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PYDVIIRDGLWFDGTGGAALTRTLGIRDGVLVDVAESLDEAGCPEVIDAAGKWVLPGFIDVHTHYDAEVL LDPGLRESVRHGVTTVLLGNCSLSTVYADSQDAADLFSRVEAVPREYVYGALSSNRTWSTAADYVKAVDA LPLGPNVGSLLGHSDLRAAVLGLDRATDATVRPTDAELEKMAALLDEALDAGLLGMSGMDAAIDKLDGER FRSRALPSTFATWRERRKLIEVLRRRGRILQSAPDLDNPALALMFFLTSSRIFGRGRGVRMSMLVSADAK SMPLAVHTFGLGTRILNKLLRSSVRFQHLPVPFELYSDGIDLPVFEEFGAGTAALHLRDQLQRNELLADT DYRRRFRREFDRVKLGPSLWHRDFHDAVIVECPDKSLIGKSFGAIADERGLHPLDAFLDVLVENGERNVR WTTTVANHRPKQLDKLAADPSIHMGFSDAGAHLRNMAFYNFALRMLKRTRDAQAAGAPFLTIERAVHRLT GELADWFGIDAGTLRPGDRADFVVIDPAGLDESVDAYHEEAVPFYGGLRRMINRNDDAVVATGVGGVVVF GGSHRKGEFRDGYGHTVKSGRYLRAGQRVRAKGGAPRVTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3768 | - | - | 100% (601) | N-acyl-D-glutamate amidohydrolase |
| M. avium 104 | MAV_2959 | - | 0.0 | 56.24% (585) | N-acyl-D-glutamate amidohydrolase |
| M. avium 104 | MAV_5277 | - | 6e-35 | 27.24% (624) | amidohydrolase family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2937c | - | 0.0 | 85.52% (587) | D-amino acid aminohydrolase |
| M. gilvum PYR-GCK | Mflv_3313 | - | 1e-103 | 58.72% (327) | hypothetical protein Mflv_3313 |
| M. tuberculosis H37Rv | Rv2913c | - | 0.0 | 85.52% (587) | D-amino acid aminohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0680c | - | 0.0 | 66.44% (590) | hypothetical protein MAB_0680c |
| M. marinum M | MMAR_1795 | - | 0.0 | 81.48% (594) | D-amino acid aminohydrolase |
| M. smegmatis MC2 155 | MSMEG_6141 | - | 0.0 | 78.62% (594) | N-acyl-D-glutamate amidohydrolase |
| M. thermoresistible (build 8) | TH_2847 | - | 3e-33 | 27.44% (634) | PUTATIVE Amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_2043 | - | 0.0 | 80.98% (594) | D-amino acid aminohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3035 | - | 0.0 | 56.66% (593) | hypothetical protein Mvan_3035 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 -----MRALFDEPVTFDTIIRNGRWFDGTGAPSAVRNLGIRDGHVVSISE
MMAR_1795|M.marinum_M -------------MTYDVIIRDGLWFDGTGSAPQTRTLGIRDGVVATVSA
MUL_2043|M.ulcerans_Agy99 -------------MTYDVIIRDGLWFDGTGSAPQTRTLGIRDGMVATVSA
Mb2937c|M.bovis_AF2122/97 MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
Rv2913c|M.tuberculosis_H37Rv MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
MAV_3768|M.avium_104 -------------MPYDVIIRDGLWFDGTGGAALTRTLGIRDGVLVDVAE
MSMEG_6141|M.smegmatis_MC2_155 -------------MSYDVIVRNGLWFDGTGRPPQVRTLGIRDGVVATVSA
MAB_0680c|M.abscessus_ATCC_199 ------------MSVYDLIIRDGLWFDGTDSEPRKANLGIKEGRVATVST
TH_2847|M.thermoresistible__bu -------------MTFDLVIRNGTIVDGLGGEPFTGDVAVADGVIVAVGT
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 DELDATGCPQVIDAVGKWVLPGMLDIHTHYDIEVLGGPSLAESLRHGVTT
MMAR_1795|M.marinum_M GPLDETGCAQVIDAAGKWVMPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MUL_2043|M.ulcerans_Agy99 GPLDETGCAQVIDAAGKWVMPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
Mb2937c|M.bovis_AF2122/97 GALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
Rv2913c|M.tuberculosis_H37Rv GALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MAV_3768|M.avium_104 S-LDEAGCPEVIDAAGKWVLPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MSMEG_6141|M.smegmatis_MC2_155 KPLDETGCPEVIDAGGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MAB_0680c|M.abscessus_ATCC_199 TALDETDCPEVIDAGGKWVLPGFVDIHTHYDAEVLLNPGLDESVRHGVTT
TH_2847|M.thermoresistible__bu ADGSGR---REIDATGLLVTPGFIDLHTHYDGQSIWSDRLNPSSAHGVTT
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 VLLGSCSLSTVYVDGVDAGDIFGRVEAIPREHVIAAVDRHK---TWTTGE
MMAR_1795|M.marinum_M VLLGNCSLSTVYAGAEDAADLFSRVEAVPRQFVLGALSAAKSERAWSNAA
MUL_2043|M.ulcerans_Agy99 VLLGNCSLSTVYAGAEDAADLFSRVEAVPRQFVLGALSAAKSERAWSNAA
Mb2937c|M.bovis_AF2122/97 VLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQ---TWSTPA
Rv2913c|M.tuberculosis_H37Rv VLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQ---TWSTPA
MAV_3768|M.avium_104 VLLGNCSLSTVYADSQDAADLFSRVEAVPREYVYGALSSNR---TWSTAA
MSMEG_6141|M.smegmatis_MC2_155 VLLGMCSLSTVYSDAEDAADLFSRVEAVPRQFVLGALESRK---TWSNPA
MAB_0680c|M.abscessus_ATCC_199 IVLGCCSMSTVYAKPEDAADLFSRVEAVPRKHVIGALNEFQ---DWTDPE
TH_2847|M.thermoresistible__bu ALMGNCGVGFAPCRPEDHDVLVDVMAGV--EDIPGVVMAEGLPWTWETFP
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 EYIAALESRPLGPNVAAFIGHSDMRTATMGLDRATRKDERPTGSEQAQME
MMAR_1795|M.marinum_M EYITAIDSLPLGPNVSSLLGHSDLRATVLGLERATDASVRPSEAELGRMA
MUL_2043|M.ulcerans_Agy99 EYITAIDSLPLGPNVSSLLGHSDLRATVLGLERATDASVRPSEAELGRMA
Mb2937c|M.bovis_AF2122/97 EYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMA
Rv2913c|M.tuberculosis_H37Rv EYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMA
MAV_3768|M.avium_104 DYVKAVDALPLGPNVGSLLGHSDLRAAVLGLDRATDATVRPTDAELEKMA
MSMEG_6141|M.smegmatis_MC2_155 EYVAAIDALPLGPNIASLLGHSDLRASVLGLDRATTRGVVPTDDELETMA
MAB_0680c|M.abscessus_ATCC_199 SYVKKIDALPLGPNVTSFLGHSDLRTAVMGLGRATNNWSFPTRKELDRMA
TH_2847|M.thermoresistible__bu QYLDAVASRPRDIDVAAYLPHSPLRVYVMGRRGVDREPATP--DDLERMR
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 RMLTEALRAGFVGMSSQQLLFDKLDGEVCRSRTLPSTYAKPRELRRLKS-
MMAR_1795|M.marinum_M TLLDEALDAGMLGMSGMDSAIDKLDGERFRSRALPSTFATWRERRRLIK-
MUL_2043|M.ulcerans_Agy99 TLLDEALDAGMLGMSGMDSAIDKLDGERFRSRALPSTFATWRERRRLIK-
Mb2937c|M.bovis_AF2122/97 KLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLIS-
Rv2913c|M.tuberculosis_H37Rv KLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLIS-
MAV_3768|M.avium_104 ALLDEALDAGLLGMSGMDAAIDKLDGERFRSRALPSTFATWRERRKLIE-
MSMEG_6141|M.smegmatis_MC2_155 DRLDAALDAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRRLIK-
MAB_0680c|M.abscessus_ATCC_199 DMLDKALDAGMLGMSGMDAPIDKLDGDRYRSRALPSTYAWWHERWRLIN-
TH_2847|M.thermoresistible__bu ALAAEAVAAGALGFASSRFALHKTES----GSPIPTYDAAQEEIAAIARG
Mflv_3313|M.gilvum_PYR-GCK ------------------------MFQS---LGIVRNPLKTSLLSAADVK
Mvan_3035|M.vanbaalenii_PYR-1 LLRRSGRVLQSGPDITNPLNVASQVFQS---LGLVRNPLKTSLLSAADVK
MMAR_1795|M.marinum_M VLRKRGRILQSAPNVDKPASALLFFLAS-SRILNRRKGVRMSLLVSADSK
MUL_2043|M.ulcerans_Agy99 VLRKRGRILQSAPNVDKPASALLFFLAS-SRILNRRKGVRMSLLVSADSK
Mb2937c|M.bovis_AF2122/97 VLRHRGRILQSAPDVDNPVSALLFFLAS-SRIFNRRKGVRMSMLVSADAK
Rv2913c|M.tuberculosis_H37Rv VLRHRGRILQSAPDVDNPVSALLFFLAS-SRIFNRRKGVRMSMLVSADAK
MAV_3768|M.avium_104 VLRRRGRILQSAPDLDNPALALMFFLTS-SRIFGRGRGVRMSMLVSADAK
MSMEG_6141|M.smegmatis_MC2_155 VLRKRGRILQSAPNVAKAQEALNFFLES-SSLFGRRRGVRMSLLVSADAK
MAB_0680c|M.abscessus_ATCC_199 VLRKRDRILQSAPNINNPLTAVLFFLSTGTRFFKRRKAVPVSLLVAADSK
TH_2847|M.thermoresistible__bu VADAGGGLLQFVPDIP-AGGYESVLRQVFEVGAETGLPVTFSLLTGNAGE
. : *:* . :
Mflv_3313|M.gilvum_PYR-GCK ----SNPVAVKLLGPLARLANR-LGGNFRWQHLPVPFEVYADGIDLVIFE
Mvan_3035|M.vanbaalenii_PYR-1 ----SNPVAVKLLGPLARLANR-LGGNFRWQHLPVPFEVYADGIDLVIFE
MMAR_1795|M.marinum_M ----SMPMAVHTFGLGARLLNKLLAASVRFQHLPVPFELYSDGIDLPVFE
MUL_2043|M.ulcerans_Agy99 ----SMPMAVRTFGLGARLLNKLLAASVRFQHLPVPFELYSDGIDLPVFE
Mb2937c|M.bovis_AF2122/97 ----SMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFE
Rv2913c|M.tuberculosis_H37Rv ----SMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFE
MAV_3768|M.avium_104 ----SMPLAVHTFGLGTRILNKLLRSSVRFQHLPVPFELYSDGIDLPVFE
MSMEG_6141|M.smegmatis_MC2_155 ----SSPGAARVIGMGTRLLNKTLDAKVRFQHLPVPFELYSDGIDLPVFE
MAB_0680c|M.abscessus_ATCC_199 ----SIKGANVFFSAAARIGNKVFKSNVKFQHMPLPFTLYSDGIDLPVFE
TH_2847|M.thermoresistible__bu PTWPQALNLVEKFNAAAGGAAPAVTAQVFPRPIGMVMSLELSANPFVMYP
. :. : . ... : : : : : .. : ::
Mflv_3313|M.gilvum_PYR-GCK EFGSGAAALHLKDEVERNALLRDENYRREFRKDYD-AKFGMRVWHRDFFD
Mvan_3035|M.vanbaalenii_PYR-1 EFGSGAAALHLADEVDRNALLRDESYRRRFRKDYD-ARFGMRVWHRDFFD
MMAR_1795|M.marinum_M EFGAGTAALHLREQVQRNQLLADESYRREFRREFDRTKLGPSLWHKDFHD
MUL_2043|M.ulcerans_Agy99 EFGAGTAALHLREQVQRNQLLADESYRSEFRREFDRTKLGPSLWHKDFHD
Mb2937c|M.bovis_AF2122/97 EFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHD
Rv2913c|M.tuberculosis_H37Rv EFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHD
MAV_3768|M.avium_104 EFGAGTAALHLRDQLQRNELLADTDYRRRFRREFDRVKLGPSLWHRDFHD
MSMEG_6141|M.smegmatis_MC2_155 EFGAGTAALHLRDQLERNKLLADPEYRRRFRRSFDRRKLGPTLWHRDFHD
MAB_0680c|M.abscessus_ATCC_199 EFGAGTAALHIREQLDRNKLMADKEYRRKFRREFAIKKHKPGLWHKDFHD
TH_2847|M.thermoresistible__bu SY-REIAGLPLPQQVAEMRKPEVRERILNDKPAGDGHPLFFMTQAWDWIY
.: *.* : ::: . . : *:
Mflv_3313|M.gilvum_PYR-GCK AEIVACPDPAVIGKSFGEVGRDRGGLHPVDAFLDLVLEHG-NELRWRTT-
Mvan_3035|M.vanbaalenii_PYR-1 AQIVACPDVSVIGKSFGEVGRERGGLHPVDAFLDLVLEHG-KGLRWRTT-
MMAR_1795|M.marinum_M AVIVECPDESLIGKSFGAIADERG-LHPLDAFLDVLVENGERNVRWTTV-
MUL_2043|M.ulcerans_Agy99 AVIVECPDESLIGKSFGAIADERG-LHPLDAFLDVLVENGERNVRWTTV-
Mb2937c|M.bovis_AF2122/97 AVIVECPDKSLIGKSFGAIADERG-LHPLDAFLDVLVDNGERNVRWTTI-
Rv2913c|M.tuberculosis_H37Rv AVIVECPDKSLIGKSFGAIADERG-LHPLDAFLDVLVDNGERNVRWTTI-
MAV_3768|M.avium_104 AVIVECPDKSLIGKSFGAIADERG-LHPLDAFLDVLVENGERNVRWTTT-
MSMEG_6141|M.smegmatis_MC2_155 ATIVECPDESLIGKTFGRIADERG-IHPLDAFLDVLVDNGEKNVRWTTI-
MAB_0680c|M.abscessus_ATCC_199 AVIVECPDASLVGKTFGQIGDERG-IAPLDAFLDVLVDNGEKNVRWTTT-
TH_2847|M.thermoresistible__bu PLGEQPDYEPDASTSIAARARARG-VSPLEEAYDRLLDDDGHAMLLIAMG
. . ..::. . ** : *:: * :::.. . : :
Mflv_3313|M.gilvum_PYR-GCK -ISNHRPEVLRKLAADSGIQMGFSDAGAHLRNMAFYNMGLRLLRHVQDAV
Mvan_3035|M.vanbaalenii_PYR-1 -ISNHRPEVLRKLAADPGIQMGFSDAGAHLRNMAFYNMGLRLLRHVQDAA
MMAR_1795|M.marinum_M -VANHRPKQLNKLAAEPGVHMGFSDAGAHLRNMAFYNFPLRLLKRTWDAE
MUL_2043|M.ulcerans_Agy99 -VANHRPKQLNKLAAEPGVHMGFSDAGAHLRNMAFYNFPLRLLKRTWDAE
Mb2937c|M.bovis_AF2122/97 -VANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDAD
Rv2913c|M.tuberculosis_H37Rv -VANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDAD
MAV_3768|M.avium_104 -VANHRPKQLDKLAADPSIHMGFSDAGAHLRNMAFYNFALRMLKRTRDAQ
MSMEG_6141|M.smegmatis_MC2_155 -VANHRPKVLDQLANDPAVHMGFSDAGAHLRNMAFYNYPLRLLKRVRDAQ
MAB_0680c|M.abscessus_ATCC_199 -VGNHRPKVLDEMAKDPNFQLGFSDAGAHLRNMAFYNFSLRFLKRMNDAQ
TH_2847|M.thermoresistible__bu NYENNSLDTVGQWMRRDDVVLGLGDGGAHYGMICDASYPTFLLAHWARDR
*: . : : . :*:.*.*** :. . :* :
Mflv_3313|M.gilvum_PYR-GCK RAGRPFMTIEAAVHRLTGELADWYRID-AGHLRLGDRADIVILDPERLDA
Mvan_3035|M.vanbaalenii_PYR-1 RSGRPFMTVEQAVHRLTGELADWYRID-AGHLRLGDRADLVIVDPERLDD
MMAR_1795|M.marinum_M RAGKPFLSLQQAVYRLTGELAEWFGVD-AGTLREGDRADFVVIDPAHLDE
MUL_2043|M.ulcerans_Agy99 RAGKPFLSLQQAVYRLTGELAEWFGVD-AGTLREGDRADFVVIDPAHLDE
Mb2937c|M.bovis_AF2122/97 RAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTHLDE
Rv2913c|M.tuberculosis_H37Rv RAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTHLDE
MAV_3768|M.avium_104 AAGAPFLTIERAVHRLTGELADWFGID-AGTLRPGDRADFVVIDPAGLDE
MSMEG_6141|M.smegmatis_MC2_155 LSGRPFLTTERAVYRLTAEVADWFGVD-AGTLREGDRADFVVIDPNCLNS
MAB_0680c|M.abscessus_ATCC_199 KAGKPVMSLGQAVHRLTGELASWFGLD-AGYLREGDRADFVIIDPEKLDG
TH_2847|M.thermoresistible__bu ASGR--LTVAEAVRALTSVPARVAGFGDRGRIAVGYKADLNVID----HA
:* :: ** **. * .. * : * :**: ::* .
Mflv_3313|M.gilvum_PYR-GCK SLDAYAEETVDQYGGLSRMVNRNDDTVSAVFVGGRAVFNGG-----VPTP
Mvan_3035|M.vanbaalenii_PYR-1 TLDRYAEEPVEQYGGLSRMVNRNDDTVAAVFVGGRAVFLDG-----RPTP
MMAR_1795|M.marinum_M SVDGYHEAQVPFYGGLSRMVNRNDATVIATGVAGAVVFGSG----QFRDG
MUL_2043|M.ulcerans_Agy99 SVDGYHEAQVPFYGGLSRMVNRNDATVIATGVAGAVVFGTG----QFRDG
Mb2937c|M.bovis_AF2122/97 SVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDG
Rv2913c|M.tuberculosis_H37Rv SVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDG
MAV_3768|M.avium_104 SVDAYHEEAVPFYGGLRRMINRNDDAVVATGVGGVVVFGGSHRKGEFRDG
MSMEG_6141|M.smegmatis_MC2_155 DVDAYHEETVPFYGGLSRMVNRNDDAVVATAVNGTVVFGKG----EFRDG
MAB_0680c|M.abscessus_ATCC_199 TVDAYNEAQAPFFDNLSRMVNRNDETVVATAVGGKVVFRLG----EFIEG
TH_2847|M.thermoresistible__bu ALRLHRPVILHDLPSGGRRLDQRADGYVATVVSGHIIAENG---------
: : . * :::. *. * * : .
Mflv_3313|M.gilvum_PYR-GCK LVGEHRTGRFLRAAHRVPALPATEGVLTHAG
Mvan_3035|M.vanbaalenii_PYR-1 LVGAERTGRFLRAAHKAPALLAQNGALAHAG
MMAR_1795|M.marinum_M YGQTVRSGRYLRAGQRYTAAS----VSA---
MUL_2043|M.ulcerans_Agy99 YGQTVRSGRYLRAGQRYTAAS----VSA---
Mb2937c|M.bovis_AF2122/97 YGQNVKSGRYLRAGELGAALS----RSA---
Rv2913c|M.tuberculosis_H37Rv YGQNVKSGRYLRAGELGAALS----RSA---
MAV_3768|M.avium_104 YGHTVKSGRYLRAGQRVRAKGGAPRVTA---
MSMEG_6141|M.smegmatis_MC2_155 YGDTVKSGRYLRAGADSRLKT-----AV---
MAB_0680c|M.abscessus_ATCC_199 YGHDLQTGRYLKAGEKLALR-----------
TH_2847|M.thermoresistible__bu VPTDARPGTLVRGRQPAPKVAG---------
:.* ::.