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VIVFGGDHRRAFRHVVPAFGVALSASILAEGGHPAGNLDVPSAVARRLCEHLLSAGFDVAACRDIGLDHA FAQPVRDLLGDLAVKPVIPLPVNCATAPLPTGRRVAEFGAEVGRFLDGIAERVLVIGTGGLSHSPPSLEV DTYDLSDEDRARIIAEGMAAARTKIRPDWDAEVLDAMSNWDVASLIRLVDTAHTRAGAGANEVRTWLAAG AAGGGRPVTPMVYEPVPEWITGMAVAASA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2652 | mhpB | - | 100% (240) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
| M. avium 104 | MAV_1947 | mhpB | e-109 | 78.33% (240) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2402 | mhpB | 8e-29 | 34.60% (263) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4372 | mhpB | 2e-29 | 30.94% (265) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
| M. marinum M | MMAR_4776 | mhpB | 2e-29 | 32.20% (264) | extradiol dioxygenase, MhpB |
| M. smegmatis MC2 155 | MSMEG_4865 | mhpB | 6e-28 | 30.80% (263) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
| M. thermoresistible (build 8) | TH_0969 | - | 6e-35 | 37.40% (262) | metapyrocatechase 1 |
| M. ulcerans Agy99 | MUL_0347 | mhpB | 3e-28 | 31.82% (264) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4244 | mhpB | 2e-31 | 35.96% (267) | 3-(2,3-dihydroxyphenyl)propionate dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4865|M.smegmatis_MC2_155 ----------MSHSPLLNLPGPSAELLDQITDAIADARKFVEQFDPELVV
TH_0969|M.thermoresistible__bu ----------MSHSPLLNLPGPPPEVLDDIAAALGRARDFVTAYDPELVV
Mflv_2402|M.gilvum_PYR-GCK MAKSQIALCCMSHSPLLNLPGPAQELLDEIDKAIAAARDFVAEFDPELVV
Mvan_4244|M.vanbaalenii_PYR-1 ----------MSHSPLLNLPGPAQELLDDIEGAIAAAREFVAAFDPDLVV
MMAR_4776|M.marinum_M ----------MSHSPLLNLPGPRLDLLDEVHAAIAEAAEFVRAYDPDLVV
MUL_0347|M.ulcerans_Agy99 ----------------------------------------MRAYDPDLVV
MAB_4372|M.abscessus_ATCC_1997 -MLMTCALVGLSHSPLVGKNDPASDTLARINSAIEHARSFVHEFRPELVV
MAV_2652|M.avium_104 -----------------------------------------------MVI
:*:
MSMEG_4865|M.smegmatis_MC2_155 TFSPDHYNGFFYRLMPPFCIGTAAAGVGDYGTYQGPLPVDADIANACAES
TH_0969|M.thermoresistible__bu IFAPDHYNGFFYRLMPPFCISTAASGVGDYGSHAGPLDVPADLASRCAEA
Mflv_2402|M.gilvum_PYR-GCK TFSPDHYNGFFYRAMPPFCIGTAAEGVGDYGTHEGPLDVPSDLATDCARA
Mvan_4244|M.vanbaalenii_PYR-1 TFSPDHYNGFFYRAMPPFCVGTAAAGVGDYGTYQGPLDVPADLAIDCARA
MMAR_4776|M.marinum_M IFSPDHYNGFFYRAMPPFCIGMYASAVGDYGTHIGALDVPTDLAADCAKA
MUL_0347|M.ulcerans_Agy99 IFSPDHYNGFFYRAMHPFCIGMYASAVGDYGTHIGALDVPTDLAADCAKA
MAB_4372|M.abscessus_ATCC_1997 LYAPDHYNGFFYKEMPPFCLATEAHAVGDFGSPAGQLSVDSDAAQLLARG
MAV_2652|M.avium_104 VFGGDHRR-AFRHVVPAFGVALSASILAEGGHPAGNLDVPSAVARRLCEH
:. ** . * : : .* :. * :.: * * * * : * ..
MSMEG_4865|M.smegmatis_MC2_155 LWESGVDIAISTAMDVDHGTVQPLQELFGDATARPVVPIFINSVATPLGP
TH_0969|M.thermoresistible__bu VLDAGVDVAISAGIEVDHGTVQPLQILFGDAAARPVIPIFINSVATPLGP
Mflv_2402|M.gilvum_PYR-GCK VLDHDVDVALSAAMDVDHGTVQPLQKLFGDATAKPVIPVFINSVATPLGP
Mvan_4244|M.vanbaalenii_PYR-1 VLDSDVDVAVSAAMDVDHGTVQPLQKLFGDATAKPVIPVFVNSVATPLGP
MMAR_4776|M.marinum_M VLGADVDVAVSASMDVDHGTVQPLEKLFGTATARPVIPIFINAIAAPLGP
MUL_0347|M.ulcerans_Agy99 VLGADVDVAVSASMDVDHGTVQPLEKLFGTATARPVIPIFINAIAAPLGP
MAB_4372|M.abscessus_ATCC_1997 VLSRNVDLTVSARMTVDHGFTQPLEMLFGGIDRVPMVPIFINGVAGPFGP
MAV_2652|M.avium_104 LLSAGFDVAACRDIGLDHAFAQPVRDLLGDLAVKPVIPLPVNCATAPLPT
: ..*:: . : :**. .**:. *:* *::*: :* : *: .
MSMEG_4865|M.smegmatis_MC2_155 LSRSRALGAAVGTFLATLDKRVLIVGSGGLSHDPPVPTLATAPPAALDRI
TH_0969|M.thermoresistible__bu LHRSRALGRAVGEFLAGLDERVLVIGSGGLSHDPPVPTLATAPPAALERI
Mflv_2402|M.gilvum_PYR-GCK IRRVRALGAAVGAHLATLGKRVLVIGSGGLSHDPPVPTLATAPPAALDRI
Mvan_4244|M.vanbaalenii_PYR-1 MRRVRALGAAVGTHLAGLGKRVLVIGSGGLSHDPPVPTLATAPPAALDRI
MMAR_4776|M.marinum_M LRRCRALGTAVGTFLSTLDMRVLVIGSGGLSHSPPVPTLHSADPQVRERI
MUL_0347|M.ulcerans_Agy99 LRRCRALGTAVGTFLSTLDLRVLVIGSGGLSHSPPVPTLHSADPQVRERI
MAB_4372|M.abscessus_ATCC_1997 LNRIRALGTALGHEAAALGRRVLFLASGGLSHDPPVPVLQGAPPRVADAL
MAV_2652|M.avium_104 GRRVAEFGAEVGRFLDGIAERVLVIGTGGLSHSPPS------------LE
* :* :* : ***.:.:*****.**
MSMEG_4865|M.smegmatis_MC2_155 VHGAPMTPEQRMARQEAVIKAAHDFAHGQSPLRSLNPDWDRSLLEIFDEG
TH_0969|M.thermoresistible__bu VEGRPMTPEQRMARQSAVIAAAESFARGEGGLQPLNPDWDRRLLDIFDQN
Mflv_2402|M.gilvum_PYR-GCK VRGVPMTTDQRQARQTAVIEAAREFASGRGTLAPLNPDWDRAFLDIVDSG
Mvan_4244|M.vanbaalenii_PYR-1 VRGVPMTTEQRQARQAAVIEAAREFASGQGALAPLNPDWDRAFLDLLDNG
MMAR_4776|M.marinum_M VHGQPLTPAQRQARQTVVMEAAKSFAAGNSDLQPLNPAWDQRFLEIIDNG
MUL_0347|M.ulcerans_Agy99 VHGQPLTPAQRQARQTVVMEAAKSFAAGNSDLQPLNPAWDQRFLEIIDNG
MAB_4372|M.abscessus_ATCC_1997 IEGHPPSPEQRARGEERVLAAGREYAAGSSSRIPINPIWDNEVLDTFESG
MAV_2652|M.avium_104 VDTYDLSDEDRARIIAEGMAAAR---------TKIRPDWDAEVLDAMSNW
: : :* : *.. :.* ** .*: ...
MSMEG_4865|M.smegmatis_MC2_155 RLSDLDGWTNTFITGEGGNSAHEIRTWVAAFAALAAHGEYQTGNHFYRAA
TH_0969|M.thermoresistible__bu RLAELDGWTNESITAEAGNSAHEIRTWVAAFSALATQGDYRTGHHFYRAA
Mflv_2402|M.gilvum_PYR-GCK RLAEVDGWDNGWIAEQAGNSAHEVRTWIAAFAALAAQGEYVTENRFYRAA
Mvan_4244|M.vanbaalenii_PYR-1 RLAEVDSWDNRWIAEQAGNSAHEVRTWVAAFAALAAQGKYETGNRYYRAA
MMAR_4776|M.marinum_M HLSDLDRWSNSFVTHEGGSSAHEIRTWISAFAAMAVAGPYQTKVRYYKQA
MUL_0347|M.ulcerans_Agy99 HLSDLDRWSNSFVTHEGGSLAHEIRTWISAFAAMAVAGPYQTKVRYYKQA
MAB_4372|M.abscessus_ATCC_1997 DLEAIDSWTPEWMGSEGGGSAHEVRTWVAAYSSLAASGPYQMLTRFYAAV
MAV_2652|M.avium_104 DVASLIRLVDTAHTR-AGAGANEVRTWLAAG---AAGGGRPVTPMVYEPV
: : .* *:*:***::* *. * * .
MSMEG_4865|M.smegmatis_MC2_155 PELIAGFAIRTAVPST---------
TH_0969|M.thermoresistible__bu PELIAGFAVRTAVPDDTRERTGVPS
Mflv_2402|M.gilvum_PYR-GCK PELIAGFAIRTAVTT----------
Mvan_4244|M.vanbaalenii_PYR-1 PELIAGFAIRTAVCTS---------
MMAR_4776|M.marinum_M ADLIAGFAIRTAVPIP---------
MUL_0347|M.ulcerans_Agy99 ADLIAGFAIRTAVPIP---------
MAB_4372|M.abscessus_ATCC_1997 PEWIAGFAVSTAMRQVGP-------
MAV_2652|M.avium_104 PEWITGMAVAASA------------
.: *:*:*: ::