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MLLSPPTAPAPPRAERGRWYALSVACLIEMLLVINSSIVAAALPATQAALRFTNSDRQWLITAYVLTLGG LLLLGGRVADMVGLRSAMIIGLSGFAIASFVGGSATNFGELVASRISQGVFGALLAPAAMSLVANSFRGS TAERHAFGIFGAVIGAASTAGLLVGGVLTQLLVWRWVMYISVLMTMTALAGTLAFVRKYPVGQRSKLDLF GSLTVTLGLFAIVFGFSRAEVRGWTASIAILSFITGLTLIGVFIRHQQRSKNPLLPLRVVCDRTRGAAFL AMFFASAGLFGVVLSLLYYLQRCLHLAPLWAGVAFLPFSATVVFASTLGNSFILPRLDGRTVLIAGGVTS AFGLLMLSHIDSHANYYTAILPGLVIGGFGKGLIFGASTHGAATGIRPEESGIASATVNVMHHVGGSLGA ALLSSVVASTATFFLARHASSDQAAAAGYSAAFWVSAASCLAAAAIALVIRPADGNSRTAPVLRGKCCTA RD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4500 | - | - | 100% (492) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_3142c | - | 2e-58 | 31.39% (462) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 2e-50 | 30.42% (424) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2871c | efpA | 7e-56 | 30.65% (447) | integral membrane efflux protein EfpA |
| M. gilvum PYR-GCK | Mflv_4046 | - | 3e-60 | 32.08% (452) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2846c | efpA | 7e-56 | 30.65% (447) | integral membrane efflux protein EfpA |
| M. leprae Br4923 | MLBr_01562 | - | 5e-53 | 31.03% (435) | putative transmembrane efflux protein |
| M. marinum M | MMAR_1887 | efpA | 1e-52 | 29.89% (455) | integral membrane efflux protein EfpA |
| M. avium 104 | MAV_3702 | - | 1e-54 | 30.18% (454) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_2619 | - | 2e-59 | 33.12% (465) | efflux protein |
| M. thermoresistible (build 8) | TH_2858 | - | 1e-59 | 32.75% (455) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_2115 | efpA | 1e-51 | 29.67% (455) | integral membrane efflux protein EfpA |
| M. vanbaalenii PYR-1 | Mvan_2306 | - | 4e-60 | 31.43% (455) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1887|M.marinum_M MTALNDTER-AVHNWTSGRQERPTSARATR--------ETETASER----
MUL_2115|M.ulcerans_Agy99 MTALNDTER-AVHNWTSGRQERPTSARATR--------ETETASER----
MAV_3702|M.avium_104 MTALNDSER-AVQNWTSARPDRPAPVRSTPPAETAPKPAAETAVKR----
Mb2871c|M.bovis_AF2122/97 MTALNDTER-AVRNWRAGRPHRPAPMRPPR--------SEETASER----
Rv2846c|M.tuberculosis_H37Rv MTALNDTER-AVRNWTAGRPHRPAPMRPPR--------SEETASER----
MLBr_01562|M.leprae_Br4923 MVTLYDHER-AVHNWTAARSDRPAPSRLTQ--------QVEPASER----
Mflv_4046|M.gilvum_PYR-GCK MTALNDAERAAIQRDAEGRGKRGSDRASGRALPARVTGSGESAGGRGGDA
Mvan_2306|M.vanbaalenii_PYR-1 MTALNDAERAAIQRDAEGSGKRGSGRASDRALPARIPGLGETAGGRGGDG
TH_2858|M.thermoresistible__bu ---------------MEG--------------------------------
MSMEG_2619|M.smegmatis_MC2_155 MTALNDAERAAARVGLAAR-------------------------------
MAB_4500|M.abscessus_ATCC_1997 -MLLSPPTAPAPPRAERGR-------------------------------
.
MMAR_1887|M.marinum_M -ASRYYPTWLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQD
MUL_2115|M.ulcerans_Agy99 -ASRYYPTWLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQD
MAV_3702|M.avium_104 -TSKYYPAWLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPRIQN
Mb2871c|M.bovis_AF2122/97 -PSRYYPTWLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQN
Rv2846c|M.tuberculosis_H37Rv -PSRYYPTWLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQN
MLBr_01562|M.leprae_Br4923 -TSK-YPTLLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQN
Mflv_4046|M.gilvum_PYR-GCK GRRGRTPAWMPSR-----RFFAAVIAIGGMQLLATMDSTIAIVALPKIQD
Mvan_2306|M.vanbaalenii_PYR-1 ARAGRTPAWVPSR-----RFFAAVIAIGGMQLLATMDSTIAIVALPKIQD
TH_2858|M.thermoresistible__bu --ANKLPTWLPSR-----RFIAAVFAIGGMQLLATMDSTIAIVALPRIQD
MSMEG_2619|M.smegmatis_MC2_155 -----LPSWFPSWG-----FLSAVIAIGGMQLLATMDSTVAIVALPKIQD
MAB_4500|M.abscessus_ATCC_1997 --------------------WYALSVACLIEMLLVINSSIVAAALPATQA
*: . :::* .::*::. .*** *
MMAR_1887|M.marinum_M ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
MUL_2115|M.ulcerans_Agy99 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
MAV_3702|M.avium_104 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
Mb2871c|M.bovis_AF2122/97 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
Rv2846c|M.tuberculosis_H37Rv ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
MLBr_01562|M.leprae_Br4923 ELSLSDAGRSWGITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIS
Mflv_4046|M.gilvum_PYR-GCK ELGLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTIA
Mvan_2306|M.vanbaalenii_PYR-1 ELNLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVTLFTIA
TH_2858|M.thermoresistible__bu ELNLTDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVTLFTIA
MSMEG_2619|M.smegmatis_MC2_155 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVMLFTIA
MAB_4500|M.abscessus_ATCC_1997 ALRFTNSDRQWLITAYVLTLGGLLLLGGRVADMVGLRSAMIIGLSGFAIA
* ::::.*.* *******:***:*****:.* :* : ::*:*: *:*:
MMAR_1887|M.marinum_M SVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATA
MUL_2115|M.ulcerans_Agy99 SVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPTRNAATA
MAV_3702|M.avium_104 SVLCAVAWDEATMVIARLSQGVGSAIASPTGLALVATTFPKGPARNFATA
Mb2871c|M.bovis_AF2122/97 SVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATA
Rv2846c|M.tuberculosis_H37Rv SVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATA
MLBr_01562|M.leprae_Br4923 SVLCAVAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATA
Mflv_4046|M.gilvum_PYR-GCK SVLCGIAWDEATLVIARLLQGVGAAIASPTALALIATTFPKGPARNAATA
Mvan_2306|M.vanbaalenii_PYR-1 SVLCGIAWDEATLVIARLLQGVGAAIASPTALALIATTFPKGPARNAATA
TH_2858|M.thermoresistible__bu SVLCGIAWDEATLVIARLLQGVGAAIASPTGLALVATTFPKGPARNAATA
MSMEG_2619|M.smegmatis_MC2_155 SVLCGIAWNETTLVTARLLQGVGAAIASPTGLALVATTFPKGPARNAATA
MAB_4500|M.abscessus_ATCC_1997 SFVGGSATNFGELVASRISQGVFGALLAPAAMSLVANSFRGSTAERHAFG
*.: . * : :* :*: **: .*: :*:.::*:*.:* ..:.. * .
MMAR_1887|M.marinum_M VFAAMTAVGSVMGLVVGGALTEVS-WRLAFMVNVPIGLVMIYLARTALRE
MUL_2115|M.ulcerans_Agy99 VFAAMTAVGSVMGLVVGGALTEVS-WRLAFMVNVPIGLVMIYLARTALRE
MAV_3702|M.avium_104 VFAAMTAVGSVMGLVVGGALTEVS-WRLAFLVNVPIGLVMMYLARTALRE
Mb2871c|M.bovis_AF2122/97 VFAAMTAIGSVMGLVVGGALTEVS-WRWAFLVNVPIGLVMIYLARTALRE
Rv2846c|M.tuberculosis_H37Rv VFAAMTAIGSVMGLVVGGALTEVS-WRWAFLVNVPIGLVMIYLARTALRE
MLBr_01562|M.leprae_Br4923 VFAAMTAIGSVMGLVVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHE
Mflv_4046|M.gilvum_PYR-GCK VFAAMTGVGSVMGLVVGGALTEVS-WRLAFLVNVPIGLIMIYLARKTLRE
Mvan_2306|M.vanbaalenii_PYR-1 VFAAMTGVGSVMGLVVGGALTEVS-WRLAFLVNVPIGLIMIYLARKTLRE
TH_2858|M.thermoresistible__bu VFAAMTGVGSVMGLVVGGALTEVS-WRLAFLVNVPIGLLVIYLARRTLRE
MSMEG_2619|M.smegmatis_MC2_155 VFGAMTAIGSVMGLVVGGALTEVS-WRWAFLVNVPIGLVMVYLARTALQE
MAB_4500|M.abscessus_ATCC_1997 IFGAVIGAASTAGLLVGGVLTQLLVWRWVMYISVLMTMTALAGTLAFVRK
:*.*: . .*. **:***.**:: ** .: :.* : : : : :::
MMAR_1887|M.marinum_M TNR-ERMKLDAAGAILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFA
MUL_2115|M.ulcerans_Agy99 TNR-ERMKLDAAGAILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFA
MAV_3702|M.avium_104 TNR-ERMKLDATGAVLATLACTAAVFAFSMGPEKGWISLTTISSGVVALG
Mb2871c|M.bovis_AF2122/97 TNK-ERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALA
Rv2846c|M.tuberculosis_H37Rv TNK-ERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALA
MLBr_01562|M.leprae_Br4923 THK-ERMKLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALV
Mflv_4046|M.gilvum_PYR-GCK TNR-ERLKLDAAGALLATMGCTAAVFGFSMGPEAGWMSPVTIGSGIAAVG
Mvan_2306|M.vanbaalenii_PYR-1 TNK-ERLKLDAAGALLATMGCTAAVFAFSMGPESGWASPVTVASAVAAVG
TH_2858|M.thermoresistible__bu THR-ERLKLDAAGAILATLGCTAAVFAFSMGPERGWASVITIATGAAALV
MSMEG_2619|M.smegmatis_MC2_155 TNR-ERMKLDAAGALLATLACTAAVFAFTQGPESGWLAPITLASGAAALV
MAB_4500|M.abscessus_ATCC_1997 YPVGQRSKLDLFGSLTVTLGLFAIVFGFSRAEVRGWTASIAILSFITGLT
:* *** *:: .*:. * **.*: . ** : :: : ...
MMAR_1887|M.marinum_M AALGFVLVERTAENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGL
MUL_2115|M.ulcerans_Agy99 AALGFVLVERTAENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGL
MAV_3702|M.avium_104 AALAFVIVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVMFTLTVCIGL
Mb2871c|M.bovis_AF2122/97 AAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGL
Rv2846c|M.tuberculosis_H37Rv AAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGL
MLBr_01562|M.leprae_Br4923 AAIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGL
Mflv_4046|M.gilvum_PYR-GCK CLIAFLWVERTAENPVVPFELFLDRNRVATFAAVFLAGGVMFTLTVTIGL
Mvan_2306|M.vanbaalenii_PYR-1 CLLAFLWVERTAENPVVPFALFHDRNRVATFAAVFLAGGVMFTLTVTIGL
TH_2858|M.thermoresistible__bu FLLAFLYVERTADNPVVPFSLFRDRNRVATFGAIFLAGGVMFTLTVLIGL
MSMEG_2619|M.smegmatis_MC2_155 FGLAFLIAERNAENPVVPFALFRERNRVATFAAIFLAGGVLFTLTVLIGL
MAB_4500|M.abscessus_ATCC_1997 LIGVFIRHQQRSKNPLLPLRVVCDRTRGAAFLAMFFASAGLFGVVLSLLY
* :: :.**::*: :. :*.* .:* *:::*.. :* :.: :
MMAR_1887|M.marinum_M YVQDVLGYSALRAGVGFIPFVIAMGIGLGVS-SQLVSRFSPRVLTIGGGY
MUL_2115|M.ulcerans_Agy99 YVQDVLGYSALRAGVGFIPFVIAMGIGLGVS-SQLVSRFSPRVLTIGGGY
MAV_3702|M.avium_104 YVQDILGYSALRAGVGFIPFVIAMGIGLGVS-SQLVARFSPRVLTIAGGY
Mb2871c|M.bovis_AF2122/97 YVQDILGYSALRAGVGFIPFVIAMGIGLGVS-SQLVSRFSPRVLTIGGGY
Rv2846c|M.tuberculosis_H37Rv YVQDILGYSALRAGVGFIPFVIAMGIGLGVS-SQLVSRFSPRVLTIGGGY
MLBr_01562|M.leprae_Br4923 YIQDILGYSALRAGIGFIPFVIAMGIGLGVS-SQLVSRFSPRVLTIGGGW
Mflv_4046|M.gilvum_PYR-GCK YVQDIMGYSALRAGVGFIPFVIALGIGLGVS-SALVSKYPPRVLVIGGGV
Mvan_2306|M.vanbaalenii_PYR-1 YVQDIMGYSALRAGIGFIPFVIALGIGLGLS-SALVSKFPPRVLVIGGGV
TH_2858|M.thermoresistible__bu YVQDIMGYSPLRAGIGFIPFVIALGIGLAAS-SQLVRLFPPRVLVFGGGV
MSMEG_2619|M.smegmatis_MC2_155 YVQDILGYSALRAGVGFIPFVIGMGIGLGAA-SQLVRSIPPRVLVIAGGI
MAB_4500|M.abscessus_ATCC_1997 YLQRCLHLAPLWAGVAFLPFSATVVFASTLGNSFILPRLDGRTVLIAGGV
*:* : :.* **:.*:** : :. . * :: *.: :.**
MMAR_1887|M.marinum_M LLVCAMIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVG
MUL_2115|M.ulcerans_Agy99 LLVCAMIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVG
MAV_3702|M.avium_104 LLVLAMLYGWWCMHRGVPYFPNLVLPIVVGGIGIGMAVVPLTLSAIAGVG
Mb2871c|M.bovis_AF2122/97 LLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVG
Rv2846c|M.tuberculosis_H37Rv LLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVG
MLBr_01562|M.leprae_Br4923 LLMVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVG
Mflv_4046|M.gilvum_PYR-GCK LVLAAMIYG-STLDANIPYFPNLVLPITIGGLGIGMIVVPLMISAIAGVG
Mvan_2306|M.vanbaalenii_PYR-1 LVLAAMIYG-STLDAGIPYFPNLVLPITIGGFGIGMIVVPLMISAIAGVG
TH_2858|M.thermoresistible__bu LVLGAMLYG-STLHADIPYFPNLVVPIVVGGIGIGVIVVPLTVSAIAGVG
MSMEG_2619|M.smegmatis_MC2_155 LVLGAMIYG-STLHRGIPYFPNLVLPITIGGIGIGTIVVPLTLSAIAGVN
MAB_4500|M.abscessus_ATCC_1997 TSAFGLLML-SHIDSHANYYTAILPGLVIGGFGKGLIFGASTHGAATGIR
.:: :. *:. :: :.:**:* * . . .* :*:
MMAR_1887|M.marinum_M FDRIGPVSALTLMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDA
MUL_2115|M.ulcerans_Agy99 FDRIGPVSALTLMLQSLGGPLVLAGIQAVITSRTLYLGGTTGPVKFMNDA
MAV_3702|M.avium_104 FDQIGPVSAVTLMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKTMNDA
Mb2871c|M.bovis_AF2122/97 FDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDV
Rv2846c|M.tuberculosis_H37Rv FDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDV
MLBr_01562|M.leprae_Br4923 FDRIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDA
Mflv_4046|M.gilvum_PYR-GCK FDQIGPVSAIALMLQNLGGPVVLAIIQAVITSRTLYLGGTTGPVKDMNAA
Mvan_2306|M.vanbaalenii_PYR-1 FDQIGPVSAIALMLQNLGGPVVLAVIQAVITSRTLYLGGTTGPVKDMNAA
TH_2858|M.thermoresistible__bu FDQIGPVSAIALMLQNLGGPLVLAVVQAVITSRTLYLGGTTGPVQNMDTA
MSMEG_2619|M.smegmatis_MC2_155 LDRIGPASAIALMLQNLGGPLVLAVIQAVITSRTLFLGGTTGPVKAMNDE
MAB_4500|M.abscessus_ATCC_1997 PEESGIASATVNVMHHVGGSLGAALLSSVVASTATFFLAR-------HAS
:. * .** . ::: :**.: * :.:*::* : :: . .
MMAR_1887|M.marinum_M QLHALDHGYTYGLLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAG
MUL_2115|M.ulcerans_Agy99 QLHALDHGYTYGLLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAG
MAV_3702|M.avium_104 QLQALDHGYTYGLLWVAGAAVIVGAAALFIGYTPEQVAHAQEVKEAMDAG
Mb2871c|M.bovis_AF2122/97 QLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAG
Rv2846c|M.tuberculosis_H37Rv QLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAG
MLBr_01562|M.leprae_Br4923 QLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAG
Mflv_4046|M.gilvum_PYR-GCK QMHALDQGYSYGLLWVAAVAVIVGAVALFIGYTAQQVAHAQEVKDAIDAG
Mvan_2306|M.vanbaalenii_PYR-1 QLHALDQGYSYGLLWVAAVAVIVGGAALFIGYTAEQVAHAQEVKDAIDAG
TH_2858|M.thermoresistible__bu QLHALDQGYTYGLLWVAAVAVLVGGAALFIGYTAKQVAHAQEVKDAIDAG
MSMEG_2619|M.smegmatis_MC2_155 QIGALDAAYTYGLLWVAAVAVLVGAAALFIGYTSQQVAHAQDVKDAMDAG
MAB_4500|M.abscessus_ATCC_1997 SDQAAAAGYSAAFWVSAASCLAAAAIALVIRPADGNSRTAPVLRGKCCTA
. * .*: .: *. : .. *:.* : : * :: :.
MMAR_1887|M.marinum_M EL--------
MUL_2115|M.ulcerans_Agy99 EL--------
MAV_3702|M.avium_104 EL--------
Mb2871c|M.bovis_AF2122/97 EL--------
Rv2846c|M.tuberculosis_H37Rv EL--------
MLBr_01562|M.leprae_Br4923 EL--------
Mflv_4046|M.gilvum_PYR-GCK EL--------
Mvan_2306|M.vanbaalenii_PYR-1 EL--------
TH_2858|M.thermoresistible__bu EL--------
MSMEG_2619|M.smegmatis_MC2_155 EIEVDQPPIG
MAB_4500|M.abscessus_ATCC_1997 RD--------
.