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PPPYGPGHAGFGLVSAAVLASLVLLGWAAVWIARRADPLQRLWQRATHNAVVDEALAWLRDRIGDRGRAL ARRFPVSEIAGVALLLGLAAVALLAVGFTEVLDDVLEGDGIAVIDHPVTRWLAAHRDLWLTTVLQAITVA GGPLFLAALALPISVVAAWRYRSWRPVLLAVVAGAGVPVMLFTAKALVGRHRPPLPFALVDADGYSFPSG HATGTAAMMAISAWLLTRWLIPGWTGRVLVWALAIGAVLLIGFSRIYLGVHYLSDVLSGWMLGTAWAFAV MLVGTWWDNTRPARERQRQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3216 | - | - | 100% (301) | PAP2 superfamily protein |
| M. avium 104 | MAV_4854 | - | 2e-16 | 37.35% (166) | PAP2 superfamily protein |
| M. avium 104 | MAV_0210 | - | 4e-06 | 38.26% (115) | PAP2 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0316 | - | 2e-11 | 33.33% (147) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0312 | - | 2e-14 | 34.15% (205) | phosphoesterase, PA-phosphatase related |
| M. tuberculosis H37Rv | Rv0308 | - | 2e-11 | 33.33% (147) | integral membrane protein |
| M. leprae Br4923 | MLBr_00094 | - | 9e-09 | 36.03% (136) | hypothetical protein MLBr_00094 |
| M. abscessus ATCC 19977 | MAB_0200c | - | 1e-14 | 33.33% (213) | phosphoesterase, PA-phosphatase related protein |
| M. marinum M | MMAR_0558 | - | 4e-12 | 29.26% (229) | hypothetical protein MMAR_0558 |
| M. smegmatis MC2 155 | MSMEG_0634 | - | 3e-16 | 32.56% (215) | PAP2 superfamily protein |
| M. thermoresistible (build 8) | TH_3242 | - | 5e-16 | 41.67% (180) | PUTATIVE putative phosphoesterase, PA-phosphatase related |
| M. ulcerans Agy99 | MUL_1222 | - | 3e-12 | 29.26% (229) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_0429 | - | 1e-14 | 36.81% (163) | phosphoesterase, PA-phosphatase related |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0634|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0429|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0312|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0200c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3242|M.thermoresistible__bu --------------------------------------------------
Mb0316|M.bovis_AF2122/97 --------------------------------------------------
Rv0308|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0558|M.marinum_M --------------------------------------------------
MUL_1222|M.ulcerans_Agy99 --------------------------------------------------
MAV_3216|M.avium_104 MPPPYGPGHAGFGLVSAAVLASLVLLGWAAVWIARRADPLQRLWQRATHN
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MSMEG_0634|M.smegmatis_MC2_155 --------------------------MERTRGLLIASALVAVAVYALMWI
Mvan_0429|M.vanbaalenii_PYR-1 --------------------------MR--SGWLIGSAAAALGVYLLMWV
Mflv_0312|M.gilvum_PYR-GCK ----------------------MTPDNRR----LLAGVVAALAVYGLLWA
MAB_0200c|M.abscessus_ATCC_199 ----------------------MPARSDRGYVWPLLSAAAALIVFALLWL
TH_3242|M.thermoresistible__bu --------------------------VNRRTVGLIGSAVAAVVVYGLLWF
Mb0316|M.bovis_AF2122/97 -------------------------MTRPQALLAVSLAFVATAVYAVMWV
Rv0308|M.tuberculosis_H37Rv -------------------------MTRPQALLAVSLAFVATAVYAVMWV
MMAR_0558|M.marinum_M -------------------------MTRPRMTLPLLLALAAIVVYALMWI
MUL_1222|M.ulcerans_Agy99 -------------------------MTRPRMTLPLLLALAAIVVYALMWI
MAV_3216|M.avium_104 AVVDEALAWLRDRIGDRGRALARRFPVSEIAGVALLLGLAAVALLAVGFT
MLBr_00094|M.leprae_Br4923 -------------------------MPEDKAPTGELAAIAAVQSVLVDRP
.* :
MSMEG_0634|M.smegmatis_MC2_155 GYRSGWPWLVSFDDAGLDPAFRFGTEHPAWVTAWNVFCTVLG--PYSFRA
Mvan_0429|M.vanbaalenii_PYR-1 GYVQGWVWLAGIDADVLNPANRFGDGRPRWVTAWDVLCTLLG--PGAFRL
Mflv_0312|M.gilvum_PYR-GCK GWAQDWGWLTRADDAALDAAHRVGESHSGWVTAWDVFCTVLG--PGAFRL
MAB_0200c|M.abscessus_ATCC_199 GYAQQWNGLSRLDVGALTPAHHYGIAHPGWVTVWDVFATALG--PGAFRI
TH_3242|M.thermoresistible__bu ATAHGWDRLARLDAAALSAAHDFGADRPAWVMSWAVFCTVLG--PMAFRL
Mb0316|M.bovis_AF2122/97 GHSQDWGWLHSFDWSLLNAAHDIGIKNPAWVRFWDGVSLILG--PVVLRP
Rv0308|M.tuberculosis_H37Rv GHSQDWGWLHSFDWSLLNAAHDIGIKNPAWVRFWDGVSLILG--PVVLRP
MMAR_0558|M.marinum_M GYRQDWGWLHAMDWSLLNASHDIGVKHPGWVNFWFAVSFVLG--PITTRI
MUL_1222|M.ulcerans_Agy99 GYRQDWGWLHAMDWSLLNASHDIGVKHPGWVNFWFAVSFVLG--PITTRI
MAV_3216|M.avium_104 EVLDDVLEGDGIAVIDHPVTRWLAAHRDLWLTTVLQAITVAGGPLFLAAL
MLBr_00094|M.leprae_Br4923 GVLPTARGMS-----------HFGEHSIGWLAIS-----LLG--------
. *: *
MSMEG_0634|M.smegmatis_MC2_155 VFAVFIVVALIRRHFRPAVFALLSVELSGLVTQLAKLASDRPRP--PTAL
Mvan_0429|M.vanbaalenii_PYR-1 AVLVVIVVALVRRRFRLAVFLTVTVELSAVVTETAKYIVDRPRP--DTAM
Mflv_0312|M.gilvum_PYR-GCK AVLVLIVLALLRRRIRLAVFLVVTVELSGLVTEIAKHLAGRARP--DTAF
MAB_0200c|M.abscessus_ATCC_199 GGAIIIIVLLVRGQRRPAVFLLVTIELSALVTELAKLLAGRPRP--ATKL
TH_3242|M.thermoresistible__bu AALIAVVAAVRRRSPRVAVFLLATVVFNGVLIEGAKWLADRPRP--ATAL
Mb0316|M.bovis_AF2122/97 LGLLAAMVALAKRKIRIALLLLACLPLNAIMTIAAKSVAHRPRP--ATAL
Rv0308|M.tuberculosis_H37Rv LGLLAAMVALAKRKIRIALLLLACLPLNAIMTIAAKSVAHRPRP--ATAL
MMAR_0558|M.marinum_M VGLVAITIALVQRKMRMALLLLACVPLNWIITMIAKGLADRPRP--VTKL
MUL_1222|M.ulcerans_Agy99 VGLVAITIALVQRKMRMALLLLACVPLNWIVTMIAKGLADRPRP--VTKL
MAV_3216|M.avium_104 ALPISVVAAWRYRSWRPVLLAVVAGAGVPVMLFTAKALVGRHRPPLPFAL
MLBr_00094|M.leprae_Br4923 ----AILVPCRRRYWLVAGAGVFAAHVAAVLIKRMVRRIRPNHPAVTVNV
. :: :* .
MSMEG_0634|M.smegmatis_MC2_155 VYASWTSFPSGHALGVMVCVPALLALVWPLLRGA--WRGWAVAAGALVIV
Mvan_0429|M.vanbaalenii_PYR-1 VSALSTSFPSGHALGVMVSVAALLTVVLPVVRPA--LRGWLVALGIAVIL
Mflv_0312|M.gilvum_PYR-GCK VDAWGLSFPSGHALGVLVAVAALLSVAVPAVAPS--RRAWLIALGVVIVV
MAB_0200c|M.abscessus_ATCC_199 VDAYGTSFPSGHALGIMVCVLALLTVFTPKVVAA--WRPWLGVLGGVLIL
TH_3242|M.thermoresistible__bu VPAWSTAFPSGHAVGVLLAVLALLTVFWPKIDR---RAGWTLAA-AVVVF
Mb0316|M.bovis_AF2122/97 VSAHSTSFPSGHALEATASVLALLTVLLPMLHSRF-TRHIAITVGALCVL
Rv0308|M.tuberculosis_H37Rv VSAHSTSFPSGHALEATASVLALLTVLLPMLHSRF-TRHIAITVGALCVL
MMAR_0558|M.marinum_M VAAHSASFPSGHALELTASVLAMLTFLLPMIRVHW-MRILAVVVGALSVL
MUL_1222|M.ulcerans_Agy99 VAAHSASFPSGHALELTASVLAMLTFLLPMIRVHW-MRILAVVVGALSVL
MAV_3216|M.avium_104 VDADGYSFPSGHATGTAAMMAISAWLLTRWLIPGWTGRVLVWALAIGAVL
MLBr_00094|M.leprae_Br4923 GTPSPLSFPSAHATSTAAAAILIGRAS----------RLPKGIVAAVLVA
. :***.** :
MSMEG_0634|M.smegmatis_MC2_155 AIGVGRVVLNVHHPSDVVAGWALGYAFFVVCLL--LAPPYPD--------
Mvan_0429|M.vanbaalenii_PYR-1 VVGIGRVVLNVHHPSDVIAGWALGYAYFVACLL--LVWPSVP--------
Mflv_0312|M.gilvum_PYR-GCK TVGVGRVILNVHHPSDVLAGWALGYAYFLVCLR--LVPPAT---------
MAB_0200c|M.abscessus_ATCC_199 LIGISRVLLNVHNPSDVLAGWALGYAYFIVCLL--ALPPWT---------
TH_3242|M.thermoresistible__bu AIGAGRVVLNVHHPSDVLAGWALGYAWFVGCYLGCLRPTWPD--------
Mb0316|M.bovis_AF2122/97 TVGVARVALNVHHPTDVVAGWALGYLYFLVCLC-VFRPPSIFGAQRASHA
Rv0308|M.tuberculosis_H37Rv TVGVARVALNVHHPTDVVAGWALGYLYFLVCLC-VFRPPSIFGAQRASHA
MMAR_0558|M.marinum_M LVGISRVALNVHHPSDVIAGWALGYVYFLFWLW-VLR-------------
MUL_1222|M.ulcerans_Agy99 LVGISRVALNVHHPSDVIAGWALGYVYFLFWLW-VLR-------------
MAV_3216|M.avium_104 LIGFSRIYLGVHYLSDVLSGWMLGTAWAFAVMLVGTWWDNTR--------
MLBr_00094|M.leprae_Br4923 PMALSRIVLGVHYPSDVAFGVVLGAAVAGTTARFDSRLSRR---------
:. .*: *.** :** * **
MSMEG_0634|M.smegmatis_MC2_155 ----VRARGE-------IPEVRGIAT-
Mvan_0429|M.vanbaalenii_PYR-1 ----VIERAE-------KPAVLDNAH-
Mflv_0312|M.gilvum_PYR-GCK ----LTRRDE-------TPAELDIAR-
MAB_0200c|M.abscessus_ATCC_199 ----VTAADG-------TPPAPGNAP-
TH_3242|M.thermoresistible__bu ----RPARAEPVTGGARTPAGPDSAP-
Mb0316|M.bovis_AF2122/97 LSPPVEVSRQ-------PEPEVDTAR-
Rv0308|M.tuberculosis_H37Rv LSPPVEVSRQ-------PEPEVDTAR-
MMAR_0558|M.marinum_M ---PVPVAEQ-------EPAELVSAG-
MUL_1222|M.ulcerans_Agy99 ---PVPVAEQ-------EPAELVSAG-
MAV_3216|M.avium_104 -----PARER-----------QRQA--
MLBr_00094|M.leprae_Br4923 ----WTVQHG---------LSSGSAVK
*