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SSEGVGDGAGVNLDLSLRFFSELTGVSDLRHGQFGVGNFFLPNDPASHAEAEQVIEQALRAQGFTILLSR DVPVNNDAIRPAAIKYQLPIRQWVFRSDSERKTHEALMAIESVAYTRPELLGLYPLSLSTRTQVLKGRLN SNEVVPYFSDLSDPRMEVHSMFFHTRFSTNTAPNATMAQPFRLMAHNGELNTDKKNRLSENAIARARNRA IIRPVGQSDSCRLDQTLQSRVLEDDLDLVTAVVAMMPPAWENDTTLSPRVTAMLEYFSLYEEKNDGPAAL IFGDGNIIGARLDRLGLRPLRTVETAEYLGVMSEAGQIYFEPDSVLERGRIEAGGMRYYDHSEGRSYNTV EALEMLAARHDYPAMLAQARVNIADLPHVPPAGQGSPARYDGDLDRHQRYVAYSLNQESFKFLMDPMLAT GQEKISAMGYGAAINALSNQEGGVAKYFSQRFAQVTNPPLDSIREADGMTLRVALGAKPNSGAQPAPQIV VPSPILTHLDMLKIREQGRTPVRRFGMRYRVDLTDAVSNAERIVRAIDDLCDAVEEFARETGGIAVISDR HVSSERAAMPLIIVISAINQRLIEEGLRLRVSLIAESGQLCSSHHVAAVLGFGASAVYPLAVQMRAEEKY GPDVDDAVNAFKHFAKAAEKSLMKTMGRVGLCTVESYIGGEFFEPNYLDTSDPVLRKYFPNVVSPVAGVG FSTLAAAVADWHARALAVTGEKDVPLLGLFKERAEGAGHSYGTTAVRGFVDMTEESISFGDEARPENPDM ADPTYLRLLPLHQLEGAFGLDDEAYRNNSFDELPTRAIDSFDITPGYRNFVRAMNSERTRRPAALRDVLA LPADVNFVRTADEFRREMGQFARLGNNDFQVRGLSCQQTDDVFVLRLAHSPERLAALASSLRTRFGREIT HHEIVGDELRITATGQAADYLAQIRTAPESIPLSSVQPASEITPTLTSGAMSHGALVAPAHEAVAHGTNL VGGLSNCGEGGEHISRYGTIRGSRIKQFASGRFGVWAGYLADPMLQELEIKIGQGAKPGEGGQLPAPKVT VQIAAARGGTPGVELVSPPPHHDTYSIEDLAQLIHDCKAARVRVIVKLVSSEGIGTIAVGVAKAGADVIN VAGNTGGTGAAAVTSLKYAGRSAEIGVAEVHQALCANGIRQKVVLRCSGAHQTASDVVKSALLGADSFEF GTTALMMLKCVMAKNCNIKCPAGLTTNAEVFEGDPRALAQYLLNIAHEVREILAALGMRTLREARGRSDL LHLLDHPSSIGTLDLRRMLAVAEEFVVENPVYMEKDYSVDDAFAAQFDARGAVLKPVTLTNQNKSVGGQL AIDIERSLNYQNIEGPAVATDERGRRYLLPESIAITTTGSAGQSYGVFCNDGMVLTHTGTCNDGVGKSAC GGTITVRSPGGGSSEPGGNVLIGNFALFGASGGRLFVQGQAGDRFAVRNSGATAVVEGTGEFLCEYMTNG AVLNIGDFGKGVANGMSGGFLYQYDPHGQLPSKVSHDSVLVLPITDAPFHEAAAHILLQWHVAATGSTKG QALLDDWQSARDHMVYTMSRALLQYQDSDAILQGKTRKELLDELTAALAGYQVHKFKLSYRDRRDVVGGT VPAYGDTDTEGMYALLNTYTVLNMAQQLALSRMPNVTDVTDPRIGKAVRNLVLTEDFFLIQKLQKYAREA IDGYSDEDLAVLIADKRLTDYKDALSQRNVLSMDSPGTYGWILHQSAKNIDKIGRLPSFEELFAHRALPA VALSGPSLQTT*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2486c | - | - | 100% (1762) | glutamate synthase, large subunit |
M. abscessus ATCC 19977 | MAB_0091 | - | e-126 | 42.99% (649) | putative ferredoxin-dependent glutamate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3889c | gltB | 1e-128 | 41.48% (704) | putative ferredoxin-dependent glutamate synthase |
M. gilvum PYR-GCK | Mflv_1114 | - | 1e-130 | 42.70% (651) | glutamate synthase (ferredoxin) |
M. tuberculosis H37Rv | Rv3859c | gltB | 1e-128 | 41.48% (704) | ferredoxin-dependent glutamate synthase |
M. leprae Br4923 | MLBr_00061 | gltB | 1e-124 | 42.48% (652) | putative ferredoxin-dependent glutamate synthase |
M. marinum M | MMAR_5413 | gltB | 1e-129 | 41.62% (704) | ferredoxin-dependent glutamate synthase |
M. avium 104 | MAV_0166 | - | 1e-128 | 42.66% (647) | ferredoxin-dependent glutamate synthase 1 |
M. smegmatis MC2 155 | MSMEG_6459 | - | 1e-128 | 41.37% (684) | ferredoxin-dependent glutamate synthase 1 |
M. thermoresistible (build 8) | TH_2102 | gltB | 1e-129 | 43.21% (648) | PROBABLE FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE |
M. ulcerans Agy99 | MUL_5037 | gltB | 1e-128 | 41.48% (704) | ferredoxin-dependent glutamate synthase |
M. vanbaalenii PYR-1 | Mvan_5698 | - | 1e-130 | 42.77% (650) | glutamate synthase (ferredoxin) |
CLUSTAL 2.0.9 multiple sequence alignment Mb3889c|M.bovis_AF2122/97 -------------MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDK Rv3859c|M.tuberculosis_H37Rv -------------MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDK MAV_0166|M.avium_104 -----------MHMTPKRAGLYNPAFEHDACGVAMVVDMHGRRSRDIVDK MMAR_5413|M.marinum_M -------------MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDK MUL_5037|M.ulcerans_Agy99 -------------MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDK MLBr_00061|M.leprae_Br4923 -------------MTAKRVGLYNPAFEHDSCGVAMVVDMYGRRTRDIVDK Mflv_1114|M.gilvum_PYR-GCK -------------MAPSRQGLYDPAFEHDSCGVAMVADIHGRRSRDIVEK Mvan_5698|M.vanbaalenii_PYR-1 ----------------------------------MVADMHGRRSRDIVDK MSMEG_6459|M.smegmatis_MC2_155 MGMTPSSFGGSGRSSRDNRGLYNPAYEHDACGVAMVADMHGRRSRDIVDK TH_2102|M.thermoresistible__bu -------------MTPKAQGLYNPAFEHDACGVAMVADMYGRRSRDIVDK MAB_2486c|M.abscessus_ATCC_199 -------------------------------------------------- Mb3889c|M.bovis_AF2122/97 AITALLNLEHRGAQGAEPRSGDGAGILIQVPDEFLREAV----DFELPAP Rv3859c|M.tuberculosis_H37Rv AITALLNLEHRGAQGAEPRSGDGAGILIQVPDEFLREAV----DFELPAP MAV_0166|M.avium_104 AITALLNLEHRGAQGAEPRSGDGAGILIQVPDAFLREVV----DFELPPE MMAR_5413|M.marinum_M AITALLNLEHRGAAGAEPRSGDGAGILIQVPDAFLREVV----DFELPAP MUL_5037|M.ulcerans_Agy99 AITALLNLEHRGAAGAEPRSGDGAGILIQVPDAFLREVV----DFELPAP MLBr_00061|M.leprae_Br4923 AITALLNLEHRGAQGAEPRSGDGAGILIQVPDAFLRAVV----DFELPAA Mflv_1114|M.gilvum_PYR-GCK AITALLNLEHRGAQGAEPNTGDGAGILLQVPDEFFRAVC----GFDLPEP Mvan_5698|M.vanbaalenii_PYR-1 AITALLNLEHRGAQGAEPNTGDGAGILLQVPDEFFRAVCEKE-GFDLPEA MSMEG_6459|M.smegmatis_MC2_155 AITALVNLEHRGAQGAEPNTGDGAGILIQVPDAFLRAVV----DFDLPEP TH_2102|M.thermoresistible__bu AITALLNLEHRGAQGAEPNTGDGAGILLQVPDEFLRAVVEEQGDFELPPP MAB_2486c|M.abscessus_ATCC_199 --------------MSSEGVGDGAGVNLDLSLRFFSELT----GVSDLRH :. *****: :::. *: ... Mb3889c|M.bovis_AF2122/97 GSYATGIAFLPQSSKDAAAACAAVQKIAEAEGLQVLGWRSVPTDDSSLGA Rv3859c|M.tuberculosis_H37Rv GSYATGIAFLPQSSKDAAAACAAVQKIAEAEGLQVLGWRSVPTDDSSLGA MAV_0166|M.avium_104 GSYATGIAFLPQSSKDAATACAAVEKIAEAEGLTVLGWRNVPTDDSSLGA MMAR_5413|M.marinum_M GSYATGIAFLPQSSKDAAAACAAVEKIAEAEGLQVLGWRNVPTDDSSLGA MUL_5037|M.ulcerans_Agy99 GSYATGIAFLPQSSKDAAAACAAVEKIGEAEGLQVLGWRNVPTDDSSLGA MLBr_00061|M.leprae_Br4923 SSYATGIAFLPQSSKDAAAACAAVEKIAVAEGLHVLGWRNVPTDASSLGA Mflv_1114|M.gilvum_PYR-GCK GSFATGIAFLPQSAKDAATACESVEKIAEAEGLRVLGWRDVPTDDSSLGA Mvan_5698|M.vanbaalenii_PYR-1 GSYATGMAFLPQSSKDAAIACAAVEKIAEAEGLQVLGWRDVPTDDSSLGA MSMEG_6459|M.smegmatis_MC2_155 GSYATGMAFLPQSSRDAAAACESVEKIAEAEGLEVLGWREVPTDDSSLGA TH_2102|M.thermoresistible__bu GSYATGIAFLPQSAKDAAQACDAVEKIVEAEGLTVLGWREVPIDDSSLGA MAB_2486c|M.abscessus_ATCC_199 GQFGVGNFFLPNDPASHAEAEQVIEQALRAQGFTILLSRDVPVNNDAIRP ..:..* ***:.. . * * ::: *:*: :* *.** : .:: . Mb3889c|M.bovis_AF2122/97 LSRDAMPTFRQVFLAGASGMALERRCYVVRKRAEHELGTKGPGQDGPGRE Rv3859c|M.tuberculosis_H37Rv LSRDAMPTFRQVFLAGASGMALERRCYVVRKRAEHELGTKGPGQDGPGRE MAV_0166|M.avium_104 LSRDAMPTFRQVFMAGASGMTLERRAYLVRKRAEHELGTKGPGQDGPGRE MMAR_5413|M.marinum_M LSRDAMPTFRQVFLAGASDMTLERRCYVIRKRAEHELGTKGPGQDGPGRE MUL_5037|M.ulcerans_Agy99 LSRDAMPTFRQVFLAGASDMALERRCYVIRKRAEHELGTKGPGQDGPGRE MLBr_00061|M.leprae_Br4923 LSRDAMPTFRQVFMAGATGLTLERRAYVIRKRAEHELGTKGPGQDGPGRE Mflv_1114|M.gilvum_PYR-GCK LARDAMPTFRQVFMAGAEGMDLERRAYVVRKRAEHELGTKGPGQDGPGRE Mvan_5698|M.vanbaalenii_PYR-1 LARDAMPTFRQIFLAGASGMELERRAYVVRKRAEHELGTKGPGQDGPGRE MSMEG_6459|M.smegmatis_MC2_155 LARDAMPTFRQLFLGGASGMELERRAYVVRKRAEHELGTKGPGQDGPGRE TH_2102|M.thermoresistible__bu LARDAMPTFRQLFLGGATGIDLERRAYVVRKRAEHELGTKGPGQDGPGRE MAB_2486c|M.abscessus_ATCC_199 AAIKYQLPIRQWVFRSDS----------ERKTHEALMAIESVAYTRPELL : . .:** .: . ** * :. :. . * Mb3889c|M.bovis_AF2122/97 TVYFPSLSGQTLVYKGMLTTPQLKAFYLDLQDERLTSALGIVHSRFSTNT Rv3859c|M.tuberculosis_H37Rv TVYFPSLSGQTLVYKGMLTTPQLKAFYLDLQDERLTSALGIVHSRFSTNT MAV_0166|M.avium_104 TVYFPSLSGQTFVYKGMLTTPQLKAFYLDLQDDRLTSALGIVHSRFSTNT MMAR_5413|M.marinum_M TVYFPSLSGRTFVYKGMLTTPQLKAFYLDLQDDRLTSALGIVHSRFSTNT MUL_5037|M.ulcerans_Agy99 TVYFPSLSGRTFVYKGMLTTPQLKAFYLDLQDDRLTSALGIVHSRFSTNT MLBr_00061|M.leprae_Br4923 TIYFPSLSSQTFVYKGMLTTPQLKAFYRDLQDERLTSALGIVHSRFSTNT Mflv_1114|M.gilvum_PYR-GCK TVYFPSLSGQTFVYKGMLTTPQLKAFYLDLQDERMTSALGIVHSRFSTNT Mvan_5698|M.vanbaalenii_PYR-1 TVYFPSLSGQTFVYKGMLTTPQLKAFYLDLQDERMTSALGIVHSRFSTNT MSMEG_6459|M.smegmatis_MC2_155 TVYFPSLSGQTFVYKGMLTTPQLKQFYLDLQDERLESALGIVHSRFSTNT TH_2102|M.thermoresistible__bu TVYFPSLSGQTFVYKGMLTTPQLKAFYLDLQDERLTSALAIVHSRFSTNT MAB_2486c|M.abscessus_ATCC_199 GLYPLSLSTRTQVLKGRLNSNEVVPYFSDLSDPRMEVHSMFFHTRFSTNT :* *** :* * ** *.: :: :: **.* *: :.*:****** Mb3889c|M.bovis_AF2122/97 FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDIFGSAADVEKL Rv3859c|M.tuberculosis_H37Rv FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDIFGSAADVEKL MAV_0166|M.avium_104 FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDVFGTEADVEKL MMAR_5413|M.marinum_M FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDVFGTEANVEKL MUL_5037|M.ulcerans_Agy99 FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDVFGTEANVEKL MLBr_00061|M.leprae_Br4923 FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALMKTDIFGSKADMEKL Mflv_1114|M.gilvum_PYR-GCK FPSWPLAHPFRRVAHNGEINTVTGNENWMRAREALIKTDVFGAKADLDKI Mvan_5698|M.vanbaalenii_PYR-1 FPSWPLAHPFRRVAHNGEINTVTGNENWMRAREALIKTDIFGGQ-DLEKV MSMEG_6459|M.smegmatis_MC2_155 FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIRTDVFGSD-GLDKI TH_2102|M.thermoresistible__bu FPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIRTDLFGGQ-DLEKV MAB_2486c|M.abscessus_ATCC_199 APNATMAQPFRLMAHNGELNTDKKNR---------LSENAIARARNRAII *. .:*:*** :*****:** . *. : : :. . : Mb3889c|M.bovis_AF2122/97 FPICTPGASDTARFDEVLELLHLGG-RSLAHAVLMMIPEAWERHESMDPA Rv3859c|M.tuberculosis_H37Rv FPICTPGASDTARFDEVLELLHLGG-RSLAHAVLMMIPEAWERHESMDPA MAV_0166|M.avium_104 FPICTPGASDTARFDEVLELLHLGG-RSLAHAVLMMIPEAWERHESMDPA MMAR_5413|M.marinum_M FPICTPGASDTARFDEVLELLHLGG-RSLAHAVLMMIPEAWERHASMDPS MUL_5037|M.ulcerans_Agy99 FPICTPGASDTARFDEVLELLHLGG-RSLAHAVLMMIPEAWERHASMDPS MLBr_00061|M.leprae_Br4923 FPICTPGASDTARFDEALELLHLGG-RSLVHAVLMMIPEAWERHESMDPA Mflv_1114|M.gilvum_PYR-GCK TPICTPGASDTARFDEVLELLHLGG-RSLPHAVLMMIPEAWERHESMDPA Mvan_5698|M.vanbaalenii_PYR-1 TPICTPGASDTARFDEVLELLHLGG-RSLPHAVLMMIPEAWERHESMDPA MSMEG_6459|M.smegmatis_MC2_155 VPVCTPGASDTARFDEVLELLHLGG-RSLPHAVLMMIPEAWERHEDMDPA TH_2102|M.thermoresistible__bu APICTPGASDTARFDEVLELLHLGG-RSLPHAVLMMIPEAWEQHESMDPA MAB_2486c|M.abscessus_ATCC_199 RPVGQ---SDSCRLDQTLQSRVLEDDLDLVTAVVAMMPPAWENDTTLSPR *: **:.*:*:.*: * . .* **: *:* ***.. :.* Mb3889c|M.bovis_AF2122/97 RRAFYQYHASLMEPWDGPASMTFTDGTVVGAVLDRNGLRPSRIWVTDDGL Rv3859c|M.tuberculosis_H37Rv RRAFYQYHASLMEPWDGPASMTFTDGTVVGAVLDRNGLRPSRIWVTDDGL MAV_0166|M.avium_104 RRAFYQYHASLMEPWDGPASMTFTDGTVIGAVLDRNGLRPSRIWVTEDGL MMAR_5413|M.marinum_M RRAFYQYHSSLMEPWDGPASMTFTDGTIIGAVLDRNGLRPSRIWVTEDGL MUL_5037|M.ulcerans_Agy99 RRAFYQYHSSLMEPWDGPASMTFTDGTMVGAVLDRNGLRPSRIWVTEDGL MLBr_00061|M.leprae_Br4923 RRAFYQYHASLMEPWDGPASMTFTDGVVVGAVLDRNGLRPSRIWITDAGL Mflv_1114|M.gilvum_PYR-GCK RRAFYEFHDSLMEPWDGPAAVCFTDGTVIGAVLDRNGLRPSRIWVTEDGL Mvan_5698|M.vanbaalenii_PYR-1 RRAFYQYHASLMEPWDGPAAVCFTDGTVVGAVLDRNGLRPSRIWVTSDGL MSMEG_6459|M.smegmatis_MC2_155 RRAFYEYHASLMEPWDGPASVCFTDGTVIGAVLDRNGLRPSRIWVTDDGL TH_2102|M.thermoresistible__bu RRAFYEFHDSLMEPWDGPASVCFTDGTVIGAVLDRNGLRPSRIWVTADGL MAB_2486c|M.abscessus_ATCC_199 VTAMLEYFSLYEEKNDGPAALIFGDGNIIGARLDRLGLRPLRTVETAEYL *: ::. * ****:: * ** ::** *** **** * * * Mb3889c|M.bovis_AF2122/97 VVMASEAGVLDLHPSTVVRRMRLQPGRMFLVDTAQGRIVSDEEIKADLAA Rv3859c|M.tuberculosis_H37Rv VVMASEAGVLDLHPSTVVRRMRLQPGRMFLVDTAQGRIVSDEEIKADLAA MAV_0166|M.avium_104 VVMASEAGVLDLDPATVVRRMRLQPGRMFLVDTAQGRIVSDEEIKAELAA MMAR_5413|M.marinum_M VVMASEAGVLDLDPSTVVQRMRLQPGRMFLVDTAQGRIVSDEEIKAELAA MUL_5037|M.ulcerans_Agy99 VVMASEAGVLDLDPSTVVQRMRLQPGRMFLVDTAQGRIVSDEAIKAELAA MLBr_00061|M.leprae_Br4923 VVMASEAGVLDLDPSIVVRRMRLQPGRMFLVDTAQGRIVSDEEIKAKLAA Mflv_1114|M.gilvum_PYR-GCK VVMASEAGVLDLDPSTVVKKMRLQPGRMFLVDTAQGRIVDDEEIKAQLAA Mvan_5698|M.vanbaalenii_PYR-1 VVMASEAGVLDLDPGTVVQKMRLQPGRMFLVDTAQGRIVSDEEIKAELAA MSMEG_6459|M.smegmatis_MC2_155 VVMASEAGVLPLDPAKVVKKMRLQPGRMFLVDTAQGRIVDDEEVKAELAA TH_2102|M.thermoresistible__bu VVMASEAGVLNLDPATVVRKMRLQPGRMFLVDTAQGRIIDDEEIKAELAA MAB_2486c|M.abscessus_ATCC_199 GVMS-EAGQIYFEPDSVLERGRIEAGGMRYYDHSEGRSYNTVEALEMLAA **: *** : :.* *:.: *::.* * * ::** . *** Mb3889c|M.bovis_AF2122/97 EHPYQEWLDNGLVPLDELPEGKDVRMPHHRIVM-------RQLAFGYTYE Rv3859c|M.tuberculosis_H37Rv EHPYQEWLDNGLVPLDELPEGKDVRMPHHRIVM-------RQLAFGYTYE MAV_0166|M.avium_104 EHPYQEWLDRNLVPLDDLPQGDYKRMPHDRLVK-------RQQTFGYTYE MMAR_5413|M.marinum_M EHPYQEWLDNNLVPLEKLPSGEYARMAHERVVL-------RQLVFGYTYE MUL_5037|M.ulcerans_Agy99 EHPYQEWLDNNLVPLEKLPSGEYARMAHERVVL-------RQLVFGYTYE MLBr_00061|M.leprae_Br4923 EHPYQEWLDKGLVPIDELPAGKYVRMPHHRLVM-------RQLAFGYTYE Mflv_1114|M.gilvum_PYR-GCK EHPYQEWLDAGLFQLDELPPGDYVRMPHHRVVL-------RQQIFGYTYE Mvan_5698|M.vanbaalenii_PYR-1 GQPYQEWLDAGLFHLDELPQGDYVRMPHHRVVL-------RQQIFGYTYE MSMEG_6459|M.smegmatis_MC2_155 AEPYQEWLEQGLFHLDELPPGDYVRMPHHRVVL-------RQQIFGYTYE TH_2102|M.thermoresistible__bu EHPYQEWLDAGLFPLDELPQGDYQRMPHHRVVL-------RQRVFGYTSE MAB_2486c|M.abscessus_ATCC_199 RHDYPAMLAQARVNIADLPHVPPAGQGSPARYDGDLDRHQRYVAYSLNQE . * * . : .** * :. . * Mb3889c|M.bovis_AF2122/97 ELNLLVAPMARLGAEPIGSMGTDTPVAVLSQRPRMLYDYFHQLFAQVTNP Rv3859c|M.tuberculosis_H37Rv ELNLLVAPMARLGAEPIGSMGTDTPVAVLSQRPRMLYDYFHQLFAQVTNP MAV_0166|M.avium_104 ELNLLVAPMVRTGAEPIGSMGTDTPVAVLSQRPRMLYDYFQQLFAQVTNP MMAR_5413|M.marinum_M ELNLLVAPMVRTGAEPIGSMGTDTPIAVLSRRPRMLYDYFQQLFAQVTNP MUL_5037|M.ulcerans_Agy99 ELNLLVAPMVRTGAEPIGSMGTDTPIAVLSRRPRMLYDYFQQLFAQVTNP MLBr_00061|M.leprae_Br4923 ELNLLVAPMVRAGSEPIGSMGADTPIAVLSRRPRMLYDYFHQLFAQVTNP Mflv_1114|M.gilvum_PYR-GCK ELNLLVAPMARNGAEALGSMGTDTPIAVLSSRPRMLYDYFQQLFAQVTNP Mvan_5698|M.vanbaalenii_PYR-1 ELNLLVAPMARSGAEALGSMGTDTPIAVLSARPRMLFDYFQQLFAQVTNP MSMEG_6459|M.smegmatis_MC2_155 ELNLLVAPMARTGAEALGSMGTDTPIAVLSARPRMLFDYFQQLFAQVTNP TH_2102|M.thermoresistible__bu ELNLIVGPMARTGAEPLGSMGTDTPIAVLSQRSRLLFDYFQQMFAQVTNP MAB_2486c|M.abscessus_ATCC_199 SFKFLMDPMLATGQEKISAMGYGAAINALSNQEGGVAKYFSQRFAQVTNP .::::: ** * * :.:** .:.: .** : : .** * ******* Mb3889c|M.bovis_AF2122/97 PLDAIREEVVTSLQGTTGGERDLLNPDENSCHQIVLPQPILRNHELAKLV Rv3859c|M.tuberculosis_H37Rv PLDAIREEVVTSLQGTTGGERDLLNPDQNSCHQIVLPQPILRNHELAKLV MAV_0166|M.avium_104 PLDAIREEVVTSLQGTTGGERDLLTPTELSCHQIVLSQPILRNRELAKLV MMAR_5413|M.marinum_M PLDAIREEVVTSLQGTTGGERDLLNPDENSCHQIQLPQPILRNHELAKLI MUL_5037|M.ulcerans_Agy99 PLDAIREEVVTSLQGTTGGERDLLNPDENSCHQIQLPQPILRNHELAKLI MLBr_00061|M.leprae_Br4923 PLDAIREEVVTSLQGTTGGEYDLLSPDENSCHQIWLPQPILRNYELAKLV Mflv_1114|M.gilvum_PYR-GCK PLDAIREEVVTSLQGAMGPEGDLLNPGPESCRQIVLPQPILRNAELSKLI Mvan_5698|M.vanbaalenii_PYR-1 PLDAIREEVVTSLQGTVGPEGDLLNPDAESCRQIVLPNPILRNAELSKLI MSMEG_6459|M.smegmatis_MC2_155 PLDAIREEVVTSLQGTVGPEGDLLNPGPESCRQIVLPQPILRNADLSKLI TH_2102|M.thermoresistible__bu PLDAIREEVITSLQGVIGPEGDLLNPGPESCRQIVLPQPILRNHELAKLI MAB_2486c|M.abscessus_ATCC_199 PLDSIREADGMTLRVALGAKP---NSGAQPAPQIVVPSPILTHLDMLKIR ***:*** :*: . * : .. .. ** :..*** : :: *: Mb3889c|M.bovis_AF2122/97 SLDPNDKVNGRPHGLRSKVIRCLYRVSEGGAGLAAALEEVRGAAAAAIAD Rv3859c|M.tuberculosis_H37Rv SLDPNDKVNGRPHGLRSKVIRCLYRVSEGGAGLAAALEEVRGAAAAAIAD MAV_0166|M.avium_104 NLNPDDEVNGRPHGMRSKVIRCLYPVAEGGAGLAAALEDVRAQASAAIAD MMAR_5413|M.marinum_M NLDPETVINGRPHGLKSKVVRCLYPVAEGGAGLAAALNEVRAQASAAIAD MUL_5037|M.ulcerans_Agy99 NLDPETVINGRPHGLKSKVVRCLYPVAEGGSGLAAALNEVRAQASAAIAD MLBr_00061|M.leprae_Br4923 NLDPADEVNGRPHGMRSTVVSCLYPVADAGAGLAAALTEVRAQASAAIVG Mflv_1114|M.gilvum_PYR-GCK CVDPDHEIRGHKHGMRAAVIRCLYPVNRGGQGLKEALDNVRAKVSSAIRD Mvan_5698|M.vanbaalenii_PYR-1 CVDPDHEIRGHKHGMRAAVIRCLYPVNRGGRGLKEALDNVRAKVSAAIRD MSMEG_6459|M.smegmatis_MC2_155 CVDPDHEIRGHKHGMRAAVIRCLYPVNRGGVGLKEALDNVRAKVSEAIRE TH_2102|M.thermoresistible__bu NVDPDHEVRGRKHGMRAAVVRCLFPVNRGGQGLKEALDRVRAKVSAAIRE MAB_2486c|M.abscessus_ATCC_199 EQG---RTPVRRFGMRYRVD--LTDAVSNAERIVRAIDDLCDAVEEFARE . : .*:: * * . . : *: : . Mb3889c|M.bovis_AF2122/97 GARIIILSDRESDEEMAPIPSLLAVAGVHHHLVRERTRTQVGLVVESGDA Rv3859c|M.tuberculosis_H37Rv GARIIILSDRESDEEMAPIPSLLAVAGVHHHLVRERTRTQVGLVVESGDA MAV_0166|M.avium_104 GARVIILSDRESDEKMAPIPSLLAVAGVHHHLVRDRTRTHVGLVVESGDA MMAR_5413|M.marinum_M GARIIVLSDRESDERMAPIPALLAVAGVHHHLVRERSRTKVGLVVESGDA MUL_5037|M.ulcerans_Agy99 GARIIVLSDRESDERMAPIPALLAVAGVHHHLVRERTRTKVGLVVESGDA MLBr_00061|M.leprae_Br4923 GARVIILSDRNSDEQMAPIPSLLSVAAVHHHLVRDRTRTHVGLVVESGDA Mflv_1114|M.gilvum_PYR-GCK GARIIVLSDRESDEQMAPIPSLLSVSAVHHHLVRERTRTQVGLIVEAGDA Mvan_5698|M.vanbaalenii_PYR-1 GARIIVLSDRESNEQMAPIPSLLSVSAVHHHLVRDRTRTKVGLVVEAGDA MSMEG_6459|M.smegmatis_MC2_155 GARIIVLSDRESNETMAPIPSLLSVAAVHHHLVRERTRTKVGLVVEAGDA TH_2102|M.thermoresistible__bu GARIIVLSDRESDEQLAPIPSLLSVAAVHHHLVRDRTRTQVGLVVEAGDA MAB_2486c|M.abscessus_ATCC_199 TGGIAVISDRHVSSERAAMPLIIVISAINQRLIEEGLRLRVSLIAESGQL . : ::***. .. *.:* :: ::.::::*:.: * :*.*:.*:*: Mb3889c|M.bovis_AF2122/97 REVHHMAALVGFGAAAINPYLVFESIEDMLDRGVIEGIDRTAALNNYIKA Rv3859c|M.tuberculosis_H37Rv REVHHMAALVGFGAAAINPYLVFESIEDMLDRGVIEGIDRTAALNNYIKA MAV_0166|M.avium_104 REVHHMAALVGFGAAAINPYMVFESIEDMLDRGVIEGIDRNTALNNYVKA MMAR_5413|M.marinum_M REVHHMAMLLGCGAAAVNPYLAFESIEDMLDRGVIDGIDRNTALSNYVKA MUL_5037|M.ulcerans_Agy99 REVHHMAMLLGCGAAAVNPYLAFASIEDMLDRGVIDGIDRNTALSNYVKA MLBr_00061|M.leprae_Br4923 REVHHMAALIGFGAAAVNPYLVFESIEEMLDRGVIDGIDRKTALNNYIKA Mflv_1114|M.gilvum_PYR-GCK REVHHMAALCGFGAAAINPYMAFESIEDMVDRGVITDITSDQAKANYVKA Mvan_5698|M.vanbaalenii_PYR-1 REVHHMAALCGFGAAAINPYMAFESIEDMVDRGVISGISSDQAKANYVKA MSMEG_6459|M.smegmatis_MC2_155 REVHHMATLVGFGAAAINPYMAFESIEDMVDRGVITGLTSDQAKANYVKA TH_2102|M.thermoresistible__bu REVHHMAALIGFGASAINPYLAFESIEDMLDRNLLEGLDRETALNNYIKA MAB_2486c|M.abscessus_ATCC_199 CSSHHVAAVLGFGASAVYPLAVQMRAEEKYGPDVDDAVN---AFKHFAKA . **:* : * **:*: * . *: . .: : * :: ** Mb3889c|M.bovis_AF2122/97 AGKGVLKVMSKMGISTLASYTGAQLFQA--VGISEQVLDEYFTGLTCPTG Rv3859c|M.tuberculosis_H37Rv AGKGVLKVMSKMGISTLASYTGAQLFQA--VGISEQVLDEYFTGLTCPTG MAV_0166|M.avium_104 AGKGVLKVMSKMGISTLASYTGAQLFQA--VGISEDVLDEYFTGLSCPIG MMAR_5413|M.marinum_M AGKGVLKVMSKMGISTLASYTGAQLFQA--VGVSEEVLNEYFSGLTCATG MUL_5037|M.ulcerans_Agy99 AGKGVLKVMSKMGISTLASYTGAQLFQA--VGVSEEVLNEYFSGLTCATG MLBr_00061|M.leprae_Br4923 TGQGVLKIMSKMGISTLASYVGAQLFQA--VGISEDVLDEYFSGLSCPTG Mflv_1114|M.gilvum_PYR-GCK AGKGVLKVMSKMGISTLASYTGAQLFQA--IGINQQVLDDYFTGLTCPVG Mvan_5698|M.vanbaalenii_PYR-1 AGKGVLKVMSKMGISTLASYTGAQLFQA--IGISQAVLDEYFAGLSCPVG MSMEG_6459|M.smegmatis_MC2_155 AGKGVLKVMSKMGISTLASYTGAQLFQA--IGISQQVLDEYFTGLSCPVG TH_2102|M.thermoresistible__bu AGKGVLKVMSKMGISTLRSYTGAQLFQA--IGISQEVLDEYFTGLSCPTG MAB_2486c|M.abscessus_ATCC_199 AEKSLMKTMGRVGLCTVESYIGGEFFEPNYLDTSDPVLRKYFPNVVSPVA : :.::* *.::*:.*: ** *.::*:. :. .: ** .**..: .. . Mb3889c|M.bovis_AF2122/97 GITLDDIAADVAARHRLAYLDRPD-------------------------- Rv3859c|M.tuberculosis_H37Rv GITLDDIAADVAARHRLAYLDRPD-------------------------- MAV_0166|M.avium_104 GITLDDIAADVAARHALAYLDRPN-------------------------- MMAR_5413|M.marinum_M GITLDDIAADVATRHTLAYLDRPD-------------------------- MUL_5037|M.ulcerans_Agy99 GITLDDIAADVASRHTLAYLDRPD-------------------------- MLBr_00061|M.leprae_Br4923 GITLDDIAAEVAVRHRVAYLDRPD-------------------------- Mflv_1114|M.gilvum_PYR-GCK GIDLDDIAADIASRHALAYLDRPD-------------------------- Mvan_5698|M.vanbaalenii_PYR-1 GIDLDDIADDVATRHALAYLDRPD-------------------------- MSMEG_6459|M.smegmatis_MC2_155 GIDLEDIAADVAARHSLAFLDRPD-------------------------- TH_2102|M.thermoresistible__bu GIDLDDIAADVARRHELAYLDRPE-------------------------- MAB_2486c|M.abscessus_ATCC_199 GVGFSTLAAAVADWHARALAVTGEKDVPLLGLFKERAEGAGHSYGTTAVR *: :. :* :* * * : Mb3889c|M.bovis_AF2122/97 -------------ERAHRELEVGGEYQWRREGEYHLFN------------ Rv3859c|M.tuberculosis_H37Rv -------------ERAHRELEVGGEYQWRREGEYHLFN------------ MAV_0166|M.avium_104 -------------ERAHRELEVGGEYQWRREGEYHLFN------------ MMAR_5413|M.marinum_M -------------ERAHRELEVGGEYQWRREGEYHLFN------------ MUL_5037|M.ulcerans_Agy99 -------------ERAHRELEVGGEYQWRREGEYHLFN------------ MLBr_00061|M.leprae_Br4923 -------------ERAHRELEVGGEYQWRREGEYHLFN------------ Mflv_1114|M.gilvum_PYR-GCK -------------EWAHRELEVGGEYQWRREGEYHLFN------------ Mvan_5698|M.vanbaalenii_PYR-1 -------------EWAHRELEVGGEYQWRREGEYHLFN------------ MSMEG_6459|M.smegmatis_MC2_155 -------------ERAHRELEVGGEYQWRREGEYHLFN------------ TH_2102|M.thermoresistible__bu -------------EWAHRELEVGGEYQWRREGEYHLFN------------ MAB_2486c|M.abscessus_ATCC_199 GFVDMTEESISFGDEARPENPDMADPTYLRLLPLHQLEGAFGLDDEAYRN : *: * .: : * * :: Mb3889c|M.bovis_AF2122/97 -------------------PETVFKLQHSTRTGQYKIFKEYTRLVDDQ-- Rv3859c|M.tuberculosis_H37Rv -------------------PETVFKLQHSTRTGQYKIFKEYTRLVDDQ-- MAV_0166|M.avium_104 -------------------PETVFKLQHATRTGQYKIFKDYTRLVDDQ-- MMAR_5413|M.marinum_M -------------------PETVFKLQHSTRTGQYKIFKEYTRLVDDQ-- MUL_5037|M.ulcerans_Agy99 -------------------PETVFKLQHSTRTGQYKIFKEYTRLVDDQ-- MLBr_00061|M.leprae_Br4923 -------------------PETVFKLQHATRSGQYKIFKEYTRLVDDQ-- Mflv_1114|M.gilvum_PYR-GCK -------------------PDTVFKLQHSTRTGQYSIFKEYTQLVDDQ-- Mvan_5698|M.vanbaalenii_PYR-1 -------------------PDTVFKLQHSTRTGQYSVFKEYTSLVDDQ-- MSMEG_6459|M.smegmatis_MC2_155 -------------------PDTVFKLQHSTRTGQYSIFKEYTKLVDDQ-- TH_2102|M.thermoresistible__bu -------------------PDTVFKLQHSTRTGQYEIFKEYTRLVDDQ-- MAB_2486c|M.abscessus_ATCC_199 NSFDELPTRAIDSFDITPGYRNFVRAMNSERTRRPAALRDVLALPADVNF ...: :: *: : ::: * * Mb3889c|M.bovis_AF2122/97 -------------------------------------------SERMASL Rv3859c|M.tuberculosis_H37Rv -------------------------------------------SERMASL MAV_0166|M.avium_104 -------------------------------------------SERMASL MMAR_5413|M.marinum_M -------------------------------------------SERMASL MUL_5037|M.ulcerans_Agy99 -------------------------------------------SERMASL MLBr_00061|M.leprae_Br4923 -------------------------------------------SERMASL Mflv_1114|M.gilvum_PYR-GCK -------------------------------------------SERMASL Mvan_5698|M.vanbaalenii_PYR-1 -------------------------------------------SERMASL MSMEG_6459|M.smegmatis_MC2_155 -------------------------------------------SERIASL TH_2102|M.thermoresistible__bu -------------------------------------------SERMASL MAB_2486c|M.abscessus_ATCC_199 VRTADEFRREMGQFARLGNNDFQVRGLSCQQTDDVFVLRLAHSPERLAAL .**:*:* Mb3889c|M.bovis_AF2122/97 RGLLKFRTG------------------------------VRPPVPLDEVE Rv3859c|M.tuberculosis_H37Rv RGLLKFRTG------------------------------VRPPVPLDEVE MAV_0166|M.avium_104 RGLLKFRAG------------------------------VRPPVPLEEVE MMAR_5413|M.marinum_M RGLLKFRAG------------------------------VRPPIPLDEVE MUL_5037|M.ulcerans_Agy99 RGLLKFRAG------------------------------VRPPIPLDEVE MLBr_00061|M.leprae_Br4923 RGLLKFRSG------------------------------VRTPVPLDEVE Mflv_1114|M.gilvum_PYR-GCK RGLLKFRDG------------------------------ERPSVPLDEVE Mvan_5698|M.vanbaalenii_PYR-1 RGLLKFREG------------------------------VRPPVPLEEVE MSMEG_6459|M.smegmatis_MC2_155 RGLLKFREG------------------------------HRPPVPIEEVE TH_2102|M.thermoresistible__bu RGLLKFKEG------------------------------VRPPVPIEEVE MAB_2486c|M.abscessus_ATCC_199 ASSLRTRFGREITHHEIVGDELRITATGQAADYLAQIRTAPESIPLSSVQ . *: : * .:*:..*: Mb3889c|M.bovis_AF2122/97 PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGARSNCGEGGEDVKRF Rv3859c|M.tuberculosis_H37Rv PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGARSNCGEGGEDVKRF MAV_0166|M.avium_104 PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGEDVKRF MMAR_5413|M.marinum_M PASEIVKRFSTGAMSFGSISAEAHETLAIAMNRLGGRSNSGEGGEDVGRF MUL_5037|M.ulcerans_Agy99 PASEIVKRFSTGAMSFGSISAEAHETLAIAMNRLGGRSNSGEGGEDVGRF MLBr_00061|M.leprae_Br4923 PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGEDVNRF Mflv_1114|M.gilvum_PYR-GCK PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGESVSRF Mvan_5698|M.vanbaalenii_PYR-1 PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGESVTRF MSMEG_6459|M.smegmatis_MC2_155 PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGEAVHRF TH_2102|M.thermoresistible__bu PASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGARSNSGEGGEHVSRF MAB_2486c|M.abscessus_ATCC_199 PASEITPTLTSGAMSHGALVAPAHEAVAHGTNLVGGLSNCGEGGEHISRY *****. :::****.*:: * ***::* . * :*. **.***** : *: Mb3889c|M.bovis_AF2122/97 DRDPNGDWRRSAIKQVASARFGVTSHYLTN--CTDLQIKMAQGAKPGEGG Rv3859c|M.tuberculosis_H37Rv DRDPNGDWRRSAIKQVASARFGVTSHYLTN--CTDLQIKMAQGAKPGEGG MAV_0166|M.avium_104 DRDPDGSWRRSAIKQVASGRFGVTSHYLTN--CTDIQIKMAQGAKPGEGG MMAR_5413|M.marinum_M EQDPNGDWRRSAIKQVASARFGVTSHYLTN--CTDIQIKMAQGAKPGEGG MUL_5037|M.ulcerans_Agy99 EQDPNGDWRRSAIKQVASARFGVTSHYLTN--CTDIQIKMAQGAKPGEGG MLBr_00061|M.leprae_Br4923 EPDPNGDWRRSAIKQVASARFGVTSHYLTN--CTDIQIKMAQGAKPGEGG Mflv_1114|M.gilvum_PYR-GCK DRDENGDWRRSAIKQVASGRFGVTSHYLTN--CTDIQIKMAQGAKPGEGG Mvan_5698|M.vanbaalenii_PYR-1 DPDENGDWRRSAIKQVASGRFGVTSHYLAN--CTDIQIKMAQGAKPGEGG MSMEG_6459|M.smegmatis_MC2_155 NPDENGDWRRSAIKQVASGRFGVTSHYLAN--CTDIQIKMAQGAKPGEGG TH_2102|M.thermoresistible__bu DPDDNGDWRRSAIKQVASGRFGVTSHYLTN--CTDIQIKMAQGAKPGEGG MAB_2486c|M.abscessus_ATCC_199 G-----TIRGSRIKQFASGRFGVWAGYLADPMLQELEIKIGQGAKPGEGG * * ***.**.**** : **:: :::**:.********* Mb3889c|M.bovis_AF2122/97 QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP Rv3859c|M.tuberculosis_H37Rv QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MAV_0166|M.avium_104 QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MMAR_5413|M.marinum_M QLPGHKVYPWVAKVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MUL_5037|M.ulcerans_Agy99 QLPGHKVYPWVAKVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MLBr_00061|M.leprae_Br4923 QLPGRKVYPWIAQVRNSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP Mflv_1114|M.gilvum_PYR-GCK QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP Mvan_5698|M.vanbaalenii_PYR-1 QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MSMEG_6459|M.smegmatis_MC2_155 QLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP TH_2102|M.thermoresistible__bu QLPGNKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANP MAB_2486c|M.abscessus_ATCC_199 QLPAPKVTVQIAAARGGTPGVELVSPPPHHDTYSIEDLAQLIHDCKAAR- ***. ** :* .* .**** *:******* ************ * *. Mb3889c|M.bovis_AF2122/97 SARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG Rv3859c|M.tuberculosis_H37Rv SARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG MAV_0166|M.avium_104 AARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG MMAR_5413|M.marinum_M SARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG MUL_5037|M.ulcerans_Agy99 SARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG MLBr_00061|M.leprae_Br4923 SARVHVKLVSENGVGTVAAGVSKAHADVVLVSGHDGGTGATPLTSMKHSG Mflv_1114|M.gilvum_PYR-GCK QARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG Mvan_5698|M.vanbaalenii_PYR-1 QARIHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAG MSMEG_6459|M.smegmatis_MC2_155 AARIHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGASPLTSLKHAG TH_2102|M.thermoresistible__bu QARVHVKLVSEAGVGTVAAGVSKAHADVVLISGHDGGTGASPLTSLKHAG MAB_2486c|M.abscessus_ATCC_199 -VRVIVKLVSSEGIGTIAVGVAKAGADVINVAGNTGGTGAAAVTSLKYAG .*: *****. *:**:*.**:** ***: ::*: *****:.:**:*::* Mb3889c|M.bovis_AF2122/97 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGAEEFGF Rv3859c|M.tuberculosis_H37Rv APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGAEEFGF MAV_0166|M.avium_104 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIAALLGAEEFGF MMAR_5413|M.marinum_M APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGGEEFGF MUL_5037|M.ulcerans_Agy99 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGGEEFGF MLBr_00061|M.leprae_Br4923 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIAALLGAEEFGF Mflv_1114|M.gilvum_PYR-GCK APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVVVAALLGAEEFGF Mvan_5698|M.vanbaalenii_PYR-1 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVVVAALLGAEEFGF MSMEG_6459|M.smegmatis_MC2_155 APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVVIAALLGAEEFGF TH_2102|M.thermoresistible__bu APWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVVIAALLGAEEFGF MAB_2486c|M.abscessus_ATCC_199 RSAEIGVAEVHQALCANGIRQKVVLRCSGAHQTASDVVKSALLGADSFEF . *:*:**.:*:* **:*:::*:: .* :*. **: ::***.:.* * Mb3889c|M.bovis_AF2122/97 ATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRERFTGKPEFVENFFMFI Rv3859c|M.tuberculosis_H37Rv ATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRERFTGKPEFVENFFMFI MAV_0166|M.avium_104 ATAPLVVSGCIMMRVCHLDTCPVGVATQNPVLRERFTGKPEFVENFFMFI MMAR_5413|M.marinum_M ATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRERFNGKPEFVENFFMFI MUL_5037|M.ulcerans_Agy99 ATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRERFNGKPEFVENFFMFI MLBr_00061|M.leprae_Br4923 ATAPLVVAGCIMMRVCHLDTCPVGVATQNPLLRKRFNGKPEFVENFFMFI Mflv_1114|M.gilvum_PYR-GCK ATAPLVVAGCIMMRVCHLDTCPVGVATQNPVLRKRFNGQPEFVENFFMFI Mvan_5698|M.vanbaalenii_PYR-1 ATAPLVVTGCIMMRVCHLDTCPVGVATQNPLLRQRFNGKPEFVENFFMFI MSMEG_6459|M.smegmatis_MC2_155 ATAPLVVSGCIMMRVCHLDTCPVGVATQNPLLRQRFNGKPEFVENFFMFI TH_2102|M.thermoresistible__bu ATAPLVVSGCVMMRVCHLDTCPVGVATQNPVLRQRFTGKPEFVENFFLFI MAB_2486c|M.abscessus_ATCC_199 GTTALMMLKCVMAKNCNIK-CPAGLTTN----AEVFEGDPRALAQYLLNI .*:.*:: *:* : *::. **.*::*: : * *.*. : :::: * Mb3889c|M.bovis_AF2122/97 AEEVREYLAQLGFRTVNEAVGQAGALDTTLARAHWKAHKLDLAPVLHEPE Rv3859c|M.tuberculosis_H37Rv AEEVREYLAQLGFRTVNEAVGQAGALDTTLARAHWKAHKLDLAPVLHEPE MAV_0166|M.avium_104 AEEVREYMAQLGFRTLNEAVGQVKSLDTTLARAHWKAHRLDLGPVLHEPE MMAR_5413|M.marinum_M AEEVREYMAQLGFRTINEAVGQAGALDTTLARAHWKAHRLDLTPVLHEPE MUL_5037|M.ulcerans_Agy99 AEEVREYMAQLGFRTINEAVGQAGALDTTLARAHWKAHRLDLTPVLHEPE MLBr_00061|M.leprae_Br4923 AEEVREYMAQLGFRTFNEAVGQVGALDTTPVREHWKAHSIDLTPVLHEPE Mflv_1114|M.gilvum_PYR-GCK AEEVRELMAELGFRTVNEMVGQVGALDTTQAAERWKAHKLDLTPVLHEPD Mvan_5698|M.vanbaalenii_PYR-1 AEEVRELMAQLGFRTVNEMVGQVGALDTTQAAEHWKAHKLDLAPVLHEPE MSMEG_6459|M.smegmatis_MC2_155 AEEVRELMAQLGFRTVNEMVGQVGALDTTKAAEHWKAHKLDLTPVLHEPD TH_2102|M.thermoresistible__bu AEEVREYMAKMGFRTVNEMVGQVGMLDTTRAAEHWKAHKLDLSPVLHQPE MAB_2486c|M.abscessus_ATCC_199 AHEVREILAALGMRTLREARGRSDLLHLLDHPSSIGTLDLRRMLAVAEEF *.**** :* :*:**..* *: *. : : .: : Mb3889c|M.bovis_AF2122/97 SAFMNQDLYCSSRQDHGLDKALDQQLIVMSREALDSGKPVRFSTTIGNVN Rv3859c|M.tuberculosis_H37Rv SAFMNQDLYCSSRQDHGLDKALDQQLIVMSREALDSGKPVRFSTTIGNVN MAV_0166|M.avium_104 SAFMNQDLYCSSRQDHGLDKALDQQLIVMSREALDSGKPVRFSTTISNVN MMAR_5413|M.marinum_M SAFMNQDLYCSSSQDHGLDKALDQQLIVMSREALDSGKPVRFATTISNVN MUL_5037|M.ulcerans_Agy99 SAFMNQGLYCSSSQDHGLDKALDQQLIVMSREALDSGKPVRFATTISNVN MLBr_00061|M.leprae_Br4923 SAFMNQDLYCSSRQDHGLDKVLDQQLIAVSRDALDFGKPVRFSTTIGNVN Mflv_1114|M.gilvum_PYR-GCK SAFMNQDLYCSSRQDHGLDKALDQQLITQSREAIDNGTPVRFSTTIANVN Mvan_5698|M.vanbaalenii_PYR-1 SAFMNQDLYCSSRQDHGLDKALDQQLIAQCREALDRGTPVRFSTTIANVN MSMEG_6459|M.smegmatis_MC2_155 SAFMNQDLYCSSRQDHGLDKALDQQLIVQSREALDSGTPVRFTAKITNVN TH_2102|M.thermoresistible__bu SAFMNQDLYCSSRQDHGLDKALDQQLITMCREALDNGTPVRFSTTIANVN MAB_2486c|M.abscessus_ATCC_199 VVENPVYMEKDYSVDDAFAAQFDARGAVLKPVTLTNQNKSVGGQLAIDIE . : . *..: :* : . :: . ::: Mb3889c|M.bovis_AF2122/97 RTVGTMLGHELTKAYGGQG---LPDGTIDITFDGSAGNSFGAFVPKGITL Rv3859c|M.tuberculosis_H37Rv RTVGTMLGHELTKAYGGQG---LPDGTIDITFDGSAGNSFGAFVPKGITL MAV_0166|M.avium_104 RTVGTMLGHEVTKAYGGQG---LPDGTIDITFDGSAGNSFGAFVPRGITL MMAR_5413|M.marinum_M RTVGTMLGHEVTKAYGGQG---LPDGSIDITFEGSAGNSFGAFVPKGITL MUL_5037|M.ulcerans_Agy99 RTVGTMLGHEVTKAYGGQG---LPDGSIDITFEGSAGNSFGAFVPKGITL MLBr_00061|M.leprae_Br4923 RTVGTMLGHELTKAYGAQG---LPDGTIDITFEGSAGNSFGAFVPKGITL Mflv_1114|M.gilvum_PYR-GCK RTVGTMLGHEVTKAYGGQG---LPDGTIDITFEGSAGNSFGAFLPKGITL Mvan_5698|M.vanbaalenii_PYR-1 RTVGTMLGHEVTKAYGGQG---LPDGTIDITFEGSAGNSFGAFVPKGITL MSMEG_6459|M.smegmatis_MC2_155 RTVGTMLGHEVTKAYGGQG---LPDGTIDITFEGSAGNSFGAFVPKGITL TH_2102|M.thermoresistible__bu RTVGTMLGHEVTKAYGGQG---LPDGTIDITFDGSAGNSFGAFVPRGITL MAB_2486c|M.abscessus_ATCC_199 RSLNYQNIEGPAVATDERGRRYLLPESIAITTTGSAGQSYGVFCNDGMVL *::. . : * . :* * :* ** ****:*:*.* *:.* Mb3889c|M.bovis_AF2122/97 RVYGDANDYVGKGLSGGRIVVRPSDDAPQDYVAEDNIIGGNVILFGATSG Rv3859c|M.tuberculosis_H37Rv RVYGDANDYVGKGLSGGRIVVRPSDDAPQDYVAEDNIIGGNVILFGATSG MAV_0166|M.avium_104 RVYGDANDYVGKGLSGGRIVVRPSDNAPADYVAEDNIIGGNVILFGATSG MMAR_5413|M.marinum_M RIYGDANDYVGKGLSGGRIVVRPSDNAPPGYVAEDNIIGGNVILFGATSG MUL_5037|M.ulcerans_Agy99 RIYGDANDYVGKGLSGGRIVVRPSDNAPPGYVAEDNIIGGNVILFGATSG MLBr_00061|M.leprae_Br4923 RVYGDANDYVGKGLSGGRIVVRPSDSVPLNYVAEDNIIGGNVILFGATSG Mflv_1114|M.gilvum_PYR-GCK RVYGDANDYVGKGLSGGRVVVRPSDNAPEGYVAEDNIIAGNVVLFGATSG Mvan_5698|M.vanbaalenii_PYR-1 RVYGDANDYVGKGLSGGRVVVRPSDGAPEGYAAEGNIIAGNVVLFGATSG MSMEG_6459|M.smegmatis_MC2_155 RVYGDANDYVGKGLSGGRIVVRPADEAPESFAAEDNIIAGNVVLFGATSG TH_2102|M.thermoresistible__bu RVYGDANDYVGKGLSGGRIVVRPPDNVPESFVAEDNIIAGNVILFGATSG MAB_2486c|M.abscessus_ATCC_199 THTGTCNDGVGKSACGGTITVRSPGGGSS--EPGGNVLIGNFALFGASGG * .** ***. .** :.**... . . .*:: **. ****:.* Mb3889c|M.bovis_AF2122/97 EVYLRGVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGRTGRNFA Rv3859c|M.tuberculosis_H37Rv EVYLRGVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGRTGRNFA MAV_0166|M.avium_104 EAYLRGVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGKVVVLGRTGRNFA MMAR_5413|M.marinum_M EVFLRGVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGQTGRNFA MUL_5037|M.ulcerans_Agy99 EVFLRGVVGERFAVRNSGAHVVVEGVGDHGCEYMTGGRVVILGQTGRNFA MLBr_00061|M.leprae_Br4923 EVYLRGVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGKVVILGRTGRNFA Mflv_1114|M.gilvum_PYR-GCK EMFLRGQVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGPTGRNFA Mvan_5698|M.vanbaalenii_PYR-1 QMFLRGQVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGPTGRNFA MSMEG_6459|M.smegmatis_MC2_155 EAFLRGQVGERFAVRNSGAVAVVEGVGDHGCEYMTGGRVVILGPTGRNFA TH_2102|M.thermoresistible__bu EVFLRGQVGERFAVRNSGALAVVEGVGDHGCEYMTGGRVVILGPVGRNFA MAB_2486c|M.abscessus_ATCC_199 RLFVQGQAGDRFAVRNSGATAVVEGTGEFLCEYMTNGAVLNIGDFGKGVA . :::* .*:********* .****.*:. *****.* *: :* *:..* Mb3889c|M.bovis_AF2122/97 AGMSGGVAYVYDPDGELPANLNSEMVELETLDEDDA---DWLHGTIQVHV Rv3859c|M.tuberculosis_H37Rv AGMSGGVAYVYDPDGELPANLNSEMVELETLDEDDA---DWLHGTIQVHV MAV_0166|M.avium_104 AGMSGGVAYIYDPPGEFPQHLNAEMVELESLDDDDI---EWLHGMIQAHV MMAR_5413|M.marinum_M AGMSGGIAYVYDPDGELPDNLNTEMVDVETLDDDDS---EFVHGIVQAHV MUL_5037|M.ulcerans_Agy99 AGMSGGIAYVYDPDGELPDNLNTEMVDVETLDDDDS---EFVHGIVQAHV MLBr_00061|M.leprae_Br4923 AGMSGGEAYVYDSDGELPANLNFEMVELEPLDFDDA---AWLYATIQAHV Mflv_1114|M.gilvum_PYR-GCK AGMSGGVGYVYDPQDALAGNLNAEMVELESLGDSDSDDAVFVHGMIQAHV Mvan_5698|M.vanbaalenii_PYR-1 AGMSGGIAYVYDPDNTLADNLNAEMVELEGMGGIDSDDAVFVHGIVQEHV MSMEG_6459|M.smegmatis_MC2_155 AGMSGGIAYVYDPRAALPKNLNPEMVEIEALEEADT---EWLRGILASHV TH_2102|M.thermoresistible__bu AGMSGGIAYVYDPDGVLPGRLNREMVELESLDDEDR---EWLRGFIAAHV MAB_2486c|M.abscessus_ATCC_199 NGMSGGFLYQYDPHGQLPSKVSHDSVLVLPITDAPFH-EAAAHILLQWHV ***** * **. :. .:. : * : : : ** Mb3889c|M.bovis_AF2122/97 DATDSAVGQRILSDWSGQQRHFVKVMPRDYKRVLQAIALAERDGVD---V Rv3859c|M.tuberculosis_H37Rv DATDSAVGQRILSDWSGQQRHFVKVMPRDYKRVLQAIALAERDGVD---V MAV_0166|M.avium_104 DATDSAVGQRILGDWAQQQRHFVKVMPRDYKRVLQAIAEAERDGGD---V MMAR_5413|M.marinum_M DATDSAVGQRVLADWPQQQRHFVKVMPRDYKRVLQAIAEAERDGVD---I MUL_5037|M.ulcerans_Agy99 DATDSAVGQRVLADWPQQQRHFVKVMPRDYKRVLQAIAEAERDGVD---I MLBr_00061|M.leprae_Br4923 DATDSAVGQRILAGWSEQQRYFVKVMPKDYKRVLQAIALAERNGVD---V Mflv_1114|M.gilvum_PYR-GCK GATDSAVGQRILADWSGEQVHFKKVMPRDYKRVLEAIAEAERAGADENGV Mvan_5698|M.vanbaalenii_PYR-1 DATDSAVGQRILADWNTELGHFKKVMPRDFKRVLQAIAEAQQSGADENGV MSMEG_6459|M.smegmatis_MC2_155 DATDSAVGQRILADWDNELKHFAKVMPRDYKRVLAAIAEAEAKGLTGSDI TH_2102|M.thermoresistible__bu DATDSAIGQRILNDWDEHVTHFAKVMPRDYKRVLTAIAEAEASGAD---V MAB_2486c|M.abscessus_ATCC_199 AATGSTKGQALLDDWQSARDHMVYTMSRALLQYQDSDAILQGKTRKELLD **.*: ** :* .* :: .*.: : : * : Mb3889c|M.bovis_AF2122/97 DKAIMAAAHG---------------------------------------- Rv3859c|M.tuberculosis_H37Rv DKAIMAAAHG---------------------------------------- MAV_0166|M.avium_104 DKAIMAAAHG---------------------------------------- MMAR_5413|M.marinum_M DKAIMAASHG---------------------------------------- MUL_5037|M.ulcerans_Agy99 DKAIMAASHG---------------------------------------- MLBr_00061|M.leprae_Br4923 NKVIMEPAHG---------------------------------------- Mflv_1114|M.gilvum_PYR-GCK AEAIMAAANG---------------------------------------- Mvan_5698|M.vanbaalenii_PYR-1 AEAIMAAANG---------------------------------------- MSMEG_6459|M.smegmatis_MC2_155 DDAIMAASNG---------------------------------------- TH_2102|M.thermoresistible__bu DEAIMAAANG---------------------------------------- MAB_2486c|M.abscessus_ATCC_199 ELTAALAGYQVHKFKLSYRDRRDVVGGTVPAYGDTDTEGMYALLNTYTVL . .. Mb3889c|M.bovis_AF2122/97 -------------------------------------------------- Rv3859c|M.tuberculosis_H37Rv -------------------------------------------------- MAV_0166|M.avium_104 -------------------------------------------------- MMAR_5413|M.marinum_M -------------------------------------------------- MUL_5037|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00061|M.leprae_Br4923 -------------------------------------------------- Mflv_1114|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5698|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6459|M.smegmatis_MC2_155 -------------------------------------------------- TH_2102|M.thermoresistible__bu -------------------------------------------------- MAB_2486c|M.abscessus_ATCC_199 NMAQQLALSRMPNVTDVTDPRIGKAVRNLVLTEDFFLIQKLQKYAREAID Mb3889c|M.bovis_AF2122/97 -------------------------------------------------- Rv3859c|M.tuberculosis_H37Rv -------------------------------------------------- MAV_0166|M.avium_104 -------------------------------------------------- MMAR_5413|M.marinum_M -------------------------------------------------- MUL_5037|M.ulcerans_Agy99 -------------------------------------------------- MLBr_00061|M.leprae_Br4923 -------------------------------------------------- Mflv_1114|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5698|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6459|M.smegmatis_MC2_155 -------------------------------------------------- TH_2102|M.thermoresistible__bu -------------------------------------------------- MAB_2486c|M.abscessus_ATCC_199 GYSDEDLAVLIADKRLTDYKDALSQRNVLSMDSPGTYGWILHQSAKNIDK Mb3889c|M.bovis_AF2122/97 ----------------------------- Rv3859c|M.tuberculosis_H37Rv ----------------------------- MAV_0166|M.avium_104 ----------------------------- MMAR_5413|M.marinum_M ----------------------------- MUL_5037|M.ulcerans_Agy99 ----------------------------- MLBr_00061|M.leprae_Br4923 ----------------------------- Mflv_1114|M.gilvum_PYR-GCK ----------------------------- Mvan_5698|M.vanbaalenii_PYR-1 ----------------------------- MSMEG_6459|M.smegmatis_MC2_155 ----------------------------- TH_2102|M.thermoresistible__bu ----------------------------- MAB_2486c|M.abscessus_ATCC_199 IGRLPSFEELFAHRALPAVALSGPSLQTT