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SKVSQESTEWTVQGLLDLFEVRPDGQDRFTADTAGDIGAGGDERQVVEGTQVLAQAIVAVAKRFGDKSVR SAHAVFSRAVAVGPPIELVLDVVAEGRSTATAVVAVHQNGRRCLSITVLADVPTGDVIRHQLPRPDVAGP ADANPSPMPMVGRELRLVDVVDVNSPDEVGPPELYAWLHYDPIPTRDDLAKALLAYFTGHLGISTTMRAH PGIGTAQAHLTVSTAPMSISVAFHEPVRWDGWLLYSHESTQVGAGMSYVRGTVHTEQGELLASFAQEALI RPLRTSDTAIDSRARF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5130 | - | - | 100% (297) | hypothetical protein MAV_5130 |
| M. avium 104 | MAV_2540 | - | 3e-11 | 25.59% (297) | acyl-CoA thioesterase |
| M. avium 104 | MAV_3483 | tesB | 7e-08 | 24.80% (246) | acyl-CoA thioesterase II |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2637c | tesB2 | 4e-09 | 24.90% (253) | acyl-CoA thioesterase II |
| M. gilvum PYR-GCK | Mflv_3790 | - | 1e-127 | 76.39% (288) | hypothetical protein Mflv_3790 |
| M. tuberculosis H37Rv | Rv2605c | tesB2 | 6e-09 | 24.90% (253) | acyl-CoA thioesterase II |
| M. leprae Br4923 | MLBr_01278 | tesB | 3e-05 | 24.30% (251) | acyl CoA thioesterase II |
| M. abscessus ATCC 19977 | MAB_2891c | - | 2e-10 | 27.24% (257) | acyl-CoA thioesterase II TesB2 |
| M. marinum M | MMAR_0392 | - | 1e-136 | 81.44% (291) | hypothetical protein MMAR_0392 |
| M. smegmatis MC2 155 | MSMEG_2997 | - | 1e-132 | 79.24% (289) | hypothetical protein MSMEG_2997 |
| M. thermoresistible (build 8) | TH_0539 | - | 1e-121 | 74.38% (281) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3249 | tesB2 | 7e-10 | 26.40% (250) | acyl-CoA thioesterase II TesB2 |
| M. vanbaalenii PYR-1 | Mvan_2604 | - | 1e-133 | 78.97% (290) | hypothetical protein Mvan_2604 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5130|M.avium_104 ---MSKVSQES--TEWTVQGLLDLFEVRPDGQDRFTADTAGDIGAGGDER
MMAR_0392|M.marinum_M ---MSALTTDSEQAQWSVDGLLELFQVRAEGVDRFTADTG---IAGHDGR
MSMEG_2997|M.smegmatis_MC2_155 MTTESTETAPGASVQWTLQMLLDLFEVEPAGENRFTAPTG---LAGADDR
TH_0539|M.thermoresistible__bu -------------------MLLDLFDVEPAGENRFTAPSG---IAGTDER
Mflv_3790|M.gilvum_PYR-GCK ----------MAEAQWTVQGLLDLFDAEPTGDNMFTVQTG---PAGEDER
Mvan_2604|M.vanbaalenii_PYR-1 --MTTESAQTAGSVQWTVQGLLDLFDAEPAGEDTFTAQTG---PAGEDER
Mb2637c|M.bovis_AF2122/97 ------------------MSIEEILDLEQLEVNIYRGSVF---SPESGFL
Rv2605c|M.tuberculosis_H37Rv ------------------MSIEEILDLEQLEVNIYRGSVF---SPESGFL
MUL_3249|M.ulcerans_Agy99 ------------------MAIEEILDLEQLEVNIYRGSVF---SPESGFL
MAB_2891c|M.abscessus_ATCC_199 -----------------MADIEEILTLEQLEKDIFRGNVT---PSN---L
MLBr_01278|M.leprae_Br4923 -----MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHP---SKN---P
: :: . : :
MAV_5130|M.avium_104 QVVEGTQVLAQAIVAVAKRFG-DKSVRSAHAVFSRAVAVGP-PIELVLDV
MMAR_0392|M.marinum_M QVVEGTQVVAQAIMAVASRFE-GKSVRSAHAVFCRAVIVGP-PLELVLDV
MSMEG_2997|M.smegmatis_MC2_155 QVVEGTQVLAQAIVAAAKRFP-DKSVRSVQAVFARAVLVGP-PVELDLDV
TH_0539|M.thermoresistible__bu QVVEGSQVLSAALVAAAKRFG-DKSIRSAYAVFARVVLVGP-PIEFDIDV
Mflv_3790|M.gilvum_PYR-GCK QVVEGTQILAASIVAAAKRFP-DKSIRSVYTVFARAVMVAAGPVELEIDV
Mvan_2604|M.vanbaalenii_PYR-1 QVVEGTQVLAQSIVAAAKRFP-DKSIRSVYSVFARAVMVGAGPVELEIDV
Mb2637c|M.bovis_AF2122/97 QRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG-YFLRPGDAKERTVFLVER
Rv2605c|M.tuberculosis_H37Rv QRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG-YFLRPGDAKERTVFLVER
MUL_3249|M.ulcerans_Agy99 QRTFGGHVAGQSLVSAVRTVDPRYQVHSLHG-YFLRSGDAQEPTVFLVER
MAB_2891c|M.abscessus_ATCC_199 RRTFGGQVAGQSLVSAVRTVEPEYLVHSLHG-YFLRPGNPNEPTVFLVDR
MLBr_01278|M.leprae_Br4923 LRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTAKEIEFHVVR
. * :: . :::: . * . : :
MAV_5130|M.avium_104 VAEGRSTATAVVAVHQNGRRCLSITVLADVPTGDVIRHQLPRPDVAGPAD
MMAR_0392|M.marinum_M VHEGRSTATAIVAANQNGKRCLTVTVLADIPTGDVIKHHLPRPPVVAPAD
MSMEG_2997|M.smegmatis_MC2_155 VSEGRSTATAVVTASQNGKRCMTFTVFTDVPSADVIRHHLPRPDVAGPAD
TH_0539|M.thermoresistible__bu ISEGRSTTTAVVTASQNGKRCVTVTVLADVPSEDVIRHHLPRPQVVGPDE
Mflv_3790|M.gilvum_PYR-GCK VSEGRSTATAVVTAKQNGKRCITTTVLADVPTGDVIRHHLPKPEVAGPAE
Mvan_2604|M.vanbaalenii_PYR-1 ISEGRSTASAVVTAKQNGKRCITTTVLADVPTDDVIRHHLPKPDVAGPAE
Mb2637c|M.bovis_AF2122/97 IRDGGSLCTRRVNAVQHGE-TIFSMAASFQTEQEGITHQDVMPAAPPPDG
Rv2605c|M.tuberculosis_H37Rv IRDGGSFCTRRVNAVQHGE-TIFSMAASFQTEQEGITHQDVMPAAPPPDG
MUL_3249|M.ulcerans_Agy99 TRDGGSFVTRRVNAVQHGE-VIFSMGASFQTAQNGISHQDAMPAAPPPDD
MAB_2891c|M.abscessus_ATCC_199 VRDGRSFVTRRVTAIQDGQ-AIFSMSASFQTLDTGIEHQDLMPPVPDPED
MLBr_01278|M.leprae_Br4923 LRDERRFANRRVDAIQDGM-LLSSAMASYMSGGCGLEHAVEPPEAAEPHT
: . * . *.* : : . : * * . *
MAV_5130|M.avium_104 ANPSPMPMVGRELRLVDVVD---------VNSPDEVG------PPELYAW
MMAR_0392|M.marinum_M ANVSEMPMAGRQLRLVDVVD---------VNSPDEVG------PPELYAW
MSMEG_2997|M.smegmatis_MC2_155 ANVAHMPMTGRELRLVDVVD---------VNSPDEVG------PPELYAW
TH_0539|M.thermoresistible__bu ANVCDMPMVGRQVKLVDIVD---------VNSPDEVG------PPEIHAW
Mflv_3790|M.gilvum_PYR-GCK AHLSPMPMAGRELRLVDVVD---------VNSPDEVG------PPELYAW
Mvan_2604|M.vanbaalenii_PYR-1 ANASPMPMAGRELRLVDVVD---------VNSPDEVG------PPELYAW
Mb2637c|M.bovis_AF2122/97 LPGLNSIKVFDDAGFRQFD------EWDVCIVPRERLRLLPGKASQQQVW
Rv2605c|M.tuberculosis_H37Rv LPGLNSIKVFDDAGFRQFD------EWDVCIVPRERLRLLPGKASQQQVW
MUL_3249|M.ulcerans_Agy99 LPGLRSVRVFDDAGFRQFE------EWDVRIVPRDLLAPLPGKASQQQVW
MAB_2891c|M.abscessus_ATCC_199 LPDAQEQDSFNRDLFRQFA------EWDIRIVPDELMDRNPRLAAQQRVW
MLBr_01278|M.leprae_Br4923 RPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVMRNKGQRLAYNRVW
. .. * . .*
MAV_5130|M.avium_104 LHY-DPIPTRDDLAKALLAYFTGHLGISTTMRAHPGIGTAQAHLTVSTAP
MMAR_0392|M.marinum_M LHY-EPIPDRDDLAKALIAYFTGHLGISTTMRAHPGIGTSQAHLSVSTAP
MSMEG_2997|M.smegmatis_MC2_155 LHY-DPVPTRDDLAKALIAYFTGHLGISTTMRAHEGIGTAQAHLTVSTAP
TH_0539|M.thermoresistible__bu LHY-DPVPQRSDLAKALLAYFTGHLGISTTMRAHDGIGTAQSHVTVSTAP
Mflv_3790|M.gilvum_PYR-GCK LHY-DPIPDRDDLAKALIAYFTGHLGISTTMRAHEGIGTAQAHLTVSTAP
Mvan_2604|M.vanbaalenii_PYR-1 LHY-DPIPSRDDLAKALIAYFTGHLGISTTMRAHEGIGTAQAHLTVSTAP
Mb2637c|M.bovis_AF2122/97 LRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVR-----DQLQVAS
Rv2605c|M.tuberculosis_H37Rv LRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVR-----DQLQVAS
MUL_3249|M.ulcerans_Agy99 FRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLAER-----EHLQVAS
MAB_2891c|M.abscessus_ATCC_199 FRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPHRDT-------VLQTAS
MLBr_01278|M.leprae_Br4923 VKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWG---FDRIFAVS
.: :* * . : * :. :.: * : ...
MAV_5130|M.avium_104 MSISVAFHEPVRWDGWLLYSHESTQVGAGMSYVRGTVHTEQGELLASFAQ
MMAR_0392|M.marinum_M MTISVAFHEPVHWDGWLLYSHESTQVGAGMSYVRGTVHTEQGALIASFAQ
MSMEG_2997|M.smegmatis_MC2_155 MTVNVSFHEPAAWDGWLLYSHESTQVGAGMSYVRGTVHTESGELIASFSQ
TH_0539|M.thermoresistible__bu MTISVSFHEPAGWDGWLLYSHESTQVGAGMSYVRGTVHTEAGELIASFTQ
Mflv_3790|M.gilvum_PYR-GCK MTVSVSFHEPVTWGGWLLYTHESTQVGSGMSYVRGAVHTEEGELIASFTQ
Mvan_2604|M.vanbaalenii_PYR-1 MTVSVSFHEPVRWDGWLLYSHESTQVGAGMSYVRGTVHTEEGELIASFTQ
Mb2637c|M.bovis_AF2122/97 LDHAMWFMRPFRADEWLLYDQSSPSASGGRALTRGEIFTRSGEMVAAVMQ
Rv2605c|M.tuberculosis_H37Rv LDHAMWFMRPFRADEWLLYDQSSPSASGGRALTRGEIFTRSGEMVAAVMQ
MUL_3249|M.ulcerans_Agy99 LDHAMWFMRGFRADEWLLYDQSSPSAGGGRALTHGKIFTQGGELVAAVMQ
MAB_2891c|M.abscessus_ATCC_199 LDHALWFLRPFRADEWMLYDETSPSAGFGRALTQGRIFNRDGTMVAAVVQ
MLBr_01278|M.leprae_Br4923 ANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQ
: * . . *:** *. .. . . * :. . * ::*:. *
MAV_5130|M.avium_104 EALIRPLRTSDTAIDSRARF-
MMAR_0392|M.marinum_M EALIRPLRTSDTSIDARSRF-
MSMEG_2997|M.smegmatis_MC2_155 DAMIRPLRTVDTNISANARL-
TH_0539|M.thermoresistible__bu DALIRPLRKIDAAIKEQARL-
Mflv_3790|M.gilvum_PYR-GCK DALIRPLRTTDTAIKEQSRL-
Mvan_2604|M.vanbaalenii_PYR-1 DALIRPLRTTDTSIKHQSRL-
Mb2637c|M.bovis_AF2122/97 EGLTRHRRG--HRSVGQ----
Rv2605c|M.tuberculosis_H37Rv EGLTRHRRG--HRSVGQ----
MUL_3249|M.ulcerans_Agy99 EGLTRYPSG--YQPGEN----
MAB_2891c|M.abscessus_ATCC_199 EGLTRIERNPEQASVARGNMA
MLBr_01278|M.leprae_Br4923 EGVLKYFPASHR---------
:.: :