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MSLGVARRIATAGAVVMLAMSSQLATGSMHVMATAHAFAPLPVDPSMLPGPRPPAPIEPTEQKELCRFPG IDPKRDLNKVPTQQRGLDLPLVWQLSRGAGQTVAVIDTGVARSPRLPPLIPGGDYVFEGGNGTQDCDAHG TIVAGIIAAAPDPTGASAFSGIAPDVSLITIRQSSAKFAVKNKGGNDRDDPSKISGVGNVDTLAMAVRTA ADMGATVINISEVACASAKQFLDDRPLGAALQYAVDVKNVVVVVAAGNVGDGQCKSQNPPPDPARPNTPD WDSVLETVSPAWYNDLVLTVGSIGPDGQPSKFSLGGPWVDVSAPGEDIVSLDPNRDALTNAYMGDQGPVP IQGTSFSAPVVSGVVALVRSRFPQLSAREVMDRIKNTAHRPPGGWDPYLGFGVVDALAAVSDDLGTTSDL ARANAAKKLVLPPAPPPPDPRPRRVALIGIAVCAAFLAAALAMLAPVRRLRQSREHPDE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3758 | - | - | 100% (479) | putative protease |
| M. abscessus ATCC 19977 | MAB_2225c | - | 2e-80 | 39.28% (471) | peptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3479 | - | 1e-119 | 52.46% (467) | secreted serine protease |
| M. gilvum PYR-GCK | Mflv_4961 | - | 1e-111 | 51.95% (462) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. tuberculosis H37Rv | Rv3449 | mycP4 | 1e-119 | 52.46% (467) | membrane-anchored mycosin |
| M. leprae Br4923 | MLBr_00041 | - | 1e-91 | 44.67% (441) | putative secreted protease |
| M. marinum M | MMAR_1100 | mycP4 | 1e-115 | 51.81% (469) | membrane-anchored serine protease (mycosin), MycP4 |
| M. avium 104 | MAV_4393 | - | 1e-115 | 54.38% (445) | peptidase |
| M. smegmatis MC2 155 | MSMEG_1533 | - | 1e-114 | 54.38% (445) | subtilase family protein |
| M. thermoresistible (build 8) | TH_3410 | - | 1e-115 | 54.27% (422) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_0858 | mycP4 | 1e-114 | 51.18% (467) | membrane-anchored serine protease (mycosin), MycP4 |
| M. vanbaalenii PYR-1 | Mvan_1445 | - | 1e-112 | 53.72% (443) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1533|M.smegmatis_MC2_155 --------MMVAQRVTATLMTVAVVSLTLVPAPPAAAVTPPTVDDAYLPP
TH_3410|M.thermoresistible__bu -------VVRSAPARLARGLAIAVTASLVGAAPGAHAVTPPPIDHARLPH
Mb3479|M.bovis_AF2122/97 ---------MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPE
Rv3449|M.tuberculosis_H37Rv ---------MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPE
MMAR_1100|M.marinum_M ----------MTSRFGHLLAACALAAPCWCAMPAAHAVTPPPVDERWLPQ
MUL_0858|M.ulcerans_Agy99 ----------MTSRFGHLLAACALAAPCWCAMPAAHAVTPPPVDERWLPQ
MAV_4393|M.avium_104 ---------------MRLLAVSALTMLPVFETPPAHAVSPPAVDDKWLPK
Mflv_4961|M.gilvum_PYR-GCK ----------MT---RTWRVAAVTAIALMHTTPTAAAIGPPPVDTLRLPT
Mvan_1445|M.vanbaalenii_PYR-1 ----------MTGPARPWRVLIVVALLLVYTAPSADAVGPPAVDERLLPA
MAB_3758|M.abscessus_ATCC_1997 MSLGVARRIATAGAVVMLAMSSQLATGSMHVMATAHAFAPLPVDPSMLPG
MLBr_00041|M.leprae_Br4923 ----------------MHRILLMMVALALLYAPPALAINPPSIDPGAVP-
. . * *. * .:* :*
MSMEG_1533|M.smegmatis_MC2_155 AAPPAPPHPTEQRRPCFD-NRGRD----DDETRS--LSPALEPVWRLTRG
TH_3410|M.thermoresistible__bu AGPAAPPQRTEQQGPCLRPAQRRT----GDAVLSGFTAADLAAVWRLTRG
Mb3479|M.bovis_AF2122/97 SALPAPPRPTVQREVCTEVTAESGRAFGRAERSAQLA--DLDQVWRLTRG
Rv3449|M.tuberculosis_H37Rv SALPAPPRPTVQREVCTEVTAESGRAFGRAERSAQLA--DLDQVWRLTRG
MMAR_1100|M.marinum_M PAPPGPPSRTRQREVCAAATWAPE----RPEAAAQLAGLDLPEAWRLTRG
MUL_0858|M.ulcerans_Agy99 PAPPGPPSRTRQREVCAAATWAPE----RPEAAAQLAGLDLPEAWRLTRG
MAV_4393|M.avium_104 PARPAPPWPTAQREVCATLTADSG-----PGRRGPAGGSDLSAVWQLSRG
Mflv_4961|M.gilvum_PYR-GCK ADPPAPAQPTVQFTDCVAAPPAAG------SAPGQLAGMDLPTVWALTRG
Mvan_1445|M.vanbaalenii_PYR-1 PGPVAPAHPTVQHDECVTAPTSPV------DVPGRPHGIDLPSVWALTRG
MAB_3758|M.abscessus_ATCC_1997 PRPPAPIEPTEQKELCRFPGIDPKR--DLNKVPTQQRGLDLPLVWQLSRG
MLBr_00041|M.leprae_Br4923 PDVTGPDQPTEQKVMCSAPTTLPDS--SFHDPPWSNIYIGVSEAHKFATG
. .* * * * : . :: *
MSMEG_1533|M.smegmatis_MC2_155 RGQVVAVIDTGVARHRWLPRLVGGGDYVS-NGDGTADCDGHGTIVAGIIG
TH_3410|M.thermoresistible__bu GGQAVAVIDTGVARHRLLPRVIPGGDFVH-RGDGTDDCDGHGTIVAGLIA
Mb3479|M.bovis_AF2122/97 AGQRVAVIDTGVARHRRLPKVVAGGDYVF-TGDGTADCDAHGTLVAGIIA
Rv3449|M.tuberculosis_H37Rv AGQRVAVIDTGVARHRRLPKVVAGGDYVF-TGDGTADCDAHGTLVAGIIA
MMAR_1100|M.marinum_M SGQRVAVIDTGVAHHRRLAHLVAGGDYVF-TGDGTQDCDAHGTIVAGIIA
MUL_0858|M.ulcerans_Agy99 SGQRVAVIDTGVAHHRRLAHLVAGGDYVF-TGDGTQDCDAHGTIVAGIIA
MAV_4393|M.avium_104 TGQRVAVIDTGVARHRRLPAVVPGGDYVS-TGDGIQDCDAHGTLVAGIIA
Mflv_4961|M.gilvum_PYR-GCK AGQTVAVIDTGTARHRRLPHLVPGGDYVS-HRDGTDDCDGHGTLVAGIIG
Mvan_1445|M.vanbaalenii_PYR-1 AGQTVAVIDTGVARHRRLPHLIAGGDYVS-GQDGTSDCDGHGTIVAGIIG
MAB_3758|M.abscessus_ATCC_1997 AGQTVAVIDTGVARSPRLPPLIPGGDYVFEGGNGTQDCDAHGTIVAGIIA
MLBr_00041|M.leprae_Br4923 AGVTVAVIDTGVEASPRVP-AEPGGDFVDQAGNGLSDCDAHGTLTASIIG
* *******. :. ***:* :* ***.***:.*.:*.
MSMEG_1533|M.smegmatis_MC2_155 GAATP---DGFSGVAPEATILAIRQSSNRF--ADDAGG--------SGVG
TH_3410|M.thermoresistible__bu AAPGDG-RAGFSGIAPESSIIAIRQSSNKFRATDQPSG--------TGYG
Mb3479|M.bovis_AF2122/97 AAPDAQ-SDNFSGVAPDVTLISIRQSSSKFAPVGDPSS--------TGVG
Rv3449|M.tuberculosis_H37Rv AAPDAQ-SDNFSGVAPDVTLISIRQSSSKFAPVGDPSS--------TGVG
MMAR_1100|M.marinum_M AAPDSA-TDQFSGVAPDATVIGIRQSSAKFSPVGNRSS--------TGVG
MUL_0858|M.ulcerans_Agy99 AAPDSA-TDQFSGVAPDATVIGIRQSSAKFSPVGNRSS--------TGVG
MAV_4393|M.avium_104 AAADPK-SDEFSGIAPEATLISIRQSSAKFGPAGNRSG--------GGVG
Mflv_4961|M.gilvum_PYR-GCK ASPDAADPGGFTGIAPDVSLLSIRQSSNKFRAVDDPGG--------SGVG
Mvan_1445|M.vanbaalenii_PYR-1 ASADPADTGGFAGIAPDVSLLSIRQSSNRFRAVDDPGG--------TGVG
MAB_3758|M.abscessus_ATCC_1997 AAPDPTGASAFSGIAPDVSLITIRQSSAKFAVKNKGGNDRDDPSKISGVG
MLBr_00041|M.leprae_Br4923 GRPAPT--DGFIGVAPDVRLLSLRQTSEAFQPVGVQPN-ANDPNAIPAAG
. . * *:**: :: :**:* * . . . *
MSMEG_1533|M.smegmatis_MC2_155 DVGTLAKAVRTAADLGATVINISSVACVDADPDTDTADAGFDDRPLGAAL
TH_3410|M.thermoresistible__bu DVDTLAMAIRTAADLGASVINVSSVACLAATEPPD-------DRALGAAL
Mb3479|M.bovis_AF2122/97 DVDTMAKAVRTAADLGASVINISSIACVPAAAAPD-------DRALGAAL
Rv3449|M.tuberculosis_H37Rv DVDTMAKAVRTAADLGASVINISSIACVPAAAAPD-------DRALGAAL
MMAR_1100|M.marinum_M DVDTMARAVRTAADLGASVINISTIACVAAESPPD-------DRALGAAL
MUL_0858|M.ulcerans_Agy99 DVDTMARAVRTAADLGASVINISTIACVAAESPPD-------DRALGAAL
MAV_4393|M.avium_104 DVDTLAKAVRTAADLGASVINISSVACAPVVSAPD-------DRALGAAL
Mflv_4961|M.gilvum_PYR-GCK DVETLAAAVRTAADLGATVINISTVACLPVAAGLD-------DRTLGAAL
Mvan_1445|M.vanbaalenii_PYR-1 DVETLATAVRTAADLGATVLNISTVACLPVDAGLD-------DRALGAAL
MAB_3758|M.abscessus_ATCC_1997 NVDTLAMAVRTAADMGATVINISEVACASAKQFLD-------DRPLGAAL
MLBr_00041|M.leprae_Br4923 SIRSLARAVVHAANLGASVINISETACYKANKPLD-------ESTLGAAI
.: ::* *: **::**:*:*:* ** . * : .****:
MSMEG_1533|M.smegmatis_MC2_155 AYAVDVKNVVVVAAAGNVG-AGQCRHQNPLD------APGWDDVQSVTSP
TH_3410|M.thermoresistible__bu AYAVDVRNAVVVSAAGNVGGAGQCPHQNPVTG----RRPDWATVRAVVTP
Mb3479|M.bovis_AF2122/97 AYAVDVKNAVIVAAAGNTGGAAQCPPQAPGV--------TRDSVTVAVSP
Rv3449|M.tuberculosis_H37Rv AYAVDVKNAVIVAAAGNTGGAAQCPPQAPGV--------TRDSVTVAVSP
MMAR_1100|M.marinum_M AYAVDVKNAVIVAAAGNTGGAAQCPSQRPET--------SRDTATVVVSP
MUL_0858|M.ulcerans_Agy99 AYAVDVKNAVIVAAAGNTGGAAQCPSQRPET--------SRDTATVVVSP
MAV_4393|M.avium_104 AYAVDVKNAVVVAAAGNTGGPGQCPPQRPDA--------TWQTITVAVSP
Mflv_4961|M.gilvum_PYR-GCK SYAVEAKNVVVVTAAGNVGGPGQCQDPNPRD------VGAADQVRTVASP
Mvan_1445|M.vanbaalenii_PYR-1 AYAVDVKNVVVVTAAGNVGGAGQCTQHNPRR------PADAGAVTMVASP
MAB_3758|M.abscessus_ATCC_1997 QYAVDVKNVVVVVAAGNVG-DGQCKSQNPPPDPARPNTPDWDSVLETVSP
MLBr_00041|M.leprae_Br4923 NYAVNVKGVVIIVAAGNTG--GDCTQNPMPDVSMPNDPRGWSKVQTIATP
***:.:..*:: ****.* .:* .:*
MSMEG_1533|M.smegmatis_MC2_155 GWYDDLVLCVGSVAADGTASSFSLAGPWVDIAAPGEQVVSLHPDGDGLIA
TH_3410|M.thermoresistible__bu AWYDDLVLTVGSVNAEGHPSDFTLAGPWVDVAAPGEDVLSLDPDGEGLVD
Mb3479|M.bovis_AF2122/97 AWYDDYVLTVGSVNAQGEPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVN
Rv3449|M.tuberculosis_H37Rv AWYDDYVLTVGSVNAQGEPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVN
MMAR_1100|M.marinum_M AWYDDYVLTVGSVNANGEPSAFTLPSPWVDVAAGGENVTSLNPVGDGTVN
MUL_0858|M.ulcerans_Agy99 AWYDNYVLTVGSVNANGEPSAFTLPSPWVDVAAGGENVTSLNPVGDGTVN
MAV_4393|M.avium_104 AWYDDYVLTVGSVNADGAPSTFSLAGPWVDVAAPGEAVTSLAP-------
Mflv_4961|M.gilvum_PYR-GCK AWYDDYVLTVGSVGTDGSPSEFSLAGPWVDVAATGEGVVSLAATGDGLAD
Mvan_1445|M.vanbaalenii_PYR-1 AWYDDYVLTVGSIGSDGIASEFSLAGPWVDVAAPGESVVSLAPAGDGLVD
MAB_3758|M.abscessus_ATCC_1997 AWYNDLVLTVGSIGPDGQPSKFSLGGPWVDVSAPGEDIVSLDPNRDALTN
MLBr_00041|M.leprae_Br4923 AWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGE-PVN
.** ** **.: :* .* *:: .***.::* * : :*
MSMEG_1533|M.smegmatis_MC2_155 SL---GADKPISGTSYAAPFVAGVAALVRSRFPHLSAREVMRRIEATAVR
TH_3410|M.thermoresistible__bu ALPGPGGDTPIAGTSYAAPLVAGLAALVRARWPQLTARQVMQRIRDTART
Mb3479|M.bovis_AF2122/97 RLGGQHGSIPISGTSYAAPVVSGLAALIRARFPTLTARQVMQRIESTAHH
Rv3449|M.tuberculosis_H37Rv RLGGQHGSIPISGTSYAAPVVSGLAALIRARFPTLTARQVMQRIESTAHH
MMAR_1100|M.marinum_M GLDDHGGFRPLSGTSYAAPVVSGLAALIRARFPALTARQVMARIISTAHH
MUL_0858|M.ulcerans_Agy99 GLDDHGGFRPLSGTSYAAPVVSGLAALIRARFPALTARQVMARIISTAHH
MAV_4393|M.avium_104 --------EPVSGTSYAAPVVSGLAALIRARFPALTARQVMQRIEATAHH
Mflv_4961|M.gilvum_PYR-GCK RSP---SDAALTGTSYAVPVVSAVAALVRARFPEMTARQVMQRIEDTARP
Mvan_1445|M.vanbaalenii_PYR-1 VAP---SGLPISGTSYAVPVVSAIAALVRARSPGLTARQVMRVIEDTAHP
MAB_3758|M.abscessus_ATCC_1997 AYMGDQGPVPIQGTSFSAPVVSGVVALVRSRFPQLSAREVMDRIKNTAHR
MLBr_00041|M.leprae_Br4923 ALPGEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATARH
.: ***::.. *:.:.**:* * * ::. ::: * **
MSMEG_1533|M.smegmatis_MC2_155 PPRGWDAAVGSGVVDPLAAVSGD-----APALAPPARNTAMVAPPAPSPE
TH_3410|M.thermoresistible__bu PASGWNPLVGHGVIDPLAAVSGDP----APGRPAPAHLTRTLPAPTTPAA
Mb3479|M.bovis_AF2122/97 PPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDPAPVAVPVPRRSTPGP
Rv3449|M.tuberculosis_H37Rv PPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDPAPVAVPVPRRSTPGP
MMAR_1100|M.marinum_M PPHGWDPFVGNGTVDVLAAVSSD--PAVQPAPAQPGSPTPAAPVTTPPAQ
MUL_0858|M.ulcerans_Agy99 PPHGWDPFVGNGTVDVLAAVSSD--PAVQPAPAQPGSPTPAAPVTTPPTQ
MAV_4393|M.avium_104 PPAGWDPLVGHGTVDPLAAVSAE------TGAPPPAPRAAAVPIAAPPPA
Mflv_4961|M.gilvum_PYR-GCK SSAEWDPVVGHGVVDALAAVSGP--------GSHPAALPAAPPVDAPTPA
Mvan_1445|M.vanbaalenii_PYR-1 PPSGWDPVVGHGVVDALAAVTAT--------GSADPVSAGVAPVGPVPPR
MAB_3758|M.abscessus_ATCC_1997 PPGGWDPYLGFGVVDALAAVSDD-----LGTTSDLARANAAKKLVLPPAP
MLBr_00041|M.leprae_Br4923 PGGGVDDIVGAGVIDAVAALTWD----ITPGSASELFNVRSVPPPVITPG
. : :* *.:* :**:: . .
MSMEG_1533|M.smegmatis_MC2_155 DTG---PRRIAFGGGALCVAVA-----------LATVMLSRR---GRQGI
TH_3410|M.thermoresistible__bu DPA---PRRIAFGGALLCLAAXXPLRYRMPGFFTNVISISSRTLGGRSAG
Mb3479|M.bovis_AF2122/97 SDR--RALHTAFAGAAICLLALMATLAT----------ASRRLRPGRNGI
Rv3449|M.tuberculosis_H37Rv SDR--RALHTAFAGAAICLLALMATLAT----------ASRRLRPGRNGI
MMAR_1100|M.marinum_M PDR--RARITALSGSAICLMGLLAALASRA---FGGRSGSRHRRIHRDDV
MUL_0858|M.ulcerans_Agy99 PDR--RARITALSGSAICLMGLLGALASRA---FGGRSGSRHRRIHRDDV
MAV_4393|M.avium_104 PARDSRAPDVAVRGAAFCLVALTLAAAAG--------AVRARLRRTRDGV
Mflv_4961|M.gilvum_PYR-GCK PARVQRQGATAVRGALICVALTVCVALVS----------AVIARSRRHG-
Mvan_1445|M.vanbaalenii_PYR-1 PSES-VSGRTALHAALGCLALTACVAVVS----------TAVRRSGRPGS
MAB_3758|M.abscessus_ATCC_1997 PPPDPRPRRVALIGIAVCAAFLAAALAMLAP--------VRRLRQSREHP
MLBr_00041|M.leprae_Br4923 PDR---NTIMIVAQGILGLSIALGLG------------VLVRRALQRQ--
. *
MSMEG_1533|M.smegmatis_MC2_155 TGD--------------------------
TH_3410|M.thermoresistible__bu SGGGVSLMCFIATVNAPSPVNGRRPDTAS
Mb3479|M.bovis_AF2122/97 AGD--------------------------
Rv3449|M.tuberculosis_H37Rv AGD--------------------------
MMAR_1100|M.marinum_M VGD--------------------------
MUL_0858|M.ulcerans_Agy99 VGD--------------------------
MAV_4393|M.avium_104 AGD--------------------------
Mflv_4961|M.gilvum_PYR-GCK -----------------------------
Mvan_1445|M.vanbaalenii_PYR-1 VAQD-------------------------
MAB_3758|M.abscessus_ATCC_1997 DE---------------------------
MLBr_00041|M.leprae_Br4923 -----------------------------