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M. avium 104 MAV_3155 (-)

annotation: DNA polymerase I
coordinates: 3246170 - 3248911
length: 913

PATKAATKTATKTAAGAGEEQNRPTLMLLDGNSLAFRAFYALPAENFKTRGGLTTNAVYGFTAMLINLLR
DEAPTHIAAAFDVSRQTFRSDRYPEYKANRSATPDEFHGQIDITKEVLAALGITVLAEPGFEADDLIATL
ATQAENEGYRVLVVTGDRDSLQLVSDNVTVLYPRKGVSELTRFTPEAVVEKYGLTPQQYPDFAALRGDPS
DNLPGIPGVGEKTASKWIAEYGSLQALVDNVDSVRGKVGDALREHLASVIRNRELTDLIKDVPLAQTPDT
LRLQPWDRDQIHRLFDDLEFRVLRDRLFETLAAVEPEVDEGFDVRGGALEAGELAVWLAEHSSGKRFGLA
VAGTHLAYDADCTALAIVSADGEGRYIDTSALDPDDEAALASWLADPGPPKALHEAKLAMHDLAGRGWTL
AGVTSDTALAAYLVRPGQRSFSLDDLALRYLRRELRAENPQQQQLSLLDDTDGTDDQAVQTLILRAVAVL
DLADALDEELARINSTSLLSGMELPVQRVLAGMEKAGIAVDLDLLSELQSDFAHQIRDAAEAAYAVIGKQ
INLGSPKQLQAVLFDELQMPKTKRTKTGYTTDADALQSLFDKTGHPFLQHLLAHRDATRLKVTVDGLLNS
VASDGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTEAGRRIRDAFVVGDGYAELMTADYSQIEMRIMAHL
SQDAGLIEAFNTGEDLHSFVASRAFGVPIEEVTGELRRRVKAMSYGLAYGLSAYGLSQQLKISTEEAKEQ
MDAYFARFGGVRDYLHAVVEQARKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIK
VAMIEVDKAIKEAGLQSRILLQVHDELLFEVAAGEREQLEALARDKMGGAYPLDVPLEVSVGYGRSWDAA
AH*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_3155--100% (913)DNA polymerase I
M. avium 104MAV_2413-9e-4038.98% (254) 5'-3' exonuclease

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1655polA0.087.25% (902) DNA polymerase I
M. gilvum PYR-GCKMflv_3564-0.086.41% (905) DNA polymerase I
M. tuberculosis H37RvRv1629polA0.087.25% (902) DNA polymerase I
M. leprae Br4923MLBr_01381polA0.082.57% (901) DNA polymerase I
M. abscessus ATCC 19977MAB_2615c-0.080.57% (911) DNA polymerase I
M. marinum MMMAR_2432polA0.087.63% (897) DNA polymerase I PolA
M. smegmatis MC2 155MSMEG_3839-0.087.50% (912) DNA polymerase I
M. thermoresistible (build 8)TH_4211-0.086.70% (902) PUTATIVE DNA polymerase I
M. ulcerans Agy99MUL_1611polA0.087.18% (897) DNA polymerase I
M. vanbaalenii PYR-1Mvan_3361-0.086.85% (905) DNA polymerase I

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3564|M.gilvum_PYR-GCK          ----MSPAKTASK-KAATPAADDTPTLMLLDGNSLAFRAFYALPAENFKT
Mvan_3361|M.vanbaalenii_PYR-1       ----MSPAKTASETKAGKPDTSEKPTLMLLDGNSLAFRAFYALPAENFKT
MSMEG_3839|M.smegmatis_MC2_155      ----MSPAKTATK-KTPAKAADDTPTLMLLDGNSLAFRAFYALPAENFKT
TH_4211|M.thermoresistible__bu      ----VSPAKTTEQ-PAPAEQTSEQPTLLLLDGNSLAFRAFYALPAENFKT
MAV_3155|M.avium_104                MPATKAATKTATKTAAGAGEEQNRPTLMLLDGNSLAFRAFYALPAENFKT
MMAR_2432|M.marinum_M               --------------MSVATEQSTKPTLMLLDGNSLAFRAFYALPAENFKT
MUL_1611|M.ulcerans_Agy99           --------------MSVATEQSTKPTLMLLDGNSLAFRAFYALPAENFKT
Mb1655|M.bovis_AF2122/97            ----------MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKT
Rv1629|M.tuberculosis_H37Rv         ----------MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKT
MLBr_01381|M.leprae_Br4923          ---------MSAAMTAEVCEDHTKPMLMLLDGNSLAFRAFYALPTENFKT
MAB_2615c|M.abscessus_ATCC_199      ------------MTAPATKTGTKQPTLLLLDGNSLAFRAFYALPAENFKT
                                                   .        * *:****************:*****

Mflv_3564|M.gilvum_PYR-GCK          QGGLTTNAVYGFTAMLINLIRDEQPSHIAAAFDVSRQTFRKEKYPEYKEG
Mvan_3361|M.vanbaalenii_PYR-1       KSGLTTNAVYGFTAMLINLLRDEQPTHIAAAFDVSRQTFRKDKYPEYKEG
MSMEG_3839|M.smegmatis_MC2_155      QSGLTTNAVYGFTAMLINLLRDEQPTHIAAAFDVSRQTFRKDKYPEYKEG
TH_4211|M.thermoresistible__bu      KSGLTTNAVYGFTAMLINLLRDENPTHVAAAFDVSRQTFRLDKYPEYKAG
MAV_3155|M.avium_104                RGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRSDRYPEYKAN
MMAR_2432|M.marinum_M               RGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRSERYPEYKAN
MUL_1611|M.ulcerans_Agy99           RGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRSERYPEYKAN
Mb1655|M.bovis_AF2122/97            RGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKAN
Rv1629|M.tuberculosis_H37Rv         RGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKAN
MLBr_01381|M.leprae_Br4923          RGGLTTNAVYGFTAMLINLLREEAPTHIAAAFDVSRKTFRSECYAGYKAN
MAB_2615c|M.abscessus_ATCC_199      QSGLTTNAVYGFTSMLINLLRDEAPTHVAAAFDVSRKTFRSDRYPEYKAT
                                    :.***********:*****:*:* *:*:********:*** : *. **  

Mflv_3564|M.gilvum_PYR-GCK          RSATPDEFRGQIDITKEVLGALGITVLAEAGFEADDIIATLATQAEGEGH
Mvan_3361|M.vanbaalenii_PYR-1       RSATPDEFRGQIDITKEVLGALGITVLAEPGFEADDIIATLATQAENEGH
MSMEG_3839|M.smegmatis_MC2_155      RSATPDEFRGQIDITKEVLGALGITVLAEPGFEADDIIATLATQAEQEGY
TH_4211|M.thermoresistible__bu      RAATPDEFRGQIEITKEVLAALGITVLAEPGYEADDIIATLATQAEAEGF
MAV_3155|M.avium_104                RSATPDEFHGQIDITKEVLAALGITVLAEPGFEADDLIATLATQAENEGY
MMAR_2432|M.marinum_M               RSSTPDEFHGQIDITKEVLNALGITVLAAPGFEADDIIATLATQAEGEGY
MUL_1611|M.ulcerans_Agy99           RSSTPDEFHGQIDITKEVLNALGITVLAAPGFEADDIIATLATQAEGEGY
Mb1655|M.bovis_AF2122/97            RSSTPDEFAGQIDITKEVLGALGITVLSEPGFEADDLIATLATQAENEGY
Rv1629|M.tuberculosis_H37Rv         RSSTPDEFAGQIDITKEVLGALGITVLSEPGFEADDLIATLATQAENEGY
MLBr_01381|M.leprae_Br4923          RSSIPAEFHGQIDITKEVLGALGITVFAEAGFEADDLIATLATQAENEGY
MAB_2615c|M.abscessus_ATCC_199      RSATPDEFRGQIDITKEVLQALGITVLAEEGFEADDIIATLATQGQAEGF
                                    *:: * ** ***:****** ******::  *:****:*******.: **.

Mflv_3564|M.gilvum_PYR-GCK          RVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVQEKYGLTPAQY
Mvan_3361|M.vanbaalenii_PYR-1       RVLVVTGDRDSLQLVSDDVTVLYPRKGVSELTRFTPEAVQEKYGLTPAQY
MSMEG_3839|M.smegmatis_MC2_155      RVLVVTGDRDSLQLVSDQVTVLYPRKGVSELTRFTPDAVVEKYGLTPQQY
TH_4211|M.thermoresistible__bu      RVLIVTGDRDSLQLVTDNVTVLYPRKGVSELTRFTPEAVYEKYGLTPEQY
MAV_3155|M.avium_104                RVLVVTGDRDSLQLVSDNVTVLYPRKGVSELTRFTPEAVVEKYGLTPQQY
MMAR_2432|M.marinum_M               RVLVVTGDRDSLQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPVQY
MUL_1611|M.ulcerans_Agy99           RVLVVTGDRDSLQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPVQY
Mb1655|M.bovis_AF2122/97            RVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPRQY
Rv1629|M.tuberculosis_H37Rv         RVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPRQY
MLBr_01381|M.leprae_Br4923          RVLVVTGDRDALQLVSNDVTVLYPRKGVSELTRFTPEAVIEKYGVTPAQY
MAB_2615c|M.abscessus_ATCC_199      KVFVVTGDRDSLQLVNEDVTVLYPRKGVSDLTRFTPEAVVEKYGLTPSQY
                                    :*::******:****.::***********:******:** ****:** **

Mflv_3564|M.gilvum_PYR-GCK          PDFAALRGDPSDNLPGIPGVGEKTATKWIAEYGSLQGLVDNVDKVKGKVG
Mvan_3361|M.vanbaalenii_PYR-1       PDFAALRGDPSDNLPGIPGVGEKTATKWIAEYGSLQSLVDNVDKVKGKVG
MSMEG_3839|M.smegmatis_MC2_155      PDFAALRGDPSDNLPGIPGVGEKTATKWIVEYGSLQALVDNVDAVKGKVG
TH_4211|M.thermoresistible__bu      PDYAALRGDPSDNLPGIPGVGEKTAAKWIREYGSLQGLVDNVDAVRGKVG
MAV_3155|M.avium_104                PDFAALRGDPSDNLPGIPGVGEKTASKWIAEYGSLQALVDNVDSVRGKVG
MMAR_2432|M.marinum_M               PDFAALRGDPSDNLPGIPGVGEKTASKWIVEYGSLQGLVDQVDSVRGKVG
MUL_1611|M.ulcerans_Agy99           PDFAALRGDPSDNLPGIPGVGEKTASKWIVEYGSLQGLVDQVDSVRGKVG
Mb1655|M.bovis_AF2122/97            PDFAALRGDPSDNLPGIPGVGEKTAAKWIAEYGSLRSLVDNVDAVRGKVG
Rv1629|M.tuberculosis_H37Rv         PDFAALRGDPSDNLPGIPGVGEKTAAKWIAEYGSLRSLVDNVDAVRGKVG
MLBr_01381|M.leprae_Br4923          PDLAALRGDPSDNLPGIPGVGEKTAAKWIVDYGSLQGLVDNVESVRGKVG
MAB_2615c|M.abscessus_ATCC_199      PDFAALRGDPSDNLPGIPGVGEKTASKWILEYGSLQELVDKADTVRGKVG
                                    ** **********************:*** :****: ***:.: *:****

Mflv_3564|M.gilvum_PYR-GCK          DALRAHLSSVVLNRELTELVKDVPLAQTPDTLRMQPWDRDHIHRLFDDLE
Mvan_3361|M.vanbaalenii_PYR-1       DALRAHLSSVVLNRELTDLVKDVPLAHTPDTLRMQPWDRDQIHRLFDDLE
MSMEG_3839|M.smegmatis_MC2_155      DALRANLSSVILNRELTDLIRDVPLPQTPDTLRMQPWNRDQIHRLFDDLE
TH_4211|M.thermoresistible__bu      DALRANLSSVVLNRELTDLVRDVPLAHTPETLRMQPWDRDQIHRLFDDLE
MAV_3155|M.avium_104                DALREHLASVIRNRELTDLIKDVPLAQTPDTLRLQPWDRDQIHRLFDDLE
MMAR_2432|M.marinum_M               DSLRANLASVVRNRELTDLVRDVPLAQTPEALRLQPWDRDQIHRLFDDLE
MUL_1611|M.ulcerans_Agy99           DSLRANLASVVRNRELTDLVRDVPLAQTPEVLLLQPWDRDQIHRLFDDLE
Mb1655|M.bovis_AF2122/97            DALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDHIHRLFDDLE
Rv1629|M.tuberculosis_H37Rv         DALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDHIHRLFDDLE
MLBr_01381|M.leprae_Br4923          EALRTHLASVVRNRELTELVKDVPLVQTSDTLRLQPWDRDRIHRLFDNLE
MAB_2615c|M.abscessus_ATCC_199      DSLRANLASVILNRELTDLVRTVPLPYVPAQLALAPWDRDQIHRLFDDLE
                                    ::** :*:**: *****:*:: ***  ..  * : **:**:******:**

Mflv_3564|M.gilvum_PYR-GCK          FRVLRDRLFDTLASADP---EVEEGFDVQGEALQAGTLAPWLAENS-DGR
Mvan_3361|M.vanbaalenii_PYR-1       FRVLRDRLFDTLASADP---EVEEGFEVRGEALEAGTLAAWLAEHS-NGQ
MSMEG_3839|M.smegmatis_MC2_155      FRVLRDRLFETLVAVEP---EVEHGFDVRGRALEPGELAAWLSEHS-LGS
TH_4211|M.thermoresistible__bu      FRVLRDRLFETLSSADP---EVEHGFDVRGRALEPGELAAWLAEHS-LGN
MAV_3155|M.avium_104                FRVLRDRLFETLAAVEP---EVDEGFDVRGGALEAGELAVWLAEHS-SGK
MMAR_2432|M.marinum_M               FRVLRDRLFDTLAAVEP---EVDQGFDVRGGAVSPGAVAQWLAEHVVDGR
MUL_1611|M.ulcerans_Agy99           FRVLRDRLFDTLAAVEP---EVDQGFDVRGGAVSPGAVAQWLAEHVVDGR
Mb1655|M.bovis_AF2122/97            FRVLRDRLFDTLAAAGG--PEVDEGFDVRGGALAPGTVRQWLAEHAGDGR
Rv1629|M.tuberculosis_H37Rv         FRVLRDRLFDTLAAAGG--PEVDEGFDVRGGALAPGTVRQWLAEHAGDGR
MLBr_01381|M.leprae_Br4923          FRVLRDRLFEALAAAGERVPEVDEGFDVRGGLLESGTVGRWLAKHADDGR
MAB_2615c|M.abscessus_ATCC_199      FRVLRDRLFETLEAVEP---EVDEGFQLAGQALEPGTVAAWLAEHTGDGR
                                    *********::* :.     **:.**:: *  : .* :  **:::   * 

Mflv_3564|M.gilvum_PYR-GCK          RFGLAVVGNHLAFDSDATALTIVASGGEGRYIDTTGLDPDDEKALASWLA
Mvan_3361|M.vanbaalenii_PYR-1       RFGVAVVGNHLAFDSDATAVALVASDGDGRYIDTTRLDPEDEKALASWLA
MSMEG_3839|M.smegmatis_MC2_155      RFGVAVVGTHKAYDADATALAIVAADGDGRYIDTSTLTPEDEAALASWLA
TH_4211|M.thermoresistible__bu      RFGLAVVGTHRTFDSDATALAIVAADGEGRYIDTATLHPDDEAALASWLA
MAV_3155|M.avium_104                RFGLAVAGTHLAYDADCTALAIVSADGEGRYIDTSALDPDDEAALASWLA
MMAR_2432|M.marinum_M               RCGLTVVGTHLPHGGDATALAIAAADGEGGYIDTATLTPDDDAALGEWLA
MUL_1611|M.ulcerans_Agy99           RCGLTVVGTHLPHGGDATALAIAAADGEGGYIDTATLTPDDDAALGEWLA
Mb1655|M.bovis_AF2122/97            RAGLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLA
Rv1629|M.tuberculosis_H37Rv         RAGLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLA
MLBr_01381|M.leprae_Br4923          RSGLAIVGTHLPHGGDATALAVAAADGNGGYIDTAMLTPDDDDALAAWLA
MAB_2615c|M.abscessus_ATCC_199      RSGLAVVGTYTPYDGDATAVAIASADGDGAYIDTTTVTPDDEAALAEWLA
                                    * *:::.*.: ....*.**:::.::.*:* *:**: : *:*: **. ***

Mflv_3564|M.gilvum_PYR-GCK          DPHVPKALHEAKLAIHDLQGRGWTLAGVTSDTALAAYLVRPGQRSFALDD
Mvan_3361|M.vanbaalenii_PYR-1       DPDAPKALHEAKLAMHDLQGRGWTLAGVTSDTALAAYLVRPGQRSFALDD
MSMEG_3839|M.smegmatis_MC2_155      DPGPPKALHEAKLAMHDLAGRGWTLRGVTSDTALAAYLVRPGQRSFTLDD
TH_4211|M.thermoresistible__bu      DPGPPKALHEAKQAMHDLAGRGWRLNGVTSDTALAAYLVRPGQRSFALDD
MAV_3155|M.avium_104                DPGPPKALHEAKLAMHDLAGRGWTLAGVTSDTALAAYLVRPGQRSFSLDD
MMAR_2432|M.marinum_M               DPAKPKALHEAKLAIHDLRGRGWTLNGVTSDTALAAYLVRPGQRSFTLDD
MUL_1611|M.ulcerans_Agy99           DPAKPKALHEAKLAIHDLRGRGWTLNGVTSDTALAAYLVRPGQRSFTLDD
Mb1655|M.bovis_AF2122/97            DPAKPKALHEAKAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDD
Rv1629|M.tuberculosis_H37Rv         DPAKPKALHEAKAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDD
MLBr_01381|M.leprae_Br4923          DPDNPKALHEAKLAMHDLAGRGWTLGGITSDTALAAYLVRPGQRSFTLDD
MAB_2615c|M.abscessus_ATCC_199      DAARPKALHEAKQAIHALAGRGWELGGVTSDTALAAYLVRPGQRSFALDD
                                    *.  ******** *:* * **** * *:******************:***

Mflv_3564|M.gilvum_PYR-GCK          LSLRYLKRELRADNPEQQQLSLLDDSDGVDDQAVQTLLLRASAVVDLADA
Mvan_3361|M.vanbaalenii_PYR-1       LSLRYLKRELRADNPEQQQLSLLDDSDAVDDQAVQTLLLRAGAVVDLADA
MSMEG_3839|M.smegmatis_MC2_155      LAVRYLHRELRAETPEQQQLSLLDDSDGVDEQAVQTVILRACAVLDLADA
TH_4211|M.thermoresistible__bu      LTLRYLRRELRAEEPEQQQLSLLDESDGVDEQAVQTLLLRACAVMDLADA
MAV_3155|M.avium_104                LALRYLRRELRAENPQQQQLSLLDDTDGTDDQAVQTLILRAVAVLDLADA
MMAR_2432|M.marinum_M               LSLRYLRRELRAETPEQQQLSLLD-DDDTDVAAAQTAILRARAVIDLADA
MUL_1611|M.ulcerans_Agy99           LSLRYLRRELRAETPEQQQLSLLD-DDDTDVAAAQTAILRARAVIDLADA
Mb1655|M.bovis_AF2122/97            LSLRYLRRELRAETPQQQQLSLLD-DDDTDAETIQTTILRARAVIDLADA
Rv1629|M.tuberculosis_H37Rv         LSLRYLRRELRAETPQQQQLSLLD-DDDTDAETIQTTILRARAVIDLADA
MLBr_01381|M.leprae_Br4923          LSLRYLRRELRAETPEQEQFSLLDNVDEVDKQAIQTLILRARAVVDLAAA
MAB_2615c|M.abscessus_ATCC_199      LSLRYLRRELRAEDDGEQQLSLLDEDGAGDAKAAQAQMLRARAVIDLADA
                                    *::***:*****:   ::*:****  .  *  : *: :*** **:*** *

Mflv_3564|M.gilvum_PYR-GCK          LDEELARIDSSALLGNMELPVQRVLAELETAGIAVDLEMLSGLQSEFADQ
Mvan_3361|M.vanbaalenii_PYR-1       LDEELARIDSSALLGSMELPVQRVLAQLETVGIAVDLAMLSELQSEFAGQ
MSMEG_3839|M.smegmatis_MC2_155      LDQELARIDSLSLLSRMELPVQRTLAEMEHAGIAVDLGMLEQLQSEFADQ
TH_4211|M.thermoresistible__bu      LDEELARIDSLSLLERMELPVQRVLFEMETAGIAVDLDRLGELQSEFAGQ
MAV_3155|M.avium_104                LDEELARINSTSLLSGMELPVQRVLAGMEKAGIAVDLDLLSELQSDFAHQ
MMAR_2432|M.marinum_M               LDAELDRIDSTGLLADMELPVQHVLAEMETAGIAVDLTMLGGLQSHFADQ
MUL_1611|M.ulcerans_Agy99           LDAELDRIDSTGLLTDMELPVQHLLAEMETAGIAVDLTMLGGLQRHFADQ
Mb1655|M.bovis_AF2122/97            LDAELARIDSTALLGEMELPVQRVLAKMESAGIAVDLPMLTELQSQFGDQ
Rv1629|M.tuberculosis_H37Rv         LDAELARIDSTALLGEMELPVQRVLAKMESAGIAVDLPMLTELQSQFGDQ
MLBr_01381|M.leprae_Br4923          LDAELDLIDSTSLLGEMELPVQQVLADMEKAGIAADLRLLTELQSQFGDQ
MAB_2615c|M.abscessus_ATCC_199      LDVELERIESAGLLTDMELPVQRVLAGLESVGIAVDTDHLSSLQNQFASG
                                    ** **  *:* .**  ******: *  :* .***.*   *  ** .*.  

Mflv_3564|M.gilvum_PYR-GCK          IRDAAEAAYAVIGKQINLGSPKQLQVVLFDELEMPKTKRTKTGYTTDADA
Mvan_3361|M.vanbaalenii_PYR-1       IRDAAEAAYAVIGKQINLGSPKQLQVVLFDELEMPKTKRTKTGYTTDADA
MSMEG_3839|M.smegmatis_MC2_155      IRDAAEAAYSVIGKQINLGSPKQLQAVLFDELEMPKTKKTKTGYTTDADA
TH_4211|M.thermoresistible__bu      IRDAAEAAYAVIGKQINLGSPKQLQGVLFDELGMPKTKRTKTGYTTDADA
MAV_3155|M.avium_104                IRDAAEAAYAVIGKQINLGSPKQLQAVLFDELQMPKTKRTKTGYTTDADA
MMAR_2432|M.marinum_M               IRDAAEAAYAVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADA
MUL_1611|M.ulcerans_Agy99           IRDAAEAAYAVIGKQINLGSPKQLQVVLFDELRMPKTKRTKTGYTTDADA
Mb1655|M.bovis_AF2122/97            IRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADA
Rv1629|M.tuberculosis_H37Rv         IRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADA
MLBr_01381|M.leprae_Br4923          IRDAAEAAYAVIGKQINLSSPKQLQVVLFEELGMPKTKRTKTGYTTDADA
MAB_2615c|M.abscessus_ATCC_199      IREAADAAYAVIGKQINLGSPKQLQVVLFDELGMPKTKKTKTGYTTDADA
                                    **:**:***.********.****** ***:** *****:***********

Mflv_3564|M.gilvum_PYR-GCK          LQSLFDKTGHPFLQHLLAHRDATRLKVTVDGLLNAVASDGRIHTTFNQTI
Mvan_3361|M.vanbaalenii_PYR-1       LQSLFDKTGHPFLQHLLAHRDATRLKVTVDGLLNSVAADGRIHTTFNQTI
MSMEG_3839|M.smegmatis_MC2_155      LQSLFEKTGHPFLQHLLAHRDATRLKVTVDGLLNSVASDGRIHTTFNQTI
TH_4211|M.thermoresistible__bu      LQSLFEKTGHPFLQHLLAHRDATRLKVTVDGLLNSVAADGRIHTTFNQTI
MAV_3155|M.avium_104                LQSLFDKTGHPFLQHLLAHRDATRLKVTVDGLLNSVASDGRIHTTFNQTI
MMAR_2432|M.marinum_M               LQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLNSVADDGRIHTTFNQTI
MUL_1611|M.ulcerans_Agy99           LQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLNSVADDGRIHTTFNQTI
Mb1655|M.bovis_AF2122/97            LQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQTI
Rv1629|M.tuberculosis_H37Rv         LQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQTI
MLBr_01381|M.leprae_Br4923          LQSLFCKTEHPFLQHLLTHRDVTRLKVTVDGLLNAVAADGRIHTTFNQTI
MAB_2615c|M.abscessus_ATCC_199      LQTLFDKTGHPFLEHLLTHRDVTRLKVTVDGLLKSVAADGRIHTTFNQTI
                                    **:** ** ****:***:***.***********::** ************

Mflv_3564|M.gilvum_PYR-GCK          AATGRLSSTEPNLQNIPIRTEAGRRIRDAFVVG---DGYGELMTADYSQI
Mvan_3361|M.vanbaalenii_PYR-1       AATGRLSSTEPNLQNIPIRTEAGRRIRDGFVVG---EGYADLMTADYSQI
MSMEG_3839|M.smegmatis_MC2_155      AATGRLSSTEPNLQNIPIRTEAGRRIRDAFVVG---EGYAELMTADYSQI
TH_4211|M.thermoresistible__bu      AATGRLSSTEPNLQNIPIRTEAGRMIRDAFVVG---DGYAELMTADYSQI
MAV_3155|M.avium_104                AATGRLSSTEPNLQNIPIRTEAGRRIRDAFVVG---DGYAELMTADYSQI
MMAR_2432|M.marinum_M               AATGRLSSTEPNLQNIPIRTDAGRQIRDAFVVG---DGYSELMTADYSQI
MUL_1611|M.ulcerans_Agy99           AATGRLSSTEPNLQNIPIRTDAGRQIRDAFVVG---DGYSELMTADYSQI
Mb1655|M.bovis_AF2122/97            AATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVG---DGYAELMTADYSQI
Rv1629|M.tuberculosis_H37Rv         AATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVG---DGYAELMTADYSQI
MLBr_01381|M.leprae_Br4923          ATTGRLSSTEPNLQNIPIRTNAGRQIRDAFVVGSENNGYTELMTADYSQI
MAB_2615c|M.abscessus_ATCC_199      AATGRLSSTEPNLQNIPVRTEAGREIRDGFVVG---AGYRELMTVDYSQI
                                    *:***************:**:*** ***.****    ** :***.*****

Mflv_3564|M.gilvum_PYR-GCK          EMRIMAHLSRDEGLIEAFNTGEDLHSFVASRAFSVPIDEVTAELRRRVKA
Mvan_3361|M.vanbaalenii_PYR-1       EMRIMAHLSKDAGLIEAFNTGEDLHSFVASRAFSVPLDEVTPELRRRVKA
MSMEG_3839|M.smegmatis_MC2_155      EMRIMAHLSRDAGLIEAFNTGEDLHSFVASRAFSVPIDEVTPELRRRVKA
TH_4211|M.thermoresistible__bu      EMRIMAHLSGDEGLIEAFRTGEDLHSFVASRAFSVPIEEVTPELRRRVKA
MAV_3155|M.avium_104                EMRIMAHLSQDAGLIEAFNTGEDLHSFVASRAFGVPIEEVTGELRRRVKA
MMAR_2432|M.marinum_M               EMRIMAHLSRDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKA
MUL_1611|M.ulcerans_Agy99           EMRIMAHLSRDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKA
Mb1655|M.bovis_AF2122/97            EMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKA
Rv1629|M.tuberculosis_H37Rv         EMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKA
MLBr_01381|M.leprae_Br4923          EMRIMAHLSRDEGLIEAFHTGEDLHSFVASRAFGIPIEDITPELRRRVKA
MAB_2615c|M.abscessus_ATCC_199      EMRIMAHLSADEGLIEAFNTGEDLHSFVAARAFGVPIDEVTAELRRRVKA
                                    ********* * ******.**********:***.:*::::* ********

Mflv_3564|M.gilvum_PYR-GCK          MSYGLAYGLSAYGLSQQLKISTEEAKEQMEQYFARFGGVRDYLRDVVDQA
Mvan_3361|M.vanbaalenii_PYR-1       MSYGLAYGLSAYGLSQQLKISTEEAKEQMEQYFARFGGVRDYLRDVVDQA
MSMEG_3839|M.smegmatis_MC2_155      MSYGLAYGLSAYGLAQQLKISTEEAKVQMEQYFDRFGGVRDYLRDVVDQA
TH_4211|M.thermoresistible__bu      MSYGLAYGLSAYGLAQQLKISTEEAKVQMEQYFARFGKVRDYLQSVVEQA
MAV_3155|M.avium_104                MSYGLAYGLSAYGLSQQLKISTEEAKEQMDAYFARFGGVRDYLHAVVEQA
MMAR_2432|M.marinum_M               MSYGLAYGLSAYGLSSQLKISTEDAKVQMDQYFSRFGGVRDYLMAVVEQA
MUL_1611|M.ulcerans_Agy99           MSYGLAYGLSAYGLSSQLKISTEDAKVQMDQYFSRFGGVRDYLMAVVEQA
Mb1655|M.bovis_AF2122/97            MSYGLAYGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAVVERA
Rv1629|M.tuberculosis_H37Rv         MSYGLAYGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAVVERA
MLBr_01381|M.leprae_Br4923          MSYGLAYGLSAYGLATQLKISTEEAKLQMEQYFARFGGVRDYLMDVVEQA
MAB_2615c|M.abscessus_ATCC_199      MSYGLAYGLSAYGLATQLKISNDEAKEQMDQYFSRFGGVRDYLRAVVDQA
                                    **************: *****.::*: **: ** *** *****  **::*

Mflv_3564|M.gilvum_PYR-GCK          RKDGYTSTVFGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
Mvan_3361|M.vanbaalenii_PYR-1       RKDGYTSTVFGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
MSMEG_3839|M.smegmatis_MC2_155      RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
TH_4211|M.thermoresistible__bu      RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
MAV_3155|M.avium_104                RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
MMAR_2432|M.marinum_M               RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
MUL_1611|M.ulcerans_Agy99           RKDGYTSTVLGRRRHLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
Mb1655|M.bovis_AF2122/97            RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
Rv1629|M.tuberculosis_H37Rv         RKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVA
MLBr_01381|M.leprae_Br4923          RKDGYTSTVLGRRRYLPELDSSNRQIREAAERAALNAPIQGSAADIIKVA
MAB_2615c|M.abscessus_ATCC_199      RKDGYTSTVLGRRRYLPDLDSGDRLRREAAERAALNAPIQGSAADIIKVA
                                    *********:****:**:***.:*  ************************

Mflv_3564|M.gilvum_PYR-GCK          MINVDQAIKDAGLKSRTLLQVHDELLFEVADGERDTLDALVREHMGSAYA
Mvan_3361|M.vanbaalenii_PYR-1       MINVDQAIKEAGLSSRMLLQVHDELLFEVADGERDALDALVREHMGSAYR
MSMEG_3839|M.smegmatis_MC2_155      MINVDQAIKDAGLRSRILLQVHDELLFEVSEGEQGELEQLVREHMGNAYP
TH_4211|M.thermoresistible__bu      MINVDEAIKAAGLKSRMLLQVHDELLFEVAPGERDTLEQLVREQMGGAYP
MAV_3155|M.avium_104                MIEVDKAIKEAGLQSRILLQVHDELLFEVAAGEREQLEALARDKMGGAYP
MMAR_2432|M.marinum_M               MIEVDKALKEHALKSRMLLQVHDELLFEVAAGEREQIEALVRDKMGSAYP
MUL_1611|M.ulcerans_Agy99           MIEVDKALKEHALKSRMLLQVHDELLFEVAAGEREQIEALVRDKMGSAYP
Mb1655|M.bovis_AF2122/97            MIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERVEALVRDKMGGAYP
Rv1629|M.tuberculosis_H37Rv         MIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERVEALVRDKMGGAYP
MLBr_01381|M.leprae_Br4923          MIAVDKSLKQAKLASRMLLQVHDELLFEVAIGEREQIEAMVREQMGSAYP
MAB_2615c|M.abscessus_ATCC_199      MITTDKALRDKGLRSRMLLQVHDELLFEVAEGERESLEALVRKTMGSAYP
                                    ** .*:::.   * ** ***********:: **:  :: :.*. **.** 

Mflv_3564|M.gilvum_PYR-GCK          LDVPLEVSVGFGRSWDAAAH
Mvan_3361|M.vanbaalenii_PYR-1       LDVPLEVSVGYGRSWDSAAH
MSMEG_3839|M.smegmatis_MC2_155      LDVPLEVSVGYGRSWDAAAH
TH_4211|M.thermoresistible__bu      LDVPLEVSVGFGRSWDAAAH
MAV_3155|M.avium_104                LDVPLEVSVGYGRSWDAAAH
MMAR_2432|M.marinum_M               LDVPLEVSVGFGRSWDSAAH
MUL_1611|M.ulcerans_Agy99           LDVPLEVSVGFGRSWDSAAH
Mb1655|M.bovis_AF2122/97            LDVPLEVSVGYGRSWDAAAH
Rv1629|M.tuberculosis_H37Rv         LDVPLEVSVGYGRSWDAAAH
MLBr_01381|M.leprae_Br4923          LDVPLEVSVGFGRSWGAAAH
MAB_2615c|M.abscessus_ATCC_199      LDVPLEVSVGYGRSWDAAAH
                                    **********:****.:***