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M. avium 104 MAV_0709 (-)

annotation: short chain dehydrogenase
coordinates: 683360 - 684187
length: 275

PRFDPLPERRPAIVAGASSGIGEATAIELAAHGFPVALGARRVEKLNDIVGKINADGGEAVGFHLDVTDP
NSVKSFVAQAVDALGDIEVLVAGAGDTYFGKLAEIAGDEFESQLQIHLVGAFRLASAVLPGMLERQRGDL
IFVGSDVALRQRPHMGAYGAAKAALVAMVNNFQMELEGTGVRASVVHPGPTKTAMGWSLPAEKIGPALED
WAKWGQARHDYFLRAADLARAITFVAETPRGGFIANMELQPEAPLADNKDRQKLALGEEGMPGQ*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_0709 - - 100% (275) short chain dehydrogenase
M. avium 104 MAV_3227 - 2e-23 32.98% (191) oxidoreductase, short-chain dehydrogenase/reductase family
M. avium 104 MAV_5221 - 4e-23 34.92% (189) NAD dependent epimerase/dehydratase family protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0788c - 1e-112 72.73% (275) short chain dehydrogenase
M. gilvum PYR-GCK Mflv_1597 - 1e-134 84.98% (273) short chain dehydrogenase
M. tuberculosis H37Rv Rv0765c - 1e-112 72.73% (275) short chain dehydrogenase
M. leprae Br4923 MLBr_00429 - 4e-24 35.03% (197) putative oxidoreductase
M. abscessus ATCC 19977 MAB_1215c - 1e-110 69.34% (274) short chain dehydrogenase
M. marinum M MMAR_4931 - 1e-125 81.48% (270) short-chain alcohol dehydrogenase
M. smegmatis MC2 155 MSMEG_5862 - 1e-127 81.09% (275) short chain dehydrogenase
M. thermoresistible (build 8) TH_1257 - 1e-122 80.74% (270) short chain dehydrogenase
M. ulcerans Agy99 MUL_0474 - 1e-122 80.00% (270) short chain dehydrogenase
M. vanbaalenii PYR-1 Mvan_5160 - 1e-129 83.46% (272) short chain dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0788c|M.bovis_AF2122/97           MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAEL
Rv0765c|M.tuberculosis_H37Rv        MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAEL
MAB_1215c|M.abscessus_ATCC_199      MPRFEPHPARRPSIIAGASSGIGAATAIELAGRGFPVALGARRVDKLTEL
Mflv_1597|M.gilvum_PYR-GCK          MPRFDPLPDRRPALVAGASSGIGEATAIRLAANGFPVALGARRVEKLEEI
Mvan_5160|M.vanbaalenii_PYR-1       MPRFDPLPDRRPALVAGASSGIGEATAIALAAHGFPVALGARRVEKCQEI
MAV_0709|M.avium_104                MPRFDPLPERRPAIVAGASSGIGEATAIELAAHGFPVALGARRVEKLNDI
MMAR_4931|M.marinum_M               MPRFQPHPDRRPAIVAGASSGIGAATAVELAAHGFPVALGARRVQKCEEI
MUL_0474|M.ulcerans_Agy99           MPRFQPHPDRRPAIVAGASPGIGAATAVDLAAHGFPDALGARRVQKCEKI
TH_1257|M.thermoresistible__bu      MPRFDPHPERRPAIVAGASSGIGAATAKELAARGFPVALGARRVEKCEEL
MSMEG_5862|M.smegmatis_MC2_155      MARFEPHPARRPAIVAGASSGIGAATATELAAHGFPVALGARRVEKCQEL
MLBr_00429|M.leprae_Br4923          MPIPAPSPEAR-AVVTGASQNIGEALATELAAHGHSLIVIARREDVLVDL
                                    *.   * *  * ::::*** .** * *  **..*..  : *** :   .:

Mb0788c|M.bovis_AF2122/97           VDKIRADGGEAVAF-PLDVTDPESVKSFVAQTVEALGEVELLVSSAGDML
Rv0765c|M.tuberculosis_H37Rv        VDKIRADGGEAVAF-PLDVTDPESVKSFVAQTVEALGEVELLVSSAGDML
MAB_1215c|M.abscessus_ATCC_199      VEKIRSDGGEAVAF-PLDVTDADSVKSFVAESIDALGEIDLLVSGAGDMY
Mflv_1597|M.gilvum_PYR-GCK          VGKIRADGGEAIAV-HLDVTEPDSVKAAVEQTTSQLGDIEVLVAGAGDTY
Mvan_5160|M.vanbaalenii_PYR-1       VDKIRADGGEAIAV-HLDVTDPDSVKSAVEQTTVELGEIEVLVAGAGDTY
MAV_0709|M.avium_104                VGKINADGGEAVGF-HLDVTDPNSVKSFVAQAVDALGDIEVLVAGAGDTY
MMAR_4931|M.marinum_M               VEKIRADGGDAVAL-ALDVTDADSVKDFVHQATERLGDIEVLVAGAGDTY
MUL_0474|M.ulcerans_Agy99           VEKIRADGGDAVAL-ALDVTDADSVKDFVHQATERLGDIEVLVAGAGDTY
TH_1257|M.thermoresistible__bu      VEQIRADGGEAVAL-HLDVTDPDSVKSFVHGAAEKLGDIEVLVAGAGDTF
MSMEG_5862|M.smegmatis_MC2_155      VDQITARGGEAVAL-PLDVTDADSVKSFVHAATEALGDIEVLIAGAGDTD
MLBr_00429|M.leprae_Br4923          AARLADKYRVAVEVRPADLTDPSERVKLADELTVRP--ISILCANAGTAT
                                    . ::      *: .   *:*:...    .         :.:* :.**   

Mb0788c|M.bovis_AF2122/97           PGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVG
Rv0765c|M.tuberculosis_H37Rv        PGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVG
MAB_1215c|M.abscessus_ATCC_199      PGRVHEMSAATFAAQIQVHLLGANQLATEVVPDMVSRRRGDVVFIGSDVA
Mflv_1597|M.gilvum_PYR-GCK          FGKLDSISTEQFESQIQIHLIGANRVAGAVLPGMIERRRGDLIFVGSDVA
Mvan_5160|M.vanbaalenii_PYR-1       FGKLDAISTEEFESQIQIHLIGANRVATAVLPGMIERRRGDLIFVGSDVA
MAV_0709|M.avium_104                FGKLAEIAGDEFESQLQIHLVGAFRLASAVLPGMLERQRGDLIFVGSDVA
MMAR_4931|M.marinum_M               FGRLYEIDTETFESQVQIHLIGANRLATAVLPGMLERQRGDLIFVGSDVA
MUL_0474|M.ulcerans_Agy99           FGRLYEIDTETFESQVQIHLIGANRLATAVLPGMLERQRGDLIFVGSDVA
TH_1257|M.thermoresistible__bu      FGRLHEISTEEFESQVQIHLIGANRLATAVLPGMVERRRGDLIFVGSDVA
MSMEG_5862|M.smegmatis_MC2_155      FGRLHEISTEEFEQQVQIHLIGANRMATAVLPGMVERRRGDVIFVGSDVS
MLBr_00429|M.leprae_Br4923          FGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAG
                                     * :  :       *:*:: :..  ::  *:* *: *: *.::: ** ..

Mb0788c|M.bovis_AF2122/97           LRQRPHMGAYGAAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQ
Rv0765c|M.tuberculosis_H37Rv        LRQRPHMGAYGAAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQ
MAB_1215c|M.abscessus_ATCC_199      LHQRPHMGAYGAAKAALLAMVNTMRMELEGTGVRASIVHPGPTLTSMGWQ
Mflv_1597|M.gilvum_PYR-GCK          LRQRPHMGAYGAAKAALVAMVTNYQMELEGTGVRASIVHPGPTKTSMGWS
Mvan_5160|M.vanbaalenii_PYR-1       LRQRPHMGAYGAAKAALVAMVTNYQMELEGTGVRASIVHPGPTKTAMGWS
MAV_0709|M.avium_104                LRQRPHMGAYGAAKAALVAMVNNFQMELEGTGVRASVVHPGPTKTAMGWS
MMAR_4931|M.marinum_M               LRQRPHMGAYGAAKAALVAMVTNLQMELEGTGLRASIVHPGPTKTAMGWS
MUL_0474|M.ulcerans_Agy99           LRQRPHMGAYGAAKAALVAMVTNLQMELEGTGLRASIVHPGRTKTAMGWS
TH_1257|M.thermoresistible__bu      LRQRPHMGGYGAAKAGLLAMVHNLQMELEGTGVRASIVHPGPTKTAMGWS
MSMEG_5862|M.smegmatis_MC2_155      LRQRPHMGAYGAAKAGLLAMVNNLQMELEGTGVRASIVHPGPTRTSMGWS
MLBr_00429|M.leprae_Br4923          NSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRTELPDH
                                        *: . *.*:**   ::  . : **.*:*::.::: ** . * :   

Mb0788c|M.bovis_AF2122/97           LSAEQVGPMLADWAKWGQARHNYFLRPSDLAR-AIAFVAETPRGCVVVNM
Rv0765c|M.tuberculosis_H37Rv        LSAEQVGPMLADWAKWGQARHNYFLRPSDLAR-AIAFVAETPRGCVVVNM
MAB_1215c|M.abscessus_ATCC_199      LSAEQVGPMLEDWKSWGQARHSYFLRPSDIAR-AVTFVAETPRGAHIPEM
Mflv_1597|M.gilvum_PYR-GCK          LPAELIGPALEDWAKWGQARHDYFLRADDLAR-AITFVAETPRGGFIANM
Mvan_5160|M.vanbaalenii_PYR-1       LPAELIGPALEDWAKWGQARHDYFLRAADLAR-AITFVAETPRGGFIASM
MAV_0709|M.avium_104                LPAEKIGPALEDWAKWGQARHDYFLRAADLAR-AITFVAETPRGGFIANM
MMAR_4931|M.marinum_M               LPVESIGPALEDWAKWGQARHDYFLRASDIAR-AITFVAETPRGGFVANM
MUL_0474|M.ulcerans_Agy99           LPVESIGPALEDWAKWGQARHDYFLRASDIAR-AITFVAETPRGGFVANM
TH_1257|M.thermoresistible__bu      LPPDRIEQALNDWAKWGQARHDYFLRASDLAR-AIAFVAETPRGGFIANM
MSMEG_5862|M.smegmatis_MC2_155      LPAEKIGPALEDWAKWGQARHDYFLRAADLAR-AITFVAETPRGGFIANL
MLBr_00429|M.leprae_Br4923          DEASLVEKLVPDFL-WISTEHTARLSLDALERNKMRVVPGLTSKAMSVAS
                                       . :   : *:  * .:.*   *    : *  : .*.  .        

Mb0788c|M.bovis_AF2122/97           EIQPEAPLRDAPAHRQKLVLGEEGMPG-
Rv0765c|M.tuberculosis_H37Rv        EIQPEAPLRDAPAHRQKLVLGEEGMPG-
MAB_1215c|M.abscessus_ATCC_199      EVQPEAPLKDAPADKQKLELGEEGMPS-
Mflv_1597|M.gilvum_PYR-GCK          ELQPEAPLSEAKD-RQKLALGEEGMPS-
Mvan_5160|M.vanbaalenii_PYR-1       ELQPEAPLASVKD-RQQLKVDKEALNS-
MAV_0709|M.avium_104                ELQPEAPLADNKD-RQKLALGEEGMPGQ
MMAR_4931|M.marinum_M               ELQPEAPLAATTN-RQQLKVDEKAKDS-
MUL_0474|M.ulcerans_Agy99           ELQPEAPLAATTN-RQQLKVDEKAKDS-
TH_1257|M.thermoresistible__bu      ELQPEAPLADAPKERQQLTYPETS----
MSMEG_5862|M.smegmatis_MC2_155      EIQPEAPLAEVTD-RQKLALGEEGMPNQ
MLBr_00429|M.leprae_Br4923          RYAPRAIVASIVG-NFYKKLGGG-----
                                    .  *.* :      .

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_0709	-	-	100% (275)	short chain dehydrogenase
M. avium 104	MAV_3227	-	2e-23	32.98% (191)	oxidoreductase, short-chain dehydrogenase/reductase family
M. avium 104	MAV_5221	-	4e-23	34.92% (189)	NAD dependent epimerase/dehydratase family protein