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M. leprae Br4923 MLBr_01615 (trmD)

annotation: tRNA (guanine-N(1)-)-methyltransferase
coordinates: 1938665 - 1939381
length: 238

KIDIVTIFPAYLDPLRQSLPGKAIESGLVDVQVHDLRRWTHDVHHSVDDVPYGGGPGMVMKAPVWGEALD
EICFDETLLVIPTPAGALFTQATAQCWSTERHLVFACGRYEGIDQRVVDDAVRRMRVEEVSIGDYVLPGG
ESAAVVMIEAVLRLVAGVLGNPASHRDDSHSPDLGRLLEGPSYTRPPTWRGLDVPPVLLSGDHARIAAWR
REASLRRTRKRRPDLSGARFVWGLGLS*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. leprae Br4923 MLBr_01615 trmD - 100% (238) tRNA (guanine-N(1)-)-methyltransferase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2930c trmD 1e-116 87.22% (227) tRNA (guanine-N(1)-)-methyltransferase
M. gilvum PYR-GCK Mflv_4172 trmD 1e-107 80.53% (226) tRNA (guanine-N(1)-)-methyltransferase
M. tuberculosis H37Rv Rv2906c trmD 1e-116 87.22% (227) tRNA (guanine-N(1)-)-methyltransferase
M. abscessus ATCC 19977 MAB_3226c - 1e-102 77.63% (228) tRNA (guanine-N(1)-)-methyltransferase (TrmD)
M. marinum M MMAR_1802 trmD 1e-115 85.46% (227) tRNA (guanine-N1)-methyltransferase TrmD
M. avium 104 MAV_3760 trmD 1e-114 86.73% (226) tRNA (guanine-N(1)-)-methyltransferase
M. smegmatis MC2 155 MSMEG_2438 trmD 1e-107 79.65% (226) tRNA (guanine-N(1)-)-methyltransferase
M. thermoresistible (build 8) TH_2387 trmD 1e-107 78.76% (226) PROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD
M. ulcerans Agy99 MUL_2050 trmD 1e-115 85.90% (227) tRNA (guanine-N(1)-)-methyltransferase
M. vanbaalenii PYR-1 Mvan_2190 trmD 1e-108 81.86% (226) tRNA (guanine-N(1)-)-methyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4172|M.gilvum_PYR-GCK          MRIDVVTIFPAFLDALRQALPGKAIEAGIIDLAVHDLRDWTHDVHRSVDD
Mvan_2190|M.vanbaalenii_PYR-1       MRIDVVTIFPAFLDALRQALPGKAIEAGIVALAVHDLRDWTHDVHRSVDD
Mb2930c|M.bovis_AF2122/97           MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDD
Rv2906c|M.tuberculosis_H37Rv        MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDD
MLBr_01615|M.leprae_Br4923          MKIDIVTIFPAYLDPLRQSLPGKAIESGLVDVQVHDLRRWTHDVHHSVDD
MMAR_1802|M.marinum_M               MKIDVVTIFPAYLDPLRQSLPGRAIASGLVDLQVHDLRRWTYDVHHSVDD
MUL_2050|M.ulcerans_Agy99           MKIDVVTIFPAYLDPLRQSLPGRAIASGLVDLQVHDLRRWTYDVHHSVDD
MAV_3760|M.avium_104                MRIDVVTIFPAYLDPLRQSLPGKAIQSGLVDLRVHDLRRWTHDVHRSVDD
MSMEG_2438|M.smegmatis_MC2_155      MRIDVISIFPAYLDPIRQSLPGKAIDAGIVSVEVHDLRNWTHDVHRSVDD
TH_2387|M.thermoresistible__bu      VRIDVITIFPRYLDPLRESLPGKAIEAGIVDLRVHDLRRWTHDVHRSVDD
MAB_3226c|M.abscessus_ATCC_199      MKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSVDD
                                    ::**:::***  *:.:*::***:** :*:: : ***** **:***:****

Mflv_4172|M.gilvum_PYR-GCK          SPYGGGPGMVMKAPVWGAALDEICSPETLLVVPSPAGRLFTQATAQRWST
Mvan_2190|M.vanbaalenii_PYR-1       SPYGGGPGMVMKAPIWGAALDEICSPETLLVVPSPAGRLFTQATAQRWSG
Mb2930c|M.bovis_AF2122/97           APYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTT
Rv2906c|M.tuberculosis_H37Rv        APYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTT
MLBr_01615|M.leprae_Br4923          VPYGGGPGMVMKAPVWGEALDEICFDETLLVIPTPAGALFTQATAQCWST
MMAR_1802|M.marinum_M               SPYGGGPGMVMKAPVWGEALDEICSAETLLVVPTPAGSLFDQATARRWSA
MUL_2050|M.ulcerans_Agy99           SPYGGGPGMVMKAPVWGEALDEICSAETLLVVPTPAGSLFDQATAQRWSA
MAV_3760|M.avium_104                APYGGGPGMVMKAPVWGEALDEIASAETLLVVPTPAGALFDQATAARWSA
MSMEG_2438|M.smegmatis_MC2_155      SPYGGGPGMVMKAPVWGEALDEICSEETLLVVPTPAGRLFDQRTAQRWST
TH_2387|M.thermoresistible__bu      TPYGGGPGMVMTAPVWGEALDEICTEQTLLVVPTPAGRLFTQNVAQRWAG
MAB_3226c|M.abscessus_ATCC_199      SPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWST
                                     **********...:** *****.  :***::*:***  * * .*  *: 

Mflv_4172|M.gilvum_PYR-GCK          ERHLVFACGRYEGIDQRVVEDAATRMRVEEVSLGDYVLPGGESAAVVMVE
Mvan_2190|M.vanbaalenii_PYR-1       EEHLVFACGRYEGIDQRVIDDAARRMRVEEVSIGDYVLPGGESAAVVMIE
Mb2930c|M.bovis_AF2122/97           ESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVE
Rv2906c|M.tuberculosis_H37Rv        ESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVE
MLBr_01615|M.leprae_Br4923          ERHLVFACGRYEGIDQRVVDDAVRRMRVEEVSIGDYVLPGGESAAVVMIE
MMAR_1802|M.marinum_M               EQHLVFACGRYEGIDQRVAEDSARRMRVEEVSIGDYVLPGGESAAVVMIE
MUL_2050|M.ulcerans_Agy99           EQHLVFACGRYEGIDQRVAEDSARRMRVEEVSIGDYVLPGGESAAVVMIE
MAV_3760|M.avium_104                ERHLVFACGRYEGIDQRVVEDAARRMRVEEVSIGDYVLPGGESAAVVMIE
MSMEG_2438|M.smegmatis_MC2_155      ERHLVFACGRYEGIDQRVVDDAARRMRVEEVSIGDYVLNGGEAATLVMVE
TH_2387|M.thermoresistible__bu      ESHLVFACGRYEGIDQRVIDDAARRMRVEEVSIGDYVLAGGEAAALVMIE
MAB_3226c|M.abscessus_ATCC_199      EDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIE
                                    * ***:************ :*:. ****.***:***** ***:*::*::*

Mflv_4172|M.gilvum_PYR-GCK          AVVRLLPDVLGNPASHQDDSHSEFVGGLLEGPSYTRPASWRGLDVPDVLL
Mvan_2190|M.vanbaalenii_PYR-1       AVVRLLPDVLGNPASHQDDSHSELVGGLLEGPSYTRPASWRGLDVPDVLL
Mb2930c|M.bovis_AF2122/97           AVLRLLAGVLGNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLL
Rv2906c|M.tuberculosis_H37Rv        AVLRLLAGVLGNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLL
MLBr_01615|M.leprae_Br4923          AVLRLVAGVLGNPASHRDDSHSPDLGRLLEGPSYTRPPTWRGLDVPPVLL
MMAR_1802|M.marinum_M               AVLRLLTGVLGNPASHQEDSFSPELDRLLEGPSYTRPPSWRGLDVPEILL
MUL_2050|M.ulcerans_Agy99           AVLRLLTGVLGNPASHQEDSFSPELDRLLEGPSYTRPPSWRGLDVPEILL
MAV_3760|M.avium_104                AVLRLLDGVLGNPASRHDDSHSPALDRRLEGPSYTRPPSWRGLDVPEVLL
MSMEG_2438|M.smegmatis_MC2_155      AVVRLLPDVLGNPASHQQDSHS---DGLLEGPSYTRPPSWRGLDVPPVLL
TH_2387|M.thermoresistible__bu      AVVRLLPGVMGNPASHQEDSHSGRYRGLLEGPSYTRPPSWRGLDVPEVLL
MAB_3226c|M.abscessus_ATCC_199      AVLRLVPGVLGNALSAQEDSHSEGMASLLEGPSYTRPPSWRGMDVPPVLL
                                    **:**: .*:**. * ::**.*      *********.:***:*** :**

Mflv_4172|M.gilvum_PYR-GCK          SGDHARIAAWRHQQGLERTRERRPDLLPPDAS----------
Mvan_2190|M.vanbaalenii_PYR-1       SGDHARIAAWRREQGLQRTRERRPDLLD--------------
Mb2930c|M.bovis_AF2122/97           SGDHARIAAWRREVSLQRTRERRPDLSHPD------------
Rv2906c|M.tuberculosis_H37Rv        SGDHARIAAWRREVSLQRTRERRPDLSHPD------------
MLBr_01615|M.leprae_Br4923          SGDHARIAAWRREASLRRTRKRRPDLSGARFVWGLGLS----
MMAR_1802|M.marinum_M               SGDHARIATWRREVSLRRTRERRPDLAP----PE--------
MUL_2050|M.ulcerans_Agy99           SGDHARIATWRREVSLRRTRERRPDLAP----PE--------
MAV_3760|M.avium_104                SGDHARIAAWRREVSLQRTRERRPELLADPVGPQDGPGL---
MSMEG_2438|M.smegmatis_MC2_155      SGDHAKVAAWRHEQALQRTRERRPDLLD--------------
TH_2387|M.thermoresistible__bu      SGNHAKIAAWRREQALKRTRERRPDLLDSEGDPPGEQA----
MAB_3226c|M.abscessus_ATCC_199      SGDHAKIAAWRAEQSRQRTIERRPDLLGFDSPTGEHGGDGLS
                                    **:**::*:** : . .** :***:*

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_01615	trmD	-	100% (238)	tRNA (guanine-N(1)-)-methyltransferase