFYR
Mflv_0070|M.gilvum_PYR-GCK          RECGHDALIASLTFLAVAGRRVQQEIFNQFDLPINMERVLHRDQKLVFHR
Mvan_0842|M.vanbaalenii_PYR-1       KEYGYDALVASLTFLAVAGRRVQEEIFNQFDLPINMERVLHRDQKLIFHR
MSMEG_0948|M.smegmatis_MC2_155      KECGHDNLIAPLTFLAVAGRRVQLDLFDKFDVPINLERVLHRDQKLIFHR
TH_3830|M.thermoresistible__bu      RECGYDALIAPLTFLAVAGRRVQLEIFNHFDVPINLERMMHRDQKIIFHR
MAB_3996|M.abscessus_ATCC_1997      -----SGVVAPITFLAVAGRRVQHKIFTEMDLPINVARVLHRDQKLKFHR
                                           ::*.:****:****** .:* .:.:***: *::*****: *:*

Mb0516c|M.bovis_AF2122/97           PILANDKLYFDTYLDSVIESHGTVLAEIRSEVTDAEGKPVVTSVVTMLGE
Rv0504c|M.tuberculosis_H37Rv        PILANDKLYFDTYLDSVIESHGTVLAEIRSEVTDAEGKPVVTSVVTMLGE
MAV_4646|M.avium_104                PILAHDRLYFDTYLDSVIESHGTVLAEIRSEVTDADGKPIVTSVVTMLGE
MLBr_02425|M.leprae_Br4923          TILAQDKLYFDTYLDSVIESHGTVIAEVRSEVTDTEGKAVVTSIVTMLGE
MMAR_0832|M.marinum_M               PIVTGDKLYFHTYLDSVLESHGTVIAEIRSEVTDDEGKPVVTSVVTMLGE
MUL_4576|M.ulcerans_Agy99           PIVTGDKLYFHTYLDSVLESHGTVIAEIRSEVTDDEGKPVVTSVVTMLGE
Mflv_0070|M.gilvum_PYR-GCK          PILAGDKLWFDSYLDSVTESHGAVLTEIRGEITDDEGNPIITSIVTVMGE
Mvan_0842|M.vanbaalenii_PYR-1       PILAGDKLWFDSYLDSVTESHGAVLTEIRGEVTDDNGEPVITSIVTVMGE
MSMEG_0948|M.smegmatis_MC2_155      PIVVGDKLWFDSYLDSVIESHGTVICEIRAEVTDDDGKPVATSIVTMLGE
TH_3830|M.thermoresistible__bu      PIVAGDKLYFDSYLDSVIESHGTVITEVRGECTDADGNPVITSVVTILGE
MAB_3996|M.abscessus_ATCC_1997      PIRVGDRLYFDSYLDSVLESHGMVTAEVRAEVTDENGDPVATSIVTMIGE
                                    .* . *:*:*.:***** **** *  *:*.* ** :*..: **:**::**

Mb0516c|M.bovis_AF2122/97           AAH------------HEADADATVAAIASI-------------------
Rv0504c|M.tuberculosis_H37Rv        AAH------------HEADADATVAAIASI-------------------
MAV_4646|M.avium_104                AAH------------QEADAAATAAAVASISAGKLGAI-----------
MLBr_02425|M.leprae_Br4923          LAR------------QDATAEETVAAIASI-------------------
MMAR_0832|M.marinum_M               AAH------------HEAEADAAVAAIASI-------------------
MUL_4576|M.ulcerans_Agy99           AAH------------HEAEADAAVAAIASI-------------------
Mflv_0070|M.gilvum_PYR-GCK          AAHETEADELTAQIAAKRDADALAKFVAGQKGQID--------------
Mvan_0842|M.vanbaalenii_PYR-1       AESDTEADELTAQIAAKRDAAALSKFVAGQSPQAD--------------
MSMEG_0948|M.smegmatis_MC2_155      AEI-DEADEISSQIAAARDA-AIAKMVAGQKSSS---------------
TH_3830|M.thermoresistible__bu      AAHPDEADELTAQIAARRDA-ALKQFVASQNRPATGGASAEEGAAPAGQ
MAB_3996|M.abscessus_ATCC_1997      AEG------------HERDAAAMAANIASHRKN----------------
                                                       *      :*.