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M. avium 104 MAV_3911 (-)

annotation: NADP-dependent alcohol dehydrogenase c
coordinates: 4040239 - 4041279
length: 346

MSTVSAYAATSATEPLTKTTIERRDPGPRDVAIDIKFAGICHSDIHTAKGEWGHTNYPVVVGHEIAGVVT
EVGAEVTKYKVGDHVGVGCMVNSCRQCSSCTAGLEQYCKRGATFTYNSIDRDGSVTQGGYSQAIVVDEDF
VVRIPDSLPLDKAAPLLCAGITLFSPLRHWKAGPGTRLAIVGLGGLGHMGVKLGAAMGAEVTVLSQSLKK
MEDGLRLGAKHYHATADPDTFTKLRGSFDLMLNTVSANLKLNDYLSLLDVDGTLVELGIPEHPMEVGAFP
LALARRSLSGSNIGGIAETQEMLDFCAEHNVTPEIELIEPDYINEAYERVLASDVRYRFVIDISKL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_3911--100% (346)NADP-dependent alcohol dehydrogenase c
M. avium 104MAV_2812-5e-4531.68% (322) aldehyde dehydrogenase family protein
M. avium 104MAV_2857-6e-3330.84% (321) zinc-binding alcohol dehydrogenase family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3071adhC1e-16983.53% (346) NADP-dependent alcohol dehydrogenase ADHC
M. gilvum PYR-GCKMflv_4279-1e-15073.78% (347) alcohol dehydrogenase
M. tuberculosis H37RvRv3045adhC1e-16983.53% (346) NADP-dependent alcohol dehydrogenase ADHC
M. leprae Br4923MLBr_01730adhA1e-16683.24% (346) alcohol dehydrogenase
M. abscessus ATCC 19977MAB_3400-1e-15475.72% (346) NADP-dependent alcohol dehydrogenase C
M. marinum MMMAR_1649adh1e-17284.10% (346) NADP-dependent alcohol dehydrogenase Adh
M. smegmatis MC2 155MSMEG_2317-1e-15577.52% (347) alcohol dehydrogenase, zinc-containing
M. thermoresistible (build 8)TH_4581-1e-15175.14% (346) PUTATIVE alcohol dehydrogenase, zinc-containing
M. ulcerans Agy99MUL_1885adh1e-17284.10% (346) NADP-dependent alcohol dehydrogenase Adh
M. vanbaalenii PYR-1Mvan_2080-1e-15073.78% (347) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4279|M.gilvum_PYR-GCK          ----------------MSTVSAYAATSATEPLTKTTITRREVGPHDVAFD
Mvan_2080|M.vanbaalenii_PYR-1       ----------------MTTVSAYAATSADGPLTRTTVTRRDVGPHDVAFD
MSMEG_2317|M.smegmatis_MC2_155      ----------------MSTVSAYAATSATEPLTKTTITRRAVGPHDVAFD
TH_4581|M.thermoresistible__bu      ----------------MTTVSAYAATSVSEPLTRTTITRREMGPHDVTIA
MMAR_1649|M.marinum_M               ----------------MNTVSAYAALSATEPLTKTTITRRDPGPHDVAID
MUL_1885|M.ulcerans_Agy99           ----------------MNTVSAYAALSATEPLTKTTITRRDPGPHDVAID
Mb3071|M.bovis_AF2122/97            ----------------MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAID
Rv3045|M.tuberculosis_H37Rv         ----------------MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAID
MLBr_01730|M.leprae_Br4923          MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQ
MAV_3911|M.avium_104                ----------------MSTVSAYAATSATEPLTKTTIERRDPGPRDVAID
MAB_3400|M.abscessus_ATCC_1997      ----------------MVTVSAYAATSGKDPLVPTTIERREVGPHDVFID
                                                    * **:**** *   **. .*: **  **:** : 

Mflv_4279|M.gilvum_PYR-GCK          IHFAGICHSDVHTVRAEWGQPAYPVVPGHEIAGIVTEVGPEVTRYKVGDR
Mvan_2080|M.vanbaalenii_PYR-1       IHFAGICHSDIHTVRGEWGGIDYPLVPGHEIAGIVTEVGSAVTKFTVGDR
MSMEG_2317|M.smegmatis_MC2_155      IHFAGICHSDIHTVKAEWGVPNYPVVPGHEIAGVVTEVGSEVTKYKVGDR
TH_4581|M.thermoresistible__bu      IHFAGICHSDIHTVKGEWGEPAFPLVPGHEIAGVVTAVGSEVTRYRVGDR
MMAR_1649|M.marinum_M               IKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVSAVGSQVTKHKVGDH
MUL_1885|M.ulcerans_Agy99           IKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVSAVGSQVTKHKVGDH
Mb3071|M.bovis_AF2122/97            IKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQGDR
Rv3045|M.tuberculosis_H37Rv         IKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQGDR
MLBr_01730|M.leprae_Br4923          IKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGTEVTKHKVGDR
MAV_3911|M.avium_104                IKFAGICHSDIHTAKGEWGHTNYPVVVGHEIAGVVTEVGAEVTKYKVGDH
MAB_3400|M.abscessus_ATCC_1997      IKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVGSEVTKFKPGDH
                                    *:********:**.: ***   :*:* ******::: **. **:.  **:

Mflv_4279|M.gilvum_PYR-GCK          VGVGCFVDSCRECEECRAGEQQYCTGGGMVGTYNGVGRDGEPTQGGYSGA
Mvan_2080|M.vanbaalenii_PYR-1       VGVGCFVDSCRECDACRDGEEQYCTGGGMVGTYNGVGRDGQRTQGGYSGA
MSMEG_2317|M.smegmatis_MC2_155      VGVGCFVDSCRECDNCKAGLEQYCTGTGMVGTYNAIDRDGTPTHGGYSGA
TH_4581|M.thermoresistible__bu      VGVGCFVDSCRECRHCLAGDEQYCVR-GMTGTYNGVDRDGRPTQGGYSGA
MMAR_1649|M.marinum_M               VGVGCFVDSCRECSCCERGIEQYCKR-GATFTYNSVGKDGQPTQGGYSKA
MUL_1885|M.ulcerans_Agy99           VGVGCFVDSCRECSCCERGIEQYCKR-GATFTYNSVGKDGQPTQGGYSKA
Mb3071|M.bovis_AF2122/97            VGVGCFVDSCRECNSCTRGIEQYCKP-GANFTYNSIGKDGQPTQGGYSEA
Rv3045|M.tuberculosis_H37Rv         VGVGCFVDSCRECNSCTRGIEQYCKP-GANFTYNSIGKDGQPTQGGYSEA
MLBr_01730|M.leprae_Br4923          VGVGCMVGSCGECSSCLAGIEQYCKR-GATFTYNSIGTDGQSTQGGYSQA
MAV_3911|M.avium_104                VGVGCMVNSCRQCSSCTAGLEQYCKR-GATFTYNSIDRDGSVTQGGYSQA
MAB_3400|M.abscessus_ATCC_1997      AGVGCFVNSCRECPSCLAGLEQFCER-GMVGTYGAKDRDGTQTQGGYSQA
                                    .****:*.** :*  *  * :*:*   *   **.. . **  *:**** *

Mflv_4279|M.gilvum_PYR-GCK          IVVDENYVLRIPDSISLDKAAPLLCAGITTYSPLHHWNAGPGKKIAVIGL
Mvan_2080|M.vanbaalenii_PYR-1       IVVDENYVLNIPDAIPLDKAAPLLCAGITTYSPLHHWNAGPGTKVAVIGL
MSMEG_2317|M.smegmatis_MC2_155      IVVDENYVLRIPDSLPLDAAAPLLCAGITTYSPLRHWNAGPGKKVAVIGL
TH_4581|M.thermoresistible__bu      IVVDENYVLRIPDSLPLDAAAPLLCAGITTYSPLRHWNVGPGTRVAVVGL
MMAR_1649|M.marinum_M               IVVDESYVLRIPDALPLDAAAPLLCAGITLFSPLRHWNAGPGKRIAVIGL
MUL_1885|M.ulcerans_Agy99           IVVDESYVLRIPDALPLDAAAPLLCAGITLFSPLRHWNAGPGKRIAVIGL
Mb3071|M.bovis_AF2122/97            IVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAIIGL
Rv3045|M.tuberculosis_H37Rv         IVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAIIGL
MLBr_01730|M.leprae_Br4923          IVVDENFVVHIPDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAIIGL
MAV_3911|M.avium_104                IVVDEDFVVRIPDSLPLDKAAPLLCAGITLFSPLRHWKAGPGTRLAIVGL
MAB_3400|M.abscessus_ATCC_1997      IVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGKRVAVVGL
                                    *****.:*:.*** :.** ********** :***:**:. ...::*::**

Mflv_4279|M.gilvum_PYR-GCK          GGLGHLAVKIAVAMGAEVTVLSQSLKKMEDGLRLGATDYRATSDRDTFKD
Mvan_2080|M.vanbaalenii_PYR-1       GGLGHLAVKLAAAMGAEVTVLSQSLKKMEDGLRLGATEYRATSDRDTFKE
MSMEG_2317|M.smegmatis_MC2_155      GGLGHVAVKLAKAMGADVTVLSQSLKKMEDGLRLGASAYYATSDPETFDK
TH_4581|M.thermoresistible__bu      GGLGHMAVKLGKALGADVTVLSQSLKKREDGLRLGAGAYYATSDPDTFRA
MMAR_1649|M.marinum_M               GGLGHMGVKLATAMGAEVTVLSQSLKKMEDGLRLGASHYYATSDPDTFRK
MUL_1885|M.ulcerans_Agy99           GGLGHMGVKLATAMGAEVTVLSQSLKKMEDGLRLGASHYYATSDPDTFRK
Mb3071|M.bovis_AF2122/97            GGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRK
Rv3045|M.tuberculosis_H37Rv         GGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRK
MLBr_01730|M.leprae_Br4923          GGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYATADPDTFRK
MAV_3911|M.avium_104                GGLGHMGVKLGAAMGAEVTVLSQSLKKMEDGLRLGAKHYHATADPDTFTK
MAB_3400|M.abscessus_ATCC_1997      GGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKS
                                    *****:.**:.  :*.:********** ****:***  * **:* :**  

Mflv_4279|M.gilvum_PYR-GCK          LKGTFDLIINTVSANLDLSDYLKLLKLDGTLVELGMPEHPMEVPAGALIF
Mvan_2080|M.vanbaalenii_PYR-1       LRGRFDLILNTVSANLNLEDYLKLLKIDGTLVELGMPEHPMSVPAGALIS
MSMEG_2317|M.smegmatis_MC2_155      LAGSFDLILNTVSANLDLGAYLGLLKLDGALVELGLPEHPMEVPAFPLLA
TH_4581|M.thermoresistible__bu      LRSSFDVVINTVSANLDLGRYLMLLDVDGTLVELGMPEKPMTVPAAPLVG
MMAR_1649|M.marinum_M               LRGSFDLILNTVSANLDMGQYLNLLDVDGTLVELGIPEHPMEVPAFALAL
MUL_1885|M.ulcerans_Agy99           LRGSFDLILNTVSANLDMGQYLNLLDVDGTLVELGIPEHPMEVPAFALAL
Mb3071|M.bovis_AF2122/97            LRGGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALAL
Rv3045|M.tuberculosis_H37Rv         LRGGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALAL
MLBr_01730|M.leprae_Br4923          LRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALAL
MAV_3911|M.avium_104                LRGSFDLMLNTVSANLKLNDYLSLLDVDGTLVELGIPEHPMEVGAFPLAL
MAB_3400|M.abscessus_ATCC_1997      LRNSFDLILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLT
                                    * . **:::****:**.:  ** ** ::*:*****:**:*: * . .*  

Mflv_4279|M.gilvum_PYR-GCK          GRRSIAGSLIGGIAETQEMLDFCAEHDVTPEIEVVAPDYINEAYERMLAS
Mvan_2080|M.vanbaalenii_PYR-1       GRRSIAGSMIGGIAETQEMLDFCAEHDVTPEIEIIEPDYINEAYERVMAS
MSMEG_2317|M.smegmatis_MC2_155      QRRNLTGSMIGGIPETQEMLDFCAEHDVRPEIEIITPDYINEAYERVLAS
TH_4581|M.thermoresistible__bu      GRRRLAGSLIGGIAETQEMLDFCAEHGVLPEIEVIEPEYINTAYERVLAS
MMAR_1649|M.marinum_M               MRRSLSGSNIGGIAETQEMLDFCAEHGVTPEIELIEPDYINEAYERVLAS
MUL_1885|M.ulcerans_Agy99           MRRSLSGSNIGGIAETQEMLDFCAEHGVTPEIELIEPDYINEAYERVLAS
Mb3071|M.bovis_AF2122/97            MRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDAYERVLAS
Rv3045|M.tuberculosis_H37Rv         MRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDAYERVLAS
MLBr_01730|M.leprae_Br4923          MRRSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDYINEAYERVLAS
MAV_3911|M.avium_104                ARRSLSGSNIGGIAETQEMLDFCAEHNVTPEIELIEPDYINEAYERVLAS
MAB_3400|M.abscessus_ATCC_1997      NRRSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDASYINEAYERVVAS
                                     ** ::** ****.*****::*.*:*.: .***:: ..*** ****::**

Mflv_4279|M.gilvum_PYR-GCK          DVRYRFVIDTASLR-
Mvan_2080|M.vanbaalenii_PYR-1       DVRYRFVIDTASLR-
MSMEG_2317|M.smegmatis_MC2_155      DVRYRFVIDTASLRS
TH_4581|M.thermoresistible__bu      DVRYRFVIDTASLRG
MMAR_1649|M.marinum_M               DVRYRFVIDTSSL--
MUL_1885|M.ulcerans_Agy99           DVRYRFVIDTSSL--
Mb3071|M.bovis_AF2122/97            DVRYRFVIDISAL--
Rv3045|M.tuberculosis_H37Rv         DVRYRFVIDISAL--
MLBr_01730|M.leprae_Br4923          DVRYRFVINISSL--
MAV_3911|M.avium_104                DVRYRFVIDISKL--
MAB_3400|M.abscessus_ATCC_1997      DVRYRFVIDTQTL--
                                    ********:   *