For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. avium 104 MAV_2183 (-)

annotation: beta-lactamase
coordinates: 2186881 - 2187699
length: 272

MAALDALDEWPVGAVAAAVIGPTGVLAGHGDAERVFALASVTKPLAARAVHVAVEEGAVELDAAAGPPGA
TIRHLLAHTSGLSMHSDQVLAPPGTRRIYSNQGFTVLGETLEEETGIEFARYLHEAVCQPLGMTATRLDG
GAVAAGFGATSTVADLAAFAGDLLRPTTVSARLHAEATTVQFPGLDGVLPGYGVQRPNDWGLGFELRDGK
APHWTGAANSARTYGHFGQAGGFIWADPDIERALVVLTDRDFGEWALDRWPAISDAVISEYS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_2183--100% (272)beta-lactamase
M. avium 104MAV_1030-4e-0528.10% (153) penicillin-binding protein 4

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2281c-1e-12476.84% (272) hypothetical protein Mb2281c
M. gilvum PYR-GCKMflv_2769-1e-10165.31% (271) beta-lactamase
M. tuberculosis H37RvRv2257c-1e-12476.84% (272) hypothetical protein Rv2257c
M. leprae Br4923MLBr_01782-1e-12376.10% (272) hypothetical protein MLBr_01782
M. abscessus ATCC 19977MAB_1870-8e-9964.58% (271) putative beta-lactamase
M. marinum MMMAR_3348-1e-12073.53% (272) hypothetical protein MMAR_3348
M. smegmatis MC2 155MSMEG_4337-1e-10265.91% (264) beta-lactamase
M. thermoresistible (build 8)TH_1504-1e-11168.75% (272) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_1294-1e-11972.79% (272) hypothetical protein MUL_1294
M. vanbaalenii PYR-1Mvan_3764-1e-10869.00% (271) beta-lactamase

CLUSTAL 2.0.9 multiple sequence alignment


MAV_2183|M.avium_104                MAALDALDEWPVGAVAAAVIGPTGVLAGHGDAERVFALASVTKPLAARAV
MLBr_01782|M.leprae_Br4923          MVALDALDDWPVPTTAAAVVGPTGVLAARGDTEQVFPLASVTKPLVARAV
Mb2281c|M.bovis_AF2122/97           MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAA
Rv2257c|M.tuberculosis_H37Rv        MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAA
MMAR_3348|M.marinum_M               MAALDALDDWPVPAAAAAVIGPTGVLATHGNVEKVFALASVTKPMAARAA
MUL_1294|M.ulcerans_Agy99           MAALDALDDWPVPAAAAAVIGPTGVLATHGNVEKVFALASVTKPMAARAA
MSMEG_4337|M.smegmatis_MC2_155      -----MIDEWPVPTAAAAVIGPSGVLATHGDDAKPFALASVTKLLVARAA
TH_1504|M.thermoresistible__bu      MGALDVLADWPVDNVAATVVGPDGVRADRGDLRREFALASVTKPLAARAA
Mflv_2769|M.gilvum_PYR-GCK          MSALDVLSDWPVPNVAAAVVGGKGVLADHGDTRHRFPLASVTKLLVARAA
Mvan_3764|M.vanbaalenii_PYR-1       MSALDALNDWPVPTAAAAVVGPSGVLARHGDTGRRFPLASVTKPLVARAA
MAB_1870|M.abscessus_ATCC_1997      MGALDLVADWPVSTVAAAVVAPEGIRAQIGPVTQQFALASVTKPLVARAA
                                          :  ***  .**:*:.  *: *  *   : *.****** :.***.

MAV_2183|M.avium_104                HVAVEEGAVELDAAAGPPGATIRHLLAHTSGLSMHSDQVLAPPGTRRIYS
MLBr_01782|M.leprae_Br4923          QIAIEEGVVDLDTVAGPPGSTIRHLLAHASGLAMHSKYVMAPPGTRRIYS
Mb2281c|M.bovis_AF2122/97           QVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYS
Rv2257c|M.tuberculosis_H37Rv        QVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYS
MMAR_3348|M.marinum_M               QIAIEEGVVDLDTPAGPPDSTIRHLLAHTSGLSMHTNQVLARPGTRRMYS
MUL_1294|M.ulcerans_Agy99           QIAIEEGVVDLDTPAGPPDSTIRHLLAHTSGLPMHTNQVLARPGTRRMYS
MSMEG_4337|M.smegmatis_MC2_155      QVAIEEGVVELDTPAGPDGSTVRHLLAHTSGVAMNSADTVAQVGQRRVYS
TH_1504|M.thermoresistible__bu      QIAVEEGVVELDTPAGPPGSTVRHLLAHTSGVSMNSAETLNEPGQRRVYS
Mflv_2769|M.gilvum_PYR-GCK          QIAVEEGAVELDSAAGPTGSTVRHLLAHTAGYEMTSSKVIARPGTRRVYS
Mvan_3764|M.vanbaalenii_PYR-1       QVAVEEGAVDLDSEAGPPGATVRHLLAHAAGYEMSSSKVLAAPGTRRIYS
MAB_1870|M.abscessus_ATCC_1997      QVALEEGAVDLTTPAGPSGSTVEHLLAHASGLSLLSGAVMAKPGTRRIYS
                                    ::*:***.*:* : *** .:*:.*****::*  : :  .:   * **:**

MAV_2183|M.avium_104                NQGFTVLGETLEEETGIEFARYLHEAVCQPLGMTATRLDGGAVAAGFGAT
MLBr_01782|M.leprae_Br4923          NYGFRVLAETVQREAGIGFSRYLTEAVLEPLAMTATKLEDGTWAAGFGAT
Mb2281c|M.bovis_AF2122/97           NYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGAT
Rv2257c|M.tuberculosis_H37Rv        NYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGAT
MMAR_3348|M.marinum_M               NYGFTALAEAVAQESGIEFSSYLAEAVFEPLGMSTSKLEGGAAAAGFGAT
MUL_1294|M.ulcerans_Agy99           NYGFTALAEAVAQESGIEFSSYLAEAVFEPLGMSTSKLEGGAAAAGFGAT
MSMEG_4337|M.smegmatis_MC2_155      NFGFGLLAHAIEDAAEIEFGRYLTEAVFEPLGMSTSKLLGGADAAGFGVT
TH_1504|M.thermoresistible__bu      NYGFRLLAEKIEQESGIGFAEYFHEAVCEPLGMSDTALPGGAAAAGFGAG
Mflv_2769|M.gilvum_PYR-GCK          NYGFTVLAETIESESLIPFPDYLAESVFAPLNLGDTDLDGGAEAAGYGVT
Mvan_3764|M.vanbaalenii_PYR-1       NYGFTVLAEKIEAESSIPFATYLAESVFEPLAMSGTALDGGAEAAGYGVT
MAB_1870|M.abscessus_ATCC_1997      NYGFAVLAHAVEAGATIEFDAYLREAVLEPLGMSSTTLPGGADTAGYGAS
                                    * **  *.. :   : * *  *: *:*  ** :  : * .*. :**:*. 

MAV_2183|M.avium_104                STVADLAAFAGDLLRPTTVSARLHAEATTVQFPGLDGVLPGYGVQRPNDW
MLBr_01782|M.leprae_Br4923          STVADLAAFANDLLRPATVSAQIHAEATSVQFPDLDGVLPGHGVQRPNDW
Mb2281c|M.bovis_AF2122/97           STVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDW
Rv2257c|M.tuberculosis_H37Rv        STVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDW
MMAR_3348|M.marinum_M               STVGDLALFAGDLLRPSTVSPPMHAEAIAVQFPGLDGVLPGFGVQRPNDW
MUL_1294|M.ulcerans_Agy99           STVGDLALFTGDLLRPSTVSPPMHAEAIAVQFPGLDGVLPGFGVQRPNDW
MSMEG_4337|M.smegmatis_MC2_155      STVSDLARFAGDLLRPALVSQQMHDEATSVQFPGVNGVLPGFGSQRPNDW
TH_1504|M.thermoresistible__bu      STVADLALFAVDLLRPRLVSQQMHDEATSVQFPGLDGVLPGFGVQRPNDW
Mflv_2769|M.gilvum_PYR-GCK          STVEDLVAFAGDLLTPALVSQQMHDDAISVQFPGLDGVLPGFGVQRPNDW
Mvan_3764|M.vanbaalenii_PYR-1       STVEDLVAFARDLLEPVTVSEQMHREAISVQFPGLDGVLPGFGVQRPNDW
MAB_1870|M.abscessus_ATCC_1997      STVADLAAFVGDLLRPHLVSAETHQRATHVVFPGLDGVLPGYGVQRPNDW
                                    *** **. *. *** *  **   *  *  * **.::*****.* ******

MAV_2183|M.avium_104                GLGFELRDGKAPHWTGAANSARTYGHFGQAGGFIWADPDIERALVVLTDR
MLBr_01782|M.leprae_Br4923          GLGYEIKNSKLPHWTGTLNSARTYGHFGQSGGFIWADPEAELALVVLTDR
Mb2281c|M.bovis_AF2122/97           GLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTAR
Rv2257c|M.tuberculosis_H37Rv        GLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTAR
MMAR_3348|M.marinum_M               GLGFEIKSAKSPHWTGIRNSPRTYGHFGQAGGFIWVDPEADLALVVLTDR
MUL_1294|M.ulcerans_Agy99           GLGFEIKSAKSPHWTGIRNSPRTYGHFGQAGGFIWVDPEADLALVVLTDR
MSMEG_4337|M.smegmatis_MC2_155      GLGFEIRDGKTPHWTGSSNSPRTFGHFGQSGTFLWVDPVADLALLVLTDR
TH_1504|M.thermoresistible__bu      GLGFEIRGTKSPHWTGSANSPRTFGHFGQSGTFLWVDPAVDLALVVLTDR
Mflv_2769|M.gilvum_PYR-GCK          GLGFEIRDGKSPHWTGGGNSPGTFGHFGQSGTFLWVDPGASVALIVLTDR
Mvan_3764|M.vanbaalenii_PYR-1       GLGFEIRGGKSPHWTGSANSTRTFGHFGQSGTFLWVDPDAALALVVLTDR
MAB_1870|M.abscessus_ATCC_1997      GLGFEIKGSKLPHWTGAENSPATYGHFGQAGTFIWVDPAVDLGLVVLTDR
                                    ***:*::. * *****  **. *:*****:* *:*.**    .*:*** *

MAV_2183|M.avium_104                DFGEWALDRWPAISDAVISEYS--
MLBr_01782|M.leprae_Br4923          DFGEWALQLWPAISDAVISEYAR-
Mb2281c|M.bovis_AF2122/97           DFGDWALDLWPAISDAVLAEYT--
Rv2257c|M.tuberculosis_H37Rv        DFGDWALDLWPAISDAVLAEYT--
MMAR_3348|M.marinum_M               DFGDWAREPWPALSDSVLAEYA--
MUL_1294|M.ulcerans_Agy99           DFGDWAREPWPALSDSVLAEYA--
MSMEG_4337|M.smegmatis_MC2_155      DFGDWTYPLWPAISDGVLREIGTH
TH_1504|M.thermoresistible__bu      NFGNWAYERWPALSDGVLREFASH
Mflv_2769|M.gilvum_PYR-GCK          TFGDWAHAVMPALSDEVLREFGAD
Mvan_3764|M.vanbaalenii_PYR-1       KFGDWAHTVMPALSDEVLREFGAD
MAB_1870|M.abscessus_ATCC_1997      PFDGWANQVWPQLSDAVLAEFG--
                                     *. *:    * :** *: *