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MENCVAVKDHAALYRAKLTDPDTAILAVTSGSAVAVGQAACQPPALLQALAARAERREIDRVRLFYYHAE RPMADTVLRYELMGRFLPNSMFLQAAERDLIAHGEHDGRKVVQFIPNSFSNAVRLFTETISVDTTIVTVS PMDEQGYFTFGTNNDYTSSVARQARHLIVEVNPNMPRVFGHSMLHVDEVDAIVENDAPLPELPQRPISEL DRVIATHVAALVPEQACLQIGVGGLPQAVCEQLRDRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGA AVFTFALGDRKTYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTVEMDLTGACNSEHVNGHQFTGA GGQLDFVRGAYASRGGKSIIAFASTTRGGTISKIVPRLSGPVTTPRSETHYVATEFGTVNLKGLSSSARA EALIGLAHPDYRPWLAECAQHMHLI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4023 | - | - | 100% (445) | acetyl-CoA hydrolase/transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2115 | - | 2e-48 | 33.18% (440) | 4-hydroxybutyrate CoA-transferase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1175 | - | 4e-47 | 34.69% (418) | 4-hydroxybutyrate CoA-transferase AbfT |
| M. marinum M | MMAR_4160 | - | 0.0 | 98.88% (445) | acetyl-CoA hydrolase/transferase |
| M. avium 104 | MAV_5071 | - | 2e-22 | 27.72% (303) | acetyl-CoA hydrolase/transferase |
| M. smegmatis MC2 155 | MSMEG_6310 | - | 7e-51 | 34.37% (419) | 4-hydroxybutyrate coenzyme A transferase |
| M. thermoresistible (build 8) | TH_3697 | - | 3e-23 | 27.62% (315) | PUTATIVE putative acetyl-CoA hydrolase/transferase |
| M. vanbaalenii PYR-1 | Mvan_5591 | - | 5e-49 | 33.73% (415) | acetyl-CoA hydrolase/transferase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4023|M.ulcerans_Agy99 MENCVAVKDHAALYRAKLTDPDTAILAVTSGSAVAVGQAACQPPALLQAL
MMAR_4160|M.marinum_M MENCVAVKDHAALYRAKLADPDTAILAVTSGSAVAVGQAACQPPALLQAL
Mflv_2115|M.gilvum_PYR-GCK ----MPQELTADQAAARLEPADALGIPLGPG----------QPPAFLRAL
Mvan_5591|M.vanbaalenii_PYR-1 ----MPQELTAEEAAARLAPADSLGIPLGPG----------QPPAFLRAL
MAB_1175|M.abscessus_ATCC_1997 ----MPLELTAEQAAARLNPVDTLGIPLGPG----------QPPAFLRAL
MSMEG_6310|M.smegmatis_MC2_155 ----MPTELTAEQAAARLHAADTVGLPLGPG----------QPPSFLQAL
MAV_5071|M.avium_104 -----MTETLAALLHRLSRPEVTIALGDGVG----------GLTTLDSGV
TH_3697|M.thermoresistible__bu VTTDLLRSPLAAELRARLRPGMTVALGDGVG----------ALRCADDGT
. * : : * .
MUL_4023|M.ulcerans_Agy99 AARAERREIDRVRLFYYHAERPMADTVLRYELMGRFLPNSMFLQAAERDL
MMAR_4160|M.marinum_M AARAERREIDRVRLFYYHAERPMADTVLRYELMGRLLPNSMFLQAAERDL
Mflv_2115|M.gilvum_PYR-GCK GERTDWTDLR-----VYGALLAVGTELFSWPGVHYLSGFYGPLERALRDS
Mvan_5591|M.vanbaalenii_PYR-1 GARTDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFYGPLERALRDA
MAB_1175|M.abscessus_ATCC_1997 GVRKDWTDLR-----VYGALLAVGTELFSRPGVHYLSGFFGPLERALRDM
MSMEG_6310|M.smegmatis_MC2_155 GVRKDWTDLR-----VYGALLAVLTELFSRPGVHFISGFYGPLERALRDA
MAV_5071|M.avium_104 SIGETVSRFA-----ADTGAVSLILGWCPVPPQGLCADAFARIVTLMPGW
TH_3697|M.thermoresistible__bu SVAATLSALA-----AELGDIRLVLGWLTAPLDGLATEVFRDIVALMPGW
. : . : : .
MUL_4023|M.ulcerans_Agy99 IAHGEHDGRKVVQFIPNSFSNAVRLFTETISVDTTIVTVSPMDEQGYFTF
MMAR_4160|M.marinum_M IAHGEHDGRKVVQFIPNSFSDAVRLFTETISVDTTIVTVSPMDEQGYFTF
Mflv_2115|M.gilvum_PYR-GCK GANIEFTPADFRRFGPLLERQAPRVMTAVATPPDADGWCSLSLHAG----
Mvan_5591|M.vanbaalenii_PYR-1 GADVDFTPADFRRFGPLMEHQSPRVMTTVATPPDADGWCSLSLHAG----
MAB_1175|M.abscessus_ATCC_1997 GADIEFAAADFRRFGPLLERQSPRVMTTVATPPGPDGWCSLSLHAG----
MSMEG_6310|M.smegmatis_MC2_155 GADVDFAPADFRRFGPLMRAQSPRAMATAAAPPDTDGWCSLSLHAG----
MAV_5071|M.avium_104 GMR-ELLSSHVVHSIPTSMAAIPGLLAGHLRPDALITRMAHS--GDGLQF
TH_3697|M.thermoresistible__bu GVR-DVLRAPNARFVPVRLSAIAALLRDALCPDVLLTRVIHR--DGSFHF
: : * : .
MUL_4023|M.ulcerans_Agy99 GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
MMAR_4160|M.marinum_M GTNNDYTSSVARQARHLIVEVNPNMPRVFGHSM-----LHVDEVDAIVEN
Mflv_2115|M.gilvum_PYR-GCK GTVEELRRAGADPQRVLVVETSDAFPRTFGLGERYRHALHLDEIDVLVPS
Mvan_5591|M.vanbaalenii_PYR-1 GTVGELRRAGADPDRLLVVEVSDAYPRTFGHGE-HRHALHVDEIDVLVRS
MAB_1175|M.abscessus_ATCC_1997 GTIGELRRAGADPERLLIVEVSEAYPRTFGVGEQHRHALHVDEIDVLVSS
MSMEG_6310|M.smegmatis_MC2_155 GTVDELRRAGTDPERLLIVEVSEAFPRTYGLGDTHRHALHVDEIDILIRS
MAV_5071|M.avium_104 CSEVSWQQALVDAGVPLWAVLDDSAPKASAEAP-----IPLDAVTIIGRA
TH_3697|M.thermoresistible__bu GTEVSWQRELVDSGVPVLAVVDDGV-CADAGPP-----LPASAMRVVGRS
: . . : . . . . : . : :
MUL_4023|M.ulcerans_Agy99 DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
MMAR_4160|M.marinum_M DAPLPELPQ--RPISELDRVIATHVAALVPEQACLQIGVGGLPQAVCEQL
Mflv_2115|M.gilvum_PYR-GCK TDAPLALPT--APPTDVDTRIARHAVTFIRSGATLQTGIGSIPSQIATLL
Mvan_5591|M.vanbaalenii_PYR-1 TDAPLALPG--PPPTDTDTAIARHAVAFIPSGATLQTGIGSIPSQIATLL
MAB_1175|M.abscessus_ATCC_1997 TDAPLALPGGDAAPSDVDRAIARHAVGFIGPGATLQTGIGAIPNQIATLL
MSMEG_6310|M.smegmatis_MC2_155 TAQPMSLPGDRATPSDVDRAIAKHAVAYMPSGATLQTGIGSIPNQIAALL
MAV_5071|M.avium_104 GSGTAEIPV--RSADSIHDDLADRVLRFIPAGARLQYGPG----QLGTAL
TH_3697|M.thermoresistible__bu ADRPVTIPS--RAPEPVHEALADAVLRFVPEGARLQYGPG----QLGTAL
:* . . :* . : * ** * * : *
MUL_4023|M.ulcerans_Agy99 R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
MMAR_4160|M.marinum_M R--DRSDLGIHSEVFTPALADLVRRGVVTGRHKAINRGAAVFTFALGDRK
Mflv_2115|M.gilvum_PYR-GCK AEGDGGDYGLHSEMFTDGCMQLHRAGKVTNAAKEHFAGVSVTTFAMGSSE
Mvan_5591|M.vanbaalenii_PYR-1 AEGDGGGYGLHSEMFTDGCMQLHRAGKVTNTAKGRFDGVSVTTFAFGSTE
MAB_1175|M.abscessus_ATCC_1997 AEGDGGGYGLHSEMFTDGCMKLHRAGKVTNTGKGQYDGVSVTTFAFGSPD
MSMEG_6310|M.smegmatis_MC2_155 AEGDGGEYGLHSEMFTDGCMKLHRAGKVTNTHKGLYDGVSVTTFAFGSPD
MAV_5071|M.avium_104 LRRTKIPLSIDTGLLTDAVIDLERRGLLVGQ--------PSATYLLGSAE
TH_3697|M.thermoresistible__bu LDRIRQPVSIDTGLLTDAVLGLERKGLLAGT--------PSATYLFGSEA
.:.: ::* . * * * :.. . *: :*.
MUL_4023|M.ulcerans_Agy99 TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTVEMDLTGACNSEH
MMAR_4160|M.marinum_M TYEFMDNNPKLESYPVDYVNDPAVIARNDNVVSVNSTIEMDLTGACNSEH
Mflv_2115|M.gilvum_PYR-GCK LYAWLDGNTDVAFLPVEVVNSPEEIAANRHMVSINGALAVDLQGQVVADT
Mvan_5591|M.vanbaalenii_PYR-1 LYAWLDGNEDVAFLPVEIVNSPEVIGANHNMISINGALAVDIHGQVVADT
MAB_1175|M.abscessus_ATCC_1997 LYAWLDGNADVAFLPVEIVNAPEVIGANNDMISINGALSIDIQGQVVADT
MSMEG_6310|M.smegmatis_MC2_155 LYEWLDGNRDVAFLPVEIVNSPEVIARNHQMVTINGALAVDIHGQVVADT
MAV_5071|M.avium_104 LYRWADRRP--ILRGVGYTHDVSRLSRGAPFVAVNTAIEIDPYGQINVEG
TH_3697|M.thermoresistible__bu LYTWADGRP--ILRGIEHTHDLTRLSRGTPLVAVNTAIEIDPFGQVNVEG
* : * . : .: :. . .:::* :: :* * :
MUL_4023|M.ulcerans_Agy99 VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
MMAR_4160|M.marinum_M VNGHQFTGAGGQLDFVRGAYASRGGKSIIAFASTTR---GGTISKIVPRL
Mflv_2115|M.gilvum_PYR-GCK INGDQFSGIGGAEDFVAGTGLELSDRSLVCLPSTFE-KDGVLQSRIVPWF
Mvan_5591|M.vanbaalenii_PYR-1 IAGDQFSGIGGAEDFVAGVGIELTDRSLICLPSTFQ-KDGRLQSRIVPQF
MAB_1175|M.abscessus_ATCC_1997 INGGQFSGIGGAEDFVAGAGLELSDRSLICLPSTFE-KGGALQSRIVPWF
MSMEG_6310|M.smegmatis_MC2_155 IDGSQFSGIGGAEDFVAGAGLELSDRSLICLPSTYTTKDGHVRSRIVPWF
MAV_5071|M.avium_104 IADKVVGGIGGHPDYCVAARLSRNGLSIIAVPARFN-----GRSPLVERL
TH_3697|M.thermoresistible__bu VGDKVVGGIGGHPDYCAAGAMSRGGLSIIAVPSTVN-----GRSPYVERL
: . . * ** *: . . . *::...: * * :
MUL_4023|M.ulcerans_Agy99 SG--PVTTPRSETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
MMAR_4160|M.marinum_M SG--PVTTPRNETHYVATEFGTVNLKGLSSSARAEALIGLAHPDYRPWLA
Mflv_2115|M.gilvum_PYR-GCK GPGAVITTPRHHVDVIVTEFGAAELEGRTVQERGHALAAIAHPDFRADLA
Mvan_5591|M.vanbaalenii_PYR-1 AAGAIITTPRHHVDVIVTEYGAAELEGKTVQQRGHALAAIAHPLFRDELL
MAB_1175|M.abscessus_ATCC_1997 GPGAVITTPRHQVDVVITEYGAAELEGRTVRERGEALAAIAHPQFRDALR
MSMEG_6310|M.smegmatis_MC2_155 GPGAVITTPRHHVDVIVTEYGTAELEGLTVRERGSALAAIAHPQFRDDLL
MAV_5071|M.avium_104 SR--PASTPAHDVDMIITEHAHVDLRGADWCQRHRLISELFDRAA-----
TH_3697|M.thermoresistible__bu SR--PASTPAHDIDVIVTESGHADLRGADWTQRRRLIAALFE--------
. :** . . : ** . .:*.* * : : .
MUL_4023|M.ulcerans_Agy99 ECAQHMHLI-----
MMAR_4160|M.marinum_M ECAQHMHLI-----
Mflv_2115|M.gilvum_PYR-GCK AAADRAAKGRSPVL
Mvan_5591|M.vanbaalenii_PYR-1 AAADRAAPRRT---
MAB_1175|M.abscessus_ATCC_1997 AAATRAANGRSPVS
MSMEG_6310|M.smegmatis_MC2_155 EAAERTVNGRSALA
MAV_5071|M.avium_104 --------------
TH_3697|M.thermoresistible__bu --------------