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SGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLSGDETGGVDSYGRNSNPTWRQLESALAELEGAVG ALVFGSGMAAISAVLRALAPPGSTVVVPADGYYQVRRHAAEDLAPAGVTVIEASSAQIYDAAATADVVLA ETPTNPALDVVDLHRLATVCHGRGARLVVDNTAATPLGQQPLSLGADAVVASATKALSGHSDLLAGYVAT SRPELLAAVERQRLLAGAILGGFEAWLLLRSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEH PGHAVARAQMRRFGGLVAVELADAAAVRALLDGSELLIASTSFGGLHTSVDRRARWGDAVPDGFARISLG IEDTDDLLADIERALLTLH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3867 | - | - | 100% (370) | cystathionine gamma-lyase |
| M. avium 104 | MAV_1203 | - | 2e-60 | 42.31% (338) | cystathionine gamma-synthase |
| M. avium 104 | MAV_4773 | metZ | 2e-43 | 35.45% (347) | O-succinylhomoserine sulfhydrylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1108 | metB | 8e-59 | 38.58% (381) | cystathionine gamma-synthase |
| M. gilvum PYR-GCK | Mflv_4220 | - | 1e-145 | 71.31% (366) | cystathionine gamma-lyase |
| M. tuberculosis H37Rv | Rv1079 | metB | 8e-59 | 38.58% (381) | cystathionine gamma-synthase |
| M. leprae Br4923 | MLBr_02394 | metB | 3e-55 | 38.08% (344) | cystathionine gamma-synthase |
| M. abscessus ATCC 19977 | MAB_3287c | - | 1e-132 | 68.42% (361) | cystathionine gamma-lyase |
| M. marinum M | MMAR_4388 | metB | 2e-60 | 38.85% (381) | cystathionine gamma-synthase MetB (cgs) |
| M. smegmatis MC2 155 | MSMEG_2394 | - | 1e-152 | 74.86% (366) | cystathionine gamma-lyase |
| M. thermoresistible (build 8) | TH_3359 | - | 1e-151 | 73.50% (366) | PUTATIVE putative cystathionine gamma-synthase |
| M. ulcerans Agy99 | MUL_0201 | metB | 7e-60 | 38.58% (381) | cystathionine gamma-synthase |
| M. vanbaalenii PYR-1 | Mvan_2142 | - | 1e-146 | 71.86% (366) | cystathionine gamma-lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2394|M.smegmatis_MC2_155 -------MDGTYGDSTRSVKAVGVDAVPGQPVAPMPVPASTYHLS-PDAT
TH_3359|M.thermoresistible__bu -------VDGQYGDSTRTVRAVSFPAEPGSPVAPSPVTASTYHLS-PDES
Mflv_4220|M.gilvum_PYR-GCK -------MAGTHGDSTRSVKAVASQDVPGTAVAAPPVFASAYHLA-ADED
Mvan_2142|M.vanbaalenii_PYR-1 -------MAGTYGDSTRSVKAVGAEAIPGLPVSSPPVPAAAYHLA-PDED
MAV_3867|M.avium_104 -------MSGNYGDSTRSLKAVDPQAVSGQPVAPQPVLAATYHLS-GDET
MAB_3287c|M.abscessus_ATCC_199 -------MP-EPGISTRAVVAATAEPVAGQPFLAGPVFASAYHLP-VPED
Mb1108|M.bovis_AF2122/97 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGL
Rv1079|M.tuberculosis_H37Rv MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGL
MLBr_02394|M.leprae_Br4923 MSEDYRGHHGITGLATKAIHAGYRPDPATGAVNVPIYASSTFAQDGVGEL
MMAR_4388|M.marinum_M MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGL
MUL_0201|M.ulcerans_Agy99 MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGL
* :*::: : . .. ::::
MSMEG_2394|M.smegmatis_MC2_155 EPLDSYGRSSNPSWRQLESALAELEGASWALTYGSGMAAITSTLRALTRP
TH_3359|M.thermoresistible__bu EPLDVYGRYSNPTWRQLESALAALEGAAAALTFGSGMAAITSTLRVLAKP
Mflv_4220|M.gilvum_PYR-GCK DTLDSYGRRSNPTWRQLESALAQLEGAAAALSFASGMAALTAVLRVLAQP
Mvan_2142|M.vanbaalenii_PYR-1 GSLDSYGRSSNPTWRQLESALARLEGAATALVFGSGMAALTSVLRVVAEP
MAV_3867|M.avium_104 GGVDSYGRNSNPTWRQLESALAELEGAVGALVFGSGMAAISAVLRALAPP
MAB_3287c|M.abscessus_ATCC_199 DSLDTYGRASNPSWRQWESGLAALEQADAALVFGSGMGAIASTLRALVRP
Mb1108|M.bovis_AF2122/97 RGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRP
Rv1079|M.tuberculosis_H37Rv RGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRP
MLBr_02394|M.leprae_Br4923 RGGFEYARTGNPMRAALEASLATVEEGVFARAFSSGMAASDCALRVMLRP
MMAR_4388|M.marinum_M RGGYEYARTGNPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAMLRP
MUL_0201|M.ulcerans_Agy99 RGGYEYARTGNPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAMLRP
*.* .** *:.** :* . . :.***.* ..**.: *
MSMEG_2394|M.smegmatis_MC2_155 GTTLVVPADGYYQVRRYGAEYLAQQGVSVIEAHSHEMCDAAEKAD----V
TH_3359|M.thermoresistible__bu GSTLVVPADGYYQVRRYAAEYLAPQGIKIIQARASEMCEAAGAAD----V
Mflv_4220|M.gilvum_PYR-GCK GHTLVVPADGYYQVRAYAREYLASRGVTVVEARCADLGDAAARAD----V
Mvan_2142|M.vanbaalenii_PYR-1 GHTLVVPADGYYQVRAYAKEYLAPRGVTVVEARCAEMCDAARDAD----V
MAV_3867|M.avium_104 GSTVVVPADGYYQVRRHAAEDLAPAGVTVIEASSAQIYDAAATAD----V
MAB_3287c|M.abscessus_ATCC_199 GQTLLVPEDGYYQTRRYASENLAALGINVITATSDQIVAAAAQAD----V
Mb1108|M.bovis_AF2122/97 GDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRL
Rv1079|M.tuberculosis_H37Rv GDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRL
MLBr_02394|M.leprae_Br4923 GDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVPLSDLDAVRAAITSRTRL
MMAR_4388|M.marinum_M GDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTTRL
MUL_0201|M.ulcerans_Agy99 GDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTTRL
* :::* * * . : :: .: . :: . :
MSMEG_2394|M.smegmatis_MC2_155 VLAETPANPGLDVVDLHRLAMICRARKATLVVDNTTATPMGQQPLSLGAD
TH_3359|M.thermoresistible__bu VLAETPANPGLDVVDLHRLGLVCRSRGATLVVDNTAATPLGQQPLSLGAD
Mflv_4220|M.gilvum_PYR-GCK VLAETPSNPELDVVDLHRLALTCRSRGTVLVVDNTTATPFGQQPLSLGAD
Mvan_2142|M.vanbaalenii_PYR-1 VLAETPSNPGLDVVDLHRLAMTCRAQRTLLVVDNTTATPFGQQPLSLGAD
MAV_3867|M.avium_104 VLAETPTNPALDVVDLHRLATVCHGRGARLVVDNTAATPLGQQPLSLGAD
MAB_3287c|M.abscessus_ATCC_199 VVAETPSNPRLDVVDLALLARETHARGGVLVVDNTTATPMGQRPLGLGAD
Mb1108|M.bovis_AF2122/97 IWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGAD
Rv1079|M.tuberculosis_H37Rv IWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGAD
MLBr_02394|M.leprae_Br4923 IWVETPTNPLLSIADITSIGELGKKHSVKVLVDNTFASPALQQPLMLGAD
MMAR_4388|M.marinum_M IWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLGAD
MUL_0201|M.ulcerans_Agy99 IWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLGAD
: .***:** *.:.*: :. ::**** *:* *:** ****
MSMEG_2394|M.smegmatis_MC2_155 LVVASATKSLSGHSDLIAGYVAGCQPELAERIERDRLLAGPILGAFEAWL
TH_3359|M.thermoresistible__bu LVVASATKALSGHSDLIAGYVAGSNPDLMAAVERDRLLAGPILGAFEAWL
Mflv_4220|M.gilvum_PYR-GCK LVVASATKALAGHSDVLAGYVAGSHPELMERVERERLHAGAILGAFEAWL
Mvan_2142|M.vanbaalenii_PYR-1 LVVASATKALAGHHDVLAGYVAGSQPELMERVQRERLHAGPILGAFEAWL
MAV_3867|M.avium_104 AVVASATKALSGHSDLLAGYVATSRPELLAAVERQRLLAGAILGGFEAWL
MAB_3287c|M.abscessus_ATCC_199 LVVASATKALSGHSDLIAGYVAGSRAELVAAVAQERSRAGAILGPFEAWL
Mb1108|M.bovis_AF2122/97 VVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYL
Rv1079|M.tuberculosis_H37Rv VVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYL
MLBr_02394|M.leprae_Br4923 VVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYL
MMAR_4388|M.marinum_M VVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDAYL
MUL_0201|M.ulcerans_Agy99 VVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDAYL
*: *:** :.** *::.* :. :* . : **.: . *:*:*
MSMEG_2394|M.smegmatis_MC2_155 VLRSLGSAGLRFERQCQNALALAVMLRGHPAVRSVRYPGLPEDPAHAVAA
TH_3359|M.thermoresistible__bu VLRSLGSAGLRFERQCQNARALAVMLRGHPAVRWVRYPGLPDDPSYPVAA
Mflv_4220|M.gilvum_PYR-GCK VTRSLGSAGLRFDRQCQNAAAVALTLRSHPAVRSVRFPGLADDPSHEVAA
Mvan_2142|M.vanbaalenii_PYR-1 VLRSLGSAGLRFERQCQNAAALALMLRSHPAVHTVRYPGLPEDPSHAVAS
MAV_3867|M.avium_104 LLRSLGTAGLRFERQCQNARAVATLLARHPAVRAVRYPGLAEHPGHAVAR
MAB_3287c|M.abscessus_ATCC_199 GARSLATAGLRFERQCQNALAVATMLREHPAVTSVRYPGLPSDPSYSVAS
Mb1108|M.bovis_AF2122/97 TMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA
Rv1079|M.tuberculosis_H37Rv TMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA
MLBr_02394|M.leprae_Br4923 TMRGLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEVAA
MMAR_4388|M.marinum_M TMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAA
MUL_0201|M.ulcerans_Agy99 TMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAA
*.* : **::*: :** ::* * **:: * :***...*.: :*
MSMEG_2394|M.smegmatis_MC2_155 EQMKHFGGLVSFELAD-AAAVNALVERSELLIASTSFGGIHTSVDRRARW
TH_3359|M.thermoresistible__bu DQMKRFGGLLAVEFES-AAAVNALVERSELVIAATSFGGIHTSIDRRARW
Mflv_4220|M.gilvum_PYR-GCK RQMRRFGGIVSFELAD-ADAVHALVDRSALLVAATSFGGIHTSVDRRARW
Mvan_2142|M.vanbaalenii_PYR-1 MQMRRFGGIVAAELGD-AQAVHDLVRRSALLIASTSFGGIHTSVDRRARW
MAV_3867|M.avium_104 AQMRRFGGLVAVELAD-AAAVRALLDGSELLIASTSFGGLHTSVDRRARW
MAB_3287c|M.abscessus_ATCC_199 AQMSRFGSLVSIELSS-AEAVHALTRRSELLASSTSFGGVHTSVDRRARW
Mb1108|M.bovis_AF2122/97 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAM
Rv1079|M.tuberculosis_H37Rv RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAM
MLBr_02394|M.leprae_Br4923 RQMRGFGGMVSLRMRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPSAM
MMAR_4388|M.marinum_M RQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGGVESLIEHPSAM
MUL_0201|M.ulcerans_Agy99 RQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGSVESLIEHPSAM
** **.::: .: *.. * : :. : *:*.:.: ::: :
MSMEG_2394|M.smegmatis_MC2_155 GDP--------VPEGFVRISAGIEDTDDLLADVERALPAG--
TH_3359|M.thermoresistible__bu GDE--------VSDGFARFSLGIEDTDDLIADIERALR----
Mflv_4220|M.gilvum_PYR-GCK GDS--------VAAGFARMSMGIEDTDDLVSDLQQALGPA--
Mvan_2142|M.vanbaalenii_PYR-1 GDH--------VSDGFARISLGIEDTDDLVDDVRQALGAG--
MAV_3867|M.avium_104 GDA--------VPDGFARISLGIEDTDDLLADIERALLTLH-
MAB_3287c|M.abscessus_ATCC_199 GDA--------VPDGFARISLGIEDTDDLLADIEAALAAGTV
Mb1108|M.bovis_AF2122/97 THASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG----
Rv1079|M.tuberculosis_H37Rv THASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG----
MLBr_02394|M.leprae_Br4923 THASTTGSQLEVPDDLVRLSVGIEDVGDLLCDLKQALN----
MMAR_4388|M.marinum_M THASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG----
MUL_0201|M.ulcerans_Agy99 THASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG----
. *. .:.*:* **** **: *:. **