For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. leprae Br4923 MLBr_01352 (tyrS)

annotation: tyrosyl-tRNA synthetase
coordinates: 1612108 - 1613388
length: 426

VSSSILNELGWRGLVAQSTDLDALADELRRGPMTVYAGFDPTAPSLHVGHLVPLLVLRRFQRAGHRPIVL
AGGATGMIGDPRDIGERTLNEAYTVAEWAERIRGQLERFVEFDDVAKSRNGAIVVNNLEWTSPMSAIEFL
RDVGKHFSINLMLDRDTIRRRLNGQGISYTEFSYMLLQANDYAELHQRHGCALQIGGSDQWGNIIAGVRL
VRQKLGATVHALTVPLVTAADGAKLGKSTGGGSLWLDPEMTSPYAWYQYFINTSDADVIRYLRWFTFLLP
EELVELEQTTVSRPQERAAQRRLATELTVLVHGAAATQAVEHASRALFGQGELARLDEATLATALRETVV
AELKPGNPDGIVDLLVASGLSPSRGAARRTIDEGGVLVNNIRIQSEEWTPRTSDFLHGRWLVLRRGKRNI
AGIERV
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_01352tyrS-100% (426)tyrosyl-tRNA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1715tyrS0.083.57% (426) tyrosyl-tRNA synthetase
M. gilvum PYR-GCKMflv_3513-0.077.49% (422) tyrosyl-tRNA synthetase
M. tuberculosis H37RvRv1689tyrS0.083.57% (426) tyrosyl-tRNA synthetase
M. abscessus ATCC 19977MAB_2354-0.072.60% (427) tyrosyl-tRNA synthetase (TyrS)
M. marinum MMMAR_2488tyrS0.082.35% (425) tyrosyl-tRNA synthase, TyrS
M. avium 104MAV_3082tyrS0.082.16% (426) tyrosyl-tRNA synthetase
M. smegmatis MC2 155MSMEG_3758tyrS0.075.47% (428) tyrosyl-tRNA synthetase
M. thermoresistible (build 8)TH_1553tyrS1e-15075.81% (339) Probable Tyrosyl-tRNA synthase tyrS (TYRRS)
M. ulcerans Agy99MUL_1668tyrS0.082.12% (425) tyrosyl-tRNA synthetase
M. vanbaalenii PYR-1Mvan_3294-0.077.93% (426) tyrosyl-tRNA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3513|M.gilvum_PYR-GCK          ------MSTP-----DILDDLEWRGLIAQSTDREALGEMLAAGPATVYSG
Mvan_3294|M.vanbaalenii_PYR-1       ------MGT------SILDELEWRGLIAQSTDRDALAEALAEGPVTVYSG
MSMEG_3758|M.smegmatis_MC2_155      MIVPVTSSAT-----GILDELDWRGLIAQSTDREALASDLAKGPMTVYSG
Mb1715|M.bovis_AF2122/97            ------MSG------MILDELSWRGLIAQSTDLDTLAAEAQRGPMTVYAG
Rv1689|M.tuberculosis_H37Rv         ------MSG------MILDELSWRGLIAQSTDLDTLAAEAQRGPMTVYAG
MMAR_2488|M.marinum_M               ------MSSNSSGSAGILDELGWRGLIAQSTDLDALAADVQRPPLTVYAG
MUL_1668|M.ulcerans_Agy99           ------MSSNSSGSAGILDELGWRGLIAQSTDLDALAADAQRPPLTVYAG
MAV_3082|M.avium_104                ------MSS------GILDELGWRGLIAQSTDLDALAAEAR--PMTVYAG
MLBr_01352|M.leprae_Br4923          ------MSS------SILNELGWRGLVAQSTDLDALADELRRGPMTVYAG
TH_1553|M.thermoresistible__bu      --------------------------------------------------
MAB_2354|M.abscessus_ATCC_1997      --MASPTHDLRVSGSSILDELTWRGLIAQTTDRDALAADIAKGPISVYGG
                                                                                      

Mflv_3513|M.gilvum_PYR-GCK          FDPTAPSLHAGHLIPLLTLRRFQQAGHRPIVLAGGATGMIGDPRDVGERT
Mvan_3294|M.vanbaalenii_PYR-1       FDPTAPSLHAGHLIPLLTLRRFQQAGHRPIVLAGGATGMIGDPRDVGERT
MSMEG_3758|M.smegmatis_MC2_155      FDPTAPSLHAGHLVPLLTLRRFQQAGHRPIVLAGGATGMIGDPRDTGERT
Mb1715|M.bovis_AF2122/97            FDPTAPSLHAGHLVPLLTLRRFQRAGHRPIVLAGGATGMIGDPRDVGERS
Rv1689|M.tuberculosis_H37Rv         FDPTAPSLHAGHLVPLLTLRRFQRAGHRPIVLAGGATGMIGDPRDVGERS
MMAR_2488|M.marinum_M               FDPTAASLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPRDIGERS
MUL_1668|M.ulcerans_Agy99           FDPTAASLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPRDIGERS
MAV_3082|M.avium_104                FDPTAPSLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPRDVGERT
MLBr_01352|M.leprae_Br4923          FDPTAPSLHVGHLVPLLVLRRFQRAGHRPIVLAGGATGMIGDPRDIGERT
TH_1553|M.thermoresistible__bu      ---------------------------------------------VX--T
MAB_2354|M.abscessus_ATCC_1997      FDPTAASLHAGHLVPLLTLSRFQRAGHRPIVLAGGATGLIGDPRDTSERN
                                                                                     .

Mflv_3513|M.gilvum_PYR-GCK          LNTADTVADWADRIRGQLERFVEFDDSE---TGAIVADNLTWTSELSAIE
Mvan_3294|M.vanbaalenii_PYR-1       LNTADTVADWAGRIRGQLERFVEFDDSP---TGAVVANNLSWTGELSAIE
MSMEG_3758|M.smegmatis_MC2_155      MNTEDTVADWADRIRGQLERFVEFDDSP---TGAIVENNLTWTGELSAIS
Mb1715|M.bovis_AF2122/97            LNEADTVAEWTERIRGQLERFVDFDDSP---MGAIVENNLEWTGSLSAIE
Rv1689|M.tuberculosis_H37Rv         LNEADTVAEWTERIRGQLERFVDFDDSP---MGAIVENNLEWTGSLSAIE
MMAR_2488|M.marinum_M               LNDADTVANWTERIRGQLERFVDFDGSP---TGAIVENNLEWTAAMSTVE
MUL_1668|M.ulcerans_Agy99           LNDADTVANWTERIRGQLERFVDFDGSP---TGAIVENNLEWTAAMSTVE
MAV_3082|M.avium_104                LNEADTVAEWTERIRGQLERFVDFDESA---TGAVVVNNLDWTRQLSAIE
MLBr_01352|M.leprae_Br4923          LNEAYTVAEWAERIRGQLERFVEFDDVAKSRNGAIVVNNLEWTSPMSAIE
TH_1553|M.thermoresistible__bu      LQSADVVADWADRIKGQLERFVEFTDGP---TGAIVENNLTWTGGLTAIE
MAB_2354|M.abscessus_ATCC_1997      LHGTDVVAEWADRIRGQLERFVEFNDTP---TGAIVANNLEWTGQLTALE
                                    ::   .**:*: **:*******:*        **:* :** **  ::::.

Mflv_3513|M.gilvum_PYR-GCK          FLRDVGKHFSVNVMLDRDTVRRRLEGDGISYTEFSYMLLQANDYVELHQR
Mvan_3294|M.vanbaalenii_PYR-1       FLRDVGKHFSVNVMLDRDTVRRRLEGEGISYTEFSYMLLQANDYVELHQR
MSMEG_3758|M.smegmatis_MC2_155      FLRDIGKYFSVNVMLDRETVRRRLEGDGISYTEFSYMLLQANDYVELHQR
Mb1715|M.bovis_AF2122/97            FLRDIGKHFSVNVMLARDTIRRRLAGEGISYTEFSYLLLQANDYVELHRR
Rv1689|M.tuberculosis_H37Rv         FLRDIGKHFSVNVMLARDTIRRRLAGEGISYTEFSYLLLQANDYVELHRR
MMAR_2488|M.marinum_M               FLRDVGKHFSVNVMLDRDTIRRRLEGEGISYTEFSYMLLQANDYVELHRR
MUL_1668|M.ulcerans_Agy99           FLRDVGKHFSVNVMLDRDTIRRRLEGEGISYTEFSYMLLQANDYVELHRR
MAV_3082|M.avium_104                FLRDLGKHFSVNVMLDRDTVRRRLEGDGISYTEFSYMLLQANDYVELHRR
MLBr_01352|M.leprae_Br4923          FLRDVGKHFSINLMLDRDTIRRRLNGQGISYTEFSYMLLQANDYAELHQR
TH_1553|M.thermoresistible__bu      FLRDIGKHFSVNVMLDRDTVRRRLEGEGISYTEFSYMLLQANDYVELYQR
MAB_2354|M.abscessus_ATCC_1997      FLRDLGKHFSVNVMLDRDTIRRRLEGDGISYTEFSYMLLQANDYVQLHRK
                                    ****:**:**:*:** *:*:**** *:*********:*******.:*:::

Mflv_3513|M.gilvum_PYR-GCK          YGCTLQVGGSDQWGNIIAGVRLVRQKAGAAVHAMTTPLVTDSEGKKFGKS
Mvan_3294|M.vanbaalenii_PYR-1       YGCTLQVGGSDQWGNIIAGVRLVRQKAGASVHALTTPLVTDSEGKKFGKS
MSMEG_3758|M.smegmatis_MC2_155      HGCALQVGGSDQWGNIVAGVRLVRQKIGATVHAMTTPLVTDSEGKKFGKS
Mb1715|M.bovis_AF2122/97            HGCTLQIGGADQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKS
Rv1689|M.tuberculosis_H37Rv         HGCTLQIGGADQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKS
MMAR_2488|M.marinum_M               HGCTLQIGGSDQWGNIIAGVRLVRQKSGAAVHALTVPLVTAADGTKFGKS
MUL_1668|M.ulcerans_Agy99           HGCTLQIGGSDQWGNIIAGVRLVRQKSGAAVHALTVPLVTAADGTKFGKS
MAV_3082|M.avium_104                YGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKS
MLBr_01352|M.leprae_Br4923          HGCALQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGAKLGKS
TH_1553|M.thermoresistible__bu      YGCRLQIGGSDQWGNIVAGVRLVRQKLSATVHGLTVPLVTAADGTKFGKS
MAB_2354|M.abscessus_ATCC_1997      YGCSLQIGGSDQWGNIVAGVRLARQQDGASVHALTVPLVTAADGTKFGKS
                                    :** **:**:******:*****.**: .*:**.:*.**** ::* *:***

Mflv_3513|M.gilvum_PYR-GCK          TGGGSLWLDPEMTSPYAWYQYFINTADADVVPYLRWFTFLTAEELAELEL
Mvan_3294|M.vanbaalenii_PYR-1       TGGGSLWLDPEMTSPYAWYQYFINTADADVLPYLRWFTFLSADELVELEQ
MSMEG_3758|M.smegmatis_MC2_155      TGGGNLWLDPEMTSPYAWYQYFVNTADADVLGYLRWFTFLTPDELAELAD
Mb1715|M.bovis_AF2122/97            TGGGSLWLDPQMTSPYAWYQYFVNTADADVIRYLRWFTFLSADELAELEQ
Rv1689|M.tuberculosis_H37Rv         TGGGSLWLDPQMTSPYAWYQYFVNTADADVIRYLRWFTFLSADELAELEQ
MMAR_2488|M.marinum_M               TGGGSLWLDPEMTSPYAWYQYFVNTADADVIRYLRWFTFLVAEELTELEQ
MUL_1668|M.ulcerans_Agy99           TGGGSLWLDPEMTSPYAWYQYFVNTADADVIRYLRWFTFLVAEELTELEQ
MAV_3082|M.avium_104                TGGGSLWLDPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELER
MLBr_01352|M.leprae_Br4923          TGGGSLWLDPEMTSPYAWYQYFINTSDADVIRYLRWFTFLLPEELVELEQ
TH_1553|M.thermoresistible__bu      TGGGNLWLDPDMTSPYTWYQYFINTADADVIRYLRWFTFLSAEELAELQE
MAB_2354|M.abscessus_ATCC_1997      TGGGNLWLDPEMTSPYAWYQYFINTADADVVRYLRWFTFLSAEEIGELET
                                    ****.***** :*:**:*****.**:****: ******** .:*: **  

Mflv_3513|M.gilvum_PYR-GCK          ATAERPHERAAQRRLARELTNLVHGEAATAAVELASQALFGRGELADLDE
Mvan_3294|M.vanbaalenii_PYR-1       ATTERPHERAAQRRLARELTNLVHGEAATAAVELASQALFGRAELGELDE
MSMEG_3758|M.smegmatis_MC2_155      ATENRPHERAAQRRLARELTTLVHGEGATKSVEYASRALFGRGELADLDE
Mb1715|M.bovis_AF2122/97            ATAQRPQQRAAQRRLASELTVLVHGEAATAAVEHASRALFGRGELARLDE
Rv1689|M.tuberculosis_H37Rv         ATAQRPQQRAAQRRLASELTVLVHGEAATAAVEHASRALFGRGELARLDE
MMAR_2488|M.marinum_M               ATAERPHQRAAQRRLAAELTTLVHGEAATEAVEHASRALFGHGELSRLDE
MUL_1668|M.ulcerans_Agy99           ATAERAHQRAAQRRLAAELTTLVHGEAATEAVEHASRALFGHGELSRLDE
MAV_3082|M.avium_104                ATAERPQQRAAQRRLARELTVLVHGEAATEAVEHASRALFGQGELERLDA
MLBr_01352|M.leprae_Br4923          TTVSRPQERAAQRRLATELTVLVHGAAATQAVEHASRALFGQGELARLDE
TH_1553|M.thermoresistible__bu      ATEQRPHERAAQRRLARELTTLVHGQQATESAEHASRALFGRGELDRLDE
MAB_2354|M.abscessus_ATCC_1997      ATTERAHERAAQRRLAAEVTTLVHGESATLAVEHASGALFGRGDLDRLDE
                                    :* .*.::******** *:* ****  ** :.* ** ****:.:*  ** 

Mflv_3513|M.gilvum_PYR-GCK          NTLAGAVREAA---VAQLDPGGPDSIVDLLVATGLSASKGAARRTVAEGG
Mvan_3294|M.vanbaalenii_PYR-1       PTLAAALREAS---VAQLAPGGPDSIIDLLVASGLSASKGAARRTVAEGG
MSMEG_3758|M.smegmatis_MC2_155      STLSAALREAGNGQVAELAPGGPDSIVDLLVATGLSNSKGAARRTVAEGG
Mb1715|M.bovis_AF2122/97            ATLAAALRETT---VAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGG
Rv1689|M.tuberculosis_H37Rv         ATLAAALRETT---VAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGG
MMAR_2488|M.marinum_M               ATLGAALRETS---IAELEPGTPDGIVDLLVATGLSASKGAARRTIGEGG
MUL_1668|M.ulcerans_Agy99           ATLGAALRETS---IAELEPGTPDGIVDLLVATGLSASKGAARRTIGEGG
MAV_3082|M.avium_104                ATLAAALRETS---VAELKPGAPDGIVDLLVASGLSESRKAARRTLGEGG
MLBr_01352|M.leprae_Br4923          ATLATALRETV---VAELKPGNPDGIVDLLVASGLSPSRGAARRTIDEGG
TH_1553|M.thermoresistible__bu      PTLAAALQEAS---VADLEPGAPDSIVDLLVASGLVQSRGAARRTVAEGG
MAB_2354|M.abscessus_ATCC_1997      GTLTAALTEAGNGEPARIADGEPDTIVDLLVSSGLSESKGAARRTVKEGG
                                     **  *: *:     * :  * ** *:****::**  *: *****: ***

Mflv_3513|M.gilvum_PYR-GCK          VYVNNAKVTADDWVPQPSDFLHGRWLVLRRGKRNIAGVERVG------
Mvan_3294|M.vanbaalenii_PYR-1       AYVNNVKIATDEWIPQASDFLHDRWLVLRRGKRNIAGIERVG------
MSMEG_3758|M.smegmatis_MC2_155      VYVNNARVESDEWVPQESDFLHEGWLVLRRGKRHIAGVRRVTASDQGK
Mb1715|M.bovis_AF2122/97            VSVNNIRVDNEEWVPQSSDFLHGRWLVLRRGKRSIAGVERIG------
Rv1689|M.tuberculosis_H37Rv         VSVNNIRVDNEEWVPQSSDFLHGRWLVLRRGKRSIAGVERIG------
MMAR_2488|M.marinum_M               VSVNNIRVETDEWVPQTSDFLHGRWLVLRRGKRNIAGVERVG------
MUL_1668|M.ulcerans_Agy99           VSVNNIRVETDEWVPQTSDFLHGRWLVLRRGKRNIAGVERVG------
MAV_3082|M.avium_104                VSVNNVRIDREDWAPQPSDFLHGKWLVLRRGKRTIAGVEKL-------
MLBr_01352|M.leprae_Br4923          VLVNNIRIQSEEWTPRTSDFLHGRWLVLRRGKRNIAGIERV-------
TH_1553|M.thermoresistible__bu      AYVNNRRIEAEDWVPEPSDYLHGRWLVLRRGKRNIAGVRRVG------
MAB_2354|M.abscessus_ATCC_1997      VYVNNTRVDAEDWTPGDGDYLTGGWLVLRRGKRNIAGVQRLR------
                                    . *** ::  ::* *  .*:*   ********* ***:.::