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NPLTRVDFTAALRAALRPGMTVVLGDGVGALGCLDDGGSVGAALSAAAREVGSVRLVLGWLPAPIDGLDA DAFGEVVALMPGWGVREVLRSPKARFLPTRLAAIPALLADVLRPDVLLTRLVRRDGLLHFSTEVSWQRTV TDSGTRTLAIIDTSAPAAAAEPGLGPPGLEVLGTVRGGPLRVPQREPEPIHEALADAVLRLLPEGARIQY GPGQLGTALLRRAQVPLHIDTGLLTDAVVDLDRRGLLAGTPSATYLLGSDALYDWADGRRILRGLDYTHD LTRLSRGAPLVAVNTAIEIDQYGQVNVEGVRDKVVGGIGGHPDYCAAARVSSGGLSIIAVPTRVNGRSPL VEQLSRPTSTPAHDVDLIVTEAGYVDLRAADWPQRRTLIAELFTE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2569 | - | - | 100% (396) | acetyl-CoA hydrolase/transferase, putative |
| M. avium 104 | MAV_1834 | - | e-157 | 70.50% (383) | acetyl-CoA hydrolase/transferase |
| M. avium 104 | MAV_5071 | - | e-136 | 61.98% (384) | acetyl-CoA hydrolase/transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2115 | - | 4e-16 | 24.59% (244) | 4-hydroxybutyrate CoA-transferase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1175 | - | 3e-14 | 24.39% (246) | 4-hydroxybutyrate CoA-transferase AbfT |
| M. marinum M | MMAR_4160 | - | 1e-22 | 27.91% (301) | acetyl-CoA hydrolase/transferase |
| M. smegmatis MC2 155 | MSMEG_6310 | - | 7e-18 | 25.36% (276) | 4-hydroxybutyrate coenzyme A transferase |
| M. thermoresistible (build 8) | TH_3697 | - | 1e-155 | 69.57% (391) | PUTATIVE putative acetyl-CoA hydrolase/transferase |
| M. ulcerans Agy99 | MUL_4023 | - | 2e-22 | 27.57% (301) | acetyl-CoA hydrolase/transferase |
| M. vanbaalenii PYR-1 | Mvan_5591 | - | 7e-17 | 27.05% (244) | acetyl-CoA hydrolase/transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2115|M.gilvum_PYR-GCK ----MPQELTADQAAARLEPADALGIPLGPG----------QPPAFLRAL
Mvan_5591|M.vanbaalenii_PYR-1 ----MPQELTAEEAAARLAPADSLGIPLGPG----------QPPAFLRAL
MAB_1175|M.abscessus_ATCC_1997 ----MPLELTAEQAAARLNPVDTLGIPLGPG----------QPPAFLRAL
MSMEG_6310|M.smegmatis_MC2_155 ----MPTELTAEQAAARLHAADTVGLPLGPG----------QPPSFLQAL
MMAR_4160|M.marinum_M MENCVAVKDHAALYRAKLADPDTAILAVTSGSAVAVGQAACQPPALLQAL
MUL_4023|M.ulcerans_Agy99 MENCVAVKDHAALYRAKLTDPDTAILAVTSGSAVAVGQAACQPPALLQAL
MAV_2569|M.avium_104 -MNPLTRVDFTAALRAALRPGMTVVLGDGVG----------ALGCLDDGG
TH_3697|M.thermoresistible__bu VTTDLLRSPLAAELRARLRPGMTVALGDGVG----------ALRCADDGT
: : * * : : * . .
Mflv_2115|M.gilvum_PYR-GCK GERTDWTDLR-----VYGALLAVGTELFSWPGVHYLSGFYGPLERALRDS
Mvan_5591|M.vanbaalenii_PYR-1 GARTDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFYGPLERALRDA
MAB_1175|M.abscessus_ATCC_1997 GVRKDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFFGPLERALRDM
MSMEG_6310|M.smegmatis_MC2_155 GVRKDWTDLR-----VYGALLAVLTELFSRPGVHFISGFYGPLERALRDA
MMAR_4160|M.marinum_M AARAERREIDRVRLFYYHAERPMADTVLRYELMGRLLPNSMFLQAAERDL
MUL_4023|M.ulcerans_Agy99 AARAERREIDRVRLFYYHAERPMADTVLRYELMGRFLPNSMFLQAAERDL
MAV_2569|M.avium_104 SVGAALSAAA-----REVGSVRLVLGWLPAPIDGLDADAFGEVVALMPGW
TH_3697|M.thermoresistible__bu SVAATLSALA-----AELGDIRLVLGWLTAPLDGLATEVFRDIVALMPGW
. . : : : .
Mflv_2115|M.gilvum_PYR-GCK GANIEFTPADFRRFGPLLERQAPRVMTAVATPPDADGWCSLSLHAG----
Mvan_5591|M.vanbaalenii_PYR-1 GADVDFTPADFRRFGPLMEHQSPRVMTTVATPPDADGWCSLSLHAG----
MAB_1175|M.abscessus_ATCC_1997 GADIEFAAADFRRFGPLLERQSPRVMTTVATPPGPDGWCSLSLHAG----
MSMEG_6310|M.smegmatis_MC2_155 GADVDFAPADFRRFGPLMRAQSPRAMATAAAPPDTDGWCSLSLHAG----
MMAR_4160|M.marinum_M IAHGEHDGRKVVQFIPNSFSDAVRLFTETISVDTTIVTVSPMDEQGYFTF
MUL_4023|M.ulcerans_Agy99 IAHGEHDGRKVVQFIPNSFSNAVRLFTETISVDTTIVTVSPMDEQGYFTF
MAV_2569|M.avium_104 GVREVLRSPKAR-FLPTRLAAIPALLADVLRP--DVLLTRLVRRDGLLHF
TH_3697|M.thermoresistible__bu GVRDVLRAPNAR-FVPVRLSAIAALLRDALCP--DVLLTRVIHRDGSFHF
. . * * : . . *
Mflv_2115|M.gilvum_PYR-GCK GTVEELRRAGADPQRVLVVETSDAFPRTFGLGERYRHALHLDEIDVLVPS
Mvan_5591|M.vanbaalenii_PYR-1 GTVGELRRAGADPDRLLVVEVSDAYPRTFGHGE-HRHALHVDEIDVLVRS
MAB_1175|M.abscessus_ATCC_1997 GTIGELRRAGADPERLLIVEVSEAYPRTFGVGEQHRHALHVDEIDVLVSS
MSMEG_6310|M.smegmatis_MC2_155 GTVDELRRAGTDPERLLIVEVSEAFPRTYGLGDTHRHALHVDEIDILIRS
MMAR_4160|M.marinum_M GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
MUL_4023|M.ulcerans_Agy99 GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
MAV_2569|M.avium_104 STEVSWQRTVTDSGTRTLAIIDTSAPAAAAEPG-----LGPPGLEVLGTV
TH_3697|M.thermoresistible__bu GTEVSWQRELVDSGVPVLAVVDDGVCADAGPP------LPASAMRVVGRS
.* . . :. . . * : :
Mflv_2115|M.gilvum_PYR-GCK TDAPLALPT--APPTDVDTRIARHAVTFIRSGATLQTGIGSIPSQIATLL
Mvan_5591|M.vanbaalenii_PYR-1 TDAPLALPG--PPPTDTDTAIARHAVAFIPSGATLQTGIGSIPSQIATLL
MAB_1175|M.abscessus_ATCC_1997 TDAPLALPGGDAAPSDVDRAIARHAVGFIGPGATLQTGIGAIPNQIATLL
MSMEG_6310|M.smegmatis_MC2_155 TAQPMSLPGDRATPSDVDRAIAKHAVAYMPSGATLQTGIGSIPNQIAALL
MMAR_4160|M.marinum_M DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
MUL_4023|M.ulcerans_Agy99 DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
MAV_2569|M.avium_104 RGGPLRVPQ--REPEPIHEALADAVLRLLPEGARIQYGPGQLGTALLRRA
TH_3697|M.thermoresistible__bu ADRPVTIPS--RAPEPVHEALADAVLRFVPEGARLQYGPGQLGTALLDRI
:* . :* . : * :* * * : :
Mflv_2115|M.gilvum_PYR-GCK AEGDGGDYGLHSEMFTDGCMQLHRAGKVTNAAKEHFAGVSVTTFAMGSSE
Mvan_5591|M.vanbaalenii_PYR-1 AEGDGGGYGLHSEMFTDGCMQLHRAGKVTNTAKGRFDGVSVTTFAFGSTE
MAB_1175|M.abscessus_ATCC_1997 AEGDGGGYGLHSEMFTDGCMKLHRAGKVTNTGKGQYDGVSVTTFAFGSPD
MSMEG_6310|M.smegmatis_MC2_155 AEGDGGEYGLHSEMFTDGCMKLHRAGKVTNTHKGLYDGVSVTTFAFGSPD
MMAR_4160|M.marinum_M R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
MUL_4023|M.ulcerans_Agy99 R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
MAV_2569|M.avium_104 Q----VPLHIDTGLLTDAVVDLDRRGLLAGTPS--------ATYLLGSDA
TH_3697|M.thermoresistible__bu R----QPVSIDTGLLTDAVLGLERKGLLAGTPS--------ATYLFGSEA
:.: ::* . * * * ::. . *: :*.
Mflv_2115|M.gilvum_PYR-GCK LYAWLDGNTDVAFLPVEVVNSPEEIAANRHMVSINGALAVDLQGQVVADT
Mvan_5591|M.vanbaalenii_PYR-1 LYAWLDGNEDVAFLPVEIVNSPEVIGANHNMISINGALAVDIHGQVVADT
MAB_1175|M.abscessus_ATCC_1997 LYAWLDGNADVAFLPVEIVNAPEVIGANNDMISINGALSIDIQGQVVADT
MSMEG_6310|M.smegmatis_MC2_155 LYEWLDGNRDVAFLPVEIVNSPEVIARNHQMVTINGALAVDIHGQVVADT
MMAR_4160|M.marinum_M TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTIEMDLTGACNSEH
MUL_4023|M.ulcerans_Agy99 TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTVEMDLTGACNSEH
MAV_2569|M.avium_104 LYDWADGRR--ILRGLDYTHDLTRLSRGAPLVAVNTAIEIDQYGQVNVEG
TH_3697|M.thermoresistible__bu LYTWADGRP--ILRGIEHTHDLTRLSRGTPLVAVNTAIEIDPFGQVNVEG
* : *.. :: .: :. . ::::* :: :* * :
Mflv_2115|M.gilvum_PYR-GCK INGDQFSGIGGAEDFVAGTGLELSDRSLVCLPSTFE-KDGVLQSRIVPWF
Mvan_5591|M.vanbaalenii_PYR-1 IAGDQFSGIGGAEDFVAGVGIELTDRSLICLPSTFQ-KDGRLQSRIVPQF
MAB_1175|M.abscessus_ATCC_1997 INGGQFSGIGGAEDFVAGAGLELSDRSLICLPSTFE-KGGALQSRIVPWF
MSMEG_6310|M.smegmatis_MC2_155 IDGSQFSGIGGAEDFVAGAGLELSDRSLICLPSTYTTKDGHVRSRIVPWF
MMAR_4160|M.marinum_M VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
MUL_4023|M.ulcerans_Agy99 VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
MAV_2569|M.avium_104 VRDKVVGGIGGHPDYCAAARVSSGGLSIIAVPTRVN-----GRSPLVEQL
TH_3697|M.thermoresistible__bu VGDKVVGGIGGHPDYCAAGAMSRGGLSIIAVPSTVN-----GRSPYVERL
: . . * ** *: . . . *::...: * * :
Mflv_2115|M.gilvum_PYR-GCK GPGAVITTPRHHVDVIVTEFGAAELEGRTVQERGHALAAIAHPDFRADLA
Mvan_5591|M.vanbaalenii_PYR-1 AAGAIITTPRHHVDVIVTEYGAAELEGKTVQQRGHALAAIAHPLFRDELL
MAB_1175|M.abscessus_ATCC_1997 GPGAVITTPRHQVDVVITEYGAAELEGRTVRERGEALAAIAHPQFRDALR
MSMEG_6310|M.smegmatis_MC2_155 GPGAVITTPRHHVDVIVTEYGTAELEGLTVRERGSALAAIAHPQFRDDLL
MMAR_4160|M.marinum_M SG--PVTTPRNETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
MUL_4023|M.ulcerans_Agy99 SG--PVTTPRSETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
MAV_2569|M.avium_104 SR--PTSTPAHDVDLIVTEAGYVDLRAADWPQRRTLIAELFTE-------
TH_3697|M.thermoresistible__bu SR--PASTPAHDIDVIVTESGHADLRGADWTQRRRLIAALFE--------
. :** . . : ** * .:*.. * : :
Mflv_2115|M.gilvum_PYR-GCK AAADRAAKGRSPVL
Mvan_5591|M.vanbaalenii_PYR-1 AAADRAAPRRT---
MAB_1175|M.abscessus_ATCC_1997 AAATRAANGRSPVS
MSMEG_6310|M.smegmatis_MC2_155 EAAERTVNGRSALA
MMAR_4160|M.marinum_M ECAQHMHLI-----
MUL_4023|M.ulcerans_Agy99 ECAQHMHLI-----
MAV_2569|M.avium_104 --------------
TH_3697|M.thermoresistible__bu --------------