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LREEDQIITRPAEDELADIARRLYEAEQNRTPIRQLSLDYPGMTIEDAYAVQRELVALKVADGRVVKGRK IGLTSKVMQRAVSIDEPDYGALFDDMFIEDGGSVPLRRFIRPRVEVELAFVLGDELRGPGVTLFDVLRAT EFVTPALEVLDARVQMSDPETGHLRTIVDTIADNAADAGLVLGGRVVRPLDVDLRWVAALLLRNGVIEES GVAAAVLNHPGNGVAWLANRLSPHGVSLQPGEVILSGSFTKPVFAEPGDTFVADYGPLGTVSVSFGDEAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1906 | hpaH | - | 100% (280) | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase |
| M. avium 104 | MAV_2617 | hpaH | e-140 | 90.84% (273) | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase |
| M. avium 104 | MAV_0625 | - | 6e-55 | 43.41% (258) | 2-keto-4-pentenoate hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3566c | - | 8e-55 | 44.19% (258) | hydratase |
| M. gilvum PYR-GCK | Mflv_1520 | - | 2e-53 | 43.19% (257) | 4-oxalocrotonate decarboxylase |
| M. tuberculosis H37Rv | Rv3536c | - | 8e-55 | 44.19% (258) | hydratase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0624 | - | 8e-48 | 40.47% (257) | hydratase/decarboxylase |
| M. marinum M | MMAR_5023 | - | 2e-52 | 43.19% (257) | 2-keto-4-pentenoate hydratase |
| M. smegmatis MC2 155 | MSMEG_5940 | - | 3e-52 | 41.29% (264) | 2-keto-4-pentenoate hydratase |
| M. thermoresistible (build 8) | TH_0369 | - | 1e-51 | 41.63% (257) | PROBABLE HYDRATASE |
| M. ulcerans Agy99 | MUL_4097 | - | 3e-53 | 42.65% (272) | 2-keto-4-pentenoate hydratase |
| M. vanbaalenii PYR-1 | Mvan_0595 | - | 5e-58 | 46.18% (262) | 4-oxalocrotonate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5940|M.smegmatis_MC2_155 --------------------------------------------------
TH_0369|M.thermoresistible__bu --------------------------------------------------
Mflv_1520|M.gilvum_PYR-GCK --------------------------------------------------
Mb3566c|M.bovis_AF2122/97 --------------------------------------------------
Rv3536c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5023|M.marinum_M --------------------------------------------------
MUL_4097|M.ulcerans_Agy99 MRRQGQPPCRRRRFRPRRRRSPVMSCRTRYRIARVGRYWPGHHDARKTRG
MAB_0624|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_1906|M.avium_104 --------------------------------------------MREEDQ
Mvan_0595|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5940|M.smegmatis_MC2_155 ---MLSDEVRARLAADLAQAERSRQPITPLTDGNPDIDVVDAYEIQLINI
TH_0369|M.thermoresistible__bu ---MLSAQVREQLAAELAQAERSRVPITPLTDRHPGIDVVDAYEIQLINI
Mflv_1520|M.gilvum_PYR-GCK ---MLPAEVREKLAADLAEAEQSRKPISPLTDAHPDIDVVDAYEIQLINI
Mb3566c|M.bovis_AF2122/97 ---MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLINI
Rv3536c|M.tuberculosis_H37Rv ---MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLINI
MMAR_5023|M.marinum_M ---MLADSTRDKIAADLAQAERSRQPITPLTPSYPDIDVVDAYQIQLINI
MUL_4097|M.ulcerans_Agy99 LREMLADSTRDKIAADLAQAERSRQPITPLTPSYPDIDVVDAYQIQLINI
MAB_0624|M.abscessus_ATCC_1997 ---MLSSEVRDSIAADLAEAERTRVAIAPPTDTHPDFDVVDAYEIQLMNI
MAV_1906|M.avium_104 IITRPAEDELADIARRLYEAEQNRTPIRQLSLDYPGMTIEDAYAVQRELV
Mvan_0595|M.vanbaalenii_PYR-1 -MTMP-RDLIEHAADLLAVADADAAPIGQLTQRYPQMDIADAYAIQQVNL
* * *: .* : * : : *** :* :
MSMEG_5940|M.smegmatis_MC2_155 RQRIAEGAKVVGHKVGLSSKAMQEMMGVDEPDYGHLLDDMQVYEDQPVKS
TH_0369|M.thermoresistible__bu RQRVAEGARVVGHKVGLSSEAMQKMMGVDEPDYGHLLDDMQVFEDKPVKS
Mflv_1520|M.gilvum_PYR-GCK RRRVADGARIIGHKVGLSSEAMQKMMGVDEPDYGHLLEEMQVFEDVPVGS
Mb3566c|M.bovis_AF2122/97 RQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQA
Rv3536c|M.tuberculosis_H37Rv RQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQA
MMAR_5023|M.marinum_M RRRVAEGGRVVGHKVGLSSPVMQQMMGVDEPDYGHLLDNMRVFEDAPVRT
MUL_4097|M.ulcerans_Agy99 RRRVAEGGRVVGHKVGLSSPVMQQMMGVDEPDYGHLLDNMRVFEDAPVRT
MAB_0624|M.abscessus_ATCC_1997 RSRLADGAKVVGHKVGLSSEAMQKMMGVHEPDYGHLLADMELFEDVAASA
MAV_1906|M.avium_104 ALKVADGRVVKGRKIGLTSKVMQRAVSIDEPDYGALFDDMFIEDGGSVPL
Mvan_0595|M.vanbaalenii_PYR-1 AKRVDQGRIVVGRKIGLTSEPMQTLLGVDQPDFGYLLDDMVVPSGATLPR
:: :* : *:*:**:* ** :.:.:**:* *: :* : .. .
MSMEG_5940|M.smegmatis_MC2_155 ANYLYPRVEVEVGFILADDLPGAGCTEEDVLAATAAFAPAIELIDTRITN
TH_0369|M.thermoresistible__bu ANYLYPRVEVEVGFILAADLPGADCTEEDVLAATEAFAPAIELIDTRITD
Mflv_1520|M.gilvum_PYR-GCK GRYLYPRVEVEVGFILSDDLPGAGCTEDDVLAATAAFAPAIELIDTRITN
Mb3566c|M.bovis_AF2122/97 SRYLSPRVEVEVGFILAADLPGAGCTEDDVLAATEALVPAIELIDTRIKD
Rv3536c|M.tuberculosis_H37Rv SRYLSPRVEVEVGFILAADLPGAGCTEDDVLAATEALVPAIELIDTRIKD
MMAR_5023|M.marinum_M ANYLYPRVEVEVGFILAADLPGADCTEDDVLAATEALVPSIELIDTRIKD
MUL_4097|M.ulcerans_Agy99 ANYLYPRVEVEVGFILAADLPGADCTEDDVLAATEALVPSIELIDTRIKD
MAB_0624|M.abscessus_ATCC_1997 SKFLFPRVEVEVGFILAADLPGEDCTEDDVLAATAAYVPSIEVVDSRITN
MAV_1906|M.avium_104 RRFIRPRVEVELAFVLGDELRGPGVTLFDVLRATEFVTPALEVLDARVQM
Mvan_0595|M.vanbaalenii_PYR-1 NRFCAPRVEPEVAFLLDQPLRGPGITVQQVRAATAAVAAALEIVDSRIAE
.: **** *:.*:* * * . * :* ** ..::*::*:*:
MSMEG_5940|M.smegmatis_MC2_155 WQ------IKLCDTIADNASSAGWVLGEARVSPKDIDIRNIDAVLKNNGE
TH_0369|M.thermoresistible__bu WK------IKLCDTIADNASSAGWVLGEARVSPEEIDITTIEATLTNNGE
Mflv_1520|M.gilvum_PYR-GCK WQ------IKLCDTIADNASSAGWVLGEARVSPKDVDIRAIDAVLTNNGE
Mb3566c|M.bovis_AF2122/97 WQ------IKICDTIADNASAAGFVLGAARVPPADLDVRAIDAKLTRNGE
Rv3536c|M.tuberculosis_H37Rv WQ------IKICDTIADNASAAGFVLGAARVPPADLDVRAIDAKLTRNGE
MMAR_5023|M.marinum_M WQ------IKICDTIADNASAAGFVLGAARVSPAEVDVKAIDAVLTRNGE
MUL_4097|M.ulcerans_Agy99 WQ------IKICDTIADNASAAGFVLGAARVSPAEVDVKAIDAVLTRNGE
MAB_0624|M.abscessus_ATCC_1997 WQ------IKICDTIADNASSAGFVVGKQRVSPKDIDIKSIDAVLTCNGE
MAV_1906|M.avium_104 SDPETGHLRTIVDTIADNAADAGLVLGGRVVRPLDVDLRWVAALLLRNGV
Mvan_0595|M.vanbaalenii_PYR-1 WK------LTLCDTVADNASSGAVVLGPWLPFTDDIDLASARASLCLNGT
. .: **:****: .. *:* . ::*: * * **
MSMEG_5940|M.smegmatis_MC2_155 VVAEGRSDAVLGNPVTAVAWLARKVESFGVRLKAGDIVLPGSCTRAIDAP
TH_0369|M.thermoresistible__bu VVAQGRSDAVLGNPVTAVAWLARKVDSFGVRLKAGDIVLPGSCTRAIDAP
Mflv_1520|M.gilvum_PYR-GCK VVAEGRSDAVLGNPVTAVAWLARKVEAFGVRLKAGDIVLPGSCTRAIDAP
Mb3566c|M.bovis_AF2122/97 VVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAVEAR
Rv3536c|M.tuberculosis_H37Rv VVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAVEAR
MMAR_5023|M.marinum_M LAAEGRSDAVLGNPATAVAWLARKVEGFGVRLRKGDIVLPGSCTFAVDAN
MUL_4097|M.ulcerans_Agy99 LAAEGRSDAVLGNPATAVAWLARKVEGFGVRLRKGDIVLPGSCTFAVDAN
MAB_0624|M.abscessus_ATCC_1997 KLAEGRSDAVLGNPVTSVAWLARKVASFGVRLRAGDVVLPGSCTRAFDAH
MAV_1906|M.avium_104 IEESGVAAAVLNHPGNGVAWLANRLSPHGVSLQPGEVILSGSFTKPVFAE
Mvan_0595|M.vanbaalenii_PYR-1 EIDTGLGSAVLGDPAAAVAWLANALAPFGVALQPGQFVMSGSFTTAAFVE
* . ***..* .***** : .** *: *:.::.** * . .
MSMEG_5940|M.smegmatis_MC2_155 AGSDFVADFAGLGSVHLRFE----
TH_0369|M.thermoresistible__bu AGSHFVADFSGLGSVQLSFE----
Mflv_1520|M.gilvum_PYR-GCK PGSRFVADFTGLGSVRLDFE----
Mb3566c|M.bovis_AF2122/97 AGDEFVADFTGLGLVRLSFE----
Rv3536c|M.tuberculosis_H37Rv AGDEFVADFTGLGLVRLSFE----
MMAR_5023|M.marinum_M AGDEFVADFTGLGSVRLSFQ----
MUL_4097|M.ulcerans_Agy99 AGDEFVADFTGLGSVRLSFQ----
MAB_0624|M.abscessus_ATCC_1997 PGDEFLAEFAGLGSVRLAFE----
MAV_1906|M.avium_104 PGDTFVADYGPLGTVSVSFGDEAS
Mvan_0595|M.vanbaalenii_PYR-1 PGDDASAAVSGLGTVSVTFT----
.*. * ** * : *