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MTILDGQLTATRVDSAIRLAEKRAAHNYSPLPIVAASAQGAWITDVDGRRYLDCLSAYSAVNFGHRHPEI VATAHAQLDTVTLVSRAVHSDKLGPFCAALAYLCDKDMVLPMNSGAEAVESGLKVARKWGAEVKGVPAGQ ANIIVADNNFHGRTISIVSFSSDAAARDGFGPFTPGFRSVPFGDAGALAQAIDDNTVAVLLEPIQGEAGI VVPPDDYLPAVRALCSEHNVLMIADEIQSGLARTGYTFACDRWRVVPDVYLLGKALGGGVVPLSAVVADR EILGVLHPGEHGSTFGGNPLAAAIGTTVVSMLARGEYQARATALGAHLQRRLRALVGHGVDEVRGLGLWA GVDIDPSLGSGRQMSLRLAERGVLVKDTHGATLRFAPPLVVTAQEIDWAVGQLAAVLREAAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2086 | rocD | - | 100% (412) | ornithine--oxo-acid transaminase |
| M. avium 104 | MAV_3115 | argD | 2e-64 | 36.04% (419) | acetylornithine aminotransferase |
| M. avium 104 | MAV_3470 | gabT | 5e-40 | 30.56% (445) | 4-aminobutyrate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2349c | rocD1 | 1e-83 | 70.62% (211) | ornithine aminotransferase |
| M. gilvum PYR-GCK | Mflv_5071 | - | 0.0 | 79.70% (394) | ornithine aminotransferase |
| M. tuberculosis H37Rv | Rv2322c | rocD1 | 1e-83 | 70.62% (211) | ornithine aminotransferase |
| M. leprae Br4923 | MLBr_01409 | argD | 9e-61 | 35.58% (385) | acetylornithine aminotransferase |
| M. abscessus ATCC 19977 | MAB_3841 | - | 0.0 | 78.52% (391) | ornithine aminotransferase RocD1 |
| M. marinum M | MMAR_3622 | rocD | 0.0 | 83.09% (414) | ornithine aminotransferase RocD1 and RocD2 |
| M. smegmatis MC2 155 | MSMEG_1413 | rocD | 0.0 | 76.54% (405) | ornithine--oxo-acid transaminase |
| M. thermoresistible (build 8) | TH_3529 | - | 4e-66 | 37.82% (386) | PUTATIVE aminotransferase |
| M. ulcerans Agy99 | MUL_1243 | rocD | 0.0 | 83.09% (414) | ornithine aminotransferase RocD1 and RocD2 |
| M. vanbaalenii PYR-1 | Mvan_1287 | - | 0.0 | 78.17% (394) | ornithine aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2349c|M.bovis_AF2122/97 MTN---------------LADATQATMALVERHAAHNYSPLPVVAASAEG
Rv2322c|M.tuberculosis_H37Rv MTN---------------LADATQATMALVERHAAHNYSPLPVVAASAEG
MMAR_3622|M.marinum_M MTILDAP--------VSVEVDETGDAIALVEKHAAHNYSPLPVVAASAEG
MUL_1243|M.ulcerans_Agy99 MTILDAP--------VSVGVDETGDAIALVEKHAAHNYSPLPVVAASAEG
MAV_2086|M.avium_104 MTILDGQ--------LTATRVDS--AIRLAEKRAAHNYSPLPIVAASAQG
Mflv_5071|M.gilvum_PYR-GCK MTA---------------VHASTDALIAAEARHVAHNYSPLPVVAASAQG
Mvan_1287|M.vanbaalenii_PYR-1 MTVG--------------IMGNTEATIELDHRHVAHNYAPLPVVAASAEG
MSMEG_1413|M.smegmatis_MC2_155 MTILDNVNHGLDPHDAGAAATSIAEAIALDDRYVAHNYSPLPVVAASAEG
MAB_3841|M.abscessus_ATCC_1997 MTVTEAPG-------MSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEG
MLBr_01409|M.leprae_Br4923 ---------------MTPTQTNTATMQQRWETVMMNNYGTPPIVLASGNG
TH_3529|M.thermoresistible__bu ----------------VSGSKGRHTLLDRWQGVMMNNYGTPPLALVSGDG
:**.. *:. .:*
Mb2349c|M.bovis_AF2122/97 AWIADIDGLRYLDWLAAYSAVNLGHRNPASTATAHAQVDTVTLLNRALHA
Rv2322c|M.tuberculosis_H37Rv AWIADIDGLRYLDWLAAYSAVNLGHRNPASTATAHAQVDTVTLLNRALHA
MMAR_3622|M.marinum_M AWITDVEGRRYLDCLSAYSAVNFGHCNPEIIATAHAQLDTVTLVSRAFHS
MUL_1243|M.ulcerans_Agy99 AWITDVEGRRYLDCLSAYSAVNFGHCNPEIIATAHAQLDTVTLVSRAFHS
MAV_2086|M.avium_104 AWITDVDGRRYLDCLSAYSAVNFGHRHPEIVATAHAQLDTVTLVSRAVHS
Mflv_5071|M.gilvum_PYR-GCK AWITDVEGRRHLDCLAAYSAVNFGHRNPEIIAAAHAQLDAVTLVSRAFHS
Mvan_1287|M.vanbaalenii_PYR-1 AWITDVEGRRYLDCLAAYSAVNFGHRNPEVIATAHAQLDAVTLVSRAFHS
MSMEG_1413|M.smegmatis_MC2_155 VWITDVTGRRYLDCLAAYSAVNFGHRNPEIVATAHAQLDRLTLVSRAFHS
MAB_3841|M.abscessus_ATCC_1997 AWIEDVDGKRYLDCLAAYSAVNFGHGNPEILATSHAQLDTVTLVSRAFHS
MLBr_01409|M.leprae_Br4923 AVVTDVDSNTYLDLLGGIAVNVLGHRHPAVIEAVTHQITTLGHTSNLYAT
TH_3529|M.thermoresistible__bu AVVTDADGKSYLDLLGGIAVNILGHRHPAVIEAVTRQLNTLGHTSNLYAT
. : * . :** *.. :. :** :* : *: : .. :
Mb2349c|M.bovis_AF2122/97 DRLGPLGAALAQLCGKD---VVLPMNSDAEAVESGLRVARKWGADVNGLP
Rv2322c|M.tuberculosis_H37Rv DRLGPLGAALAQLCGKD---VVLPMNSDAEAVESGLRVARKWGADVNGLP
MMAR_3622|M.marinum_M DRLGPFCAALSELCGKD---MVLPMNSGAEAVESGLKVARKWGADVKGVP
MUL_1243|M.ulcerans_Agy99 DRLGPFCAALSELCGKD---MVLPMNSGAEAVESGLKVARKWGADVKGVP
MAV_2086|M.avium_104 DKLGPFCAALAYLCDKD---MVLPMNSGAEAVESGLKVARKWGAEVKGVP
Mflv_5071|M.gilvum_PYR-GCK DQLGPFAEALAGLCGKD---MVLPMNSGAEAVESGIKVARKWGTDVKGVS
Mvan_1287|M.vanbaalenii_PYR-1 DRLAPFCAALADLCGKD---MVLPMNSGAEAVESGIKVARKWGVDVKGVK
MSMEG_1413|M.smegmatis_MC2_155 DQLGPFAQALATLCGKD---MILPMNSGAEAVESGIKVARKWGTDVKGVA
MAB_3841|M.abscessus_ATCC_1997 DRLGRFCRDLARLCGKG---MVLPMNTGAEAVESGIKVARKWGTDVKGVP
MLBr_01409|M.leprae_Br4923 EPSITLAEELVALLGADTQTRVFFCNSGTEANELAFKLSRLTG-------
TH_3529|M.thermoresistible__bu EPGVALAEALVGHLGAP--ARVFFCNSGAEANEVAFKISRLTG-------
: : * . :: *:.:** * .::::* *
Mb2349c|M.bovis_AF2122/97 AGRHDIILANNNFHGHTSSVVSFSSDPAAGSGVEPSTPGLRSVPFGDAAA
Rv2322c|M.tuberculosis_H37Rv AGRHDIILANNNFHGHTSSVVSFSSDPAAGSGVEPSTPGLRSVPFGDAAA
MMAR_3622|M.marinum_M EGQANIVVADNNFHGRTISIVSFSSDPVARGGFGPFTPGFRSVPFGDSTA
MUL_1243|M.ulcerans_Agy99 EGQANIVVADNNFHGRTISIVSFSSDPVARGGFGPFTPGFRSVPFGDSTA
MAV_2086|M.avium_104 AGQANIIVADNNFHGRTISIVSFSSDAAARDGFGPFTPGFRSVPFGDAGA
Mflv_5071|M.gilvum_PYR-GCK D--STIIVARNNFHGRTTTIISFSDDDTARRGFGPYTPGFRSVPFGDADA
Mvan_1287|M.vanbaalenii_PYR-1 T--PNIVVAHNNFHGRTTTIISFSDDETARRGFGPYTPGFRSVPFGDADA
MSMEG_1413|M.smegmatis_MC2_155 AGQSNIVVARNNFHGRTTTIISFSDDETARRGFGPYTPGFRSVPFGDAAA
MAB_3841|M.abscessus_ATCC_1997 VDQANIVVAHNNFHGRTISIVSFSSDETARGGFGPFTPGFRIVPFGDAAA
MLBr_01409|M.leprae_Br4923 --RTKLVAAQAAFHGRTMGSLALTGQPAKQAAFEPLPGHVTHVPYGQVDA
TH_3529|M.thermoresistible__bu --RTKVVAAEGGFHGRTMGALALTGQPSKREPFEPLPGDVIHVPYGDAGA
:: * ***:* ::::.: . * . . **:*: *
Mb2349c|M.bovis_AF2122/97 PAQTIDDNTVADLLEPIPGQAGIIVPADDYLPAASSTTC-----------
Rv2322c|M.tuberculosis_H37Rv PAQTIDDNTVADLLEPIPGQAGIIVPADDYLPAASSTTC-----------
MMAR_3622|M.marinum_M LARAIDENTVAVLLEPIQGEAGIVVPPDDYLPDVRALCSEHNVLMIADEI
MUL_1243|M.ulcerans_Agy99 LARAIDENTVAVLLEPIQGEAGIVVPPDDYLPDVRALCSEHNVLMIADEI
MAV_2086|M.avium_104 LAQAIDDNTVAVLLEPIQGEAGIVVPPDDYLPAVRALCSEHNVLMIADEI
Mflv_5071|M.gilvum_PYR-GCK LEQAIDGNTVAVLLEPIQGEAGIIVPPDDYLPRVRALCTEHDVLMIADEI
Mvan_1287|M.vanbaalenii_PYR-1 LAPAVDDDTVAVLIEPIQGEAGIIVPPDDYLPRVRALCTERNVLMIADEI
MSMEG_1413|M.smegmatis_MC2_155 VADAIDDNTVAVLLEPIQGEAGIIVPPPDFLPRVREICTQRNVLMIADEI
MAB_3841|M.abscessus_ATCC_1997 LERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEI
MLBr_01409|M.leprae_Br4923 LAAAVDNDTAAVFLEPIMGESGVIVPPEGYLAAARDITTRHGALLVIDEV
TH_3529|M.thermoresistible__bu LERAVDDTTAAVFLEPIMGEGGVVVPPAGYLAAAREVTARHGALLVLDEV
::* *.* ::**: *:.*:::*. .:*. .
Mb2349c|M.bovis_AF2122/97 --------------------------------------------------
Rv2322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3622|M.marinum_M QSGLGRTGYTFACDYWDVVPDVFLLGKALGGGVVPLSAVVADRDVLGVLN
MUL_1243|M.ulcerans_Agy99 QSGLGRTGYTFACDYWDVVPDVFLLGKALGGGVVPLSAVVADRDVLGVLN
MAV_2086|M.avium_104 QSGLARTGYTFACDRWRVVPDVYLLGKALGGGVVPLSAVVADREILGVLH
Mflv_5071|M.gilvum_PYR-GCK QSGLARTGRTFACDHWGVVPDVYLLGKALGGGVVPLSAVVADRDVLGVLH
Mvan_1287|M.vanbaalenii_PYR-1 QSGLARTGRTFACDHWGVVPDIYLLGKALGGGVLPLSAVVADRDILGVLH
MSMEG_1413|M.smegmatis_MC2_155 QSGLARTGRTFACEHWGVVPDVYLLGKALGGGVVPLSAVVADRDVLGVLH
MAB_3841|M.abscessus_ATCC_1997 QAGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLH
MLBr_01409|M.leprae_Br4923 QTGIGRTGAFFAHQHDSITPDVVTLAKGLGGG-LPIGAFLATGPAAELLT
TH_3529|M.thermoresistible__bu QTGIGRTGTFFAHQHDGITPDVVTLAKGLGGG-LPIGACLAVGPAGDLLT
Mb2349c|M.bovis_AF2122/97 --------------------------------------------------
Rv2322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3622|M.marinum_M PGEHGSTFGGNPLAAAIGTTVVSMLERGEFQSRSAELGARLHARLGALIG
MUL_1243|M.ulcerans_Agy99 PGEHGSTFGGNPLAAAIGTTVVSMLERGEFQSRSAELGARLHARLGALIG
MAV_2086|M.avium_104 PGEHGSTFGGNPLAAAIGTTVVSMLARGEYQARATALGAHLQRRLRALVG
Mflv_5071|M.gilvum_PYR-GCK PGEHGSTFGGNPLAAAIGRTVVDILERGEFQQRATELGAHLQARLSTLTG
Mvan_1287|M.vanbaalenii_PYR-1 PGEHGSTFGGNPLAAAIGSTVVDILRRGEFQRRSTELGAHLHARLNGLKG
MSMEG_1413|M.smegmatis_MC2_155 PGEHGSTFGGNPLATAIGSTVVAMLRRGEFQQRSTELGAHLHARLQDLIG
MAB_3841|M.abscessus_ATCC_1997 PGEHGSTFGGNPLGAAIGSTVVAILERGEFQRRASVLGRHLRTRLDALIG
MLBr_01409|M.leprae_Br4923 LGLHGSTFGGNPVCTAAALAVLRVLATQGLVRRAEVLGDSMRIGIESLSH
TH_3529|M.thermoresistible__bu PGMHGSTFGGNPVCTAAAVAVLGALAEGDLINRADVLGKKLSHGIEELRH
Mb2349c|M.bovis_AF2122/97 --------------------------------------------------
Rv2322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3622|M.marinum_M EGVLEVRGLGLWAGVDVDPALATGKEISLRLADRGVLVKDTHGSTLRFAP
MUL_1243|M.ulcerans_Agy99 EGVLEVRGLGLWAGVDVDPALATGKEISLRLADRGVLVKDTHGSTLRFAP
MAV_2086|M.avium_104 HGVDEVRGLGLWAGVDIDPSLGSGRQMSLRLAERGVLVKDTHGATLRFAP
Mflv_5071|M.gilvum_PYR-GCK RGVVAVRGKGLWAGVDIDPAHGTGKQISLRLAERGVLVKDTHGSTLRFAP
Mvan_1287|M.vanbaalenii_PYR-1 RGVLAVRGRGLWAGVDIDPAHGTGKQVSLRLAERGVLVKDTHGSTLRFAP
MSMEG_1413|M.smegmatis_MC2_155 RGVLAVRGRGLWAGVDIDPALGTGKELSVALAERGVLVKDTHGSTLRFAP
MAB_3841|M.abscessus_ATCC_1997 HGVTEVRSLGLWAGVDIDPNLATGRQIGLRMAEFGVLVKDTHGATLRFAP
MLBr_01409|M.leprae_Br4923 PLIDQVRGRGLLLGIVLTAPRAKDIEKAAR--DAGFLVNATAPEVIRLAP
TH_3529|M.thermoresistible__bu PLVDHVRGRGLLCGVVLNAPQAKAAEAAAR--DAGFLVNAAAPEVIRLAP
Mb2349c|M.bovis_AF2122/97 -------------------------------
Rv2322c|M.tuberculosis_H37Rv -------------------------------
MMAR_3622|M.marinum_M PLVITAQEIDWAVRQFAAVLREAGS------
MUL_1243|M.ulcerans_Agy99 PLVITAQEIDWAVRQFAAVLREAGS------
MAV_2086|M.avium_104 PLVVTAQEIDWAVGQLAAVLREAAS------
Mflv_5071|M.gilvum_PYR-GCK PLVITADEIDWAVARLEEVLT----------
Mvan_1287|M.vanbaalenii_PYR-1 PLVITADEIDWAIDRFAEVLGR---------
MSMEG_1413|M.smegmatis_MC2_155 PLVVTSEEIDWAVDRFADTLAEVRR------
MAB_3841|M.abscessus_ATCC_1997 PLVITEGEIDWAVDQFADALASFR-------
MLBr_01409|M.leprae_Br4923 PLIITESQIDSFITALPGILDASIAELGKKA
TH_3529|M.thermoresistible__bu PLIITETQIDEFLAALPGVLDTAKEAS----