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PQELTAEEAAARLAPADSLGIPLGPGQPPAFLRALGARTDWTDLRVYGALLAVGTELFSRPGVHYLSGFY GPLERALRDAGADVDFTPADFRRFGPLMEHQSPRVMTTVATPPDADGWCSLSLHAGGTVGELRRAGADPD RLLVVEVSDAYPRTFGHGEHRHALHVDEIDVLVRSTDAPLALPGPPPTDTDTAIARHAVAFIPSGATLQT GIGSIPSQIATLLAEGDGGGYGLHSEMFTDGCMQLHRAGKVTNTAKGRFDGVSVTTFAFGSTELYAWLDG NEDVAFLPVEIVNSPEVIGANHNMISINGALAVDIHGQVVADTIAGDQFSGIGGAEDFVAGVGIELTDRS LICLPSTFQKDGRLQSRIVPQFAAGAIITTPRHHVDVIVTEYGAAELEGKTVQQRGHALAAIAHPLFRDE LLAAADRAAPRRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5591 | - | - | 100% (434) | acetyl-CoA hydrolase/transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2115 | - | 0.0 | 84.60% (435) | 4-hydroxybutyrate CoA-transferase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1175 | - | 0.0 | 82.84% (437) | 4-hydroxybutyrate CoA-transferase AbfT |
| M. marinum M | MMAR_4160 | - | 3e-49 | 34.02% (438) | acetyl-CoA hydrolase/transferase |
| M. avium 104 | MAV_1834 | - | 4e-21 | 28.15% (238) | acetyl-CoA hydrolase/transferase |
| M. smegmatis MC2 155 | MSMEG_6310 | - | 0.0 | 78.77% (438) | 4-hydroxybutyrate coenzyme A transferase |
| M. thermoresistible (build 8) | TH_3697 | - | 2e-23 | 31.40% (242) | PUTATIVE putative acetyl-CoA hydrolase/transferase |
| M. ulcerans Agy99 | MUL_4023 | - | 3e-49 | 33.73% (415) | acetyl-CoA hydrolase/transferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4160|M.marinum_M MENCVAVKDHAALYRAKLADPDTAILAVTSGSAVAVGQAACQPPALLQAL
MUL_4023|M.ulcerans_Agy99 MENCVAVKDHAALYRAKLTDPDTAILAVTSGSAVAVGQAACQPPALLQAL
Mvan_5591|M.vanbaalenii_PYR-1 ----MPQELTAEEAAARLAPADSLGIPLGPG----------QPPAFLRAL
Mflv_2115|M.gilvum_PYR-GCK ----MPQELTADQAAARLEPADALGIPLGPG----------QPPAFLRAL
MAB_1175|M.abscessus_ATCC_1997 ----MPLELTAEQAAARLNPVDTLGIPLGPG----------QPPAFLRAL
MSMEG_6310|M.smegmatis_MC2_155 ----MPTELTAEQAAARLHAADTVGLPLGPG----------QPPSFLQAL
MAV_1834|M.avium_104 MTTAFTDSGLATALRARISPGSTIAIGDGVG----------GLRYLDDGT
TH_3697|M.thermoresistible__bu VTTDLLRSPLAAELRARLRPGMTVALGDGVG----------ALRCADDGT
. . * *:: : : * .
MMAR_4160|M.marinum_M AARAERREIDRVRLFYYHAERPMADTVLRYELMGRLLPNSMFLQAAERDL
MUL_4023|M.ulcerans_Agy99 AARAERREIDRVRLFYYHAERPMADTVLRYELMGRFLPNSMFLQAAERDL
Mvan_5591|M.vanbaalenii_PYR-1 GARTDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFYGPLERALRDA
Mflv_2115|M.gilvum_PYR-GCK GERTDWTDLR-----VYGALLAVGTELFSWPGVHYLSGFYGPLERALRDS
MAB_1175|M.abscessus_ATCC_1997 GVRKDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFFGPLERALRDM
MSMEG_6310|M.smegmatis_MC2_155 GVRKDWTDLR-----VYGALLAVLTELFSRPGVHFISGFYGPLERALRDA
MAV_1834|M.avium_104 SVGAVVSAVA-----RDVGSVRLILGWVPAPLDDLEADAFAEIVALMPGW
TH_3697|M.thermoresistible__bu SVAATLSALA-----AELGDIRLVLGWLTAPLDGLATEVFRDIVALMPGW
. : . : . : .
MMAR_4160|M.marinum_M IAHGEHDGRKVVQFIPNSFSDAVRLFTETISVDTTIVTVSPMDEQGYFTF
MUL_4023|M.ulcerans_Agy99 IAHGEHDGRKVVQFIPNSFSNAVRLFTETISVDTTIVTVSPMDEQGYFTF
Mvan_5591|M.vanbaalenii_PYR-1 GADVDFTPADFRRFGPLMEHQSPRVMTTVATPPDADGWCSLSLHAG----
Mflv_2115|M.gilvum_PYR-GCK GANIEFTPADFRRFGPLLERQAPRVMTAVATPPDADGWCSLSLHAG----
MAB_1175|M.abscessus_ATCC_1997 GADIEFAAADFRRFGPLLERQSPRVMTTVATPPGPDGWCSLSLHAG----
MSMEG_6310|M.smegmatis_MC2_155 GADVDFAPADFRRFGPLMRAQSPRAMATAAAPPDTDGWCSLSLHAG----
MAV_1834|M.avium_104 GLRDVLAGP-TARFVPTRLSGIQALLTGVLRP--DVLVTRVVDRSGGLRF
TH_3697|M.thermoresistible__bu GVRDVLRAP-NARFVPVRLSAIAALLRDALCP--DVLLTRVIHRDGSFHF
:* * : . . *
MMAR_4160|M.marinum_M GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
MUL_4023|M.ulcerans_Agy99 GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
Mvan_5591|M.vanbaalenii_PYR-1 GTVGELRRAGADPDRLLVVEVSDAYPRTFGHGE-HRHALHVDEIDVLVRS
Mflv_2115|M.gilvum_PYR-GCK GTVEELRRAGADPQRVLVVETSDAFPRTFGLGERYRHALHLDEIDVLVPS
MAB_1175|M.abscessus_ATCC_1997 GTIGELRRAGADPERLLIVEVSEAYPRTFGVGEQHRHALHVDEIDVLVSS
MSMEG_6310|M.smegmatis_MC2_155 GTVDELRRAGTDPERLLIVEVSEAFPRTYGLGDTHRHALHVDEIDILIRS
MAV_1834|M.avium_104 STEVSWQREVVDAGVPVLAILDGTAPCADAGPP-----LAPGMVHVSGCS
TH_3697|M.thermoresistible__bu GTEVSWQRELVDSGVPVLAVVD-DGVCADAGPP-----LPASAMRVVGRS
.* . . ::. . . . * . : .
MMAR_4160|M.marinum_M DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
MUL_4023|M.ulcerans_Agy99 DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
Mvan_5591|M.vanbaalenii_PYR-1 TDAPLALPG--PPPTDTDTAIARHAVAFIPSGATLQTGIGSIPSQIATLL
Mflv_2115|M.gilvum_PYR-GCK TDAPLALPT--APPTDVDTRIARHAVTFIRSGATLQTGIGSIPSQIATLL
MAB_1175|M.abscessus_ATCC_1997 TDAPLALPGGDAAPSDVDRAIARHAVGFIGPGATLQTGIGAIPNQIATLL
MSMEG_6310|M.smegmatis_MC2_155 TAQPMSLPGDRATPSDVDRAIAKHAVAYMPSGATLQTGIGSIPNQIAALL
MAV_1834|M.avium_104 SEGPARMPR--KDPEPVHDALADAALRFVPEGARLQYGPGQLGTALLRRT
TH_3697|M.thermoresistible__bu ADRPVTIPS--RAPEPVHEALADAVLRFVPEGARLQYGPGQLGTALLDRI
:* . :* . : * ** * * : :
MMAR_4160|M.marinum_M R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
MUL_4023|M.ulcerans_Agy99 R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
Mvan_5591|M.vanbaalenii_PYR-1 AEGDGGGYGLHSEMFTDGCMQLHRAGKVTNTAKGRFDGVSVTTFAFGSTE
Mflv_2115|M.gilvum_PYR-GCK AEGDGGDYGLHSEMFTDGCMQLHRAGKVTNAAKEHFAGVSVTTFAMGSSE
MAB_1175|M.abscessus_ATCC_1997 AEGDGGGYGLHSEMFTDGCMKLHRAGKVTNTGKGQYDGVSVTTFAFGSPD
MSMEG_6310|M.smegmatis_MC2_155 AEGDGGEYGLHSEMFTDGCMKLHRAGKVTNTHKGLYDGVSVTTFAFGSPD
MAV_1834|M.avium_104 A----MPLRVDTGLLTDAVVDLDKRGLLIDIPS--------ATYLFGSEE
TH_3697|M.thermoresistible__bu R----QPVSIDTGLLTDAVLGLERKGLLAGTPS--------ATYLFGSEA
:.: ::* . * : * : . . *: :*.
MMAR_4160|M.marinum_M TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTIEMDLTGACNSEH
MUL_4023|M.ulcerans_Agy99 TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTVEMDLTGACNSEH
Mvan_5591|M.vanbaalenii_PYR-1 LYAWLDGNEDVAFLPVEIVNSPEVIGANHNMISINGALAVDIHGQVVADT
Mflv_2115|M.gilvum_PYR-GCK LYAWLDGNTDVAFLPVEVVNSPEEIAANRHMVSINGALAVDLQGQVVADT
MAB_1175|M.abscessus_ATCC_1997 LYAWLDGNADVAFLPVEIVNAPEVIGANNDMISINGALSIDIQGQVVADT
MSMEG_6310|M.smegmatis_MC2_155 LYEWLDGNRDVAFLPVEIVNSPEVIARNHQMVTINGALAVDIHGQVVADT
MAV_1834|M.avium_104 LYDWADGKS--ILRGIDYTHDISRLAGGETFVAVNTAIEIDPYGQVNVEG
TH_3697|M.thermoresistible__bu LYTWADGRP--ILRGIEHTHDLTRLSRGTPLVAVNTAIEIDPFGQVNVEG
* : *.. :: .: :. . .:::* :: :* * :
MMAR_4160|M.marinum_M VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
MUL_4023|M.ulcerans_Agy99 VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
Mvan_5591|M.vanbaalenii_PYR-1 IAGDQFSGIGGAEDFVAGVGIELTDRSLICLPSTFQ-KDGRLQSRIVPQF
Mflv_2115|M.gilvum_PYR-GCK INGDQFSGIGGAEDFVAGTGLELSDRSLVCLPSTFE-KDGVLQSRIVPWF
MAB_1175|M.abscessus_ATCC_1997 INGGQFSGIGGAEDFVAGAGLELSDRSLICLPSTFE-KGGALQSRIVPWF
MSMEG_6310|M.smegmatis_MC2_155 IDGSQFSGIGGAEDFVAGAGLELSDRSLICLPSTYTTKDGHVRSRIVPWF
MAV_1834|M.avium_104 LGEKVVGGIGGHPDYCAAARMSHSGLSIIATPTEVN-----GRSPLVEQL
TH_3697|M.thermoresistible__bu VGDKVVGGIGGHPDYCAAGAMSRGGLSIIAVPSTVN-----GRSPYVERL
: . * ** *: . . . *::. .: * * :
MMAR_4160|M.marinum_M SG--PVTTPRNETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
MUL_4023|M.ulcerans_Agy99 SG--PVTTPRSETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
Mvan_5591|M.vanbaalenii_PYR-1 AAGAIITTPRHHVDVIVTEYGAAELEGKTVQQRGHALAAIAHPLFRDELL
Mflv_2115|M.gilvum_PYR-GCK GPGAVITTPRHHVDVIVTEFGAAELEGRTVQERGHALAAIAHPDFRADLA
MAB_1175|M.abscessus_ATCC_1997 GPGAVITTPRHQVDVVITEYGAAELEGRTVRERGEALAAIAHPQFRDALR
MSMEG_6310|M.smegmatis_MC2_155 GPGAVITTPRHHVDVIVTEYGTAELEGLTVRERGSALAAIAHPQFRDDLL
MAV_1834|M.avium_104 SR--PASTPAHDIDLIVTESGYADLRGADWSQRRRLITTLFE--------
TH_3697|M.thermoresistible__bu SR--PASTPAHDIDVIVTESGHADLRGADWTQRRRLIAALFE--------
. :** . . : ** * .:*.* * : : .
MMAR_4160|M.marinum_M ECAQHMHLI-----
MUL_4023|M.ulcerans_Agy99 ECAQHMHLI-----
Mvan_5591|M.vanbaalenii_PYR-1 AAADRAAPRRT---
Mflv_2115|M.gilvum_PYR-GCK AAADRAAKGRSPVL
MAB_1175|M.abscessus_ATCC_1997 AAATRAANGRSPVS
MSMEG_6310|M.smegmatis_MC2_155 EAAERTVNGRSALA
MAV_1834|M.avium_104 --------------
TH_3697|M.thermoresistible__bu --------------