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M. leprae Br4923 MLBr_01768 (uspA)

annotation: sugar transport integral membrane protein
coordinates: 2143203 - 2144189
length: 328

MCAHFNTSMTNTGDDTEQSDEVGSISRLRGRKTHRTRALTKNHPRSIALAYALLAPSLFGVVTFLLLPII
VVIWLSLFRWDLLGPLHYVGLANWRSVLTDPNFANSLIVTAVFVAIVVPTQTMLGLLIATMLARQLPGTG
VFRTLYVLPWICAPLAIAVLWRWLLAPTDGAFSMVLRHRIEWLSDPSLALPVVSAVVVWTNVGYVSLSFL
AGLLSIPEDINAAARTDGADAWQRFWRITLPMLRPTMFFVLVTGIVSTAQVFDTVYALTDGGPKSRTDLV
AHRIYAEAFGSAAIGRASVMAVLLFVVLFGVTVVQHLYFQRRISYELT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_01768uspA-100% (328)sugar transport integral membrane protein
M. leprae Br4923MLBr_01426-1e-4032.46% (305) putative ABC-transport protein, inner membrane component
M. leprae Br4923MLBr_01087-6e-3530.22% (268) putative ABC-transport protein, inner membrane component

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2343uspA1e-13883.80% (284) sugar-transport integral membrane protein ABC transporter
M. gilvum PYR-GCKMflv_3852-3e-3328.67% (279) binding-protein-dependent transport systems inner membrane
M. tuberculosis H37RvRv2316uspA1e-13783.45% (284) sugar-transport integral membrane protein ABC transporter
M. abscessus ATCC 19977MAB_1717c-1e-11768.90% (283) sugar ABC transporter, permease protein
M. marinum MMMAR_3617uspA1e-13581.34% (284) sugar-transport integral membrane protein ABC transporter
M. avium 104MAV_2090uspA1e-13984.91% (285) ABC transporter, permease protein UspA
M. smegmatis MC2 155MSMEG_4466-1e-13280.28% (284) ABC transporter, permease protein UspA
M. thermoresistible (build 8)TH_4307-3e-3531.75% (274) PUTATIVE binding-protein-dependent transport systems inner
M. ulcerans Agy99MUL_1248uspA1e-13581.34% (284) sugar-transport integral membrane protein ABC transporter
M. vanbaalenii PYR-1Mvan_2543-2e-3428.28% (297) binding-protein-dependent transport systems inner membrane

CLUSTAL 2.0.9 multiple sequence alignment


Mb2343|M.bovis_AF2122/97            --------------------------------------MRDAPRRRTALA
Rv2316|M.tuberculosis_H37Rv         --------------------------------------MRDAPRRRTALA
MLBr_01768|M.leprae_Br4923          MCAHFNTSMTNTGDDTEQSDEVGSISRLRGRKTHRTRALTKNHPRSIALA
MAV_2090|M.avium_104                ----------------------------------MASAERRVAPRSTALG
MMAR_3617|M.marinum_M               --------------------------------------MRATPRRTTALA
MUL_1248|M.ulcerans_Agy99           --------------------------------------MRATPRRTTALA
MSMEG_4466|M.smegmatis_MC2_155      -----------------------MAPWRLLTANRFNEPMATPRVRTTALA
MAB_1717c|M.abscessus_ATCC_199      ----------------------------------------MSRSRQTAVA
Mflv_3852|M.gilvum_PYR-GCK          ---------------------MTAPADAPIQKDPGKPSVSERAKGERRLG
Mvan_2543|M.vanbaalenii_PYR-1       ---------------------MTALHEAPIQKDPGTPAVSERARGERRLG
TH_4307|M.thermoresistible__bu      ---------------------MTAAAEKADPTPAAAVARTDDTRSERRLA
                                                                                    :.

Mb2343|M.bovis_AF2122/97            YALLAPSLVGVVAFLLLPILVVVWLSLHRWDLLGP--LRYVGLTNWRSVL
Rv2316|M.tuberculosis_H37Rv         YALLAPSLVGVVAFLLLPILVVVWLSLHRWDLLGP--LRYVGLTNWRSVL
MLBr_01768|M.leprae_Br4923          YALLAPSLFGVVTFLLLPIIVVIWLSLFRWDLLGP--LHYVGLANWRSVL
MAV_2090|M.avium_104                YALLAPSLFGVLAFLLLPILVVIWLSLCRWDLLGP--LRFVGLSNWRSVL
MMAR_3617|M.marinum_M               YALLAPSLFGVLAFLLLPILVVIWLSLYRWDLLGP--LRYVGLANWRSVL
MUL_1248|M.ulcerans_Agy99           YALLAPSLFGVLAFLLLPILVVIWLSLYRWDLLGP--LRYVGLANWRSVL
MSMEG_4466|M.smegmatis_MC2_155      YALVAPSLFGVVTFLLLPMLVVVWLSLHRWDLLGP--IEFVGLDNWTSVL
MAB_1717c|M.abscessus_ATCC_199      YGLLAPSLFGVAAFLLLPILVVVWLSLCRWDLLGP--IEFVGLDNWRSVL
Mflv_3852|M.gilvum_PYR-GCK          LYLTLPSYVVMLLVTAYPLGYALVLSLYNFRLTDPEGRSFVGLGNYLVIL
Mvan_2543|M.vanbaalenii_PYR-1       IYLTLPSYVVMLLVTAYPLGYALVLSLYNFRLTDPEGRSFVGLSNYLVIL
TH_4307|M.thermoresistible__bu      YWLIAPAVLLMVAVTGYPIAYAVWLSLLRYNLAQPDDVSFVGLENYVTVL
                                      *  *: . :  .   *:  .: *** .: *  *    :*** *:  :*

Mb2343|M.bovis_AF2122/97            TDSGFADSLVVTAVFVAIVVPAQTVLGLLAASLLARRLPGTGLFRTLYVL
Rv2316|M.tuberculosis_H37Rv         TDSGFADSLVVTAVFVAIVVPAQTVLGLLAASLLARRLPGTGLFRTLYVL
MLBr_01768|M.leprae_Br4923          TDPNFANSLIVTAVFVAIVVPTQTMLGLLIATMLARQLPGTGVFRTLYVL
MAV_2090|M.avium_104                TDAGFGNSLMVTAVFVAMVVPAQTALGLLAATMLARRLPGTGLFRTVYVL
MMAR_3617|M.marinum_M               RDGDFGNSLVVTAIFVAIVVPAQTVLGLLAAMMLTRRLPGTNFFRTLYVL
MUL_1248|M.ulcerans_Agy99           RDGDFGNSLVVTAIFVAIVVPAQTVLGLLAAMMLTRRLPGTNFFRTLYVL
MSMEG_4466|M.smegmatis_MC2_155      TDPAFGKSLVVTLLFMALVVPTQTVLGLVAATMLARGLPGTGFFRTVYVL
MAB_1717c|M.abscessus_ATCC_199      TDGTFGHSLLVTLLFVALVIPVQTALGLAAATLLVRGLPGTVLFRTIYVI
Mflv_3852|M.gilvum_PYR-GCK          TDPIWWNDFVTTLAITVVTVAIELVLGFWFAFVMLRIVRGRGPLRTAILI
Mvan_2543|M.vanbaalenii_PYR-1       TDPLWWNDFVTTLAITVVTVAIELVLGFWFAFVMLRIVRGRGPLRTAILI
TH_4307|M.thermoresistible__bu      TDEYWWTAFAVTLGITVVSVAIEFVLGLALALVMHRTIFGKGVVRTAILI
                                     *  :   : .*  : .: :. :  **:  * :: * : *   .**  ::

Mb2343|M.bovis_AF2122/97            PWICAPLAIAVMWRWILAPTDGAISTVLG-HRIEWLTDPGLALPVVSAVV
Rv2316|M.tuberculosis_H37Rv         PWICAPLAIAVMWRWIVAPTDGAISTVLG-HRIEWLTDPGLALPVVSAVV
MLBr_01768|M.leprae_Br4923          PWICAPLAIAVLWRWLLAPTDGAFSMVLR-HRIEWLSDPSLALPVVSAVV
MAV_2090|M.avium_104                PWICAPLAIAVLWRWILAPTDGAVSAVLG-HSIEWLSDPSFALPLVSAVV
MMAR_3617|M.marinum_M               PWICAPLAIAVMWRWILAPTDGAISTLLG-RRIEWLTDPDLALPVVAAVV
MUL_1248|M.ulcerans_Agy99           PWICAPLAIAVMWRWILAPTDGAISTLLG-RRIEWLTDPDLALPVVAAVV
MSMEG_4466|M.smegmatis_MC2_155      PWICAPLAIAVLWRWILAPTDGALSTVLG-TRIEWLTDPSLALPVVSAVV
MAB_1717c|M.abscessus_ATCC_199      PWICAPLAIGVLWHWMLAPTDGAVNALLG-QRVEWLTDPSLALPVVAAVS
Mflv_3852|M.gilvum_PYR-GCK          PYGIVTVVSAFIWRYAFAIDSGFVNQWLNLTDFDWFGDRWSAIFVICLSE
Mvan_2543|M.vanbaalenii_PYR-1       PYGIVTVVSAFIWRYAFAIDSGFVNQWLNLTEFDWFGDRWSAIFVICLSE
TH_4307|M.thermoresistible__bu      PYGIVTVAASYSWYYAWTPGTGYLANLLPDGSAPLT-QQLPSLAIVVLAE
                                    *:  ..:. .  * :  :   * .   *         :   :: ::    

Mb2343|M.bovis_AF2122/97            VWTNVGYVSLFFLAGLMAIPQDIHNAARTDGASAWQRFWRITLPMLRPTM
Rv2316|M.tuberculosis_H37Rv         VWTNVGYVSLFFLAGLMAIPQDIHNAARTDGASAWQRFWRITLPMLRPTM
MLBr_01768|M.leprae_Br4923          VWTNVGYVSLSFLAGLLSIPEDINAAARTDGADAWQRFWRITLPMLRPTM
MAV_2090|M.avium_104                VWTNVGYVSLSFLAGLLAIPEDIHAAARTDGANAWQRFWRITMPMLRPTT
MMAR_3617|M.marinum_M               IWTNVGYVSLSFLAGLLAIPDDIHAAARTDGANAWQRFWRITLPMLRPTT
MUL_1248|M.ulcerans_Agy99           IWTNVGYVSLSFLAGLLAIPDDIHAAARTDGANAWQRFWRITLPMLRPTT
MSMEG_4466|M.smegmatis_MC2_155      VWTNVGYVTLFFLAGILNIPADLHNAARTDGADAWQRFRHITLPMLRPTM
MAB_1717c|M.abscessus_ATCC_199      VWTNVGYVALFFMAGLLAIPGDVHNAARVDGATAWQRFRRITLPMLRPTF
Mflv_3852|M.gilvum_PYR-GCK          IWKTTPFISLLLLAGLVQVPEDMQEAAKVDGATAWQRLWKITLPNMKAAI
Mvan_2543|M.vanbaalenii_PYR-1       IWKTTPFISLLLLAGLVQVPEDMQEAAKVDGATAWQRLWKITLPNMKAAI
TH_4307|M.thermoresistible__bu      VWKTTPFMALLLLAGLALVPQELLNAAQMDGANAWQRLVKIILPMIKPAI
                                    :*... :::* ::**:  :* ::  **: *** ****: :* :* ::.: 

Mb2343|M.bovis_AF2122/97            FFVLVTGIISAAQVFDTVYALTGGGPQGSTDLVAHRIYAEAFGAAAIGRA
Rv2316|M.tuberculosis_H37Rv         FFVLVTGIISAAQVFDTVYALTGGGPQGSTDLVAHRIYAEAFGAAAIGRA
MLBr_01768|M.leprae_Br4923          FFVLVTGIVSTAQVFDTVYALTDGGPKSRTDLVAHRIYAEAFGSAAIGRA
MAV_2090|M.avium_104                FFVLVTGIVSSAQVFDTVYALTGGGPAGSTDLVAHRIYAEAFGSAAIGRA
MMAR_3617|M.marinum_M               FFVLVTGIVSAAQIFDIVYALTGGGPEGSTELVAHQIYAEAFGSAAIGRA
MUL_1248|M.ulcerans_Agy99           FFVLVTGIVSAAQIFDIVYALTGGGPEGSTELVAHQIYAEAFGSAAIGRA
MSMEG_4466|M.smegmatis_MC2_155      FFVLVTGIVSAAQVFDTVYALTAGGPQGRTDLIAHRIYAEAFGAAAVGRA
MAB_1717c|M.abscessus_ATCC_199      FFVLVTGVVSAVQTFDTVYALTSGGPQNRTDLAAHRVYAEAFEAAHVGRS
Mflv_3852|M.gilvum_PYR-GCK          MVALLFRTLDAWRIFDNPYVMTAG--ANNTETISFLAYRQNVTLVNLGMG
Mvan_2543|M.vanbaalenii_PYR-1       MVALLFRTLDAWRIFDNPYVMTAG--ANNTETISFLAYRQNVTLVNLGMG
TH_4307|M.thermoresistible__bu      LVALLFRTLDAFRIFDNIYILTGG--ANNTGSVSILGYNNLFKAFNLGLG
                                    :..*:   :.: : **  * :* *   . *   :   * : .    :* .

Mb2343|M.bovis_AF2122/97            SVMAVVLFVILVGATVVQHLYFRRRISYELT---
Rv2316|M.tuberculosis_H37Rv         SVMAVVLFVILVGATVVQHLYFRRRISYELT---
MLBr_01768|M.leprae_Br4923          SVMAVLLFVVLFGVTVVQHLYFQRRISYELT---
MAV_2090|M.avium_104                SVMAVVLFVILIGVTLVQHLYFRRRISYDLT---
MMAR_3617|M.marinum_M               SVMAVVLFVILIGVTFVQHMYFRRRISYDLT---
MUL_1248|M.ulcerans_Agy99           SVMAVVLFVILIGVTFVQHMYFRRRISYDLT---
MSMEG_4466|M.smegmatis_MC2_155      AVMALVLFVLLVGVTIVQHLYFRRRISYELT---
MAB_1717c|M.abscessus_ATCC_199      AAMSLILFLILVTITVIQHRYFRARVSYDLV---
Mflv_3852|M.gilvum_PYR-GCK          SAVSVLLFLSVVAIAWIFIKVFKTDLSQVRGDQ-
Mvan_2543|M.vanbaalenii_PYR-1       SAVSVLLFLSVVGIAWIFIKVFKTDLSQVRGDQ-
TH_4307|M.thermoresistible__bu      SAISVLIFLCVAVIAFIYIKIFGTSAPGSDAERS
                                    :.:::::*: :   : :    *    .