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DRPIKTRRIKFRYQPGSLERHFVQGDLVSSHMMAMLSAVFPEGEEFFIRSVRRYSDQITDPELKKQVAGF IGQEMTHGREHRELNERLQEMGYPTAFVERLARRIFNFQTRNYPPIYTLAVTAALEHYTAVLAETLLTDQ RALDMLGEGEVRRMLLWHAFEEAEHRSVTFDVYRAVGGSERLRIWVMRRTTIAFIYTTFFETLISLMRDK AAYNPVRLVKSIAALRHLPFLSRTVRRRIGEYNRPGFHPNDSDNTELIEKWHAELFGENGQLAGHLH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3374c | - | - | 100% (278) | hypothetical protein MAB_3374c |
| M. abscessus ATCC 19977 | MAB_3373c | - | 7e-95 | 60.07% (278) | hypothetical protein MAB_3373c |
| M. abscessus ATCC 19977 | MAB_2069 | - | 5e-75 | 49.25% (266) | hypothetical protein MAB_2069 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2799c | - | 4e-22 | 29.70% (266) | hypothetical protein Mb2799c |
| M. gilvum PYR-GCK | Mflv_4629 | - | 1e-75 | 50.75% (266) | metal-dependent hydrolase |
| M. tuberculosis H37Rv | Rv2777c | - | 4e-22 | 29.70% (266) | hypothetical protein Rv2777c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3143 | - | 4e-74 | 49.25% (266) | hypothetical protein MMAR_3143 |
| M. avium 104 | MAV_3671 | - | 2e-19 | 28.36% (268) | FF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3675 | - | 2e-16 | 27.14% (269) | metal-dependent hydrolase |
| M. thermoresistible (build 8) | TH_2221 | - | 1e-15 | 28.73% (181) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_2157 | - | 2e-20 | 28.06% (278) | hypothetical protein MUL_2157 |
| M. vanbaalenii PYR-1 | Mvan_0314 | - | 2e-76 | 50.94% (267) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2799c|M.bovis_AF2122/97 MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
Rv2777c|M.tuberculosis_H37Rv MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
MUL_2157|M.ulcerans_Agy99 --------------------------------------------------
MAV_3671|M.avium_104 --------------------------------------------------
MSMEG_3675|M.smegmatis_MC2_155 --------------------------------------------------
TH_2221|M.thermoresistible__bu --------------------------------------------------
Mflv_4629|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3143|M.marinum_M --------------------------------------------------
MAB_3374c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2799c|M.bovis_AF2122/97 AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTN--LPFHYVPNEP
Rv2777c|M.tuberculosis_H37Rv AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTN--LPFHYVPNEP
MUL_2157|M.ulcerans_Agy99 -MFTVDNRAVGPHSGESGAADHERLVLEARDVEFDWAN--LPFHYVPNEP
MAV_3671|M.avium_104 -MVIIDNQAAGPHDAS---VDHERLVLEARDVDFDWAQ--LPFHYAPGEP
MSMEG_3675|M.smegmatis_MC2_155 -MLRPLRFDH--------EIDPGPVQIQARKVHFDLSD--IPLHWIPGHP
TH_2221|M.thermoresistible__bu -MLRPRRFAT--------EVDPGPVQIQARQVHFDVSG--IPLHWIPGHP
Mflv_4629|M.gilvum_PYR-GCK ------------MSDDSSTRPTTRVVPKPRRVRFDMPAETSRQHFVDGDL
Mvan_0314|M.vanbaalenii_PYR-1 ------------MSDDSSTRPTTRVVPKPRRVRFDMPAGTSRQHFVDGDL
MMAR_3143|M.marinum_M ------------MPEDRAS-TKSRVLPKPRRVRFPMPTSTKRRHFVDGDL
MAB_3374c|M.abscessus_ATCC_199 ---------------------MDRPI-KTRRIKFRYQPGSLERHFVQGDL
:.* : * *: ..
Mb2799c|M.bovis_AF2122/97 MATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMH
Rv2777c|M.tuberculosis_H37Rv MATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMH
MUL_2157|M.ulcerans_Agy99 LPTHVLNVLHLLLPAGEEFFVEVFKKTLPLIKDDQLRLDVQGFIGQEAMH
MAV_3671|M.avium_104 FATHVLNVLHLLLPAGEQFFVEVFKQALPLIRDDQLRLDVQGFIGQEGVH
MSMEG_3675|M.smegmatis_MC2_155 VASTMVNLFNVVLPVAEHWFVDTFNEALPYVRDPKLADDMRGFIGQEATH
TH_2221|M.thermoresistible__bu VASNLISLLNVVLPDAERWFVATFNEALPYVKDPKLADDMRGFIGQEATH
Mflv_4629|M.gilvum_PYR-GCK VMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEATH
Mvan_0314|M.vanbaalenii_PYR-1 VMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEATH
MMAR_3143|M.marinum_M VMSHFISVLSATFPEGEDFFIRSVKYFQSSIDDPQLLTAVKGFIGQEATH
MAB_3374c|M.abscessus_ATCC_199 VSSHMMAMLSAVFPEGEEFFIRSVRRYSDQITDPELKKQVAGFIGQEMTH
. : .: : :* .* :*: .. : * .* : ***.** *
Mb2799c|M.bovis_AF2122/97 SQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLL
Rv2777c|M.tuberculosis_H37Rv SQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLL
MUL_2157|M.ulcerans_Agy99 SQAHSGVLAHFE-AQGVDVTPYTDQIRWLFGKLLAEKPGRNPRQRHRWLL
MAV_3671|M.avium_104 SRAHANVLAHFA-ARGIDLRPYTGQIEWLFGTLLGPRPNWSPRRRQSWLL
MSMEG_3675|M.smegmatis_MC2_155 AETHDKVLEEFLTAHDVHYQPILELVDHVFNTMLAPKPATDPRRRLNDLC
TH_2221|M.thermoresistible__bu ADVHEQVMYDFMVEHGVNPEPILAQIEYMFTKVLTPSTSSDPKRRFNNLC
Mflv_4629|M.gilvum_PYR-GCK RHQHRLLNDRLQ-AMGYPTEGIDRHIKKLVGRLEKRFSP----------K
Mvan_0314|M.vanbaalenii_PYR-1 RHQHRLLNDRLQ-AMGYPTEGIDRHIKKLVGRLEKRFSP----------R
MMAR_3143|M.marinum_M RHQHRLLNERLQ-AMGYPTARIDRHVARLIKRLERRFSP----------E
MAB_3374c|M.abscessus_ATCC_199 GREHRELNERLQ-EMGYPTAFVERLARRIFNFQTRNYPP----------I
* : : . :. .
Mb2799c|M.bovis_AF2122/97 EQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHK
Rv2777c|M.tuberculosis_H37Rv EQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHK
MUL_2157|M.ulcerans_Agy99 EQVSFIAAIEHYTAVLGEWILNSPQLDVVGTDPVMLDMLRWHGAEEVEHK
MAV_3671|M.avium_104 EQISLVSAIEHYTAILGEWILDSPAHDRIGTDPVMLDMLRWHGAEEVEHK
MSMEG_3675|M.smegmatis_MC2_155 DRLWLIAAIEHYTAVLGDFVLN-CAWDDHHADPTLTDLFRWHGAEEVEHR
TH_2221|M.thermoresistible__bu ERLWLIAALEHYTAVLGDFALN-CRWDDHGAHPTMVDLYRWHGAEEVEHR
Mflv_4629|M.gilvum_PYR-GCK MRLAVTAALEHYTATFAEIILTSDEAQELIGYTEVRPILLWHALEECEHK
Mvan_0314|M.vanbaalenii_PYR-1 MRLAVTAALEHYTATFAEIILTSDEAQELIGDTEVRPILLWHALEECEHK
MMAR_3143|M.marinum_M MRLSMTSALEHYTATLAEIILTSDDAQKLIGQTEVRPILLWHAFEESEHK
MAB_3374c|M.abscessus_ATCC_199 YTLAVTAALEHYTAVLAETLLTDQRALDMLGEGEVRRMLLWHAFEEAEHR
: . :*:***** :.: * : : **. ** **:
Mb2799c|M.bovis_AF2122/97 AVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGT
Rv2777c|M.tuberculosis_H37Rv AVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGT
MUL_2157|M.ulcerans_Agy99 AVAFDTMKHLRAGYWRQVRAQLAVTPVMLLLWIRGVRFMYTVDPLLAPGT
MAV_3671|M.avium_104 AVAFDTMKHLRAGYWRQVRTQLVVTPAMLLLWIRGVRFMYSRDPYLPPHT
MSMEG_3675|M.smegmatis_MC2_155 SVAHDVAVYFQDSYLARVRAMTIAATAVYMFFQRGTWAMIRKDPTVDIGW
TH_2221|M.thermoresistible__bu NVAHDVAVYFRDSYVDRIRAMCIAMPLMWAFFERGMWYLVKTDPSVELSW
Mflv_4629|M.gilvum_PYR-GCK AVAFDVYETVGGSERTRVWGMRIASLLLFTELVIQTTRSLAGD----RAA
Mvan_0314|M.vanbaalenii_PYR-1 AVAFDVYETVGGSERTRVWGMRIASLLLFSELVIQTTRSLAGD----RAA
MMAR_3143|M.marinum_M AVAFDAYRLIGGTERTRVRGMRIASAILFGELILQTALSMASD----KAS
MAB_3374c|M.abscessus_ATCC_199 SVTFDVYRAVGGSERLRIWVMRRTTIAFIYTTFFETLISLMRD----KAA
*:.*. . :: . . *
Mb2799c|M.bovis_AF2122/97 KPRWRDYFKAARRGLVPGLPRLLRV-VGHYYKPGFHPSQLGGLGAAVDYL
Rv2777c|M.tuberculosis_H37Rv KPRWRDYFKAARRGLVPGLPRLLRV-VGHYYKPGFHPSQLGGLGAAVDYL
MUL_2157|M.ulcerans_Agy99 KPRWRDYVRSARRGLTPGPWRLIRV-VGDYYKPGFHPSQLGGLERAVDYL
MAV_3671|M.avium_104 KPRWRDYFRAAWRGLVPGPLRFVRA-VANYYRPGFHPSQLGGLQRAVDYL
MSMEG_3675|M.smegmatis_MC2_155 WKMHRLRMRDSKLGLLPKFSTLFGTNTLAYCRPSFTPDQMGSTAQAVAYL
TH_2221|M.thermoresistible__bu WQTQRQRCRDSGLGLLPKWRTLFFTNTLDYFRPGFTPEQMGSTAQAVAYL
Mflv_4629|M.gilvum_PYR-GCK YNPVRLLRSLRAFRHNPLFSRAAIERFRSYTHAGFHPDDWDSAEILERWT
Mvan_0314|M.vanbaalenii_PYR-1 YNPVRLLRSLRAFRHNPLFSSAAIERFRSYSRGGFHPDDWDSAEILECWT
MMAR_3143|M.marinum_M YNPVTLVRSLRRFSRTPMFTADALQRFRSYNRPGFHPDDWDSTAVLERWS
MAB_3374c|M.abscessus_ATCC_199 YNPVRLVKSIAALRHLPFLSRTVRRRIGEYNRPGFHPNDSDNTELIEKWH
* * : .* *.: .. :
Mb2799c|M.bovis_AF2122/97 AVSPAARASH-------
Rv2777c|M.tuberculosis_H37Rv AVSPAARASH-------
MUL_2157|M.ulcerans_Agy99 AVSPAARASH-------
MAV_3671|M.avium_104 AVSPAARASH-------
MSMEG_3675|M.smegmatis_MC2_155 ASSPAARAAHL------
TH_2221|M.thermoresistible__bu ASSPAARSARL------
Mflv_4629|M.gilvum_PYR-GCK KELFDADGGQQLRSNV-
Mvan_0314|M.vanbaalenii_PYR-1 KELFDADGRQQARSSV-
MMAR_3143|M.marinum_M KELFDQDGSQKVIAQPG
MAB_3374c|M.abscessus_ATCC_199 AELFGENGQLAGHLH--
.