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MRWSVPLVLGLLLAVIGCQQGIDGEPTAERGAGPSGPIQPAQLDQLLTPALSLAVTPGKPLFETDMQSVL WTGADPAQCQGVVGYGRHPLFPTNYTGREARTQTDNQYPNQHQLLEVSATYPGDFQASKFLESVRATVSA CQRPVAAWGDDEKHHMVTPGPVAPGSPDMVRWSTNLTGDQWICEFTMIAKANVISQLVTCSPDRSIDNQA LSDQRLQKIDELLNSKV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1507 | - | - | 100% (227) | hypothetical protein MAB_1507 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 0.0001 | 23.15% (216) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_3443 | - | 1e-08 | 27.75% (227) | hypothetical protein Mflv_3443 |
| M. tuberculosis H37Rv | Rv1266c | pknH | 6e-05 | 22.64% (212) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4171 | - | 4e-09 | 23.86% (197) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 3e-06 | 21.76% (170) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4018 | - | 5e-15 | 28.00% (225) | PUTATIVE putative hypothetical protein Mflv_3443 |
| M. ulcerans Agy99 | MUL_4150 | lppH | 8e-07 | 23.33% (210) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3880 | - | 1e-05 | 25.48% (208) | hypothetical protein Mvan_3880 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
Mflv_3443|M.gilvum_PYR-GCK --------------------------------------------------
TH_4018|M.thermoresistible__bu --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_1507|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
Mflv_3443|M.gilvum_PYR-GCK ------------------------MTIAA--------RRRTAAAASAVLC
TH_4018|M.thermoresistible__bu ------------------------MRLTP--------TRLTRAGAVAALL
Mvan_3880|M.vanbaalenii_PYR-1 ----------------------------------------MALAGLAVSL
MUL_4150|M.ulcerans_Agy99 ---------------------------------MRQRVAALAALVGGAGM
MAB_1507|M.abscessus_ATCC_1997 -------------------------------------MRWSVPLVLGLLL
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
Mflv_3443|M.gilvum_PYR-GCK TAALLAGCTRLVDDPQARP-QALAAPITELQVVDLLSP-----EVVGED-
TH_4018|M.thermoresistible__bu -AVVACGCTRTLDTATPDPGGPPVAPITAGQVGDLLSP-----EVAGGE-
Mvan_3880|M.vanbaalenii_PYR-1 WATACTSTVDGTAVRPDAAPSAVAGVLTERDLDAVLLDSAEIAALLNSPD
MUL_4150|M.ulcerans_Agy99 LVTGCTNIVDGNAVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
MAB_1507|M.abscessus_ATCC_1997 AVIGCQQGIDGEPTAERGAGPS--GPIQPAQLDQLLTPALSLAVTPGKP-
. . : : :* .
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEP
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEP
MMAR_4171|M.marinum_M IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISGLVASEP
MAV_1417|M.avium_104 MEPGKPITATDSSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNGLVSSEP
Mflv_3443|M.gilvum_PYR-GCK ---GNLFVVAEPQRCAGLAREVDPPLIEAGRPVATDGGHWTSE-------
TH_4018|M.thermoresistible__bu ---GSLFTTVEPEDCAGVAREVDPPFIEDFDPAATTGGHWRDD-------
Mvan_3880|M.vanbaalenii_PYR-1 IEVTDEIDEMTDTSADVSNPECLGALYTAEDPVYESTGYTAVLTRLASEP
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDS
MAB_1507|M.abscessus_ATCC_1997 ---LFETDMQSVLWTGADPAQCQGVVGYGRHPLFPTN-YTGREARTQTDN
:
Mb1297c|M.bovis_AF2122/97 GDNYE---HWVNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKA-
Rv1266c|M.tuberculosis_H37Rv GDNYE---HWVNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKA-
MMAR_4171|M.marinum_M GDNND---HWVNQAVVSFPSAAKASSFVETMAGKWKNCAGKTVTVTNKS-
MAV_1417|M.avium_104 GDNYD---HWVNQAVVLFPSADKAKSFLQTSLQKWKGCAGQTVTVTNKS-
Mflv_3443|M.gilvum_PYR-GCK -DGR----FYIEEMVAVYLSDFDAEGALRSARATVDECLGSRLSVTTMRD
TH_4018|M.thermoresistible__bu -VGGG---VVIEEMVGVYRADFDPQEALARARQTIDSCRDVPITVTAMSG
Mvan_3880|M.vanbaalenii_PYR-1 GDDNE---HWVEESAVLVPTAEDAEQFVERSAREWDDCAGRQVSISDGE-
MUL_4150|M.ulcerans_Agy99 VDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQ
MAB_1507|M.abscessus_ATCC_1997 QYPNQ---HQLLEVSATYPGDFQASKFLESVRATVSACQR-PVAAWGDDE
: .. * .:
Mb1297c|M.bovis_AF2122/97 KTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGY
Rv1266c|M.tuberculosis_H37Rv KTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGY
MMAR_4171|M.marinum_M KTYRWTFAQVVGSPPRITMLETQEGAEGWECQRAMSVANNVIVDINSCGY
MAV_1417|M.avium_104 KTYRWTFAQVQGAPPKITLMDTQEGADGWECQRALSVANNVIVDINACGY
Mflv_3443|M.gilvum_PYR-GCK RVYDFEVAPGAE-GPDGSVLWSLR-AVDWNCDNLFVAAYNAAVEITTCGA
TH_4018|M.thermoresistible__bu DTYDFRLLPPVDSGSPDILVWAFR-ADNWACDNTLVAAHNAAVEITTCSR
Mvan_3880|M.vanbaalenii_PYR-1 EWFDWELDAVVRDGGMVSQQSTILDSIDWQCQHTVVSVSNLIIEASVCAE
MUL_4150|M.ulcerans_Agy99 PDTIWTVSDVVNDNGMLSTSQVQEAGDGWTCQRALTVRNNVAIDVVTCAY
MAB_1507|M.abscessus_ATCC_1997 KHHMVTPGPVAPGSPDMVRWSTNLTGDQWICEFTMIAKANVISQLVTCSP
. * *: . * : *.
Mb1297c|M.bovis_AF2122/97 QITNQAGQIAAKIVDKVNKE-----
Rv1266c|M.tuberculosis_H37Rv RITNQAGQIAAKIVDKVNKE-----
MMAR_4171|M.marinum_M HITDQGGALADKIVDKIHKETKY--
MAV_1417|M.avium_104 RITDQGDQIADKIVAKIDNE-----
Mflv_3443|M.gilvum_PYR-GCK APGFDVAALAADALERIRRLADTTA
TH_4018|M.thermoresistible__bu TGGYDVLSLAQQALKRIEALANTTV
Mvan_3880|M.vanbaalenii_PYR-1 RIHDEATTVVAEMIAKASARTR---
MUL_4150|M.ulcerans_Agy99 SQSGSVAADVAQQIAAKAAKQ----
MAB_1507|M.abscessus_ATCC_1997 DRSIDNQALSDQRLQKIDELLNSKV
. . :